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Effect of recombinant growth hormone on expression of growth hormone receptor, insulin-like growth factor mRNA and serum level of leptin in growing pigs.

Science in China. Series C, Life sciences

Xu Q, Zhao Z, Ni Y, Zhao R, Chen J.
PMID: 18758711
Sci China C Life Sci. 2003 Apr;46(2):205-11. doi: 10.1360/03yc9022.

Sixteen Large White x Landrace castrated male pigs were allotted into treatment and control group. The treatment group was injected intramuscularly with recombinant porcine growth hormone (rpGH, 4 mg d(-1)) and the control group with vehicle for 28 days....

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Xu Q, Zhao Z, Ni Y, et al. Effect of recombinant growth hormone on expression of growth hormone receptor, insulin-like growth factor mRNA and serum level of leptin in growing pigs. Sci China C Life Sci. 2003;46(2):205-11doi: 10.1360/03yc9022.
Xu, Q., Zhao, Z., Ni, Y., Zhao, R., & Chen, J. (2003). Effect of recombinant growth hormone on expression of growth hormone receptor, insulin-like growth factor mRNA and serum level of leptin in growing pigs. Science in China. Series C, Life sciences, 46(2), 205-11. https://doi.org/10.1360/03yc9022
Xu, Qingfu, et al. "Effect of recombinant growth hormone on expression of growth hormone receptor, insulin-like growth factor mRNA and serum level of leptin in growing pigs." Science in China. Series C, Life sciences vol. 46,2 (2003): 205-11. doi: https://doi.org/10.1360/03yc9022
Xu Q, Zhao Z, Ni Y, Zhao R, Chen J. Effect of recombinant growth hormone on expression of growth hormone receptor, insulin-like growth factor mRNA and serum level of leptin in growing pigs. Sci China C Life Sci. 2003 Apr;46(2):205-11. doi: 10.1360/03yc9022. PMID: 18758711.
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Exosomal survivin facilitates vesicle internalization.

Oncotarget

Gonda A, Kabagwira J, Senthil GN, Ferguson Bennit HR, Neidigh JW, Khan S, Wall NR.
PMID: 30405884
Oncotarget. 2018 Oct 09;9(79):34919-34934. doi: 10.18632/oncotarget.26182. eCollection 2018 Oct 09.

Survivin, a member of the inhibitor of apoptosis (IAP) protein family plays a significant role in cell fate and function. It is significantly overexpressed in tumor cells and has been identified in most cancer cell types. A novel extracellular...

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Gonda A, Kabagwira J, Senthil GN, et al. Exosomal survivin facilitates vesicle internalization. Oncotarget. 2018;9(79):34919-34934doi: 10.18632/oncotarget.26182.
Gonda, A., Kabagwira, J., Senthil, G. N., Ferguson Bennit, H. R., Neidigh, J. W., Khan, S., & Wall, N. R. (2018). Exosomal survivin facilitates vesicle internalization. Oncotarget, 9(79), 34919-34934. https://doi.org/10.18632/oncotarget.26182
Gonda, Amber, et al. "Exosomal survivin facilitates vesicle internalization." Oncotarget vol. 9,79 (2018): 34919-34934. doi: https://doi.org/10.18632/oncotarget.26182
Gonda A, Kabagwira J, Senthil GN, Ferguson Bennit HR, Neidigh JW, Khan S, Wall NR. Exosomal survivin facilitates vesicle internalization. Oncotarget. 2018 Oct 09;9(79):34919-34934. doi: 10.18632/oncotarget.26182. eCollection 2018 Oct 09. PMID: 30405884; PMCID: PMC6201849.
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Downregulation of the let-7 family of microRNAs may promote insulin receptor/insulin-like growth factor signalling pathways in pancreatic ductal adenocarcinoma.

Oncology letters

Nweke EE, Brand M.
PMID: 32782579
Oncol Lett. 2020 Sep;20(3):2613-2620. doi: 10.3892/ol.2020.11854. Epub 2020 Jul 10.

