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α(V)β(6) integrin expression is induced in the POET and Pten(pc-/-) mouse models of prostatic inflammation and prostatic adenocarcinoma.

American journal of translational research

Garlick DS, Li J, Sansoucy B, Wang T, Griffith L, Fitzgerald T, Butterfield J, Charbonneau B, Violette SM, Weinreb PH, Ratliff TL, Liao CP, Roy-Burman P, Vietri M, Lian JB, Stein GS, Altieri DC, Languino LR.
PMID: 22611469
Am J Transl Res. 2012;4(2):165-74. Epub 2012 Apr 10.

Chronic inflammation is proposed to prime the development of prostate cancer. However, the mechanisms of prostate cancer initiation and development are not completely understood. The α(v)β(6) integrin has been shown to play a role in epithelial development, wound healing...

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Garlick DS, Li J, Sansoucy B, et al. α(V)β(6) integrin expression is induced in the POET and Pten(pc-/-) mouse models of prostatic inflammation and prostatic adenocarcinoma. Am J Transl Res. 2012;4(2):165-74
Garlick, D. S., Li, J., Sansoucy, B., Wang, T., Griffith, L., Fitzgerald, T., Butterfield, J., Charbonneau, B., Violette, S. M., Weinreb, P. H., Ratliff, T. L., Liao, C. P., Roy-Burman, P., Vietri, M., Lian, J. B., Stein, G. S., Altieri, D. C., & Languino, L. R. (2012). α(V)β(6) integrin expression is induced in the POET and Pten(pc-/-) mouse models of prostatic inflammation and prostatic adenocarcinoma. American journal of translational research, 4(2), 165-74.
Garlick, David S, et al. "α(V)β(6) integrin expression is induced in the POET and Pten(pc-/-) mouse models of prostatic inflammation and prostatic adenocarcinoma." American journal of translational research vol. 4,2 (2012): 165-74.
Garlick DS, Li J, Sansoucy B, Wang T, Griffith L, Fitzgerald T, Butterfield J, Charbonneau B, Violette SM, Weinreb PH, Ratliff TL, Liao CP, Roy-Burman P, Vietri M, Lian JB, Stein GS, Altieri DC, Languino LR. α(V)β(6) integrin expression is induced in the POET and Pten(pc-/-) mouse models of prostatic inflammation and prostatic adenocarcinoma. Am J Transl Res. 2012;4(2):165-74. Epub 2012 Apr 10. PMID: 22611469; PMCID: PMC3353537.
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Multigene Hereditary Cancer Panels Reveal High-Risk Pancreatic Cancer Susceptibility Genes.

JCO precision oncology

Hu C, LaDuca H, Shimelis H, Polley EC, Lilyquist J, Hart SN, Na J, Thomas A, Lee KY, Davis BT, Black MH, Pesaran T, Goldgar DE, Dolinsky JS, Couch FJ.
PMID: 31497750
JCO Precis Oncol. 2018;2. doi: 10.1200/PO.17.00291. Epub 2018 Jul 25.

PURPOSE: The relevance of inherited pathogenic mutations in cancer predisposition genes in pancreatic cancer is not well understood. We aimed to assess the characteristics of patients with pancreatic cancer referred for hereditary cancer genetic testing and to estimate the...

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Hu C, LaDuca H, Shimelis H, et al. Multigene Hereditary Cancer Panels Reveal High-Risk Pancreatic Cancer Susceptibility Genes. JCO Precis Oncol. 2018;2doi: 10.1200/PO.17.00291.
Hu, C., LaDuca, H., Shimelis, H., Polley, E. C., Lilyquist, J., Hart, S. N., Na, J., Thomas, A., Lee, K. Y., Davis, B. T., Black, M. H., Pesaran, T., Goldgar, D. E., Dolinsky, J. S., & Couch, F. J. (2018). Multigene Hereditary Cancer Panels Reveal High-Risk Pancreatic Cancer Susceptibility Genes. JCO precision oncology, 2. https://doi.org/10.1200/PO.17.00291
Hu, Chunling, et al. "Multigene Hereditary Cancer Panels Reveal High-Risk Pancreatic Cancer Susceptibility Genes." JCO precision oncology vol. 2 (2018). doi: https://doi.org/10.1200/PO.17.00291
Hu C, LaDuca H, Shimelis H, Polley EC, Lilyquist J, Hart SN, Na J, Thomas A, Lee KY, Davis BT, Black MH, Pesaran T, Goldgar DE, Dolinsky JS, Couch FJ. Multigene Hereditary Cancer Panels Reveal High-Risk Pancreatic Cancer Susceptibility Genes. JCO Precis Oncol. 2018;2. doi: 10.1200/PO.17.00291. Epub 2018 Jul 25. PMID: 31497750; PMCID: PMC6731034.
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Polygenic risk score and risk of monoclonal B-cell lymphocytosis in caucasians and risk of chronic lymphocytic leukemia (CLL) in African Americans.

