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The role of material deprivation and consumerism in the decisions to engage in transactional sex among young people in the urban slums of Blantyre, Malawi.

Global public health

Kamndaya M, Vearey J, Thomas L, Kabiru CW, Kazembe LN.
PMID: 25741631
Glob Public Health. 2016 Mar;11(3):295-308. doi: 10.1080/17441692.2015.1014393. Epub 2015 Mar 05.

Transactional sex has been associated with a high risk of HIV acquisition and unintended pregnancy among young women in urban slums in sub-Saharan Africa. However, few studies have explored the structural drivers of transactional sex from the perspective of...

Identification of Non-Coding RNAs in the Candida parapsilosis Species Group.

PloS one

Donovan PD, Schröder MS, Higgins DG, Butler G.
PMID: 27658249
PLoS One. 2016 Sep 22;11(9):e0163235. doi: 10.1371/journal.pone.0163235. eCollection 2016.

The Candida CTG clade is a monophyletic group of fungal species that translates CTG as serine, and includes the pathogens Candida albicans and Candida parapsilosis. Research has typically focused on identifying protein-coding genes in these species. Here, we use...

Spatial Localization and Quantitation of Androgens in Mouse Testis by Mass Spectrometry Imaging.

Analytical chemistry

Cobice DF, Livingstone DE, Mackay CL, Goodwin RJ, Smith LB, Walker BR, Andrew R.
PMID: 27676129
Anal Chem. 2016 Nov 01;88(21):10362-10367. doi: 10.1021/acs.analchem.6b02242. Epub 2016 Oct 14.

Androgens are essential for male development and reproductive function. They are transported to their site of action as blood-borne endocrine hormones but can also be produced within tissues to act in intracrine and paracrine fashions. Because of this, circulating...

No evidence for clonal transmission of urogenital carcinoma in California sea lions ( .

Wellcome open research

Ní Leathlobhair M, Gulland FMD, Murchison EP.
PMID: 28948233
Wellcome Open Res. 2017 Jun 22;2:46. doi: 10.12688/wellcomeopenres.11483.1. eCollection 2017.

Urogenital carcinoma is a highly metastatic cancer affecting California sea lions (

A Chemical Probe for the ATAD2 Bromodomain.

Angewandte Chemie (International ed. in English)

Bamborough P, Chung CW, Demont EH, Furze RC, Bannister AJ, Che KH, Diallo H, Douault C, Grandi P, Kouzarides T, Michon AM, Mitchell DJ, Prinjha RK, Rau C, Robson S, Sheppard RJ, Upton R, Watson RJ.
PMID: 27530368
Angew Chem Int Ed Engl. 2016 Sep 12;55(38):11382-6. doi: 10.1002/anie.201603928. Epub 2016 Aug 17.

ATAD2 is a cancer-associated protein whose bromodomain has been described as among the least druggable of that target class. Starting from a potent lead, permeability and selectivity were improved through a dual approach: 1) using CF2 as a sulfone...

Fast Virtual Fractional Flow Reserve Based Upon Steady-State Computational Fluid Dynamics Analysis: Results From the VIRTU-Fast Study.

JACC. Basic to translational science

Morris PD, Silva Soto DA, Feher JFA, Rafiroiu D, Lungu A, Varma S, Lawford PV, Hose DR, Gunn JP.
PMID: 28920099
JACC Basic Transl Sci. 2017 Aug 28;2(4):434-446. doi: 10.1016/j.jacbts.2017.04.003. eCollection 2017 Aug.

Fractional flow reserve (FFR)-guided percutaneous intervention is superior to standard assessment but remains underused. The authors have developed a novel "pseudotransient" analysis protocol for computing virtual fractional flow reserve (vFFR) based upon angiographic images and steady-state computational fluid dynamics....

NMR-filtered virtual screening leads to non-metal chelating metallo-β-lactamase inhibitors.

Chemical science

Li GB, Abboud MI, Brem J, Someya H, Lohans CT, Yang SY, Spencer J, Wareham DW, McDonough MA, Schofield CJ.
PMID: 28451231
Chem Sci. 2017 Feb 01;8(2):928-937. doi: 10.1039/c6sc04524c. Epub 2016 Dec 14.

