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Cholesterol level goal attainment with statins: clinical management guideline recommendations versus management in actual clinical practice

community settings

[No authors listed]
GSID: G7hqL0ln8I8J
EM Heintjes, FJA Penning‐van Beest… - … : The Journal of …, 2012 - Wiley Online Library

Study Objectives To compare the cholesterol level goal attainment rates in patients receiving simvastatin doses recommended in clinical practice guidelines and simvastatin doses most …

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Heintjes, E. M., Penning‐van Beest, F. J., Plat, A. W., Meerding, W. J., Webb, K., Sturkenboom, M. C., & Herings, R. M. (2012). Cholesterol level goal attainment with statins: clinical management guideline recommendations versus management in actual clinical practice. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 32(7), 631-641.
Heintjes, Edith M., et al. "Cholesterol level goal attainment with statins: clinical management guideline recommendations versus management in actual clinical practice." Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 32.7 (2012): 631-641.
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The impact of initial statin treatment decisions on cardiovascular outcomes in clinical care settings: estimates using the Archimedes Model.

ClinicoEconomics and outcomes research : CEOR

van Herick A, Schuetz CA, Alperin P, Bullano MF, Balu S, Gandhi S.
PMID: 23180970
Clinicoecon Outcomes Res. 2012;4:337-47. doi: 10.2147/CEOR.S35487. Epub 2012 Nov 09.

PURPOSE: Many patients treated for dyslipidemia do not achieve recommended cholesterol goals despite the widespread availability of effective statins. Pharmaceutical claims show a strong tendency for patients to remain on their initially assigned treatment. With computer simulations, the impact...

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van Herick A, Schuetz CA, Alperin P, et al. The impact of initial statin treatment decisions on cardiovascular outcomes in clinical care settings: estimates using the Archimedes Model. Clinicoecon Outcomes Res. 2012;4:337-47doi: 10.2147/CEOR.S35487.
van Herick, A., Schuetz, C. A., Alperin, P., Bullano, M. F., Balu, S., & Gandhi, S. (2012). The impact of initial statin treatment decisions on cardiovascular outcomes in clinical care settings: estimates using the Archimedes Model. ClinicoEconomics and outcomes research : CEOR, 4337-47. https://doi.org/10.2147/CEOR.S35487
van Herick, Andrew, et al. "The impact of initial statin treatment decisions on cardiovascular outcomes in clinical care settings: estimates using the Archimedes Model." ClinicoEconomics and outcomes research : CEOR vol. 4 (2012): 337-47. doi: https://doi.org/10.2147/CEOR.S35487
van Herick A, Schuetz CA, Alperin P, Bullano MF, Balu S, Gandhi S. The impact of initial statin treatment decisions on cardiovascular outcomes in clinical care settings: estimates using the Archimedes Model. Clinicoecon Outcomes Res. 2012;4:337-47. doi: 10.2147/CEOR.S35487. Epub 2012 Nov 09. PMID: 23180970; PMCID: PMC3497874.
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Effect of Daisaikoto on Expressions of SIRT1 and NF-kappaB of Diabetic Fatty Liver Rats Induced by High-Fat Diet and Streptozotocin.

Yonago acta medica

Qian W, Cai X, Zhang X, Wang Y, Qian Q, Hasegawa J.
PMID: 27493486
Yonago Acta Med. 2016 Jun 29;59(2):149-58. eCollection 2016 Jun.

BACKGROUND: Daisaikoto (DSKT), a classical traditional Chinese herbal formula, has been used for treating digestive diseases for 1800 years in China. Therefore, in this study, we are going to investigate the effect of DSKT on diabetic fatty liver rats...

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Qian W, Cai X, Zhang X, et al. Effect of Daisaikoto on Expressions of SIRT1 and NF-kappaB of Diabetic Fatty Liver Rats Induced by High-Fat Diet and Streptozotocin. Yonago Acta Med. 2016;59(2):149-58
Qian, W., Cai, X., Zhang, X., Wang, Y., Qian, Q., & Hasegawa, J. (2016). Effect of Daisaikoto on Expressions of SIRT1 and NF-kappaB of Diabetic Fatty Liver Rats Induced by High-Fat Diet and Streptozotocin. Yonago acta medica, 59(2), 149-58.
Qian, Weibin, et al. "Effect of Daisaikoto on Expressions of SIRT1 and NF-kappaB of Diabetic Fatty Liver Rats Induced by High-Fat Diet and Streptozotocin." Yonago acta medica vol. 59,2 (2016): 149-58.
Qian W, Cai X, Zhang X, Wang Y, Qian Q, Hasegawa J. Effect of Daisaikoto on Expressions of SIRT1 and NF-kappaB of Diabetic Fatty Liver Rats Induced by High-Fat Diet and Streptozotocin. Yonago Acta Med. 2016 Jun 29;59(2):149-58. eCollection 2016 Jun. PMID: 27493486; PMCID: PMC4973021.
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Early Intervention of Didang Decoction on MLCK Signaling Pathways in Vascular Endothelial Cells of Type 2 Diabetic Rats.

