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Designer Approaches for G Protein-Coupled Receptor Modulation for Cardiovascular Disease.

JACC. Basic to translational science

Grisanti LA, Schumacher SM, Tilley DG, Koch WJ.
PMID: 30175279
JACC Basic Transl Sci. 2018 Aug 28;3(4):550-562. doi: 10.1016/j.jacbts.2017.12.002. eCollection 2018 Aug.

The new horizon for cardiac therapy may lie beneath the surface, with the downstream mediators of G protein-coupled receptor (GPCR) activity. Targeted approaches have shown that receptor activation may be biased toward signaling through G proteins or through GPCR...

Cite
Grisanti LA, Schumacher SM, Tilley DG, et al. Designer Approaches for G Protein-Coupled Receptor Modulation for Cardiovascular Disease. JACC Basic Transl Sci. 2018;3(4):550-562doi: 10.1016/j.jacbts.2017.12.002.
Grisanti, L. A., Schumacher, S. M., Tilley, D. G., & Koch, W. J. (2018). Designer Approaches for G Protein-Coupled Receptor Modulation for Cardiovascular Disease. JACC. Basic to translational science, 3(4), 550-562. https://doi.org/10.1016/j.jacbts.2017.12.002
Grisanti, Laurel A, et al. "Designer Approaches for G Protein-Coupled Receptor Modulation for Cardiovascular Disease." JACC. Basic to translational science vol. 3,4 (2018): 550-562. doi: https://doi.org/10.1016/j.jacbts.2017.12.002
Grisanti LA, Schumacher SM, Tilley DG, Koch WJ. Designer Approaches for G Protein-Coupled Receptor Modulation for Cardiovascular Disease. JACC Basic Transl Sci. 2018 Aug 28;3(4):550-562. doi: 10.1016/j.jacbts.2017.12.002. eCollection 2018 Aug. PMID: 30175279; PMCID: PMC6115700.
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G protein-coupled Receptor Kinase 2 as a Therapeutic Target for Heart Failure.

Drug discovery today. Therapeutic strategies

Schumacher-Bass SM, Traynham CJ, Koch WJ.
PMID: 24839449
Drug Discov Today Ther Strateg. 2012;9(4):e155-e162. doi: 10.1016/j.ddstr.2014.01.002.

An ever-increasing number of people world-wide are developing and suffering from heart failure, and existing therapies, although improved are not ideal. Therefore, innovative treatment strategies are urgently needed. As our understanding of the underlying dysfunction of the myocardium increases,...

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Schumacher-Bass SM, Traynham CJ, Koch WJ. G protein-coupled Receptor Kinase 2 as a Therapeutic Target for Heart Failure. Drug Discov Today Ther Strateg. 2012;9(4):e155-e162doi: 10.1016/j.ddstr.2014.01.002.
Schumacher-Bass, S. M., Traynham, C. J., & Koch, W. J. (2012). G protein-coupled Receptor Kinase 2 as a Therapeutic Target for Heart Failure. Drug discovery today. Therapeutic strategies, 9(4), e155-e162. https://doi.org/10.1016/j.ddstr.2014.01.002
Schumacher-Bass, Sarah M, et al. "G protein-coupled Receptor Kinase 2 as a Therapeutic Target for Heart Failure." Drug discovery today. Therapeutic strategies vol. 9,4 (2012): e155-e162. doi: https://doi.org/10.1016/j.ddstr.2014.01.002
Schumacher-Bass SM, Traynham CJ, Koch WJ. G protein-coupled Receptor Kinase 2 as a Therapeutic Target for Heart Failure. Drug Discov Today Ther Strateg. 2012;9(4):e155-e162. doi: 10.1016/j.ddstr.2014.01.002. PMID: 24839449; PMCID: PMC4019414.
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Targeting G protein-coupled receptor kinases (GRKs) in Heart Failure.

Drug discovery today. Disease mechanisms

Brinks H, Koch WJ.
PMID: 21218155
Drug Discov Today Dis Mech. 2010;7(2):e129-e134. doi: 10.1016/j.ddmec.2010.07.007.

In the human body, over 1000 different G protein-coupled receptors (GPCRs) mediate a broad spectrum of extracellular signals at the plasma membrane, transmitting vital physiological features such as pain, sight, smell, inflammation, heart rate and contractility of muscle cells....

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Brinks H, Koch WJ. Targeting G protein-coupled receptor kinases (GRKs) in Heart Failure. Drug Discov Today Dis Mech. 2010;7(2):e129-e134doi: 10.1016/j.ddmec.2010.07.007.
Brinks, H., & Koch, W. J. (2010). Targeting G protein-coupled receptor kinases (GRKs) in Heart Failure. Drug discovery today. Disease mechanisms, 7(2), e129-e134. https://doi.org/10.1016/j.ddmec.2010.07.007
Brinks, Henriette, and Koch, Walter J. "Targeting G protein-coupled receptor kinases (GRKs) in Heart Failure." Drug discovery today. Disease mechanisms vol. 7,2 (2010): e129-e134. doi: https://doi.org/10.1016/j.ddmec.2010.07.007
Brinks H, Koch WJ. Targeting G protein-coupled receptor kinases (GRKs) in Heart Failure. Drug Discov Today Dis Mech. 2010;7(2):e129-e134. doi: 10.1016/j.ddmec.2010.07.007. PMID: 21218155; PMCID: PMC3014615.
Copy Download .nbib Format: NLM
Targeting G protein-coupled receptor kinases (GRKs) in Heart Failure.

Drug discovery today. Disease mechanisms

Brinks H, Koch WJ.
PMID: 21218155
Drug Discov Today Dis Mech. 2010;7(2):e129-e134. doi: 10.1016/j.ddmec.2010.07.007.

In the human body, over 1000 different G protein-coupled receptors (GPCRs) mediate a broad spectrum of extracellular signals at the plasma membrane, transmitting vital physiological features such as pain, sight, smell, inflammation, heart rate and contractility of muscle cells....

Cite
Brinks H, Koch WJ. Targeting G protein-coupled receptor kinases (GRKs) in Heart Failure. Drug Discov Today Dis Mech. 2010;7(2):e129-e134doi: 10.1016/j.ddmec.2010.07.007.
Brinks, H., & Koch, W. J. (2010). Targeting G protein-coupled receptor kinases (GRKs) in Heart Failure. Drug discovery today. Disease mechanisms, 7(2), e129-e134. https://doi.org/10.1016/j.ddmec.2010.07.007
Brinks, Henriette, and Koch, Walter J. "Targeting G protein-coupled receptor kinases (GRKs) in Heart Failure." Drug discovery today. Disease mechanisms vol. 7,2 (2010): e129-e134. doi: https://doi.org/10.1016/j.ddmec.2010.07.007
Brinks H, Koch WJ. Targeting G protein-coupled receptor kinases (GRKs) in Heart Failure. Drug Discov Today Dis Mech. 2010;7(2):e129-e134. doi: 10.1016/j.ddmec.2010.07.007. PMID: 21218155; PMCID: PMC3014615.
Copy Download .nbib Format: NLM
Showing 1 to 4 of 4 entries