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Showing 1 to 12 of 14 entries
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Multiple comparisons in studies of gene x gene and gene x environment interaction.

American journal of human genetics

Kraft P.
PMID: 14973784
Am J Hum Genet. 2004 Mar;74(3):582-4; author reply 584-5. doi: 10.1086/382051.

No abstract available.

10 Years of GWAS Discovery: Biology, Function, and Translation.

American journal of human genetics

Visscher PM, Wray NR, Zhang Q, Sklar P, McCarthy MI, Brown MA, Yang J.
PMID: 28686856
Am J Hum Genet. 2017 Jul 06;101(1):5-22. doi: 10.1016/j.ajhg.2017.06.005.

Application of the experimental design of genome-wide association studies (GWASs) is now 10 years old (young), and here we review the remarkable range of discoveries it has facilitated in population and complex-trait genetics, the biology of diseases, and translation...

Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium.

Behavior genetics

van den Berg SM, de Moor MH, Verweij KJ, Krueger RF, Luciano M, Arias Vasquez A, Matteson LK, Derringer J, Esko T, Amin N, Gordon SD, Hansell NK, Hart AB, Seppälä I, Huffman JE, Konte B, Lahti J, Lee M, Miller M, Nutile T, Tanaka T, Teumer A, Viktorin A, Wedenoja J, Abdellaoui A, Abecasis GR, Adkins DE, Agrawal A, Allik J, Appel K, Bigdeli TB, Busonero F, Campbell H, Costa PT, Smith GD, Davies G, de Wit H, Ding J, Engelhardt BE, Eriksson JG, Fedko IO, Ferrucci L, Franke B, Giegling I, Grucza R, Hartmann AM, Heath AC, Heinonen K, Henders AK, Homuth G, Hottenga JJ, Iacono WG, Janzing J, Jokela M, Karlsson R, Kemp JP, Kirkpatrick MG, Latvala A, Lehtimäki T, Liewald DC, Madden PA, Magri C, Magnusson PK, Marten J, Maschio A, Mbarek H, Medland SE, Mihailov E, Milaneschi Y, Montgomery GW, Nauck M, Nivard MG, Ouwens KG, Palotie A, Pettersson E, Polasek O, Qian Y, Pulkki-Råback L, Raitakari OT, Realo A, Rose RJ, Ruggiero D, Schmidt CO, Slutske WS, Sorice R, Starr JM, St Pourcain B, Sutin AR, Timpson NJ, Trochet H, Vermeulen S, Vuoksimaa E, Widen E, Wouda J, Wright MJ, Zgaga L, Porteous D, Minelli A, Palmer AA, Rujescu D, Ciullo M, Hayward C, Rudan I, Metspalu A, Kaprio J, Deary IJ, Räikkönen K, Wilson JF, Keltikangas-Järvinen L, Bierut LJ, Hettema JM, Grabe HJ, Penninx BW, van Duijn CM, Evans DM, Schlessinger D, Pedersen NL, Terracciano A, McGue M, Martin NG, Boomsma DI.
PMID: 26362575
Behav Genet. 2016 Mar;46(2):170-82. doi: 10.1007/s10519-015-9735-5. Epub 2015 Sep 11.

Extraversion is a relatively stable and heritable personality trait associated with numerous psychosocial, lifestyle and health outcomes. Despite its substantial heritability, no genetic variants have been detected in previous genome-wide association (GWA) studies, which may be due to relatively...

Age dependency of the polygenic risk score for colorectal cancer.

American journal of human genetics

Li S, Hopper JL.
PMID: 33667395
Am J Hum Genet. 2021 Mar 04;108(3):525-526. doi: 10.1016/j.ajhg.2021.02.002.

No abstract available.

Psychiatric Genetics Begins to Find Its Footing.

The American journal of psychiatry

Smoller JW.
PMID: 31366225
Am J Psychiatry. 2019 Aug 01;176(8):609-614. doi: 10.1176/appi.ajp.2019.19060643.

No abstract available.

The role of genetics in subjective well-being.

Nature human behaviour

Røysamb E, Nes RB.
PMID: 30932049
Nat Hum Behav. 2019 Jan;3(1):3. doi: 10.1038/s41562-018-0494-1.

No abstract available.

Individuals with common diseases but with a low polygenic risk score could be prioritized for rare variant screening.

Genetics in medicine : official journal of the American College of Medical Genetics

Lu T, Zhou S, Wu H, Forgetta V, Greenwood CMT, Richards JB.
PMID: 33110269
Genet Med. 2021 Mar;23(3):508-515. doi: 10.1038/s41436-020-01007-7. Epub 2020 Oct 28.

PURPOSE: Identifying rare genetic causes of common diseases can improve diagnostic and treatment strategies, but incurs high costs. We tested whether individuals with common disease and low polygenic risk score (PRS) for that disease generated from less expensive genome-wide...

Assessing the evidence for shared genetic risks across psychiatric disorders and traits.

Psychological medicine

Martin J, Taylor MJ, Lichtenstein P.
PMID: 29198204
Psychol Med. 2018 Aug;48(11):1759-1774. doi: 10.1017/S0033291717003440. Epub 2017 Dec 04.

Genetic influences play a significant role in risk for psychiatric disorders, prompting numerous endeavors to further understand their underlying genetic architecture. In this paper, we summarize and review evidence from traditional twin studies and more recent genome-wide molecular genetic...

Genetic Studies of Mental Illness: Are Children Being Left Behind?.

Journal of the American Academy of Child and Adolescent Psychiatry

Posner J, Biezonski D, Pieper S, Duarte CS.
PMID: 33385509
J Am Acad Child Adolesc Psychiatry. 2021 Jun;60(6):672-674. doi: 10.1016/j.jaac.2020.12.031. Epub 2020 Dec 29.

Understanding the genetic architecture of psychiatric disorders is paramount to linking psychopathologies to their genetic underpinnings. In turn, this knowledge can inform strategies for identifying high-risk individuals, early intervention, and development of personalized treatment approaches.

Polygenic risk scores, prediction of psychiatric disorders, and the health of all of us.

The lancet. Psychiatry

Parens E, Matthews L, Appelbaum PS.
PMID: 32445683
Lancet Psychiatry. 2020 Jun;7(6):481. doi: 10.1016/S2215-0366(20)30185-1. Epub 2020 May 20.

No abstract available.

What genome-wide association studies reveal about the association between intelligence and physical health, illness, and mortality.

Current opinion in psychology

Deary IJ, Harris SE, Hill WD.
PMID: 30071465
Curr Opin Psychol. 2019 Jun;27:6-12. doi: 10.1016/j.copsyc.2018.07.005. Epub 2018 Jul 23.

The associations between higher intelligence test scores from early life and later good health, fewer illnesses, and longer life are recent discoveries. Researchers are mapping the extent of these associations and trying to understanding them. Part of the intelligence-health...

Clinical use of current polygenic risk scores may exacerbate health disparities.

Nature genetics

Martin AR, Kanai M, Kamatani Y, Okada Y, Neale BM, Daly MJ.
PMID: 30926966
Nat Genet. 2019 Apr;51(4):584-591. doi: 10.1038/s41588-019-0379-x. Epub 2019 Mar 29.

Polygenic risk scores (PRS) are poised to improve biomedical outcomes via precision medicine. However, the major ethical and scientific challenge surrounding clinical implementation of PRS is that those available today are several times more accurate in individuals of European...

Showing 1 to 12 of 14 entries