International journal of endocrinology

Ye S, Song Z, Li J, Li C, Yang J, Chang B.
PMID: 27703477
Int J Endocrinol. 2016;2016:6704851. doi: 10.1155/2016/6704851. Epub 2016 Sep 15.

In the study, type 2 diabetic rat model was established using streptozotocin (STZ) combined with a high-fat diet, and the rats were divided into control and diabetic groups. Diabetic groups were further divided into nonintervening, simvastatin, Didang Decoction (DDD)...

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Ye S, Song Z, Li J, et al. Early Intervention of Didang Decoction on MLCK Signaling Pathways in Vascular Endothelial Cells of Type 2 Diabetic Rats. Int J Endocrinol. 2016;2016:6704851doi: 10.1155/2016/6704851.
Ye, S., Song, Z., Li, J., Li, C., Yang, J., & Chang, B. (2016). Early Intervention of Didang Decoction on MLCK Signaling Pathways in Vascular Endothelial Cells of Type 2 Diabetic Rats. International journal of endocrinology, 20166704851. https://doi.org/10.1155/2016/6704851
Ye, Shoujiao, et al. "Early Intervention of Didang Decoction on MLCK Signaling Pathways in Vascular Endothelial Cells of Type 2 Diabetic Rats." International journal of endocrinology vol. 2016 (2016): 6704851. doi: https://doi.org/10.1155/2016/6704851
Ye S, Song Z, Li J, Li C, Yang J, Chang B. Early Intervention of Didang Decoction on MLCK Signaling Pathways in Vascular Endothelial Cells of Type 2 Diabetic Rats. Int J Endocrinol. 2016;2016:6704851. doi: 10.1155/2016/6704851. Epub 2016 Sep 15. PMID: 27703477; PMCID: PMC5040811.
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The ocular toxicity and pharmacokinetics of simvastatin following intravitreal injection in mice.

International journal of ophthalmology

Tse DY, Kim SJ, Chung I, He F, Wensel TG, Wu SM.
PMID: 28944193
Int J Ophthalmol. 2017 Sep 18;10(9):1361-1369. doi: 10.18240/ijo.2017.09.05. eCollection 2017.

AIM: To investigate the retinal toxicity and pharmacokinetics of simvastatin intravitreally injected into mice.METHODS: Forty-eight 6-8-week-old C57BL/6J mice were used in this study. Simvastatin was intravitreally injected into the right eye of each mouse; the left eye was injected...

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Tse DY, Kim SJ, Chung I, et al. The ocular toxicity and pharmacokinetics of simvastatin following intravitreal injection in mice. Int J Ophthalmol. 2017;10(9):1361-1369doi: 10.18240/ijo.2017.09.05.
Tse, D. Y., Kim, S. J., Chung, I., He, F., Wensel, T. G., & Wu, S. M. (2017). The ocular toxicity and pharmacokinetics of simvastatin following intravitreal injection in mice. International journal of ophthalmology, 10(9), 1361-1369. https://doi.org/10.18240/ijo.2017.09.05
Tse, Dennis Y, et al. "The ocular toxicity and pharmacokinetics of simvastatin following intravitreal injection in mice." International journal of ophthalmology vol. 10,9 (2017): 1361-1369. doi: https://doi.org/10.18240/ijo.2017.09.05
Tse DY, Kim SJ, Chung I, He F, Wensel TG, Wu SM. The ocular toxicity and pharmacokinetics of simvastatin following intravitreal injection in mice. Int J Ophthalmol. 2017 Sep 18;10(9):1361-1369. doi: 10.18240/ijo.2017.09.05. eCollection 2017. PMID: 28944193; PMCID: PMC5596219.
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Biological Evaluation of Pupalia lappacea for Antidiabetic, Antiadipogenic, and Hypolipidemic Activity Both In Vitro and In Vivo.

Scientifica

Kumar V, Jain P, Rathore K, Ahmed Z.
PMID: 26942038
Scientifica (Cairo). 2016;2016:1062430. doi: 10.1155/2016/1062430. Epub 2016 Jan 28.