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer type characterized by dysregulated cell signalling pathways and resistance to treatment. The insulin-like growth factor (IGF) signalling pathway has been identified to have a role in tumour progression and therapy resistance....

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Nweke EE, Brand M. Downregulation of the let-7 family of microRNAs may promote insulin receptor/insulin-like growth factor signalling pathways in pancreatic ductal adenocarcinoma. Oncol Lett. 2020;20(3):2613-2620doi: 10.3892/ol.2020.11854.
Nweke, E. E., & Brand, M. (2020). Downregulation of the let-7 family of microRNAs may promote insulin receptor/insulin-like growth factor signalling pathways in pancreatic ductal adenocarcinoma. Oncology letters, 20(3), 2613-2620. https://doi.org/10.3892/ol.2020.11854
Nweke, Ekene Emmanuel, and Brand, Martin. "Downregulation of the let-7 family of microRNAs may promote insulin receptor/insulin-like growth factor signalling pathways in pancreatic ductal adenocarcinoma." Oncology letters vol. 20,3 (2020): 2613-2620. doi: https://doi.org/10.3892/ol.2020.11854
Nweke EE, Brand M. Downregulation of the let-7 family of microRNAs may promote insulin receptor/insulin-like growth factor signalling pathways in pancreatic ductal adenocarcinoma. Oncol Lett. 2020 Sep;20(3):2613-2620. doi: 10.3892/ol.2020.11854. Epub 2020 Jul 10. PMID: 32782579; PMCID: PMC7400736.
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Preclinical and phase I clinical studies of KW-2450, a dual IGF-1R/IR tyrosine kinase inhibitor, in combination with lapatinib and letrozole.

Therapeutic advances in medical oncology

Umehara H, Maekawa Y, Koizumi F, Shimizu M, Ota T, Fouad TM, Willey J, Kaito H, Shiraishi N, Nakashima D, Akinaga S, Ueno NT.
PMID: 30083253
Ther Adv Med Oncol. 2018 Jul 30;10:1758835918786858. doi: 10.1177/1758835918786858. eCollection 2018.

BACKGROUND: KW-2450 is an oral dual insulin-like growth factor-1 receptor/insulin receptor tyrosine kinase inhibitor. We investigated the METHODS: A series of RESULTS: Preclinical studies showed KW-2450 and lapatinib act synergistically to induce CONCLUSIONS: The proposed phase II study of...

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Umehara H, Maekawa Y, Koizumi F, et al. Preclinical and phase I clinical studies of KW-2450, a dual IGF-1R/IR tyrosine kinase inhibitor, in combination with lapatinib and letrozole. Ther Adv Med Oncol. 2018;10:1758835918786858doi: 10.1177/1758835918786858.
Umehara, H., Maekawa, Y., Koizumi, F., Shimizu, M., Ota, T., Fouad, T. M., Willey, J., Kaito, H., Shiraishi, N., Nakashima, D., Akinaga, S., & Ueno, N. T. (2018). Preclinical and phase I clinical studies of KW-2450, a dual IGF-1R/IR tyrosine kinase inhibitor, in combination with lapatinib and letrozole. Therapeutic advances in medical oncology, 101758835918786858. https://doi.org/10.1177/1758835918786858
Umehara, Hiroshi, et al. "Preclinical and phase I clinical studies of KW-2450, a dual IGF-1R/IR tyrosine kinase inhibitor, in combination with lapatinib and letrozole." Therapeutic advances in medical oncology vol. 10 (2018): 1758835918786858. doi: https://doi.org/10.1177/1758835918786858
Umehara H, Maekawa Y, Koizumi F, Shimizu M, Ota T, Fouad TM, Willey J, Kaito H, Shiraishi N, Nakashima D, Akinaga S, Ueno NT. Preclinical and phase I clinical studies of KW-2450, a dual IGF-1R/IR tyrosine kinase inhibitor, in combination with lapatinib and letrozole. Ther Adv Med Oncol. 2018 Jul 30;10:1758835918786858. doi: 10.1177/1758835918786858. eCollection 2018. PMID: 30083253; PMCID: PMC6066809.
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The Protective Effect of Vanadium on Cognitive Impairment and the Neuropathology of Alzheimer's Disease in APPSwe/PS1dE9 Mice.