Leukemia

Kleinstern G, Weinberg JB, Parikh SA, Braggio E, Achenbach SJ, Robinson DP, Norman AD, Rabe KG, Boddicker NJ, Vachon CM, Lesnick CE, Call TG, Brander DM, Rassenti LZ, Kipps TJ, Olson JE, Cerhan JR, Kay NE, Furman RR, Hanson CA, Shanafelt TD, Slager SL.
PMID: 34285341
Leukemia. 2021 Jul 20; doi: 10.1038/s41375-021-01344-9. Epub 2021 Jul 20.

Monoclonal B-cell lymphocytosis (MBL) is a precursor to CLL. Other than age, sex, and CLL family-history, little is known about factors associated with MBL risk. A polygenic-risk-score (PRS) of 41 CLL-susceptibility variants has been found to be associated with...

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Kleinstern G, Weinberg JB, Parikh SA, et al. Polygenic risk score and risk of monoclonal B-cell lymphocytosis in caucasians and risk of chronic lymphocytic leukemia (CLL) in African Americans. Leukemia. 2021;doi: 10.1038/s41375-021-01344-9.
Kleinstern, G., Weinberg, J. B., Parikh, S. A., Braggio, E., Achenbach, S. J., Robinson, D. P., Norman, A. D., Rabe, K. G., Boddicker, N. J., Vachon, C. M., Lesnick, C. E., Call, T. G., Brander, D. M., Rassenti, L. Z., Kipps, T. J., Olson, J. E., Cerhan, J. R., Kay, N. E., Furman, R. R., Hanson, C. A., Shanafelt, T. D., & Slager, S. L. (2021). Polygenic risk score and risk of monoclonal B-cell lymphocytosis in caucasians and risk of chronic lymphocytic leukemia (CLL) in African Americans. Leukemia, . https://doi.org/10.1038/s41375-021-01344-9
Kleinstern, Geffen, et al. "Polygenic risk score and risk of monoclonal B-cell lymphocytosis in caucasians and risk of chronic lymphocytic leukemia (CLL) in African Americans." Leukemia vol. (2021). doi: https://doi.org/10.1038/s41375-021-01344-9
Kleinstern G, Weinberg JB, Parikh SA, Braggio E, Achenbach SJ, Robinson DP, Norman AD, Rabe KG, Boddicker NJ, Vachon CM, Lesnick CE, Call TG, Brander DM, Rassenti LZ, Kipps TJ, Olson JE, Cerhan JR, Kay NE, Furman RR, Hanson CA, Shanafelt TD, Slager SL. Polygenic risk score and risk of monoclonal B-cell lymphocytosis in caucasians and risk of chronic lymphocytic leukemia (CLL) in African Americans. Leukemia. 2021 Jul 20; doi: 10.1038/s41375-021-01344-9. Epub 2021 Jul 20. PMID: 34285341.
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Genomic Analysis Using Regularized Regression in High-Grade Serous Ovarian Cancer.

Cancer informatics

Natanzon Y, Earp M, Cunningham JM, Kalli KR, Wang C, Armasu SM, Larson MC, Bowtell DD, Garsed DW, Fridley BL, Winham SJ, Goode EL.
PMID: 29434467
Cancer Inform. 2018 Feb 01;17:1176935118755341. doi: 10.1177/1176935118755341. eCollection 2018.

High-grade serous ovarian cancer (HGSOC) is a complex disease in which initiation and progression have been associated with copy number alterations, epigenetic processes, and, to a lesser extent, germline variation. We hypothesized that, when summarized at the gene level,...

