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Showing 1 to 12 of 22 entries
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Association of nutritional status with socio-economic and demographic variables of under five year old Nepalese children.

Medical journal of the Islamic Republic of Iran

Karkuki Osguei N, Mascie-Taylor CN.
PMID: 31380318
Med J Islam Repub Iran. 2019 Apr 08;33:28. doi: 10.34171/mjiri.33.28. eCollection 2019.

No abstract available.

Predicting novel candidate human obesity genes and their site of action by systematic functional screening in Drosophila.

PLoS biology

Agrawal N, Lawler K, Davidson CM, Keogh JM, Legg R, Barroso I, Farooqi IS, Brand AH.
PMID: 34748544
PLoS Biol. 2021 Nov 08;19(11):e3001255. doi: 10.1371/journal.pbio.3001255. eCollection 2021 Nov.

The discovery of human obesity-associated genes can reveal new mechanisms to target for weight loss therapy. Genetic studies of obese individuals and the analysis of rare genetic variants can identify novel obesity-associated genes. However, establishing a functional relationship between...

Genetically modulated educational attainment and coronary disease risk.

European heart journal

Zeng L, Ntalla I, Kessler T, Kastrati A, Erdmann J, Danesh J, Watkins H, Samani NJ, Deloukas P, Schunkert H.
PMID: 31170283
Eur Heart J. 2019 Aug 01;40(29):2413-2420. doi: 10.1093/eurheartj/ehz328.

AIMS: Genetic disposition and lifestyle factors are understood as independent components underlying the risk of multiple diseases. In this study, we aim to investigate the interplay between genetics, educational attainment-an important denominator of lifestyle-and coronary artery disease (CAD) risk.METHODS...

Advances in Genomic Discovery and Implications for Personalized Prevention and Medicine: Estonia as Example.

Journal of personalized medicine

Prins BP, Leitsalu L, Pärna K, Fischer K, Metspalu A, Haller T, Snieder H.
PMID: 33946982
J Pers Med. 2021 Apr 29;11(5). doi: 10.3390/jpm11050358.

The current paradigm of personalized medicine envisages the use of genomic data to provide predictive information on the health course of an individual with the aim of prevention and individualized care. However, substantial efforts are required to realize the...

Predicting novel candidate human obesity genes and their site of action by systematic functional screening in Drosophila.

PLoS biology

Agrawal N, Lawler K, Davidson CM, Keogh JM, Legg R, Barroso I, Farooqi IS, Brand AH.
PMID: 34748544
PLoS Biol. 2021 Nov 08;19(11):e3001255. doi: 10.1371/journal.pbio.3001255. eCollection 2021 Nov.

The discovery of human obesity-associated genes can reveal new mechanisms to target for weight loss therapy. Genetic studies of obese individuals and the analysis of rare genetic variants can identify novel obesity-associated genes. However, establishing a functional relationship between...

Optimizing Surveillance and Re-intervention Strategy Following Elective Endovascular Repair of Abdominal Aortic Aneurysms.

Annals of surgery

Kim LG, Sweeting MJ, Epstein D, Venermo M, Rohlffs FEV, Greenhalgh RM.
PMID: 31592810
Ann Surg. 2021 Dec 01;274(6):e589-e598. doi: 10.1097/SLA.0000000000003625.

BACKGROUND: EVAR for abdominal aortic aneurysm has an initial survival advantage over OR, but more frequent complications increase costs and long-term aneurysm-related mortality. Randomized controlled trials of EVAR versus OR have shown EVAR is not cost-effective over a patient's...

Effectiveness of different accelerated partial breast irradiation techniques for the treatment of breast cancer patients: Systematic review using indirect comparisons of randomized clinical trials.

Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology

Marta GN, Barrett J, Porfirio GJM, Martimbianco ALC, Bevilacqua JLB, Poortmans P, Riera R.
PMID: 30814916
Rep Pract Oncol Radiother. 2019 Mar-Apr;24(2):165-174. doi: 10.1016/j.rpor.2019.01.009. Epub 2019 Feb 15.