Objective. The present study assesses the effect of Pupalia lappacea (L.) Juss. (Amaranthaceae) (PL) leaves ethanolic extract on adipocytes, blood glucose level, and lipid level in streptozotocin (STZ) induced diabetic rats. Materials and Methods. Male Albino rats were rendered...

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Kumar V, Jain P, Rathore K, et al. Biological Evaluation of Pupalia lappacea for Antidiabetic, Antiadipogenic, and Hypolipidemic Activity Both In Vitro and In Vivo. Scientifica (Cairo). 2016;2016:1062430doi: 10.1155/2016/1062430.
Kumar, V., Jain, P., Rathore, K., & Ahmed, Z. (2016). Biological Evaluation of Pupalia lappacea for Antidiabetic, Antiadipogenic, and Hypolipidemic Activity Both In Vitro and In Vivo. Scientifica, 20161062430. https://doi.org/10.1155/2016/1062430
Kumar, Vivek, et al. "Biological Evaluation of Pupalia lappacea for Antidiabetic, Antiadipogenic, and Hypolipidemic Activity Both In Vitro and In Vivo." Scientifica vol. 2016 (2016): 1062430. doi: https://doi.org/10.1155/2016/1062430
Kumar V, Jain P, Rathore K, Ahmed Z. Biological Evaluation of Pupalia lappacea for Antidiabetic, Antiadipogenic, and Hypolipidemic Activity Both In Vitro and In Vivo. Scientifica (Cairo). 2016;2016:1062430. doi: 10.1155/2016/1062430. Epub 2016 Jan 28. PMID: 26942038; PMCID: PMC4749799.
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Recurrence and Severe Worsening of Hepatotoxicity After Reintroduction of Atorvastatin in Combination With Ezetimibe.

Clinical medicine insights. Case reports

Bergland Ellingsen S, Nordmo E, Lappegård KT.
PMID: 28979175
Clin Med Insights Case Rep. 2017 Sep 25;10:1179547617731375. doi: 10.1177/1179547617731375. eCollection 2017.

Severe hepatotoxicity is a rare but well-known adverse reaction to statins. However, despite the widespread use of statins, only a few cases describing statin reexposure or switch to another statin after liver injury have been published. The literature on...

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Bergland Ellingsen S, Nordmo E, Lappegård KT. Recurrence and Severe Worsening of Hepatotoxicity After Reintroduction of Atorvastatin in Combination With Ezetimibe. Clin Med Insights Case Rep. 2017;10:1179547617731375doi: 10.1177/1179547617731375.
Bergland Ellingsen, S., Nordmo, E., & Lappegård, K. T. (2017). Recurrence and Severe Worsening of Hepatotoxicity After Reintroduction of Atorvastatin in Combination With Ezetimibe. Clinical medicine insights. Case reports, 101179547617731375. https://doi.org/10.1177/1179547617731375
Bergland Ellingsen, Silje, et al. "Recurrence and Severe Worsening of Hepatotoxicity After Reintroduction of Atorvastatin in Combination With Ezetimibe." Clinical medicine insights. Case reports vol. 10 (2017): 1179547617731375. doi: https://doi.org/10.1177/1179547617731375
Bergland Ellingsen S, Nordmo E, Lappegård KT. Recurrence and Severe Worsening of Hepatotoxicity After Reintroduction of Atorvastatin in Combination With Ezetimibe. Clin Med Insights Case Rep. 2017 Sep 25;10:1179547617731375. doi: 10.1177/1179547617731375. eCollection 2017. PMID: 28979175; PMCID: PMC5617085.
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Low-density lipoprotein receptors play an important role in the inhibition of prostate cancer cell proliferation by statins.

Prostate international

Furuya Y, Sekine Y, Kato H, Miyazawa Y, Koike H, Suzuki K.
PMID: 27358845
Prostate Int. 2016 Jun;4(2):56-60. doi: 10.1016/j.prnil.2016.02.003. Epub 2016 Mar 04.

BACKGROUND: There are some reports about the antitumor effects of statins in these days. Statins decrease the level of cholesterol in the blood by inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Inhibition of this enzyme decreases intracellular cholesterol synthesis. Thus, the expression...

