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Clay-Gilmour AI, Hahn T, Preus LM, et al. Genetic association with B-cell acute lymphoblastic leukemia in allogeneic transplant patients differs by age and sex. Blood Adv. 2017;1(20):1717-1728doi: 10.1182/bloodadvances.2017006023.
Clay-Gilmour, A. I., Hahn, T., Preus, L. M., Onel, K., Skol, A., Hungate, E., Zhu, Q., Haiman, C. A., Stram, D. O., Pooler, L., Sheng, X., Yan, L., Liu, Q., Hu, Q., Liu, S., Battaglia, S., Zhu, X., Block, A. W., Sait, S. N. J., Karaesmen, E., Rizvi, A., Weisdorf, D. J., Ambrosone, C. B., Tritchler, D., Ellinghaus, E., Ellinghaus, D., Stanulla, M., Clavel, J., Orsi, L., Spellman, S., Pasquini, M. C., McCarthy, P. L., & Sucheston-Campbell, L. E. (2017). Genetic association with B-cell acute lymphoblastic leukemia in allogeneic transplant patients differs by age and sex. Blood advances, 1(20), 1717-1728. https://doi.org/10.1182/bloodadvances.2017006023
Clay-Gilmour, Alyssa I, et al. "Genetic association with B-cell acute lymphoblastic leukemia in allogeneic transplant patients differs by age and sex." Blood advances vol. 1,20 (2017): 1717-1728. doi: https://doi.org/10.1182/bloodadvances.2017006023
Clay-Gilmour AI, Hahn T, Preus LM, Onel K, Skol A, Hungate E, Zhu Q, Haiman CA, Stram DO, Pooler L, Sheng X, Yan L, Liu Q, Hu Q, Liu S, Battaglia S, Zhu X, Block AW, Sait SNJ, Karaesmen E, Rizvi A, Weisdorf DJ, Ambrosone CB, Tritchler D, Ellinghaus E, Ellinghaus D, Stanulla M, Clavel J, Orsi L, Spellman S, Pasquini MC, McCarthy PL, Sucheston-Campbell LE. Genetic association with B-cell acute lymphoblastic leukemia in allogeneic transplant patients differs by age and sex. Blood Adv. 2017 Sep 08;1(20):1717-1728. doi: 10.1182/bloodadvances.2017006023. eCollection 2017 Sep 12. PMID: 29296818; PMCID: PMC5728332.
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Blood Adv. 2017 Sep 08;1(20):1717-1728. doi: 10.1182/bloodadvances.2017006023. eCollection 2017 Sep 12.

Genetic association with B-cell acute lymphoblastic leukemia in allogeneic transplant patients differs by age and sex.

Blood advances

Alyssa I Clay-Gilmour, Theresa Hahn, Leah M Preus, Kenan Onel, Andrew Skol, Eric Hungate, Qianqian Zhu, Christopher A Haiman, Daniel O Stram, Loreall Pooler, Xin Sheng, Li Yan, Qian Liu, Qiang Hu, Song Liu, Sebastiano Battaglia, Xiaochun Zhu, AnneMarie W Block, Sheila N J Sait, Ezgi Karaesmen, Abbas Rizvi, Daniel J Weisdorf, Christine B Ambrosone, David Tritchler, Eva Ellinghaus, David Ellinghaus, Martin Stanulla, Jacqueline Clavel, Laurent Orsi, Stephen Spellman, Marcelo C Pasquini, Philip L McCarthy, Lara E Sucheston-Campbell

Affiliations

  1. Department of Cancer Genetic Epidemiology, Mayo Clinic, Rochester, MN.
  2. Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY.
  3. College of Pharmacy, The Ohio State University, Columbus, OH.
  4. Department of Pediatrics, Northwell Health, Great Neck, NY.
  5. Department of Pediatrics, The University of Chicago, Chicago, IL.
  6. Department of Biostatistics and Bioinformatics, Roswell Park Cancer Institute, Buffalo, NY.
  7. Department of Preventive Medicine, University of Southern California, Los Angeles, CA.
  8. Department of Biostatistics, State University of New York at Buffalo, Buffalo, NY.
  9. Center for Immunotherapy, Roswell Park Cancer Institute, Buffalo, NY.
  10. Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI.
  11. Clinical Cytogenetics Laboratory, Roswell Park Cancer Institute, Buffalo, NY.
  12. Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN.
  13. Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY.
  14. Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.
  15. Department of Pediatric Hematology and Oncology, Hannover Medical School, Hanover, Germany.
  16. Epidemiology and Biostatistics Sorbonne Paris Cité Centre, INSERM U1153, Paris, France.
  17. Epidemiology of Childhood and Adolescent Cancers Team, Paris Descartes University, Paris, France.
  18. Center for International Blood and Marrow Transplant Research, Minneapolis, MN; and.
  19. College of Veterinary Medicine, The Ohio State University, Columbus, OH.

PMID: 29296818 PMCID: PMC5728332 DOI: 10.1182/bloodadvances.2017006023

Abstract

The incidence and mortality rates of B-cell acute lymphoblastic leukemia (B-ALL) differ by age and sex. To determine if inherited genetic susceptibility contributes to these differences we performed 2 genome-wide association studies (GWAS) by age, sex, and subtype and subsequent meta-analyses. The GWAS included 446 B-ALL cases, and 3027 healthy unrelated blood and marrow transplant (BMT) donors as controls from the Determining the Influence of Susceptibility Conveying Variants Related to One-Year Mortality after BMT (DISCOVeRY-BMT) study. We identified 1 novel variant, rs189434316, significantly associated with odds of normal cytogenetic B-ALL (odds ratio from meta-analysis [OR

Conflict of interest statement

Conflict-of-interest disclosure: T.H. owns stock in Novartis Pharmaceuticals Corporation. D.J.W. provided consulting services to, and served on advisory boards for, Kadmon and Alexion, and received re

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