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Showing 1 to 12 of 59 entries
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Targeted therapy for breast cancer prevention.

Frontiers in oncology

den Hollander P, Savage MI, Brown PH.
PMID: 24069582
Front Oncol. 2013 Sep 23;3:250. doi: 10.3389/fonc.2013.00250.

With a better understanding of the etiology of breast cancer, molecularly targeted drugs have been developed and are being testing for the treatment and prevention of breast cancer. Targeted drugs that inhibit the estrogen receptor (ER) or estrogen-activated pathways...

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den Hollander P, Savage MI, Brown PH. Targeted therapy for breast cancer prevention. Front Oncol. 2013;3:250doi: 10.3389/fonc.2013.00250.
den Hollander, P., Savage, M. I., & Brown, P. H. (2013). Targeted therapy for breast cancer prevention. Frontiers in oncology, 3250. https://doi.org/10.3389/fonc.2013.00250
den Hollander, Petra, et al. "Targeted therapy for breast cancer prevention." Frontiers in oncology vol. 3 (2013): 250. doi: https://doi.org/10.3389/fonc.2013.00250
den Hollander P, Savage MI, Brown PH. Targeted therapy for breast cancer prevention. Front Oncol. 2013 Sep 23;3:250. doi: 10.3389/fonc.2013.00250. PMID: 24069582; PMCID: PMC3780469.
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Effect of LXR/RXR agonism on brain and CSF Aβ40 levels in rats.

F1000Research

Wang S, Wen P, Wood S.
PMID: 27239272
F1000Res. 2016 Feb 04;5:138. doi: 10.12688/f1000research.7868.1. eCollection 2016.

Alzheimer's disease (AD) is characterized pathologically by the presence of amyloid plaques and neurofibrillary tangles.  The amyloid hypothesis contends that the abnormal accumulation of Aβ, the principal component of amyloid plaques, plays an essential role in initiating the disease....

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Wang S, Wen P, Wood S. Effect of LXR/RXR agonism on brain and CSF Aβ40 levels in rats. F1000Res. 2016;5:138doi: 10.12688/f1000research.7868.1.
Wang, S., Wen, P., & Wood, S. (2016). Effect of LXR/RXR agonism on brain and CSF Aβ40 levels in rats. F1000Research, 5138. https://doi.org/10.12688/f1000research.7868.1
Wang, Songli, et al. "Effect of LXR/RXR agonism on brain and CSF Aβ40 levels in rats." F1000Research vol. 5 (2016): 138. doi: https://doi.org/10.12688/f1000research.7868.1
Wang S, Wen P, Wood S. Effect of LXR/RXR agonism on brain and CSF Aβ40 levels in rats. F1000Res. 2016 Feb 04;5:138. doi: 10.12688/f1000research.7868.1. eCollection 2016. PMID: 27239272.
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Identifying the receptor subtype selectivity of retinoid X and retinoic acid receptors via quantum mechanics.

FEBS open bio

Tsuji M, Shudo K, Kagechika H.
PMID: 28286734
FEBS Open Bio. 2017 Feb 05;7(3):391-396. doi: 10.1002/2211-5463.12188. eCollection 2017 Mar.

Understanding and identifying the receptor subtype selectivity of a ligand is an important issue in the field of drug discovery. Using a combination of classical molecular mechanics and quantum mechanical calculations, this report assesses the receptor subtype selectivity for...

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Tsuji M, Shudo K, Kagechika H. Identifying the receptor subtype selectivity of retinoid X and retinoic acid receptors via quantum mechanics. FEBS Open Bio. 2017;7(3):391-396doi: 10.1002/2211-5463.12188.
Tsuji, M., Shudo, K., & Kagechika, H. (2017). Identifying the receptor subtype selectivity of retinoid X and retinoic acid receptors via quantum mechanics. FEBS open bio, 7(3), 391-396. https://doi.org/10.1002/2211-5463.12188
Tsuji, Motonori, et al. "Identifying the receptor subtype selectivity of retinoid X and retinoic acid receptors via quantum mechanics." FEBS open bio vol. 7,3 (2017): 391-396. doi: https://doi.org/10.1002/2211-5463.12188
Tsuji M, Shudo K, Kagechika H. Identifying the receptor subtype selectivity of retinoid X and retinoic acid receptors via quantum mechanics. FEBS Open Bio. 2017 Feb 05;7(3):391-396. doi: 10.1002/2211-5463.12188. eCollection 2017 Mar. PMID: 28286734; PMCID: PMC5337894.
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EPA/DHA and Vitamin A Supplementation Improves Spatial Memory and Alleviates the Age-related Decrease in Hippocampal RXRγ and Kinase Expression in Rats.