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Natanzon Y, Earp M, Cunningham JM, et al. Genomic Analysis Using Regularized Regression in High-Grade Serous Ovarian Cancer. Cancer Inform. 2018;17:1176935118755341doi: 10.1177/1176935118755341.
Natanzon, Y., Earp, M., Cunningham, J. M., Kalli, K. R., Wang, C., Armasu, S. M., Larson, M. C., Bowtell, D. D., Garsed, D. W., Fridley, B. L., Winham, S. J., & Goode, E. L. (2018). Genomic Analysis Using Regularized Regression in High-Grade Serous Ovarian Cancer. Cancer informatics, 171176935118755341. https://doi.org/10.1177/1176935118755341
Natanzon, Yanina, et al. "Genomic Analysis Using Regularized Regression in High-Grade Serous Ovarian Cancer." Cancer informatics vol. 17 (2018): 1176935118755341. doi: https://doi.org/10.1177/1176935118755341
Natanzon Y, Earp M, Cunningham JM, Kalli KR, Wang C, Armasu SM, Larson MC, Bowtell DD, Garsed DW, Fridley BL, Winham SJ, Goode EL. Genomic Analysis Using Regularized Regression in High-Grade Serous Ovarian Cancer. Cancer Inform. 2018 Feb 01;17:1176935118755341. doi: 10.1177/1176935118755341. eCollection 2018. PMID: 29434467; PMCID: PMC5802704.
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Polygenic risk score and risk of monoclonal B-cell lymphocytosis in caucasians and risk of chronic lymphocytic leukemia (CLL) in African Americans.

Leukemia

Kleinstern G, Weinberg JB, Parikh SA, Braggio E, Achenbach SJ, Robinson DP, Norman AD, Rabe KG, Boddicker NJ, Vachon CM, Lesnick CE, Call TG, Brander DM, Rassenti LZ, Kipps TJ, Olson JE, Cerhan JR, Kay NE, Furman RR, Hanson CA, Shanafelt TD, Slager SL.
PMID: 34285341
Leukemia. 2022 Jan;36(1):119-125. doi: 10.1038/s41375-021-01344-9. Epub 2021 Jul 20.

Monoclonal B-cell lymphocytosis (MBL) is a precursor to CLL. Other than age, sex, and CLL family-history, little is known about factors associated with MBL risk. A polygenic-risk-score (PRS) of 41 CLL-susceptibility variants has been found to be associated with...

Cite
Kleinstern G, Weinberg JB, Parikh SA, et al. Polygenic risk score and risk of monoclonal B-cell lymphocytosis in caucasians and risk of chronic lymphocytic leukemia (CLL) in African Americans. Leukemia. 2021;36(1):119-125doi: 10.1038/s41375-021-01344-9.
Kleinstern, G., Weinberg, J. B., Parikh, S. A., Braggio, E., Achenbach, S. J., Robinson, D. P., Norman, A. D., Rabe, K. G., Boddicker, N. J., Vachon, C. M., Lesnick, C. E., Call, T. G., Brander, D. M., Rassenti, L. Z., Kipps, T. J., Olson, J. E., Cerhan, J. R., Kay, N. E., Furman, R. R., Hanson, C. A., Shanafelt, T. D., & Slager, S. L. (2022). Polygenic risk score and risk of monoclonal B-cell lymphocytosis in caucasians and risk of chronic lymphocytic leukemia (CLL) in African Americans. Leukemia, 36(1), 119-125. https://doi.org/10.1038/s41375-021-01344-9
Kleinstern, Geffen, et al. "Polygenic risk score and risk of monoclonal B-cell lymphocytosis in caucasians and risk of chronic lymphocytic leukemia (CLL) in African Americans." Leukemia vol. 36,1 (2022): 119-125. doi: https://doi.org/10.1038/s41375-021-01344-9
Kleinstern G, Weinberg JB, Parikh SA, Braggio E, Achenbach SJ, Robinson DP, Norman AD, Rabe KG, Boddicker NJ, Vachon CM, Lesnick CE, Call TG, Brander DM, Rassenti LZ, Kipps TJ, Olson JE, Cerhan JR, Kay NE, Furman RR, Hanson CA, Shanafelt TD, Slager SL. Polygenic risk score and risk of monoclonal B-cell lymphocytosis in caucasians and risk of chronic lymphocytic leukemia (CLL) in African Americans. Leukemia. 2022 Jan;36(1):119-125. doi: 10.1038/s41375-021-01344-9. Epub 2021 Jul 20. PMID: 34285341.
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Linkage analysis using principal components of gene expression data.

