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Showing 1 to 12 of 218 entries
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Emerging therapies for the treatment of osteoporosis.

Journal of mid-life health

Bhutani G, Gupta MC.
PMID: 24672186
J Midlife Health. 2013 Jul;4(3):147-52. doi: 10.4103/0976-7800.118991.

Osteoporosis is a chronic disease of the osseous system characterized by decreased bone strength and increased fracture risk. It is due to an imbalance in the dynamic ongoing processes of bone formation and bone resorption. Currently available osteoporosis therapies...

Past, present, and future of hormonal therapy in recurrent endometrial cancer.

International journal of women's health

Carlson MJ, Thiel KW, Leslie KK.
PMID: 24833920
Int J Womens Health. 2014 May 02;6:429-35. doi: 10.2147/IJWH.S40942. eCollection 2014.

Endometrial cancer is a heterogeneous disease. Type I cancers are hormonally driven, typically present with a low grade at an early stage, and are of endometrioid histology. These cancers are often cured by surgery, and the rate of recurrence...

Design, Synthesis and Biochemical Evaluation of Novel Selective Estrogen Receptor Ligand Conjugates Incorporating an Endoxifen-Combretastatin Hybrid Scaffold.

Biomedicines

Keely NO, Carr M, Yassin B, Ana G, Lloyd DG, Zisterer D, Meegan MJ.
PMID: 28536383
Biomedicines. 2016 Jul 20;4(3). doi: 10.3390/biomedicines4030015.

Nuclear-receptors are often overexpressed in tumours and can thereby be used as targets when designing novel selective chemotherapeutic agents. To date, many conjugates incorporating an estrogen receptor (ER) ligand have been synthesised in order to direct chemical agents to...

Fulvestrant up regulates UGT1A4 and MRPs through ERα and c-Myb pathways: a possible primary drug disposition mechanism.

SpringerPlus

Edavana VK, Penney RB, Yao-Borengasser A, Williams S, Rogers L, Dhakal IB, Kadlubar S.
PMID: 24298433
Springerplus. 2013 Nov 20;2:620. doi: 10.1186/2193-1801-2-620. eCollection 2013.

Fulvestrant (Faslodex™) is a pure antiestrogen that is effective in treating estrogen receptor-(ER) positive breast cancer tumors that are resistant to selective estrogen receptor modulators such as tamoxifen. Clinical trials investigating the utility of adding fulvestrant to other therapeutics...

Phytoestrogens as hormone replacement therapy: an evidence-based approach.

Primary care update for Ob/Gyns

Carusi D.
PMID: 11077239
Prim Care Update Ob Gyns. 2000 Nov 01;7(6):253-259. doi: 10.1016/s1068-607x(00)00055-x.

Postmenopausal women have sought nonestrogen alternatives to hormone replacement in order to avoid possible risks and side effects of the therapy. Selective estrogen receptor modulators have been developed to tailor therapy to a specific risk/benefit profile that will best...

Monitoring antiosteoporotic treatment of postmenopausal women using biochemical markers of bone turnover.

Drugs of today (Barcelona, Spain : 1998)

Kress BC, Mizrahi IA.
PMID: 12973383
Drugs Today (Barc). 1999 Mar;35(3):181-5. doi: 10.1358/dot.1999.35.3.533847.

Postmenopausal osteoporosis is preventable. An increasing number of antiresorptive therapies including estrogen, selective estrogen receptor modulators (the so-called designer estrogens), bisphosphonates and calcitonins are now available as treatment options for osteoporosis. These agents reduce the level of bone turnover...

The National Cancer Institute of Canada Clinical Trials Group MAP.3 trial: an international breast cancer prevention trial.

Current oncology (Toronto, Ont.)

Richardson H, Johnston D, Pater J, Goss P.
PMID: 17593981
Curr Oncol. 2007 Jun;14(3):89-96. doi: 10.3747/co.2007.117.

Several large phase III trials have demonstrated that tamoxifen-and more recently, raloxifene-can effectively reduce the incidence of invasive breast cancer by 50%. However, these selective estrogen receptor modulators can also be associated with several rare, but serious, adverse events....

Can biomarkers direct the optimal use of aromatase inhibitors versus selective estrogen receptor modulators?.

Nature clinical practice. Oncology

Schiff R, Lee AV.
PMID: 16520802
Nat Clin Pract Oncol. 2006 Mar;3(3):134-5. doi: 10.1038/ncponc0444.

No abstract available.

[Future prospects for the treatment of osteoporosis].

Clinical calcium

Matsumoto T.
PMID: 15775498
Clin Calcium. 2001 Jan;11(1):87-91. doi: CliCa01018791.

In order to prevent osteoporotic fractures, various drugs with anti-resorptive effects have been developed. These include new generation of bisphosphonates and selective estrogen receptor modulators. There are also agents under development with stimulatory effect on bone formation, including parathyroid...

CINP 2000. Selective estrogen receptor modulators.

IDrugs : the investigational drugs journal

Moret C.
PMID: 16049860
IDrugs. 2000 Sep;3(9):1026-9.

No abstract available.

Docking study of triphenylphosphonium cations as estrogen receptor alpha modulators.

Bioinformation

Salisbury JP, Williams JC.
PMID: 19293997
Bioinformation. 2009;3(7):303-7. doi: 10.6026/97320630003303. Epub 2009 Feb 28.

Virtual high throughput screening (VHTS) was performed to assess possible interactions which might occur between commercially available triphenylphosphonium (TPP) cations and estrogen receptor alpha (ERalpha) that could be exploited to design novel ERalpha modulators. One application of TPP cations...

Anastrozole Use in Early Stage Breast Cancer of Post-Menopausal Women.

Clinical medicine. Therapeutics

Milani M, Jha G, Potter DA.
PMID: 19794821
Clin Med Ther. 2009 Mar 31;1:141-156. doi: 10.4137/cmt.s9.

The majority of breast cancers express the estrogen receptor and depend on estradiol (E2) for their growth. Hormonal therapy aims at depriving estrogen signaling either by using selective estrogen receptor modulators (SERM)-that interfere with the binding of E2 to...

Showing 1 to 12 of 218 entries