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Schumacher-Bass SM, Traynham CJ, Koch WJ. G protein-coupled Receptor Kinase 2 as a Therapeutic Target for Heart Failure. Drug Discov Today Ther Strateg. 2012;9(4):e155-e162doi: 10.1016/j.ddstr.2014.01.002.
Schumacher-Bass, S. M., Traynham, C. J., & Koch, W. J. (2012). G protein-coupled Receptor Kinase 2 as a Therapeutic Target for Heart Failure. Drug discovery today. Therapeutic strategies, 9(4), e155-e162. https://doi.org/10.1016/j.ddstr.2014.01.002
Schumacher-Bass, Sarah M, et al. "G protein-coupled Receptor Kinase 2 as a Therapeutic Target for Heart Failure." Drug discovery today. Therapeutic strategies vol. 9,4 (2012): e155-e162. doi: https://doi.org/10.1016/j.ddstr.2014.01.002
Schumacher-Bass SM, Traynham CJ, Koch WJ. G protein-coupled Receptor Kinase 2 as a Therapeutic Target for Heart Failure. Drug Discov Today Ther Strateg. 2012;9(4):e155-e162. doi: 10.1016/j.ddstr.2014.01.002. PMID: 24839449; PMCID: PMC4019414.
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Drug Discov Today Ther Strateg. 2012;9(4):e155-e162. doi: 10.1016/j.ddstr.2014.01.002.

G protein-coupled Receptor Kinase 2 as a Therapeutic Target for Heart Failure.

Drug discovery today. Therapeutic strategies

Sarah M Schumacher-Bass, Christopher J Traynham, Walter J Koch

Affiliations

  1. Department of Pharmacology and Center for Translational Medicine, Temple University School of Medicine, Medical Education Research Building, 3500 North Broad Street, MERB 940, Philadelphia, PA 19140, USA.

PMID: 24839449 PMCID: PMC4019414 DOI: 10.1016/j.ddstr.2014.01.002

Abstract

An ever-increasing number of people world-wide are developing and suffering from heart failure, and existing therapies, although improved are not ideal. Therefore, innovative treatment strategies are urgently needed. As our understanding of the underlying dysfunction of the myocardium increases, so does our ability to target the mechanisms responsible for heart failure progression. In this review we discuss novel molecular therapies and approaches for the treatment of heart failure. We will focus on the G protein-coupled receptor kinase GRK2, an increasing target for heart failure therapy, based on its important role in disease progression and the therapeutic potential of GRK2 inhibitors.

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