BMC proceedings

Atkinson EJ, Fridley BL, Goode EL, McDonnell SK, Liu-Mares W, Rabe KG, Sun Z, Slager SL, de Andrade M.
PMID: 18466581
BMC Proc. 2007;1:S79. doi: 10.1186/1753-6561-1-s1-s79. Epub 2007 Dec 18.

The goal of this paper is to investigate the effect of using principal components as a data reduction method for expression data in linkage analysis. We used 45 probes normalized using the Affymetrix Global Scaling that had evidence of...

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Atkinson EJ, Fridley BL, Goode EL, et al. Linkage analysis using principal components of gene expression data. BMC Proc. 2007;1:S79doi: 10.1186/1753-6561-1-s1-s79.
Atkinson, E. J., Fridley, B. L., Goode, E. L., McDonnell, S. K., Liu-Mares, W., Rabe, K. G., Sun, Z., Slager, S. L., & de Andrade, M. (2007). Linkage analysis using principal components of gene expression data. BMC proceedings, 1S79. https://doi.org/10.1186/1753-6561-1-s1-s79
Atkinson, Elizabeth J, et al. "Linkage analysis using principal components of gene expression data." BMC proceedings vol. 1 (2007): S79. doi: https://doi.org/10.1186/1753-6561-1-s1-s79
Atkinson EJ, Fridley BL, Goode EL, McDonnell SK, Liu-Mares W, Rabe KG, Sun Z, Slager SL, de Andrade M. Linkage analysis using principal components of gene expression data. BMC Proc. 2007;1:S79. doi: 10.1186/1753-6561-1-s1-s79. Epub 2007 Dec 18. PMID: 18466581; PMCID: PMC2367556.
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The contribution of pathogenic variants in breast cancer susceptibility genes to familial breast cancer risk.

NPJ breast cancer

Slavin TP, Maxwell KN, Lilyquist J, Vijai J, Neuhausen SL, Hart SN, Ravichandran V, Thomas T, Maria A, Villano D, Schrader KA, Moore R, Hu C, Wubbenhorst B, Wenz BM, D'Andrea K, Robson ME, Peterlongo P, Bonanni B, Ford JM, Garber JE, Domchek SM, Szabo C, Offit K, Nathanson KL, Weitzel JN, Couch FJ.
PMID: 28649662
NPJ Breast Cancer. 2017 Jun 09;3:22. doi: 10.1038/s41523-017-0024-8. eCollection 2017.

Understanding the gene-specific risks for development of breast cancer will lead to improved clinical care for those carrying germline mutations in cancer predisposition genes. We sought to detail the spectrum of mutations and refine risk estimates for known and...

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Slavin TP, Maxwell KN, Lilyquist J, et al. The contribution of pathogenic variants in breast cancer susceptibility genes to familial breast cancer risk. NPJ Breast Cancer. 2017;3:22doi: 10.1038/s41523-017-0024-8.
Slavin, T. P., Maxwell, K. N., Lilyquist, J., Vijai, J., Neuhausen, S. L., Hart, S. N., Ravichandran, V., Thomas, T., Maria, A., Villano, D., Schrader, K. A., Moore, R., Hu, C., Wubbenhorst, B., Wenz, B. M., D'Andrea, K., Robson, M. E., Peterlongo, P., Bonanni, B., Ford, J. M., Garber, J. E., Domchek, S. M., Szabo, C., Offit, K., Nathanson, K. L., Weitzel, J. N., & Couch, F. J. (2017). The contribution of pathogenic variants in breast cancer susceptibility genes to familial breast cancer risk. NPJ breast cancer, 322. https://doi.org/10.1038/s41523-017-0024-8
Slavin, Thomas P, et al. "The contribution of pathogenic variants in breast cancer susceptibility genes to familial breast cancer risk." NPJ breast cancer vol. 3 (2017): 22. doi: https://doi.org/10.1038/s41523-017-0024-8
Slavin TP, Maxwell KN, Lilyquist J, Vijai J, Neuhausen SL, Hart SN, Ravichandran V, Thomas T, Maria A, Villano D, Schrader KA, Moore R, Hu C, Wubbenhorst B, Wenz BM, D'Andrea K, Robson ME, Peterlongo P, Bonanni B, Ford JM, Garber JE, Domchek SM, Szabo C, Offit K, Nathanson KL, Weitzel JN, Couch FJ. The contribution of pathogenic variants in breast cancer susceptibility genes to familial breast cancer risk. NPJ Breast Cancer. 2017 Jun 09;3:22. doi: 10.1038/s41523-017-0024-8. eCollection 2017. PMID: 28649662; PMCID: PMC5466608.
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Analysis of variation in NF-kappaB genes and expression levels of NF-kappaB-regulated molecules.