Frontiers in molecular neuroscience

He Z, Han S, Zhu H, Hu X, Li X, Hou C, Wu C, Xie Q, Li N, Du X, Ni J, Liu Q.
PMID: 32210760
Front Mol Neurosci. 2020 Mar 10;13:21. doi: 10.3389/fnmol.2020.00021. eCollection 2020.

Alzheimer's disease (AD) is a widely distributed neurodegenerative disease characterized clinically by cognitive deficits and pathologically by formation of amyloid-β (Aβ) plaque and neurofibrillary tangles (NFTs) in the brain. Vanadium is a biological trace element that has a function...

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He Z, Han S, Zhu H, et al. The Protective Effect of Vanadium on Cognitive Impairment and the Neuropathology of Alzheimer's Disease in APPSwe/PS1dE9 Mice. Front Mol Neurosci. 2020;13:21doi: 10.3389/fnmol.2020.00021.
He, Z., Han, S., Zhu, H., Hu, X., Li, X., Hou, C., Wu, C., Xie, Q., Li, N., Du, X., Ni, J., & Liu, Q. (2020). The Protective Effect of Vanadium on Cognitive Impairment and the Neuropathology of Alzheimer's Disease in APPSwe/PS1dE9 Mice. Frontiers in molecular neuroscience, 1321. https://doi.org/10.3389/fnmol.2020.00021
He, Zhijun, et al. "The Protective Effect of Vanadium on Cognitive Impairment and the Neuropathology of Alzheimer's Disease in APPSwe/PS1dE9 Mice." Frontiers in molecular neuroscience vol. 13 (2020): 21. doi: https://doi.org/10.3389/fnmol.2020.00021
He Z, Han S, Zhu H, Hu X, Li X, Hou C, Wu C, Xie Q, Li N, Du X, Ni J, Liu Q. The Protective Effect of Vanadium on Cognitive Impairment and the Neuropathology of Alzheimer's Disease in APPSwe/PS1dE9 Mice. Front Mol Neurosci. 2020 Mar 10;13:21. doi: 10.3389/fnmol.2020.00021. eCollection 2020. PMID: 32210760; PMCID: PMC7077345.
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Association between redundant endometrium and endometrial polyps: a pilot study.

Minerva obstetrics and gynecology

Detti L, Peregrin-Alvarez I, Saed GM.
PMID: 34282611
Minerva Obstet Gynecol. 2021 Jul 20; doi: 10.23736/S2724-606X.21.04887-9. Epub 2021 Jul 20.

OBJECTIVE: To explore the organic features of redundant endometrium (RE), we examined the expression of different endometrial hormone receptors, oncogenes, and cell replication markers, in normal endometrium (NE), endometrial polyps (EP) and RE specimens.METHODS: This was an experimental study...

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Detti L, Peregrin-Alvarez I, Saed GM. Association between redundant endometrium and endometrial polyps: a pilot study. Minerva Obstet Gynecol. 2021;doi: 10.23736/S2724-606X.21.04887-9.
Detti, L., Peregrin-Alvarez, I., & Saed, G. M. (2021). Association between redundant endometrium and endometrial polyps: a pilot study. Minerva obstetrics and gynecology, . https://doi.org/10.23736/S2724-606X.21.04887-9
Detti, Laura, et al. "Association between redundant endometrium and endometrial polyps: a pilot study." Minerva obstetrics and gynecology vol. (2021). doi: https://doi.org/10.23736/S2724-606X.21.04887-9
Detti L, Peregrin-Alvarez I, Saed GM. Association between redundant endometrium and endometrial polyps: a pilot study. Minerva Obstet Gynecol. 2021 Jul 20; doi: 10.23736/S2724-606X.21.04887-9. Epub 2021 Jul 20. PMID: 34282611.
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Revisiting the IGF-1R as a breast cancer target.

