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Showing 1 to 12 of 16 entries
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Growth-stimulating pathways in lung cancer: implications for targets of therapy.

Clinical lung cancer

Sekine I, Saijo N.
PMID: 14720364
Clin Lung Cancer. 2001 May;2(4):299-306; discussion 307. doi: 10.3816/clc.2001.n.013.

Growth-stimulating pathways activated independently of their normal tissue environment are critical to the carcinogenesis and progression of lung cancer. These pathways are comprised of extracellular growth factors; their specific receptors on the cellular membrane; signal transduction cascades in the...

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Sekine I, Saijo N. Growth-stimulating pathways in lung cancer: implications for targets of therapy. Clin Lung Cancer. 2001;2(4):299-306; discussion 307doi: 10.3816/clc.2001.n.013.
Sekine, I., & Saijo, N. (2001). Growth-stimulating pathways in lung cancer: implications for targets of therapy. Clinical lung cancer, 2(4), 299-306; discussion 307. https://doi.org/10.3816/clc.2001.n.013
Sekine, I, and Saijo, N. "Growth-stimulating pathways in lung cancer: implications for targets of therapy." Clinical lung cancer vol. 2,4 (2001): 299-306; discussion 307. doi: https://doi.org/10.3816/clc.2001.n.013
Sekine I, Saijo N. Growth-stimulating pathways in lung cancer: implications for targets of therapy. Clin Lung Cancer. 2001 May;2(4):299-306; discussion 307. doi: 10.3816/clc.2001.n.013. PMID: 14720364.
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Atypical cannabinoid ligands O-1602 and O-1918 administered chronically in diet-induced obesity.

Endocrine connections

Simcocks AC, Jenkin KA, O'Keefe L, Samuel CS, Mathai ML, McAinch AJ, Hryciw DH.
PMID: 30707678
Endocr Connect. 2019 Mar 01;8(3):203-216. doi: 10.1530/EC-18-0535.

Atypical cannabinoid compounds O-1602 and O-1918 are ligands for the putative cannabinoid receptors G protein-coupled receptor 55 and G protein-coupled receptor 18. The role of O-1602 and O-1918 in attenuating obesity and obesity-related pathologies is unknown. Therefore, we aimed...

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Simcocks AC, Jenkin KA, O'Keefe L, et al. Atypical cannabinoid ligands O-1602 and O-1918 administered chronically in diet-induced obesity. Endocr Connect. 2019;8(3):203-216doi: 10.1530/EC-18-0535.
Simcocks, A. C., Jenkin, K. A., O'Keefe, L., Samuel, C. S., Mathai, M. L., McAinch, A. J., & Hryciw, D. H. (2019). Atypical cannabinoid ligands O-1602 and O-1918 administered chronically in diet-induced obesity. Endocrine connections, 8(3), 203-216. https://doi.org/10.1530/EC-18-0535
Simcocks, Anna C, et al. "Atypical cannabinoid ligands O-1602 and O-1918 administered chronically in diet-induced obesity." Endocrine connections vol. 8,3 (2019): 203-216. doi: https://doi.org/10.1530/EC-18-0535
Simcocks AC, Jenkin KA, O'Keefe L, Samuel CS, Mathai ML, McAinch AJ, Hryciw DH. Atypical cannabinoid ligands O-1602 and O-1918 administered chronically in diet-induced obesity. Endocr Connect. 2019 Mar 01;8(3):203-216. doi: 10.1530/EC-18-0535. PMID: 30707678; PMCID: PMC6391900.
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Targeting Rac and Cdc42 GEFs in Metastatic Cancer.

Frontiers in cell and developmental biology

Maldonado MDM, Medina JI, Velazquez L, Dharmawardhane S.
PMID: 32322580
Front Cell Dev Biol. 2020 Apr 08;8:201. doi: 10.3389/fcell.2020.00201. eCollection 2020.

The Rho family GTPases Rho, Rac, and Cdc42 have emerged as key players in cancer metastasis, due to their essential roles in regulating cell division and actin cytoskeletal rearrangements; and thus, cell growth, migration/invasion, polarity, and adhesion. This review...