Frontiers in aging neuroscience

Létondor A, Buaud B, Vaysse C, Richard E, Layé S, Pallet V, Alfos S.
PMID: 27242514
Front Aging Neurosci. 2016 May 09;8:103. doi: 10.3389/fnagi.2016.00103. eCollection 2016.

Studies suggest that eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and vitamin A are critical to delay aged-related cognitive decline. These nutrients regulate gene expression in the brain by binding to nuclear receptors such as the retinoid X receptors (RXRs)...

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Létondor A, Buaud B, Vaysse C, et al. EPA/DHA and Vitamin A Supplementation Improves Spatial Memory and Alleviates the Age-related Decrease in Hippocampal RXRγ and Kinase Expression in Rats. Front Aging Neurosci. 2016;8:103doi: 10.3389/fnagi.2016.00103.
Létondor, A., Buaud, B., Vaysse, C., Richard, E., Layé, S., Pallet, V., & Alfos, S. (2016). EPA/DHA and Vitamin A Supplementation Improves Spatial Memory and Alleviates the Age-related Decrease in Hippocampal RXRγ and Kinase Expression in Rats. Frontiers in aging neuroscience, 8103. https://doi.org/10.3389/fnagi.2016.00103
Létondor, Anne, et al. "EPA/DHA and Vitamin A Supplementation Improves Spatial Memory and Alleviates the Age-related Decrease in Hippocampal RXRγ and Kinase Expression in Rats." Frontiers in aging neuroscience vol. 8 (2016): 103. doi: https://doi.org/10.3389/fnagi.2016.00103
Létondor A, Buaud B, Vaysse C, Richard E, Layé S, Pallet V, Alfos S. EPA/DHA and Vitamin A Supplementation Improves Spatial Memory and Alleviates the Age-related Decrease in Hippocampal RXRγ and Kinase Expression in Rats. Front Aging Neurosci. 2016 May 09;8:103. doi: 10.3389/fnagi.2016.00103. eCollection 2016. PMID: 27242514; PMCID: PMC4860397.
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A Novel Method for a Stereoselective Synthesis of Trisubstituted Olefin Using Tricarbonyliron Complex: A Highly Stereoselective Synthesis of (all-E)- and (9Z)-Retinoic Acids.

The Journal of organic chemistry

Wada A, Hiraishi S, Takamura N, Date T, Aoe K, Ito M.
PMID: 11671757
J Org Chem. 1997 Jun 27;62(13):4343-4348. doi: 10.1021/jo961041+.

In order to establish the stereoselective synthesis of retinoic acids, which are ligand molecules of the retinoic acid receptors (RARs, all-E-isomer) and the retinoid X receptors (RXRs, 9Z-isomer), the reaction of beta-ionone-tricarbonyliron complex 7 with carbanions was investigated. Treatment...

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Wada A, Hiraishi S, Takamura N, et al. A Novel Method for a Stereoselective Synthesis of Trisubstituted Olefin Using Tricarbonyliron Complex: A Highly Stereoselective Synthesis of (all-E)- and (9Z)-Retinoic Acids. J Org Chem. 1997;62(13):4343-4348doi: 10.1021/jo961041+.
Wada, A., Hiraishi, S., Takamura, N., Date, T., Aoe, K., & Ito, M. (1997). A Novel Method for a Stereoselective Synthesis of Trisubstituted Olefin Using Tricarbonyliron Complex: A Highly Stereoselective Synthesis of (all-E)- and (9Z)-Retinoic Acids. The Journal of organic chemistry, 62(13), 4343-4348. https://doi.org/10.1021/jo961041+
Wada, Akimori, et al. "A Novel Method for a Stereoselective Synthesis of Trisubstituted Olefin Using Tricarbonyliron Complex: A Highly Stereoselective Synthesis of (all-E)- and (9Z)-Retinoic Acids." The Journal of organic chemistry vol. 62,13 (1997): 4343-4348. doi: https://doi.org/10.1021/jo961041+
Wada A, Hiraishi S, Takamura N, Date T, Aoe K, Ito M. A Novel Method for a Stereoselective Synthesis of Trisubstituted Olefin Using Tricarbonyliron Complex: A Highly Stereoselective Synthesis of (all-E)- and (9Z)-Retinoic Acids. J Org Chem. 1997 Jun 27;62(13):4343-4348. doi: 10.1021/jo961041+. PMID: 11671757.
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The role of peroxisome proliferator-activated receptors in the development and physiology of gametes and preimplantation embryos.