NPJ precision oncology

Ekyalongo RC, Yee D.
PMID: 29152592
NPJ Precis Oncol. 2017;1. doi: 10.1038/s41698-017-0017-y. Epub 2017 May 01.

The type I insulin-like growth factor-1 receptor is a well-described target in breast cancer and multiple clinical trials examining insulin-like growth factor-1 receptor have been completed. Unfortunately, monoclonal antibodies and tyrosine kinase inhibitors targeting insulin-like growth factor-1 receptor failed...

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Ekyalongo RC, Yee D. Revisiting the IGF-1R as a breast cancer target. NPJ Precis Oncol. 2017;1doi: 10.1038/s41698-017-0017-y.
Ekyalongo, R. C., & Yee, D. (2017). Revisiting the IGF-1R as a breast cancer target. NPJ precision oncology, 1. https://doi.org/10.1038/s41698-017-0017-y
Ekyalongo, Roudy Chiminch, and Yee, Douglas. "Revisiting the IGF-1R as a breast cancer target." NPJ precision oncology vol. 1 (2017). doi: https://doi.org/10.1038/s41698-017-0017-y
Ekyalongo RC, Yee D. Revisiting the IGF-1R as a breast cancer target. NPJ Precis Oncol. 2017;1. doi: 10.1038/s41698-017-0017-y. Epub 2017 May 01. PMID: 29152592; PMCID: PMC5687252.
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Dietary chokeberry and dried jujube fruit attenuates high-fat and high-fructose diet-induced dyslipidemia and insulin resistance via activation of the IRS-1/PI3K/Akt pathway in C57BL/6 J mice.

Nutrition & metabolism

Jeong O, Kim HS.
PMID: 31171927
Nutr Metab (Lond). 2019 Jun 03;16:38. doi: 10.1186/s12986-019-0364-5. eCollection 2019.

BACKGROUND: The incidence of metabolic syndrome linked to dyslipidemia and insulin resistance has increased; thus, studies must be conducted to elucidate this phenomenon. The present study aimed to investigate the protective effects of chokeberry and dried jujube diet on...

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Jeong O, Kim HS. Dietary chokeberry and dried jujube fruit attenuates high-fat and high-fructose diet-induced dyslipidemia and insulin resistance via activation of the IRS-1/PI3K/Akt pathway in C57BL/6 J mice. Nutr Metab (Lond). 2019;16:38doi: 10.1186/s12986-019-0364-5.
Jeong, O., & Kim, H. S. (2019). Dietary chokeberry and dried jujube fruit attenuates high-fat and high-fructose diet-induced dyslipidemia and insulin resistance via activation of the IRS-1/PI3K/Akt pathway in C57BL/6 J mice. Nutrition & metabolism, 1638. https://doi.org/10.1186/s12986-019-0364-5
Jeong, Oeuk, and Kim, Hyun-Sook. "Dietary chokeberry and dried jujube fruit attenuates high-fat and high-fructose diet-induced dyslipidemia and insulin resistance via activation of the IRS-1/PI3K/Akt pathway in C57BL/6 J mice." Nutrition & metabolism vol. 16 (2019): 38. doi: https://doi.org/10.1186/s12986-019-0364-5
Jeong O, Kim HS. Dietary chokeberry and dried jujube fruit attenuates high-fat and high-fructose diet-induced dyslipidemia and insulin resistance via activation of the IRS-1/PI3K/Akt pathway in C57BL/6 J mice. Nutr Metab (Lond). 2019 Jun 03;16:38. doi: 10.1186/s12986-019-0364-5. eCollection 2019. PMID: 31171927; PMCID: PMC6547494.
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Insulin signaling pathway in the masseter muscle of dexamethasone-treated rats.

Interventional medicine & applied science

de França IR, Meneses-Santos D, Moreira GV, Lima FB, Carvalho CRO, Marçal AC.
PMID: 30792919
Interv Med Appl Sci. 2018 Dec;10(4):226-232. doi: 10.1556/1646.10.2018.44.

