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10 Years of GWAS Discovery: Biology, Function, and Translation.

American journal of human genetics

Visscher PM, Wray NR, Zhang Q, Sklar P, McCarthy MI, Brown MA, Yang J.
PMID: 28686856
Am J Hum Genet. 2017 Jul 06;101(1):5-22. doi: 10.1016/j.ajhg.2017.06.005.

Application of the experimental design of genome-wide association studies (GWASs) is now 10 years old (young), and here we review the remarkable range of discoveries it has facilitated in population and complex-trait genetics, the biology of diseases, and translation...

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Visscher PM, Wray NR, Zhang Q, et al. 10 Years of GWAS Discovery: Biology, Function, and Translation. Am J Hum Genet. 2017;101(1):5-22doi: 10.1016/j.ajhg.2017.06.005.
Visscher, P. M., Wray, N. R., Zhang, Q., Sklar, P., McCarthy, M. I., Brown, M. A., & Yang, J. (2017). 10 Years of GWAS Discovery: Biology, Function, and Translation. American journal of human genetics, 101(1), 5-22. https://doi.org/10.1016/j.ajhg.2017.06.005
Visscher, Peter M, et al. "10 Years of GWAS Discovery: Biology, Function, and Translation." American journal of human genetics vol. 101,1 (2017): 5-22. doi: https://doi.org/10.1016/j.ajhg.2017.06.005
Visscher PM, Wray NR, Zhang Q, Sklar P, McCarthy MI, Brown MA, Yang J. 10 Years of GWAS Discovery: Biology, Function, and Translation. Am J Hum Genet. 2017 Jul 06;101(1):5-22. doi: 10.1016/j.ajhg.2017.06.005. PMID: 28686856; PMCID: PMC5501872.
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Facial averageness and genetic quality: Testing heritability, genetic correlation with attractiveness, and the paternal age effect.

Evolution and human behavior : official journal of the Human Behavior and Evolution Society

Lee AJ, Mitchem DG, Wright MJ, Martin NG, Keller MC, Zietsch BP.
PMID: 26858521
Evol Hum Behav. 2016 Jan 01;37(1):61-66. doi: 10.1016/j.evolhumbehav.2015.08.003. Epub 2015 Aug 28.

Popular theory suggests that facial averageness is preferred in a partner for genetic benefits to offspring. However, whether facial averageness is associated with genetic quality is yet to be established. Here, we computed an objective measure of facial averageness...

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Lee AJ, Mitchem DG, Wright MJ, et al. Facial averageness and genetic quality: Testing heritability, genetic correlation with attractiveness, and the paternal age effect. Evol Hum Behav. 2015;37(1):61-66doi: 10.1016/j.evolhumbehav.2015.08.003.
Lee, A. J., Mitchem, D. G., Wright, M. J., Martin, N. G., Keller, M. C., & Zietsch, B. P. (2016). Facial averageness and genetic quality: Testing heritability, genetic correlation with attractiveness, and the paternal age effect. Evolution and human behavior : official journal of the Human Behavior and Evolution Society, 37(1), 61-66. https://doi.org/10.1016/j.evolhumbehav.2015.08.003
Lee, Anthony J, et al. "Facial averageness and genetic quality: Testing heritability, genetic correlation with attractiveness, and the paternal age effect." Evolution and human behavior : official journal of the Human Behavior and Evolution Society vol. 37,1 (2016): 61-66. doi: https://doi.org/10.1016/j.evolhumbehav.2015.08.003
Lee AJ, Mitchem DG, Wright MJ, Martin NG, Keller MC, Zietsch BP. Facial averageness and genetic quality: Testing heritability, genetic correlation with attractiveness, and the paternal age effect. Evol Hum Behav. 2016 Jan 01;37(1):61-66. doi: 10.1016/j.evolhumbehav.2015.08.003. Epub 2015 Aug 28. PMID: 26858521; PMCID: PMC4743547.
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Novel characterization of the multivariate genetic architecture of internalizing psychopathology and alcohol use.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

Colbert SMC, Funkhouser SA, Johnson EC, Morrison CL, Hoeffer CA, Friedman NP, Ehringer MA, Evans LM.
PMID: 34569141
Am J Med Genet B Neuropsychiatr Genet. 2021 Sep;186(6):353-366. doi: 10.1002/ajmg.b.32874. Epub 2021 Sep 27.