BMC proceedings

Liu-Mares W, Sun Z, Bamlet WR, Atkinson EJ, Fridley BL, Slager SL, de Andrade M, Goode EL.
PMID: 18466468
BMC Proc. 2007;1:S126. doi: 10.1186/1753-6561-1-s1-s126. Epub 2007 Dec 18.

The nuclear factor-kappaB (NF-kappaB) family of transcription factors regulates the expression of a variety of genes involved in apoptosis and immune response. We examined relationships between genotypes at five NF-kappaB subunits (NFKB1, NFKB2, REL, RELA, and RELB) and variable...

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Liu-Mares W, Sun Z, Bamlet WR, et al. Analysis of variation in NF-kappaB genes and expression levels of NF-kappaB-regulated molecules. BMC Proc. 2007;1:S126doi: 10.1186/1753-6561-1-s1-s126.
Liu-Mares, W., Sun, Z., Bamlet, W. R., Atkinson, E. J., Fridley, B. L., Slager, S. L., de Andrade, M., & Goode, E. L. (2007). Analysis of variation in NF-kappaB genes and expression levels of NF-kappaB-regulated molecules. BMC proceedings, 1S126. https://doi.org/10.1186/1753-6561-1-s1-s126
Liu-Mares, Wen, et al. "Analysis of variation in NF-kappaB genes and expression levels of NF-kappaB-regulated molecules." BMC proceedings vol. 1 (2007): S126. doi: https://doi.org/10.1186/1753-6561-1-s1-s126
Liu-Mares W, Sun Z, Bamlet WR, Atkinson EJ, Fridley BL, Slager SL, de Andrade M, Goode EL. Analysis of variation in NF-kappaB genes and expression levels of NF-kappaB-regulated molecules. BMC Proc. 2007;1:S126. doi: 10.1186/1753-6561-1-s1-s126. Epub 2007 Dec 18. PMID: 18466468; PMCID: PMC2367504.
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The genetics of gene expression: comparison of linkage scans using two phenotype normalization methods.

BMC proceedings

de Andrade M, Atkinson EJ, Fridley BL, Goode EL, McDonnell S, Liu-Mares W, Rabe KG, Sun Z, Slager SL.
PMID: 18466496
BMC Proc. 2007;1:S151. doi: 10.1186/1753-6561-1-s1-s151. Epub 2007 Dec 18.

The goal of this paper is to investigate the effects of normalization procedures for expression data on linkage results. We selected the two most commonly used expression data extraction and normalization methods, Affymetrix global scaling and dChip invariant. After...

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de Andrade M, Atkinson EJ, Fridley BL, et al. The genetics of gene expression: comparison of linkage scans using two phenotype normalization methods. BMC Proc. 2007;1:S151doi: 10.1186/1753-6561-1-s1-s151.
de Andrade, M., Atkinson, E. J., Fridley, B. L., Goode, E. L., McDonnell, S., Liu-Mares, W., Rabe, K. G., Sun, Z., & Slager, S. L. (2007). The genetics of gene expression: comparison of linkage scans using two phenotype normalization methods. BMC proceedings, 1S151. https://doi.org/10.1186/1753-6561-1-s1-s151
de Andrade, Mariza, et al. "The genetics of gene expression: comparison of linkage scans using two phenotype normalization methods." BMC proceedings vol. 1 (2007): S151. doi: https://doi.org/10.1186/1753-6561-1-s1-s151
de Andrade M, Atkinson EJ, Fridley BL, Goode EL, McDonnell S, Liu-Mares W, Rabe KG, Sun Z, Slager SL. The genetics of gene expression: comparison of linkage scans using two phenotype normalization methods. BMC Proc. 2007;1:S151. doi: 10.1186/1753-6561-1-s1-s151. Epub 2007 Dec 18. PMID: 18466496; PMCID: PMC2367553.
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Toward understanding the genetics of regulatory T cells in ovarian cancer.