PPAR research

Huang JC.
PMID: 18354728
PPAR Res. 2008;2008:732303. doi: 10.1155/2008/732303.

In several species, a family of nuclear receptors, the peroxisome proliferator-activated receptors (PPARs) composed of three isotypes, is expressed in somatic cells and germ cells of the ovary as well as the testis. Invalidation of these receptors in mice...

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Huang JC. The role of peroxisome proliferator-activated receptors in the development and physiology of gametes and preimplantation embryos. PPAR Res. 2008;2008:732303doi: 10.1155/2008/732303.
Huang, J. C. (2008). The role of peroxisome proliferator-activated receptors in the development and physiology of gametes and preimplantation embryos. PPAR research, 2008732303. https://doi.org/10.1155/2008/732303
Huang, Jaou-Chen. "The role of peroxisome proliferator-activated receptors in the development and physiology of gametes and preimplantation embryos." PPAR research vol. 2008 (2008): 732303. doi: https://doi.org/10.1155/2008/732303
Huang JC. The role of peroxisome proliferator-activated receptors in the development and physiology of gametes and preimplantation embryos. PPAR Res. 2008;2008:732303. doi: 10.1155/2008/732303. PMID: 18354728; PMCID: PMC2266973.
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Polyunsaturated fatty acids: From diet to binding to ppars and other nuclear receptors.

Genes & nutrition

Bordoni A, Di Nunzio M, Danesi F, Biagi PL.
PMID: 18850203
Genes Nutr. 2006 Jun;1(2):95-106. doi: 10.1007/BF02829951.

Dietary polyunsaturated fatty acids (PUFAs) function not only by altering membrane lipid composition, cellular metabolism, signal transduction, but possess also effects on gene expression by regulating the activity/abundance of different nuclear transcription factors: peroxisome proliferator activated receptors, retinoid X...

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Bordoni A, Di Nunzio M, Danesi F, et al. Polyunsaturated fatty acids: From diet to binding to ppars and other nuclear receptors. Genes Nutr. 2006;1(2):95-106doi: 10.1007/BF02829951.
Bordoni, A., Di Nunzio, M., Danesi, F., & Biagi, P. L. (2006). Polyunsaturated fatty acids: From diet to binding to ppars and other nuclear receptors. Genes & nutrition, 1(2), 95-106. https://doi.org/10.1007/BF02829951
Bordoni, A, et al. "Polyunsaturated fatty acids: From diet to binding to ppars and other nuclear receptors." Genes & nutrition vol. 1,2 (2006): 95-106. doi: https://doi.org/10.1007/BF02829951
Bordoni A, Di Nunzio M, Danesi F, Biagi PL. Polyunsaturated fatty acids: From diet to binding to ppars and other nuclear receptors. Genes Nutr. 2006 Jun;1(2):95-106. doi: 10.1007/BF02829951. PMID: 18850203; PMCID: PMC3454679.
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Liver x receptor: a novel therapeutic target.

Indian journal of pharmaceutical sciences

Patel MB, Oza NA, Anand IS, Deshpande SS, Patel CN.
PMID: 20046702
Indian J Pharm Sci. 2008 Mar-Apr;70(2):135-44. doi: 10.4103/0250-474X.41445.

The liver X receptors alpha and beta are orphan nuclear receptors that are key regulators in maintaining cholesterol homeostasis. Originally they were found to play an important role in reverse cholesterol transport, a pathway for the removal of excess...