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Furuya Y, Sekine Y, Kato H, et al. Low-density lipoprotein receptors play an important role in the inhibition of prostate cancer cell proliferation by statins. Prostate Int. 2016;4(2):56-60doi: 10.1016/j.prnil.2016.02.003.
Furuya, Y., Sekine, Y., Kato, H., Miyazawa, Y., Koike, H., & Suzuki, K. (2016). Low-density lipoprotein receptors play an important role in the inhibition of prostate cancer cell proliferation by statins. Prostate international, 4(2), 56-60. https://doi.org/10.1016/j.prnil.2016.02.003
Furuya, Yosuke, et al. "Low-density lipoprotein receptors play an important role in the inhibition of prostate cancer cell proliferation by statins." Prostate international vol. 4,2 (2016): 56-60. doi: https://doi.org/10.1016/j.prnil.2016.02.003
Furuya Y, Sekine Y, Kato H, Miyazawa Y, Koike H, Suzuki K. Low-density lipoprotein receptors play an important role in the inhibition of prostate cancer cell proliferation by statins. Prostate Int. 2016 Jun;4(2):56-60. doi: 10.1016/j.prnil.2016.02.003. Epub 2016 Mar 04. PMID: 27358845; PMCID: PMC4916060.
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Simvastatin and a Plant Galactolipid Protect Animals from Septic Shock by Regulating Oxylipin Mediator Dynamics through the MAPK-cPLA.

Molecular medicine (Cambridge, Mass.)

Apaya MK, Lin CY, Chiou CY, Yang CC, Ting CY, Shyur LF.
PMID: 26701313
Mol Med. 2016 May;21(1):988-1001. doi: 10.2119/molmed.2015.00082. Epub 2016 Mar 31.

Sepsis remains a major medical issue despite decades of research. Identification of important inflammatory cascades and key molecular mediators are crucial for developing intervention and prevention strategies. In this study, we conducted a comparative oxylipin metabolomics study to gain...

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Apaya MK, Lin CY, Chiou CY, et al. Simvastatin and a Plant Galactolipid Protect Animals from Septic Shock by Regulating Oxylipin Mediator Dynamics through the MAPK-cPLA. Mol Med. 2016;21(1):988-1001doi: 10.2119/molmed.2015.00082.
Apaya, M. K., Lin, C. Y., Chiou, C. Y., Yang, C. C., Ting, C. Y., & Shyur, L. F. (2016). Simvastatin and a Plant Galactolipid Protect Animals from Septic Shock by Regulating Oxylipin Mediator Dynamics through the MAPK-cPLA. Molecular medicine (Cambridge, Mass.), 21(1), 988-1001. https://doi.org/10.2119/molmed.2015.00082
Apaya, Maria Karmella, et al. "Simvastatin and a Plant Galactolipid Protect Animals from Septic Shock by Regulating Oxylipin Mediator Dynamics through the MAPK-cPLA." Molecular medicine (Cambridge, Mass.) vol. 21,1 (2016): 988-1001. doi: https://doi.org/10.2119/molmed.2015.00082
Apaya MK, Lin CY, Chiou CY, Yang CC, Ting CY, Shyur LF. Simvastatin and a Plant Galactolipid Protect Animals from Septic Shock by Regulating Oxylipin Mediator Dynamics through the MAPK-cPLA. Mol Med. 2016 May;21(1):988-1001. doi: 10.2119/molmed.2015.00082. Epub 2016 Mar 31. PMID: 26701313; PMCID: PMC4982475.
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The AMP-Dependent Protein Kinase (AMPK) Activator A-769662 Causes Arterial Relaxation by Reducing Cytosolic Free Calcium Independently of an Increase in AMPK Phosphorylation.

Frontiers in pharmacology

Huang Y, Smith CA, Chen G, Sharma B, Miner AS, Barbee RW, Ratz PH.
PMID: 29093683
Front Pharmacol. 2017 Oct 18;8:756. doi: 10.3389/fphar.2017.00756. eCollection 2017.

Although recent studies reveal that activation of the metabolic and Ca

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Huang Y, Smith CA, Chen G, et al. The AMP-Dependent Protein Kinase (AMPK) Activator A-769662 Causes Arterial Relaxation by Reducing Cytosolic Free Calcium Independently of an Increase in AMPK Phosphorylation. Front Pharmacol. 2017;8:756doi: 10.3389/fphar.2017.00756.
Huang, Y., Smith, C. A., Chen, G., Sharma, B., Miner, A. S., Barbee, R. W., & Ratz, P. H. (2017). The AMP-Dependent Protein Kinase (AMPK) Activator A-769662 Causes Arterial Relaxation by Reducing Cytosolic Free Calcium Independently of an Increase in AMPK Phosphorylation. Frontiers in pharmacology, 8756. https://doi.org/10.3389/fphar.2017.00756
Huang, Yi, et al. "The AMP-Dependent Protein Kinase (AMPK) Activator A-769662 Causes Arterial Relaxation by Reducing Cytosolic Free Calcium Independently of an Increase in AMPK Phosphorylation." Frontiers in pharmacology vol. 8 (2017): 756. doi: https://doi.org/10.3389/fphar.2017.00756
Huang Y, Smith CA, Chen G, Sharma B, Miner AS, Barbee RW, Ratz PH. The AMP-Dependent Protein Kinase (AMPK) Activator A-769662 Causes Arterial Relaxation by Reducing Cytosolic Free Calcium Independently of an Increase in AMPK Phosphorylation. Front Pharmacol. 2017 Oct 18;8:756. doi: 10.3389/fphar.2017.00756. eCollection 2017. PMID: 29093683; PMCID: PMC5651270.
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The effect of hydraulic retention time in onsite wastewater treatment and removal of pharmaceuticals, hormones and phenolic utility substances.