Genetic correlations suggest that the genetic relationship of alcohol use with internalizing psychopathology depends on the measure of alcohol use. Problematic alcohol use (PAU) is positively genetically correlated with internalizing psychopathology, whereas alcohol consumption ranges from not significantly correlated...

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Colbert SMC, Funkhouser SA, Johnson EC, et al. Novel characterization of the multivariate genetic architecture of internalizing psychopathology and alcohol use. Am J Med Genet B Neuropsychiatr Genet. 2021;186(6):353-366doi: 10.1002/ajmg.b.32874.
Colbert, S. M. C., Funkhouser, S. A., Johnson, E. C., Morrison, C. L., Hoeffer, C. A., Friedman, N. P., Ehringer, M. A., & Evans, L. M. (2021). Novel characterization of the multivariate genetic architecture of internalizing psychopathology and alcohol use. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 186(6), 353-366. https://doi.org/10.1002/ajmg.b.32874
Colbert, Sarah M C, et al. "Novel characterization of the multivariate genetic architecture of internalizing psychopathology and alcohol use." American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics vol. 186,6 (2021): 353-366. doi: https://doi.org/10.1002/ajmg.b.32874
Colbert SMC, Funkhouser SA, Johnson EC, Morrison CL, Hoeffer CA, Friedman NP, Ehringer MA, Evans LM. Novel characterization of the multivariate genetic architecture of internalizing psychopathology and alcohol use. Am J Med Genet B Neuropsychiatr Genet. 2021 Sep;186(6):353-366. doi: 10.1002/ajmg.b.32874. Epub 2021 Sep 27. PMID: 34569141; PMCID: PMC8556277.
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Novel Approach for Parallelizing Pairwise Comparison Problems as Applied to Detecting Segments Identical By Decent in Whole-Genome Data.

Bioinformatics (Oxford, England)

Sapin E, Keller MC.
PMID: 33705528
Bioinformatics. 2021 Mar 10; doi: 10.1093/bioinformatics/btab084. Epub 2021 Mar 10.

MOTIVATION: Pairwise comparison problems arise in many areas of science. In genomics, datasets are already large and getting larger, and so operations that require pairwise comparisons-either on pairs of SNPs or pairs of individuals-are extremely computationally challenging. We propose...

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Sapin E, Keller MC. Novel Approach for Parallelizing Pairwise Comparison Problems as Applied to Detecting Segments Identical By Decent in Whole-Genome Data. Bioinformatics. 2021;doi: 10.1093/bioinformatics/btab084.
Sapin, E., & Keller, M. C. (2021). Novel Approach for Parallelizing Pairwise Comparison Problems as Applied to Detecting Segments Identical By Decent in Whole-Genome Data. Bioinformatics (Oxford, England), . https://doi.org/10.1093/bioinformatics/btab084
Sapin, Emmanuel, and Keller, Matthew C. "Novel Approach for Parallelizing Pairwise Comparison Problems as Applied to Detecting Segments Identical By Decent in Whole-Genome Data." Bioinformatics (Oxford, England) vol. (2021). doi: https://doi.org/10.1093/bioinformatics/btab084
Sapin E, Keller MC. Novel Approach for Parallelizing Pairwise Comparison Problems as Applied to Detecting Segments Identical By Decent in Whole-Genome Data. Bioinformatics. 2021 Mar 10; doi: 10.1093/bioinformatics/btab084. Epub 2021 Mar 10. PMID: 33705528; PMCID: PMC8352502.
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Association of Antihypertensive Drug Target Genes With Psychiatric Disorders: A Mendelian Randomization Study.

JAMA psychiatry

Chauquet S, Zhu Z, O'Donovan MC, Walters JTR, Wray NR, Shah S.
PMID: 33688928
JAMA Psychiatry. 2021 Jun 01;78(6):623-631. doi: 10.1001/jamapsychiatry.2021.0005.

IMPORTANCE: Observational studies have reported associations between antihypertensive medication and psychiatric disorders, although the reported direction of association appears to be dependent on drug class.OBJECTIVE: To estimate the potential effect of different antihypertensive drug classes on schizophrenia, bipolar disorder,...