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Patel MB, Oza NA, Anand IS, et al. Liver x receptor: a novel therapeutic target. Indian J Pharm Sci. 2008;70(2):135-44doi: 10.4103/0250-474X.41445.
Patel, M. B., Oza, N. A., Anand, I. S., Deshpande, S. S., & Patel, C. N. (2008). Liver x receptor: a novel therapeutic target. Indian journal of pharmaceutical sciences, 70(2), 135-44. https://doi.org/10.4103/0250-474X.41445
Patel, M B, et al. "Liver x receptor: a novel therapeutic target." Indian journal of pharmaceutical sciences vol. 70,2 (2008): 135-44. doi: https://doi.org/10.4103/0250-474X.41445
Patel MB, Oza NA, Anand IS, Deshpande SS, Patel CN. Liver x receptor: a novel therapeutic target. Indian J Pharm Sci. 2008 Mar-Apr;70(2):135-44. doi: 10.4103/0250-474X.41445. PMID: 20046702; PMCID: PMC2792482.
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Regulation of retinoid and thyroid hormone action through homodimeric and heterodimeric receptors.

Trends in endocrinology and metabolism: TEM

Zhang XK, Kahl M.
PMID: 18407151
Trends Endocrinol Metab. 1993 Jul;4(5):156-62. doi: 10.1016/1043-2760(93)90105-n.

Biologic responses to retinoids and thyroid hormones are mediated by their intracellular receptor proteins. Many exciting advances have been made recently in understanding the molecular mechanism by which these receptor proteins operate. In contrast to the steroid hormone receptors...

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Zhang XK, Kahl M. Regulation of retinoid and thyroid hormone action through homodimeric and heterodimeric receptors. Trends Endocrinol Metab. 1993;4(5):156-62doi: 10.1016/1043-2760(93)90105-n.
Zhang, X. K., & Kahl, M. (1993). Regulation of retinoid and thyroid hormone action through homodimeric and heterodimeric receptors. Trends in endocrinology and metabolism: TEM, 4(5), 156-62. https://doi.org/10.1016/1043-2760(93)90105-n
Zhang, X K, and Kahl, M. "Regulation of retinoid and thyroid hormone action through homodimeric and heterodimeric receptors." Trends in endocrinology and metabolism: TEM vol. 4,5 (1993): 156-62. doi: https://doi.org/10.1016/1043-2760(93)90105-n
Zhang XK, Kahl M. Regulation of retinoid and thyroid hormone action through homodimeric and heterodimeric receptors. Trends Endocrinol Metab. 1993 Jul;4(5):156-62. doi: 10.1016/1043-2760(93)90105-n. PMID: 18407151.
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A Novel Biphenyl-based Chemotype of Retinoid X Receptor Ligands Enables Subtype and Heterodimer Preferences.

ACS medicinal chemistry letters

Pollinger J, Schierle S, Gellrich L, Ohrndorf J, Kaiser A, Heitel P, Chaikuad A, Knapp S, Merk D.
PMID: 31531208
ACS Med Chem Lett. 2019 Aug 16;10(9):1346-1352. doi: 10.1021/acsmedchemlett.9b00306. eCollection 2019 Sep 12.

The nuclear retinoid X receptors (RXRs) are key ligand sensing transcription factors that serve as universal nuclear receptor heterodimer partners and are thus involved in numerous physiological processes. Therapeutic targeting of RXRs holds high potential but available RXR activators...

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Pollinger J, Schierle S, Gellrich L, et al. A Novel Biphenyl-based Chemotype of Retinoid X Receptor Ligands Enables Subtype and Heterodimer Preferences. ACS Med Chem Lett. 2019;10(9):1346-1352doi: 10.1021/acsmedchemlett.9b00306.
Pollinger, J., Schierle, S., Gellrich, L., Ohrndorf, J., Kaiser, A., Heitel, P., Chaikuad, A., Knapp, S., & Merk, D. (2019). A Novel Biphenyl-based Chemotype of Retinoid X Receptor Ligands Enables Subtype and Heterodimer Preferences. ACS medicinal chemistry letters, 10(9), 1346-1352. https://doi.org/10.1021/acsmedchemlett.9b00306
Pollinger, Julius, et al. "A Novel Biphenyl-based Chemotype of Retinoid X Receptor Ligands Enables Subtype and Heterodimer Preferences." ACS medicinal chemistry letters vol. 10,9 (2019): 1346-1352. doi: https://doi.org/10.1021/acsmedchemlett.9b00306
Pollinger J, Schierle S, Gellrich L, Ohrndorf J, Kaiser A, Heitel P, Chaikuad A, Knapp S, Merk D. A Novel Biphenyl-based Chemotype of Retinoid X Receptor Ligands Enables Subtype and Heterodimer Preferences. ACS Med Chem Lett. 2019 Aug 16;10(9):1346-1352. doi: 10.1021/acsmedchemlett.9b00306. eCollection 2019 Sep 12. PMID: 31531208; PMCID: PMC6746191.
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Computational determination of human PPARG gene: SNPs and prediction of their effect on protein functions of diabetic patients.