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Maldonado MDM, Medina JI, Velazquez L, et al. Targeting Rac and Cdc42 GEFs in Metastatic Cancer. Front Cell Dev Biol. 2020;8:201doi: 10.3389/fcell.2020.00201.
Maldonado, M. D. M., Medina, J. I., Velazquez, L., & Dharmawardhane, S. (2020). Targeting Rac and Cdc42 GEFs in Metastatic Cancer. Frontiers in cell and developmental biology, 8201. https://doi.org/10.3389/fcell.2020.00201
Maldonado, Maria Del Mar, et al. "Targeting Rac and Cdc42 GEFs in Metastatic Cancer." Frontiers in cell and developmental biology vol. 8 (2020): 201. doi: https://doi.org/10.3389/fcell.2020.00201
Maldonado MDM, Medina JI, Velazquez L, Dharmawardhane S. Targeting Rac and Cdc42 GEFs in Metastatic Cancer. Front Cell Dev Biol. 2020 Apr 08;8:201. doi: 10.3389/fcell.2020.00201. eCollection 2020. PMID: 32322580; PMCID: PMC7156542.
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Molecular probes for the human adenosine receptors.

Purinergic signalling

Yang X, Heitman LH, IJzerman AP, van der Es D.
PMID: 33313997
Purinergic Signal. 2021 Mar;17(1):85-108. doi: 10.1007/s11302-020-09753-8. Epub 2020 Dec 12.

Adenosine receptors, G protein-coupled receptors (GPCRs) that are activated by the endogenous ligand adenosine, have been considered potential therapeutic targets in several disorders. To date however, only very few adenosine receptor modulators have made it to the market. Increased...

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Yang X, Heitman LH, IJzerman AP, et al. Molecular probes for the human adenosine receptors. Purinergic Signal. 2020;17(1):85-108doi: 10.1007/s11302-020-09753-8.
Yang, X., Heitman, L. H., IJzerman, A. P., & van der Es, D. (2021). Molecular probes for the human adenosine receptors. Purinergic signalling, 17(1), 85-108. https://doi.org/10.1007/s11302-020-09753-8
Yang, Xue, et al. "Molecular probes for the human adenosine receptors." Purinergic signalling vol. 17,1 (2021): 85-108. doi: https://doi.org/10.1007/s11302-020-09753-8
Yang X, Heitman LH, IJzerman AP, van der Es D. Molecular probes for the human adenosine receptors. Purinergic Signal. 2021 Mar;17(1):85-108. doi: 10.1007/s11302-020-09753-8. Epub 2020 Dec 12. PMID: 33313997; PMCID: PMC7954947.
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Altered Organelle Calcium Transport in Ovarian Physiology and Cancer.

Cancers

Caravia L, Staicu CE, Radu BM, Condrat CE, Crețoiu D, Bacalbașa N, Suciu N, Crețoiu SM, Voinea SC.
PMID: 32785177
Cancers (Basel). 2020 Aug 10;12(8). doi: 10.3390/cancers12082232.

Calcium levels have a huge impact on the physiology of the female reproductive system, in particular, of the ovaries. Cytosolic calcium levels are influenced by regulatory proteins (i.e., ion channels and pumps) localized in the plasmalemma and/or in the...

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Caravia L, Staicu CE, Radu BM, et al. Altered Organelle Calcium Transport in Ovarian Physiology and Cancer. Cancers (Basel). 2020;12(8)doi: 10.3390/cancers12082232.
Caravia, L., Staicu, C. E., Radu, B. M., Condrat, C. E., Crețoiu, D., Bacalbașa, N., Suciu, N., Crețoiu, S. M., & Voinea, S. C. (2020). Altered Organelle Calcium Transport in Ovarian Physiology and Cancer. Cancers, 12(8), . https://doi.org/10.3390/cancers12082232
Caravia, Laura, et al. "Altered Organelle Calcium Transport in Ovarian Physiology and Cancer." Cancers vol. 12,8 (2020). doi: https://doi.org/10.3390/cancers12082232
Caravia L, Staicu CE, Radu BM, Condrat CE, Crețoiu D, Bacalbașa N, Suciu N, Crețoiu SM, Voinea SC. Altered Organelle Calcium Transport in Ovarian Physiology and Cancer. Cancers (Basel). 2020 Aug 10;12(8). doi: 10.3390/cancers12082232. PMID: 32785177; PMCID: PMC7464720.
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Pre-existing Cell States Control Heterogeneity of Both EGFR and CXCR4 Signaling.