BACKGROUND AND AIMS: The treatment with glucocorticoids may induce molecular changes in the level and/or degree of phosphorylation of proteins located downstream of the insulin receptor/insulin-like growth factor receptor (IR/IGF1R) in many tissues. However, few studies have investigated the...

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de França IR, Meneses-Santos D, Moreira GV, et al. Insulin signaling pathway in the masseter muscle of dexamethasone-treated rats. Interv Med Appl Sci. 2018;10(4):226-232doi: 10.1556/1646.10.2018.44.
de França, I. R., Meneses-Santos, D., Moreira, G. V., Lima, F. B., Carvalho, C. R. O., & Marçal, A. C. (2018). Insulin signaling pathway in the masseter muscle of dexamethasone-treated rats. Interventional medicine & applied science, 10(4), 226-232. https://doi.org/10.1556/1646.10.2018.44
de França, Igor Rabelo, et al. "Insulin signaling pathway in the masseter muscle of dexamethasone-treated rats." Interventional medicine & applied science vol. 10,4 (2018): 226-232. doi: https://doi.org/10.1556/1646.10.2018.44
de França IR, Meneses-Santos D, Moreira GV, Lima FB, Carvalho CRO, Marçal AC. Insulin signaling pathway in the masseter muscle of dexamethasone-treated rats. Interv Med Appl Sci. 2018 Dec;10(4):226-232. doi: 10.1556/1646.10.2018.44. PMID: 30792919; PMCID: PMC6376360.
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HDAC6 inhibitor TST strengthens the antiproliferative effects of PI3K/mTOR inhibitor BEZ235 in breast cancer cells via suppressing RTK activation.

Cell death & disease

Sun S, Zhang Y, Zheng J, Duan B, Cui J, Chen Y, Deng W, Ye B, Liu L, Chen Y, Du J, Gu L.
PMID: 30206202
Cell Death Dis. 2018 Sep 11;9(9):929. doi: 10.1038/s41419-018-0931-0.

NVP-BEZ235 (BEZ235), an available dual PI3K/mTOR inhibitor, showed antitumor effect and provided a therapy strategy in carcinomas. However, the acquired upregulation of multiple receptor tyrosine kinases (RTKs) by NVP-BEZ235 in tumors limits its clinical efficacy. HDAC6, a class II...

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Sun S, Zhang Y, Zheng J, et al. HDAC6 inhibitor TST strengthens the antiproliferative effects of PI3K/mTOR inhibitor BEZ235 in breast cancer cells via suppressing RTK activation. Cell Death Dis. 2018;9(9):929doi: 10.1038/s41419-018-0931-0.
Sun, S., Zhang, Y., Zheng, J., Duan, B., Cui, J., Chen, Y., Deng, W., Ye, B., Liu, L., Chen, Y., Du, J., & Gu, L. (2018). HDAC6 inhibitor TST strengthens the antiproliferative effects of PI3K/mTOR inhibitor BEZ235 in breast cancer cells via suppressing RTK activation. Cell death & disease, 9(9), 929. https://doi.org/10.1038/s41419-018-0931-0
Sun, Shixiu, et al. "HDAC6 inhibitor TST strengthens the antiproliferative effects of PI3K/mTOR inhibitor BEZ235 in breast cancer cells via suppressing RTK activation." Cell death & disease vol. 9,9 (2018): 929. doi: https://doi.org/10.1038/s41419-018-0931-0
Sun S, Zhang Y, Zheng J, Duan B, Cui J, Chen Y, Deng W, Ye B, Liu L, Chen Y, Du J, Gu L. HDAC6 inhibitor TST strengthens the antiproliferative effects of PI3K/mTOR inhibitor BEZ235 in breast cancer cells via suppressing RTK activation. Cell Death Dis. 2018 Sep 11;9(9):929. doi: 10.1038/s41419-018-0931-0. PMID: 30206202; PMCID: PMC6134008.
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Growth hormone, insulin-like growth factor 1, and insulin signaling-a pharmacological target in body wasting and cachexia.