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Chauquet S, Zhu Z, O'Donovan MC, et al. Association of Antihypertensive Drug Target Genes With Psychiatric Disorders: A Mendelian Randomization Study. JAMA Psychiatry. 2021;78(6):623-631doi: 10.1001/jamapsychiatry.2021.0005.
Chauquet, S., Zhu, Z., O'Donovan, M. C., Walters, J. T. R., Wray, N. R., & Shah, S. (2021). Association of Antihypertensive Drug Target Genes With Psychiatric Disorders: A Mendelian Randomization Study. JAMA psychiatry, 78(6), 623-631. https://doi.org/10.1001/jamapsychiatry.2021.0005
Chauquet, Solal, et al. "Association of Antihypertensive Drug Target Genes With Psychiatric Disorders: A Mendelian Randomization Study." JAMA psychiatry vol. 78,6 (2021): 623-631. doi: https://doi.org/10.1001/jamapsychiatry.2021.0005
Chauquet S, Zhu Z, O'Donovan MC, Walters JTR, Wray NR, Shah S. Association of Antihypertensive Drug Target Genes With Psychiatric Disorders: A Mendelian Randomization Study. JAMA Psychiatry. 2021 Jun 01;78(6):623-631. doi: 10.1001/jamapsychiatry.2021.0005. PMID: 33688928; PMCID: PMC7948097.
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A test of the facultative calibration/reactive heritability model of extraversion.

Evolution and human behavior : official journal of the Human Behavior and Evolution Society

Haysom HJ, Mitchem DG, Lee AJ, Wright MJ, Martin NG, Keller MC, Zietsch BP.
PMID: 26880866
Evol Hum Behav. 2015 Sep;36(5):414-419. doi: 10.1016/j.evolhumbehav.2015.03.002.

A model proposed by Lukaszewski and Roney (2011) suggests that each individual's level of extraversion is calibrated to other traits that predict the success of an extraverted behavioural strategy. Under 'facultative calibration', extraversion is not directly heritable, but rather...

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Haysom HJ, Mitchem DG, Lee AJ, et al. A test of the facultative calibration/reactive heritability model of extraversion. Evol Hum Behav. 2015;36(5):414-419doi: 10.1016/j.evolhumbehav.2015.03.002.
Haysom, H. J., Mitchem, D. G., Lee, A. J., Wright, M. J., Martin, N. G., Keller, M. C., & Zietsch, B. P. (2015). A test of the facultative calibration/reactive heritability model of extraversion. Evolution and human behavior : official journal of the Human Behavior and Evolution Society, 36(5), 414-419. https://doi.org/10.1016/j.evolhumbehav.2015.03.002
Haysom, Hannah J, et al. "A test of the facultative calibration/reactive heritability model of extraversion." Evolution and human behavior : official journal of the Human Behavior and Evolution Society vol. 36,5 (2015): 414-419. doi: https://doi.org/10.1016/j.evolhumbehav.2015.03.002
Haysom HJ, Mitchem DG, Lee AJ, Wright MJ, Martin NG, Keller MC, Zietsch BP. A test of the facultative calibration/reactive heritability model of extraversion. Evol Hum Behav. 2015 Sep;36(5):414-419. doi: 10.1016/j.evolhumbehav.2015.03.002. PMID: 26880866; PMCID: PMC4752124.
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Evolutionary behavioral genetics.

Current opinion in behavioral sciences

Zietsch BP, de Candia TR, Keller MC.
PMID: 25587556
Curr Opin Behav Sci. 2015 Apr;2:73-80. doi: 10.1016/j.cobeha.2014.09.005.

We describe the scientific enterprise at the intersection of evolutionary psychology and behavioral genetics-a field that could be termed

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Zietsch BP, de Candia TR, Keller MC. Evolutionary behavioral genetics. Curr Opin Behav Sci. 2015;2:73-80doi: 10.1016/j.cobeha.2014.09.005.
Zietsch, B. P., de Candia, T. R., & Keller, M. C. (2015). Evolutionary behavioral genetics. Current opinion in behavioral sciences, 273-80. https://doi.org/10.1016/j.cobeha.2014.09.005
Zietsch, Brendan P, et al. "Evolutionary behavioral genetics." Current opinion in behavioral sciences vol. 2 (2015): 73-80. doi: https://doi.org/10.1016/j.cobeha.2014.09.005
Zietsch BP, de Candia TR, Keller MC. Evolutionary behavioral genetics. Curr Opin Behav Sci. 2015 Apr;2:73-80. doi: 10.1016/j.cobeha.2014.09.005. PMID: 25587556; PMCID: PMC4288764.
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Showing 1 to 7 of 7 entries