The Science of the total environment

Ejhed H, Fång J, Hansen K, Graae L, Rahmberg M, Magnér J, Dorgeloh E, Plaza G.
PMID: 29128774
Sci Total Environ. 2018 Mar 15;618:250-261. doi: 10.1016/j.scitotenv.2017.11.011. Epub 2017 Nov 10.

Micropollutants such as pharmaceuticals, hormones and phenolic utility chemicals in sewage water are considered to be an emerging problem because of increased use and observed adverse effects in the environment. The study provides knowledge on the removal efficiency of...

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Ejhed H, Fång J, Hansen K, et al. The effect of hydraulic retention time in onsite wastewater treatment and removal of pharmaceuticals, hormones and phenolic utility substances. Sci Total Environ. 2017;618:250-261doi: 10.1016/j.scitotenv.2017.11.011.
Ejhed, H., Fång, J., Hansen, K., Graae, L., Rahmberg, M., Magnér, J., Dorgeloh, E., & Plaza, G. (2018). The effect of hydraulic retention time in onsite wastewater treatment and removal of pharmaceuticals, hormones and phenolic utility substances. The Science of the total environment, 618250-261. https://doi.org/10.1016/j.scitotenv.2017.11.011
Ejhed, H, et al. "The effect of hydraulic retention time in onsite wastewater treatment and removal of pharmaceuticals, hormones and phenolic utility substances." The Science of the total environment vol. 618 (2018): 250-261. doi: https://doi.org/10.1016/j.scitotenv.2017.11.011
Ejhed H, Fång J, Hansen K, Graae L, Rahmberg M, Magnér J, Dorgeloh E, Plaza G. The effect of hydraulic retention time in onsite wastewater treatment and removal of pharmaceuticals, hormones and phenolic utility substances. Sci Total Environ. 2018 Mar 15;618:250-261. doi: 10.1016/j.scitotenv.2017.11.011. Epub 2017 Nov 10. PMID: 29128774.
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Double-Blind Comparison of the Efficacy and Tolerability of Simvastatin and Fluvastatin in Patients with Primary Hypercholesterolaemia.

Clinical drug investigation

Ose L, Scott R, Grossman L.
PMID: 27519196
Clin Drug Investig. 1995 Sep;10(3):127-38. doi: 10.2165/00044011-199510030-00001.

The clinical efficacy and tolerability of simvastatin and fluvastatin were compared in 432 patients with primary hypercholesterolaemia in a multinational, randomised, double-blind trial. Following at least 10 weeks on a lipid-lowering diet, patients continuing to have a total cholesterol...

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Ose L, Scott R, Grossman L. Double-Blind Comparison of the Efficacy and Tolerability of Simvastatin and Fluvastatin in Patients with Primary Hypercholesterolaemia. Clin Drug Investig. 1995;10(3):127-38doi: 10.2165/00044011-199510030-00001.
Ose, L., Scott, R., & Grossman, L. (1995). Double-Blind Comparison of the Efficacy and Tolerability of Simvastatin and Fluvastatin in Patients with Primary Hypercholesterolaemia. Clinical drug investigation, 10(3), 127-38. https://doi.org/10.2165/00044011-199510030-00001
Ose, L, et al. "Double-Blind Comparison of the Efficacy and Tolerability of Simvastatin and Fluvastatin in Patients with Primary Hypercholesterolaemia." Clinical drug investigation vol. 10,3 (1995): 127-38. doi: https://doi.org/10.2165/00044011-199510030-00001
Ose L, Scott R, Grossman L. Double-Blind Comparison of the Efficacy and Tolerability of Simvastatin and Fluvastatin in Patients with Primary Hypercholesterolaemia. Clin Drug Investig. 1995 Sep;10(3):127-38. doi: 10.2165/00044011-199510030-00001. PMID: 27519196.
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Showing 1 to 12 of 1063 entries