Journal of cachexia, sarcopenia and muscle

Trobec K, von Haehling S, Anker SD, Lainscak M.
PMID: 22207907
J Cachexia Sarcopenia Muscle. 2011 Dec;2(4):191-200. doi: 10.1007/s13539-011-0043-5. Epub 2011 Oct 20.

Cachexia is an irreversible process that can develop in the course of chronic disease. It is characterized by the remodeling of the metabolic, inflammatory, and endocrine pathways. Insulin, growth hormone (GH), and insulin-like growth factor 1 (IGF-1) are involved...

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Trobec K, von Haehling S, Anker SD, et al. Growth hormone, insulin-like growth factor 1, and insulin signaling-a pharmacological target in body wasting and cachexia. J Cachexia Sarcopenia Muscle. 2011;2(4):191-200doi: 10.1007/s13539-011-0043-5.
Trobec, K., von Haehling, S., Anker, S. D., & Lainscak, M. (2011). Growth hormone, insulin-like growth factor 1, and insulin signaling-a pharmacological target in body wasting and cachexia. Journal of cachexia, sarcopenia and muscle, 2(4), 191-200. https://doi.org/10.1007/s13539-011-0043-5
Trobec, Katja, et al. "Growth hormone, insulin-like growth factor 1, and insulin signaling-a pharmacological target in body wasting and cachexia." Journal of cachexia, sarcopenia and muscle vol. 2,4 (2011): 191-200. doi: https://doi.org/10.1007/s13539-011-0043-5
Trobec K, von Haehling S, Anker SD, Lainscak M. Growth hormone, insulin-like growth factor 1, and insulin signaling-a pharmacological target in body wasting and cachexia. J Cachexia Sarcopenia Muscle. 2011 Dec;2(4):191-200. doi: 10.1007/s13539-011-0043-5. Epub 2011 Oct 20. PMID: 22207907; PMCID: PMC3222822.
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Prevention of hyperglycemic signal pathways in metabolic syndrome carotid artery of rats.

Translational stroke research

Kawai H, Tian F, Kurata T, Deguchi K, Yamashita T, Omote Y, Kono S, Abe K.
PMID: 24323833
Transl Stroke Res. 2012 Dec;3(4):466-72. doi: 10.1007/s12975-012-0205-6. Epub 2012 Aug 14.

Obesity is the major risk factor for metabolic syndrome and atherosclerotic cardiocerebrovascular diseases and induces insulin resistance characterized by a dysfunction of insulin to activate insulin receptor /insulin receptor substrate 1(IRS-1)/phosphoinositide 3-kinase (PI3K)/Akt pathway. Zucker fatty rats (8 weeks)...

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Kawai H, Tian F, Kurata T, et al. Prevention of hyperglycemic signal pathways in metabolic syndrome carotid artery of rats. Transl Stroke Res. 2012;3(4):466-72doi: 10.1007/s12975-012-0205-6.
Kawai, H., Tian, F., Kurata, T., Deguchi, K., Yamashita, T., Omote, Y., Kono, S., & Abe, K. (2012). Prevention of hyperglycemic signal pathways in metabolic syndrome carotid artery of rats. Translational stroke research, 3(4), 466-72. https://doi.org/10.1007/s12975-012-0205-6
Kawai, Hiromi, et al. "Prevention of hyperglycemic signal pathways in metabolic syndrome carotid artery of rats." Translational stroke research vol. 3,4 (2012): 466-72. doi: https://doi.org/10.1007/s12975-012-0205-6
Kawai H, Tian F, Kurata T, Deguchi K, Yamashita T, Omote Y, Kono S, Abe K. Prevention of hyperglycemic signal pathways in metabolic syndrome carotid artery of rats. Transl Stroke Res. 2012 Dec;3(4):466-72. doi: 10.1007/s12975-012-0205-6. Epub 2012 Aug 14. PMID: 24323833.
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Showing 1 to 12 of 37 entries