There are no clinically useful inhibitors of metallo-β-lactamases (MBLs), which are a growing problem because they hydrolyse almost all β-lactam antibacterials. Inhibition by most reported MBL inhibitors involves zinc ion chelation. A structure-based virtual screening approach combined with NMR...

Altered resting-state EEG source functional connectivity in schizophrenia: the effect of illness duration.

Frontiers in human neuroscience

Di Lorenzo G, Daverio A, Ferrentino F, Santarnecchi E, Ciabattini F, Monaco L, Lisi G, Barone Y, Di Lorenzo C, Niolu C, Seri S, Siracusano A.
PMID: 25999835
Front Hum Neurosci. 2015 May 05;9:234. doi: 10.3389/fnhum.2015.00234. eCollection 2015.

Despite the increasing body of evidence supporting the hypothesis of schizophrenia as a disconnection syndrome, studies of resting-state EEG Source Functional Connectivity (EEG-SFC) in people affected by schizophrenia are sparse. The aim of the present study was to investigate...

The brain imaging data structure, a format for organizing and describing outputs of neuroimaging experiments.

Scientific data

Gorgolewski KJ, Auer T, Calhoun VD, Craddock RC, Das S, Duff EP, Flandin G, Ghosh SS, Glatard T, Halchenko YO, Handwerker DA, Hanke M, Keator D, Li X, Michael Z, Maumet C, Nichols BN, Nichols TE, Pellman J, Poline JB, Rokem A, Schaefer G, Sochat V, Triplett W, Turner JA, Varoquaux G, Poldrack RA.
PMID: 27326542
Sci Data. 2016 Jun 21;3:160044. doi: 10.1038/sdata.2016.44.

The development of magnetic resonance imaging (MRI) techniques has defined modern neuroimaging. Since its inception, tens of thousands of studies using techniques such as functional MRI and diffusion weighted imaging have allowed for the non-invasive study of the brain....

Has Uganda experienced any stalled fertility transitions? Reflecting on the last four decades (1973-2011).

Fertility research and practice

Kabagenyi A, Reid A, Rutaremwa G, Atuyambe LM, Ntozi JP.
PMID: 26779344
Fertil Res Pract. 2015 Sep 23;1(14):1-10. doi: 10.1186/s40738-015-0006-1.

BACKGROUND: Persistent high fertility is associated with mother and child mortality. While most regions in the world have experienced declines in fertility rates, there are conflicting views as to whether Uganda has entered a period of fertility transition. There...

Voxel-based, brain-wide association study of aberrant functional connectivity in schizophrenia implicates thalamocortical circuitry.

NPJ schizophrenia

Cheng W, Palaniyappan L, Li M, Kendrick KM, Zhang J, Luo Q, Liu Z, Yu R, Deng W, Wang Q, Ma X, Guo W, Francis S, Liddle P, Mayer AR, Schumann G, Li T, Feng J.
PMID: 27336032
NPJ Schizophr. 2015 May 06;1:15016. doi: 10.1038/npjschz.2015.16. eCollection 2015.

BACKGROUND: Wernicke's concept of 'sejunction' or aberrant associations among specialized brain regions is one of the earliest hypotheses attempting to explain the myriad of symptoms in psychotic disorders. Unbiased data mining of all possible brain-wide connections in large data...

Breastfeeding, lung volumes and alveolar size at school-age.

BMJ open respiratory research

Dogaru CM, Narayanan M, Spycher BD, Pescatore AM, Owers-Bradley J, Beardsmore CS, Silverman M, Kuehni CE.
PMID: 26180638
BMJ Open Respir Res. 2015 Jul 06;2(1):e000081. doi: 10.1136/bmjresp-2015-000081. eCollection 2015.

BACKGROUND: Previous studies found larger lung volumes at school-age in formerly breastfed children, with some studies suggesting an effect modification by maternal asthma. We wanted to explore this further in children who had undergone extensive lung function testing. The...

Showing 1 to 12 of 5885 entries