Clinical and translational medicine

Mustafa HA, Albkrye AMS, AbdAlla BM, Khair MAM, Abdelwahid N, Elnasri HA.
PMID: 32064572
Clin Transl Med. 2020 Feb 17;9(1):7. doi: 10.1186/s40169-020-0258-1.

BACKGROUND: The Peroxisome proliferator-activated receptor gamma gene (PPARG), encodes a member of the peroxisome-activated receptor subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) which regulate transcription of various genes. Three subtypes of PPARs are known:...

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Mustafa HA, Albkrye AMS, AbdAlla BM, et al. Computational determination of human PPARG gene: SNPs and prediction of their effect on protein functions of diabetic patients. Clin Transl Med. 2020;9(1):7doi: 10.1186/s40169-020-0258-1.
Mustafa, H. A., Albkrye, A. M. S., AbdAlla, B. M., Khair, M. A. M., Abdelwahid, N., & Elnasri, H. A. (2020). Computational determination of human PPARG gene: SNPs and prediction of their effect on protein functions of diabetic patients. Clinical and translational medicine, 9(1), 7. https://doi.org/10.1186/s40169-020-0258-1
Mustafa, Howeida Abdullah, et al. "Computational determination of human PPARG gene: SNPs and prediction of their effect on protein functions of diabetic patients." Clinical and translational medicine vol. 9,1 (2020): 7. doi: https://doi.org/10.1186/s40169-020-0258-1
Mustafa HA, Albkrye AMS, AbdAlla BM, Khair MAM, Abdelwahid N, Elnasri HA. Computational determination of human PPARG gene: SNPs and prediction of their effect on protein functions of diabetic patients. Clin Transl Med. 2020 Feb 17;9(1):7. doi: 10.1186/s40169-020-0258-1. PMID: 32064572; PMCID: PMC7024687.
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Molecular docking, dynamics, and pharmacology studies on bexarotene as an agonist of ligand-activated transcription factors, retinoid X receptors.

Journal of cellular biochemistry

Chitranshi N, Dheer Y, Kumar S, Graham SL, Gupta V.
PMID: 30746761
J Cell Biochem. 2019 Feb 11; doi: 10.1002/jcb.28455. Epub 2019 Feb 11.

Retinoid X receptors (RXRs) belong to the nuclear receptor superfamily, and upon ligand activation, these receptors control gene transcription via either homodimerization with themselves or heterodimerization with the partner-nuclear receptor. The protective effects of RXRs and RXR agonists have...

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Chitranshi N, Dheer Y, Kumar S, et al. Molecular docking, dynamics, and pharmacology studies on bexarotene as an agonist of ligand-activated transcription factors, retinoid X receptors. J Cell Biochem. 2019;doi: 10.1002/jcb.28455.
Chitranshi, N., Dheer, Y., Kumar, S., Graham, S. L., & Gupta, V. (2019). Molecular docking, dynamics, and pharmacology studies on bexarotene as an agonist of ligand-activated transcription factors, retinoid X receptors. Journal of cellular biochemistry, . https://doi.org/10.1002/jcb.28455
Chitranshi, Nitin, et al. "Molecular docking, dynamics, and pharmacology studies on bexarotene as an agonist of ligand-activated transcription factors, retinoid X receptors." Journal of cellular biochemistry vol. (2019). doi: https://doi.org/10.1002/jcb.28455
Chitranshi N, Dheer Y, Kumar S, Graham SL, Gupta V. Molecular docking, dynamics, and pharmacology studies on bexarotene as an agonist of ligand-activated transcription factors, retinoid X receptors. J Cell Biochem. 2019 Feb 11; doi: 10.1002/jcb.28455. Epub 2019 Feb 11. PMID: 30746761.
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Showing 1 to 12 of 59 entries