Oncoimmunology

Derycke MS, Charbonneau B, Preston CC, Kalli KR, Knutson KL, Rider DN, Goode EL.
PMID: 23894717
Oncoimmunology. 2013 Jun 01;2(6):e24535. doi: 10.4161/onci.24535. Epub 2013 Apr 16.

Tumor-infiltrating regulatory T cells (Tregs) promote immune evasion and are associated with poor disease outcome in patients affected by various malignancies. We have recently demonstrated that several, inherited single nucleotide polymorphisms affecting Treg-related genes influence the survival of ovarian...

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Derycke MS, Charbonneau B, Preston CC, et al. Toward understanding the genetics of regulatory T cells in ovarian cancer. Oncoimmunology. 2013;2(6):e24535doi: 10.4161/onci.24535.
Derycke, M. S., Charbonneau, B., Preston, C. C., Kalli, K. R., Knutson, K. L., Rider, D. N., & Goode, E. L. (2013). Toward understanding the genetics of regulatory T cells in ovarian cancer. Oncoimmunology, 2(6), e24535. https://doi.org/10.4161/onci.24535
Derycke, Melissa S, et al. "Toward understanding the genetics of regulatory T cells in ovarian cancer." Oncoimmunology vol. 2,6 (2013): e24535. doi: https://doi.org/10.4161/onci.24535
Derycke MS, Charbonneau B, Preston CC, Kalli KR, Knutson KL, Rider DN, Goode EL. Toward understanding the genetics of regulatory T cells in ovarian cancer. Oncoimmunology. 2013 Jun 01;2(6):e24535. doi: 10.4161/onci.24535. Epub 2013 Apr 16. PMID: 23894717; PMCID: PMC3716752.
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Genetic association with B-cell acute lymphoblastic leukemia in allogeneic transplant patients differs by age and sex.

Blood advances

Clay-Gilmour AI, Hahn T, Preus LM, Onel K, Skol A, Hungate E, Zhu Q, Haiman CA, Stram DO, Pooler L, Sheng X, Yan L, Liu Q, Hu Q, Liu S, Battaglia S, Zhu X, Block AW, Sait SNJ, Karaesmen E, Rizvi A, Weisdorf DJ, Ambrosone CB, Tritchler D, Ellinghaus E, Ellinghaus D, Stanulla M, Clavel J, Orsi L, Spellman S, Pasquini MC, McCarthy PL, Sucheston-Campbell LE.
PMID: 29296818
Blood Adv. 2017 Sep 08;1(20):1717-1728. doi: 10.1182/bloodadvances.2017006023. eCollection 2017 Sep 12.

The incidence and mortality rates of B-cell acute lymphoblastic leukemia (B-ALL) differ by age and sex. To determine if inherited genetic susceptibility contributes to these differences we performed 2 genome-wide association studies (GWAS) by age, sex, and subtype and...