Cellular and molecular bioengineering

Spinosa PC, Kinnunen PC, Humphries BA, Luker GD, Luker KE, Linderman JJ.
PMID: 33643466
Cell Mol Bioeng. 2020 Jul 27;14(1):49-64. doi: 10.1007/s12195-020-00640-1. eCollection 2021 Feb.

INTRODUCTION: CXCR4 and epidermal growth factor receptor (EGFR) represent two major families of receptors, G-protein coupled receptors and receptor tyrosine kinases, with central functions in cancer. While utilizing different upstream signaling molecules, both CXCR4 and EGFR activate kinases ERK...

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Spinosa PC, Kinnunen PC, Humphries BA, et al. Pre-existing Cell States Control Heterogeneity of Both EGFR and CXCR4 Signaling. Cell Mol Bioeng. 2020;14(1):49-64doi: 10.1007/s12195-020-00640-1.
Spinosa, P. C., Kinnunen, P. C., Humphries, B. A., Luker, G. D., Luker, K. E., & Linderman, J. J. (2021). Pre-existing Cell States Control Heterogeneity of Both EGFR and CXCR4 Signaling. Cellular and molecular bioengineering, 14(1), 49-64. https://doi.org/10.1007/s12195-020-00640-1
Spinosa, Phillip C, et al. "Pre-existing Cell States Control Heterogeneity of Both EGFR and CXCR4 Signaling." Cellular and molecular bioengineering vol. 14,1 (2021): 49-64. doi: https://doi.org/10.1007/s12195-020-00640-1
Spinosa PC, Kinnunen PC, Humphries BA, Luker GD, Luker KE, Linderman JJ. Pre-existing Cell States Control Heterogeneity of Both EGFR and CXCR4 Signaling. Cell Mol Bioeng. 2020 Jul 27;14(1):49-64. doi: 10.1007/s12195-020-00640-1. eCollection 2021 Feb. PMID: 33643466; PMCID: PMC7878609.
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Peptidyl and Non-Peptidyl Oral Glucagon-Like Peptide-1 Receptor Agonists.

Endocrinology and metabolism (Seoul, Korea)

Choe HJ, Cho YM.
PMID: 33677922
Endocrinol Metab (Seoul). 2021 Feb;36(1):22-29. doi: 10.3803/EnM.2021.102. Epub 2021 Feb 24.

Glucagon-like peptide-1 (GLP-1) receptor agonists are efficacious glucose-lowering medications with salient benefits for body weight and cardiovascular events. This class of medications is now recommended as the top priority for patients with established cardiovascular disease or indicators of high...

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Choe HJ, Cho YM. Peptidyl and Non-Peptidyl Oral Glucagon-Like Peptide-1 Receptor Agonists. Endocrinol Metab (Seoul). 2021;36(1):22-29doi: 10.3803/EnM.2021.102.
Choe, H. J., & Cho, Y. M. (2021). Peptidyl and Non-Peptidyl Oral Glucagon-Like Peptide-1 Receptor Agonists. Endocrinology and metabolism (Seoul, Korea), 36(1), 22-29. https://doi.org/10.3803/EnM.2021.102
Choe, Hun Jee, and Cho, Young Min. "Peptidyl and Non-Peptidyl Oral Glucagon-Like Peptide-1 Receptor Agonists." Endocrinology and metabolism (Seoul, Korea) vol. 36,1 (2021): 22-29. doi: https://doi.org/10.3803/EnM.2021.102
Choe HJ, Cho YM. Peptidyl and Non-Peptidyl Oral Glucagon-Like Peptide-1 Receptor Agonists. Endocrinol Metab (Seoul). 2021 Feb;36(1):22-29. doi: 10.3803/EnM.2021.102. Epub 2021 Feb 24. PMID: 33677922; PMCID: PMC7937847.
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REST-Governed Gene Expression Profiling in a Neuronal Cell Model Reveals Novel Direct and Indirect Processes of Repression and Up-Regulation.

Frontiers in cellular neuroscience

Garcia-Manteiga JM, Bonfiglio S, Folladori L, Malosio ML, Lazarevic D, Stupka E, Cittaro D, Meldolesi J.
PMID: 26617488
Front Cell Neurosci. 2015 Nov 10;9:438. doi: 10.3389/fncel.2015.00438. eCollection 2015.

The role of REST changes in neurons, including the rapid decrease of its level during differentiation and its fluctuations during many mature functions and diseases, is well established. However, identification of many thousand possible REST-target genes, mostly based on...