AIM: This systematic review was conducted to compare the effectiveness of different accelerated partial breast irradiation (APBI) techniques for the treatment of breast cancer patients.BACKGROUND: Numerous (APBI) techniques are available for clinical practice.METHODS AND MATERIALS: Systematic review of randomized...

Ten simple rules to make your computing more environmentally sustainable.

PLoS computational biology

Lannelongue L, Grealey J, Bateman A, Inouye M.
PMID: 34543272
PLoS Comput Biol. 2021 Sep 20;17(9):e1009324. doi: 10.1371/journal.pcbi.1009324. eCollection 2021 Sep.

No abstract available.

Dietary Fatty Acids, Macronutrient Substitutions, Food Sources and Incidence of Coronary Heart Disease: Findings From the EPIC-CVD Case-Cohort Study Across Nine European Countries.

Journal of the American Heart Association

Steur M, Johnson L, Sharp SJ, Imamura F, Sluijs I, Key TJ, Wood A, Chowdhury R, Guevara M, Jakobsen MU, Johansson I, Koulman A, Overvad K, Sánchez MJ, van der Schouw YT, Trichopoulou A, Weiderpass E, Wennberg M, Zheng JS, Boeing H, Boer JMA, Boutron-Ruault MC, Ericson U, Heath AK, Huybrechts I, Imaz L, Kaaks R, Krogh V, Kühn T, Kyrø C, Masala G, Melander O, Moreno-Iribas C, Panico S, Quirós JR, Rodríguez-Barranco M, Sacerdote C, Santiuste C, Skeie G, Tjønneland A, Tumino R, Verschuren WMM, Zamora-Ros R, Dahm CC, Perez-Cornago A, Schulze MB, Tong TYN, Riboli E, Wareham NJ, Danesh J, Butterworth AS, Forouhi NG.
PMID: 34796724
J Am Heart Assoc. 2021 Dec 07;10(23):e019814. doi: 10.1161/JAHA.120.019814. Epub 2021 Nov 19.

Background There is controversy about associations between total dietary fatty acids, their classes (saturated fatty acids [SFAs], monounsaturated fatty acids, and polyunsaturated fatty acids), and risk of coronary heart disease (CHD). Specifically, the relevance of food sources of SFAs...

Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases.

Nature metabolism

Ritchie SC, Lambert SA, Arnold M, Teo SM, Lim S, Scepanovic P, Marten J, Zahid S, Chaffin M, Liu Y, Abraham G, Ouwehand WH, Roberts DJ, Watkins NA, Drew BG, Calkin AC, Di Angelantonio E, Soranzo N, Burgess S, Chapman M, Kathiresan S, Khera AV, Danesh J, Butterworth AS, Inouye M.
PMID: 34750571
Nat Metab. 2021 Nov;3(11):1476-1483. doi: 10.1038/s42255-021-00478-5. Epub 2021 Nov 08.

Cardiometabolic diseases are frequently polygenic in architecture, comprising a large number of risk alleles with small effects spread across the genome

Risk Prediction Using Polygenic Risk Scores for Prevention of Stroke and Other Cardiovascular Diseases.

Stroke

Abraham G, Rutten-Jacobs L, Inouye M.
PMID: 34399584
Stroke. 2021 Aug;52(9):2983-2991. doi: 10.1161/STROKEAHA.120.032619. Epub 2021 Aug 17.

Early prediction of risk of cardiovascular disease (CVD), including stroke, is a cornerstone of disease prevention. Clinical risk scores have been widely used for predicting CVD risk from known risk factors. Most CVDs have a substantial genetic component, which...

Risk of seizure recurrence in people with single seizures and early epilepsy - Model development and external validation.

Seizure

Bonnett LJ, Kim L, Johnson A, Sander JW, Lawn N, Beghi E, Leone M, Marson AG.
PMID: 34852983
Seizure. 2022 Jan;94:26-32. doi: 10.1016/j.seizure.2021.11.007. Epub 2021 Nov 23.

PURPOSE: Following a single seizure, or recent epilepsy diagnosis, it is difficult to balance risk of medication side effects with the potential to prevent seizure recurrence. A prediction model was developed and validated enabling risk stratification which in turn...

Showing 1 to 12 of 22 entries