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Clay-Gilmour AI, Hahn T, Preus LM, et al. Genetic association with B-cell acute lymphoblastic leukemia in allogeneic transplant patients differs by age and sex. Blood Adv. 2017;1(20):1717-1728doi: 10.1182/bloodadvances.2017006023.
Clay-Gilmour, A. I., Hahn, T., Preus, L. M., Onel, K., Skol, A., Hungate, E., Zhu, Q., Haiman, C. A., Stram, D. O., Pooler, L., Sheng, X., Yan, L., Liu, Q., Hu, Q., Liu, S., Battaglia, S., Zhu, X., Block, A. W., Sait, S. N. J., Karaesmen, E., Rizvi, A., Weisdorf, D. J., Ambrosone, C. B., Tritchler, D., Ellinghaus, E., Ellinghaus, D., Stanulla, M., Clavel, J., Orsi, L., Spellman, S., Pasquini, M. C., McCarthy, P. L., & Sucheston-Campbell, L. E. (2017). Genetic association with B-cell acute lymphoblastic leukemia in allogeneic transplant patients differs by age and sex. Blood advances, 1(20), 1717-1728. https://doi.org/10.1182/bloodadvances.2017006023
Clay-Gilmour, Alyssa I, et al. "Genetic association with B-cell acute lymphoblastic leukemia in allogeneic transplant patients differs by age and sex." Blood advances vol. 1,20 (2017): 1717-1728. doi: https://doi.org/10.1182/bloodadvances.2017006023
Clay-Gilmour AI, Hahn T, Preus LM, Onel K, Skol A, Hungate E, Zhu Q, Haiman CA, Stram DO, Pooler L, Sheng X, Yan L, Liu Q, Hu Q, Liu S, Battaglia S, Zhu X, Block AW, Sait SNJ, Karaesmen E, Rizvi A, Weisdorf DJ, Ambrosone CB, Tritchler D, Ellinghaus E, Ellinghaus D, Stanulla M, Clavel J, Orsi L, Spellman S, Pasquini MC, McCarthy PL, Sucheston-Campbell LE. Genetic association with B-cell acute lymphoblastic leukemia in allogeneic transplant patients differs by age and sex. Blood Adv. 2017 Sep 08;1(20):1717-1728. doi: 10.1182/bloodadvances.2017006023. eCollection 2017 Sep 12. PMID: 29296818; PMCID: PMC5728332.
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Polygenic risk score and risk of monoclonal B-cell lymphocytosis in caucasians and risk of chronic lymphocytic leukemia (CLL) in African Americans.

Leukemia

Kleinstern G, Weinberg JB, Parikh SA, Braggio E, Achenbach SJ, Robinson DP, Norman AD, Rabe KG, Boddicker NJ, Vachon CM, Lesnick CE, Call TG, Brander DM, Rassenti LZ, Kipps TJ, Olson JE, Cerhan JR, Kay NE, Furman RR, Hanson CA, Shanafelt TD, Slager SL.
PMID: 34285341
Leukemia. 2022 Jan;36(1):119-125. doi: 10.1038/s41375-021-01344-9. Epub 2021 Jul 20.

Monoclonal B-cell lymphocytosis (MBL) is a precursor to CLL. Other than age, sex, and CLL family-history, little is known about factors associated with MBL risk. A polygenic-risk-score (PRS) of 41 CLL-susceptibility variants has been found to be associated with...

Cite
Kleinstern G, Weinberg JB, Parikh SA, et al. Polygenic risk score and risk of monoclonal B-cell lymphocytosis in caucasians and risk of chronic lymphocytic leukemia (CLL) in African Americans. Leukemia. 2021;36(1):119-125doi: 10.1038/s41375-021-01344-9.
Kleinstern, G., Weinberg, J. B., Parikh, S. A., Braggio, E., Achenbach, S. J., Robinson, D. P., Norman, A. D., Rabe, K. G., Boddicker, N. J., Vachon, C. M., Lesnick, C. E., Call, T. G., Brander, D. M., Rassenti, L. Z., Kipps, T. J., Olson, J. E., Cerhan, J. R., Kay, N. E., Furman, R. R., Hanson, C. A., Shanafelt, T. D., & Slager, S. L. (2022). Polygenic risk score and risk of monoclonal B-cell lymphocytosis in caucasians and risk of chronic lymphocytic leukemia (CLL) in African Americans. Leukemia, 36(1), 119-125. https://doi.org/10.1038/s41375-021-01344-9
Kleinstern, Geffen, et al. "Polygenic risk score and risk of monoclonal B-cell lymphocytosis in caucasians and risk of chronic lymphocytic leukemia (CLL) in African Americans." Leukemia vol. 36,1 (2022): 119-125. doi: https://doi.org/10.1038/s41375-021-01344-9
Kleinstern G, Weinberg JB, Parikh SA, Braggio E, Achenbach SJ, Robinson DP, Norman AD, Rabe KG, Boddicker NJ, Vachon CM, Lesnick CE, Call TG, Brander DM, Rassenti LZ, Kipps TJ, Olson JE, Cerhan JR, Kay NE, Furman RR, Hanson CA, Shanafelt TD, Slager SL. Polygenic risk score and risk of monoclonal B-cell lymphocytosis in caucasians and risk of chronic lymphocytic leukemia (CLL) in African Americans. Leukemia. 2022 Jan;36(1):119-125. doi: 10.1038/s41375-021-01344-9. Epub 2021 Jul 20. PMID: 34285341; PMCID: PMC8727288.
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