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Garcia-Manteiga JM, Bonfiglio S, Folladori L, et al. REST-Governed Gene Expression Profiling in a Neuronal Cell Model Reveals Novel Direct and Indirect Processes of Repression and Up-Regulation. Front Cell Neurosci. 2015;9:438doi: 10.3389/fncel.2015.00438.
Garcia-Manteiga, J. M., Bonfiglio, S., Folladori, L., Malosio, M. L., Lazarevic, D., Stupka, E., Cittaro, D., & Meldolesi, J. (2015). REST-Governed Gene Expression Profiling in a Neuronal Cell Model Reveals Novel Direct and Indirect Processes of Repression and Up-Regulation. Frontiers in cellular neuroscience, 9438. https://doi.org/10.3389/fncel.2015.00438
Garcia-Manteiga, Jose M, et al. "REST-Governed Gene Expression Profiling in a Neuronal Cell Model Reveals Novel Direct and Indirect Processes of Repression and Up-Regulation." Frontiers in cellular neuroscience vol. 9 (2015): 438. doi: https://doi.org/10.3389/fncel.2015.00438
Garcia-Manteiga JM, Bonfiglio S, Folladori L, Malosio ML, Lazarevic D, Stupka E, Cittaro D, Meldolesi J. REST-Governed Gene Expression Profiling in a Neuronal Cell Model Reveals Novel Direct and Indirect Processes of Repression and Up-Regulation. Front Cell Neurosci. 2015 Nov 10;9:438. doi: 10.3389/fncel.2015.00438. eCollection 2015. PMID: 26617488; PMCID: PMC4639699.
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Bile acids and sphingosine-1-phosphate receptor 2 in hepatic lipid metabolism.

Acta pharmaceutica Sinica. B

Kwong E, Li Y, Hylemon PB, Zhou H.
PMID: 26579441
Acta Pharm Sin B. 2015 Mar;5(2):151-7. doi: 10.1016/j.apsb.2014.12.009. Epub 2015 Feb 09.

The liver is the central organ involved in lipid metabolism. Dyslipidemia and its related disorders, including non-alcoholic fatty liver disease (NAFLD), obesity and other metabolic diseases, are of increasing public health concern due to their increasing prevalence in the...

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Kwong E, Li Y, Hylemon PB, et al. Bile acids and sphingosine-1-phosphate receptor 2 in hepatic lipid metabolism. Acta Pharm Sin B. 2015;5(2):151-7doi: 10.1016/j.apsb.2014.12.009.
Kwong, E., Li, Y., Hylemon, P. B., & Zhou, H. (2015). Bile acids and sphingosine-1-phosphate receptor 2 in hepatic lipid metabolism. Acta pharmaceutica Sinica. B, 5(2), 151-7. https://doi.org/10.1016/j.apsb.2014.12.009
Kwong, Eric, et al. "Bile acids and sphingosine-1-phosphate receptor 2 in hepatic lipid metabolism." Acta pharmaceutica Sinica. B vol. 5,2 (2015): 151-7. doi: https://doi.org/10.1016/j.apsb.2014.12.009
Kwong E, Li Y, Hylemon PB, Zhou H. Bile acids and sphingosine-1-phosphate receptor 2 in hepatic lipid metabolism. Acta Pharm Sin B. 2015 Mar;5(2):151-7. doi: 10.1016/j.apsb.2014.12.009. Epub 2015 Feb 09. PMID: 26579441; PMCID: PMC4629213.
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Mechanisms of Platelet Activation and Integrin αIIβ3.

Korean circulation journal

Joo SJ.
PMID: 22701130
Korean Circ J. 2012 May;42(5):295-301. doi: 10.4070/kcj.2012.42.5.295. Epub 2012 May 24.

Platelet aggregation is not only an essential part of hemostasis, but also initiates acute coronary syndrome or ischemic stroke. The precise understanding of the activation mechanism of platelet aggregation is fundamental for the development of more effective agents against...

