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Visscher PM, Wray NR, Zhang Q, et al. 10 Years of GWAS Discovery: Biology, Function, and Translation. Am J Hum Genet. 2017;101(1):5-22doi: 10.1016/j.ajhg.2017.06.005.
Visscher, P. M., Wray, N. R., Zhang, Q., Sklar, P., McCarthy, M. I., Brown, M. A., & Yang, J. (2017). 10 Years of GWAS Discovery: Biology, Function, and Translation. American journal of human genetics, 101(1), 5-22. https://doi.org/10.1016/j.ajhg.2017.06.005
Visscher, Peter M, et al. "10 Years of GWAS Discovery: Biology, Function, and Translation." American journal of human genetics vol. 101,1 (2017): 5-22. doi: https://doi.org/10.1016/j.ajhg.2017.06.005
Visscher PM, Wray NR, Zhang Q, Sklar P, McCarthy MI, Brown MA, Yang J. 10 Years of GWAS Discovery: Biology, Function, and Translation. Am J Hum Genet. 2017 Jul 06;101(1):5-22. doi: 10.1016/j.ajhg.2017.06.005. PMID: 28686856; PMCID: PMC5501872.
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Am J Hum Genet. 2017 Jul 06;101(1):5-22. doi: 10.1016/j.ajhg.2017.06.005.

10 Years of GWAS Discovery: Biology, Function, and Translation.

American journal of human genetics

Peter M Visscher, Naomi R Wray, Qian Zhang, Pamela Sklar, Mark I McCarthy, Matthew A Brown, Jian Yang

Affiliations

  1. Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia; Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia. Electronic address: [email protected].
  2. Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia; Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia.
  3. Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia.
  4. Departments of Genetics and Genomic Sciences and Psychiatry, Icahn School of Medicine at Mount Sinai, NY, NY 10029, USA.
  5. Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, UK; Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK; Oxford NIHR Biomedical Research Centre, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, UK.
  6. Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia.

PMID: 28686856 PMCID: PMC5501872 DOI: 10.1016/j.ajhg.2017.06.005

Abstract

Application of the experimental design of genome-wide association studies (GWASs) is now 10 years old (young), and here we review the remarkable range of discoveries it has facilitated in population and complex-trait genetics, the biology of diseases, and translation toward new therapeutics. We predict the likely discoveries in the next 10 years, when GWASs will be based on millions of samples with array data imputed to a large fully sequenced reference panel and on hundreds of thousands of samples with whole-genome sequencing data.

Copyright © 2017 American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

Keywords: SNP; auto-immune disease; genome-wide association study; heritability; obesity; schizophrenia

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