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Martin J, Taylor MJ, Lichtenstein P. Assessing the evidence for shared genetic risks across psychiatric disorders and traits. Psychol Med. 2017;48(11):1759-1774doi: 10.1017/S0033291717003440.
Martin, J., Taylor, M. J., & Lichtenstein, P. (2018). Assessing the evidence for shared genetic risks across psychiatric disorders and traits. Psychological medicine, 48(11), 1759-1774. https://doi.org/10.1017/S0033291717003440
Martin, Joanna, et al. "Assessing the evidence for shared genetic risks across psychiatric disorders and traits." Psychological medicine vol. 48,11 (2018): 1759-1774. doi: https://doi.org/10.1017/S0033291717003440
Martin J, Taylor MJ, Lichtenstein P. Assessing the evidence for shared genetic risks across psychiatric disorders and traits. Psychol Med. 2018 Aug;48(11):1759-1774. doi: 10.1017/S0033291717003440. Epub 2017 Dec 04. PMID: 29198204; PMCID: PMC6088770.
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Psychol Med. 2018 Aug;48(11):1759-1774. doi: 10.1017/S0033291717003440. Epub 2017 Dec 04.

Assessing the evidence for shared genetic risks across psychiatric disorders and traits.

Psychological medicine

Joanna Martin, Mark J Taylor, Paul Lichtenstein

Affiliations

  1. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  2. MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.

PMID: 29198204 PMCID: PMC6088770 DOI: 10.1017/S0033291717003440

Abstract

Genetic influences play a significant role in risk for psychiatric disorders, prompting numerous endeavors to further understand their underlying genetic architecture. In this paper, we summarize and review evidence from traditional twin studies and more recent genome-wide molecular genetic analyses regarding two important issues that have proven particularly informative for psychiatric genetic research. First, emerging results are beginning to suggest that genetic risk factors for some (but not all) clinically diagnosed psychiatric disorders or extreme manifestations of psychiatric traits in the population share genetic risks with quantitative variation in milder traits of the same disorder throughout the general population. Second, there is now evidence for substantial sharing of genetic risks across different psychiatric disorders. This extends to the level of characteristic traits throughout the population, with which some clinical disorders also share genetic risks. In this review, we summarize and evaluate the evidence for these two issues, for a range of psychiatric disorders. We then critically appraise putative interpretations regarding the potential meaning of genetic correlation across psychiatric phenotypes. We highlight several new methods and studies which are already using these insights into the genetic architecture of psychiatric disorders to gain additional understanding regarding the underlying biology of these disorders. We conclude by outlining opportunities for future research in this area.

Keywords: GWAS; genetic correlation; genetics; pleiotropy; twin studies

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