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Joo SJ. Mechanisms of Platelet Activation and Integrin αIIβ3. Korean Circ J. 2012;42(5):295-301doi: 10.4070/kcj.2012.42.5.295.
Joo, S. J. (2012). Mechanisms of Platelet Activation and Integrin αIIβ3. Korean circulation journal, 42(5), 295-301. https://doi.org/10.4070/kcj.2012.42.5.295
Joo, Seung-Jae. "Mechanisms of Platelet Activation and Integrin αIIβ3." Korean circulation journal vol. 42,5 (2012): 295-301. doi: https://doi.org/10.4070/kcj.2012.42.5.295
Joo SJ. Mechanisms of Platelet Activation and Integrin αIIβ3. Korean Circ J. 2012 May;42(5):295-301. doi: 10.4070/kcj.2012.42.5.295. Epub 2012 May 24. PMID: 22701130; PMCID: PMC3369959.
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Extended Phenotyping and Functional Validation Facilitate Diagnosis of a Complex Patient Harboring Genetic Variants in .

Genes

Shao Z, Masuho I, Tumber A, Maynes JT, Tavares E, Ali A, Hewson S, Schulze A, Kannu P, Martemyanov KA, Vincent A.
PMID: 34573334
Genes (Basel). 2021 Aug 29;12(9). doi: 10.3390/genes12091352.

Identifying multiple ultra-rare genetic syndromes with overlapping phenotypes is a diagnostic conundrum in clinical genetics. This study investigated the pathogenicity of a homozygous missense variant in

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Shao Z, Masuho I, Tumber A, et al. Extended Phenotyping and Functional Validation Facilitate Diagnosis of a Complex Patient Harboring Genetic Variants in . Genes (Basel). 2021;12(9)doi: 10.3390/genes12091352.
Shao, Z., Masuho, I., Tumber, A., Maynes, J. T., Tavares, E., Ali, A., Hewson, S., Schulze, A., Kannu, P., Martemyanov, K. A., & Vincent, A. (2021). Extended Phenotyping and Functional Validation Facilitate Diagnosis of a Complex Patient Harboring Genetic Variants in . Genes, 12(9), . https://doi.org/10.3390/genes12091352
Shao, Zhuo, et al. "Extended Phenotyping and Functional Validation Facilitate Diagnosis of a Complex Patient Harboring Genetic Variants in ." Genes vol. 12,9 (2021). doi: https://doi.org/10.3390/genes12091352
Shao Z, Masuho I, Tumber A, Maynes JT, Tavares E, Ali A, Hewson S, Schulze A, Kannu P, Martemyanov KA, Vincent A. Extended Phenotyping and Functional Validation Facilitate Diagnosis of a Complex Patient Harboring Genetic Variants in . Genes (Basel). 2021 Aug 29;12(9). doi: 10.3390/genes12091352. PMID: 34573334; PMCID: PMC8469011.
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Allosteric binding sites at the receptor-lipid bilayer interface: novel targets for GPCR drug discovery.

Drug discovery today

Wang Y, Yu Z, Xiao W, Lu S, Zhang J.
PMID: 33301977
Drug Discov Today. 2021 Mar;26(3):690-703. doi: 10.1016/j.drudis.2020.12.001. Epub 2020 Dec 07.

As a superfamily of membrane receptors, G-protein-coupled receptors (GPCRs) have significant roles in human physiological processes, including cell proliferation, metabolism, and neuromodulation. GPCRs are vital targets of therapeutic drugs, and their allosteric regulation represents a novel direction for drug...

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Wang Y, Yu Z, Xiao W, et al. Allosteric binding sites at the receptor-lipid bilayer interface: novel targets for GPCR drug discovery. Drug Discov Today. 2020;26(3):690-703doi: 10.1016/j.drudis.2020.12.001.
Wang, Y., Yu, Z., Xiao, W., Lu, S., & Zhang, J. (2021). Allosteric binding sites at the receptor-lipid bilayer interface: novel targets for GPCR drug discovery. Drug discovery today, 26(3), 690-703. https://doi.org/10.1016/j.drudis.2020.12.001
Wang, Ying, et al. "Allosteric binding sites at the receptor-lipid bilayer interface: novel targets for GPCR drug discovery." Drug discovery today vol. 26,3 (2021): 690-703. doi: https://doi.org/10.1016/j.drudis.2020.12.001
Wang Y, Yu Z, Xiao W, Lu S, Zhang J. Allosteric binding sites at the receptor-lipid bilayer interface: novel targets for GPCR drug discovery. Drug Discov Today. 2021 Mar;26(3):690-703. doi: 10.1016/j.drudis.2020.12.001. Epub 2020 Dec 07. PMID: 33301977.
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Showing 1 to 12 of 16 entries