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Showing 1 to 10 of 10 entries
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Sero-monitoring of health care workers reveals complex relationships between common coronavirus antibodies and SARS-CoV-2 severity.

medRxiv : the preprint server for health sciences

Gouma S, Weirick ME, Bolton MJ, Arevalo CP, Goodwin EC, Anderson EM, McAllister CM, Christensen SR, Dunbar D, Fiore D, Brock A, Weaver J, Millar J, DerOhannessian S, Frank I, Rader DJ, Wherry EJ, Hensley SE.
PMID: 33907765
medRxiv. 2021 Apr 19; doi: 10.1101/2021.04.12.21255324.

Recent common coronavirus (CCV) infections are associated with reduced COVID-19 severity upon SARS-CoV-2 infection, however the immunological mechanisms involved are unknown. We completed serological assays using samples collected from health care workers to identify antibody types associated with SARS-CoV-2...

Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection.

medRxiv : the preprint server for health sciences

Anderson EM, Goodwin EC, Verma A, Arevalo CP, Bolton MJ, Weirick ME, Gouma S, McAllister CM, Christensen SR, Weaver J, Hicks P, Manzoni TB, Oniyide O, Ramage H, Mathew D, Baxter AE, Oldridge DA, Greenplate AR, Wu JE, Alanio C, D'Andrea K, Kuthuru O, Dougherty J, Pattekar A, Kim J, Han N, Apostolidis SA, Huang AC, Vella LA, Wherry EJ, Meyer NJ, Cherry S, Bates P, Rader DJ, Hensley SE.
PMID: 33200143
medRxiv. 2020 Nov 10; doi: 10.1101/2020.11.06.20227215.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread within the human population. Although SARS-CoV-2 is a novel coronavirus, most humans had been previously exposed to other antigenically distinct common seasonal human coronaviruses (hCoVs) before the COVID-19 pandemic....

grabseqs: simple downloading of reads and metadata from multiple next-generation sequencing data repositories.

Bioinformatics (Oxford, England)

Taylor LJ, Abbas A, Bushman FD.
PMID: 32154830
Bioinformatics. 2020 Jun 01;36(11):3607-3609. doi: 10.1093/bioinformatics/btaa167.

SUMMARY: High-throughput sequencing is a powerful technique for addressing biological questions. Grabseqs streamlines access to publicly available metagenomic data by providing a single, easy-to-use interface to download data and metadata from multiple repositories, including the Sequence Read Archive, the...

Rengasvirus, a Circular Replication-Associated Protein-Encoding Single-Stranded DNA Virus-Related Genome That Is a Common Contaminant in Metagenomic Data.

Microbiology resource announcements

Keeler EL, Taylor LJ, Abbas A, Collman RG, Bushman FD.
PMID: 33958399
Microbiol Resour Announc. 2021 May 06;10(18). doi: 10.1128/MRA.00273-21.

We report the genome of a circular replication-associated protein (Rep)-encoding segmented or satellite virus, which we have provisionally named rengasvirus. In metagenomic studies of virus-enriched fractions, rengasvirus was detected widely, including in reagent-negative controls. We thus report this genome...

Redondovirus Diversity and Evolution on Global, Individual, and Molecular Scales.

Journal of virology

Taylor LJ, Dothard MI, Rubel MA, Allen AA, Hwang Y, Roche AM, Graham-Wooten J, Fitzgerald AS, Khatib LA, Ranciaro A, Thompson SR, Beggs WR, Campbell MC, Mokone GG, Mpoloka SW, Fokunang C, Njamnshi AK, Mbunwe E, Woldemeskel D, Belay G, Nyambo T, Tishkoff SA, Collman RG, Bushman FD.
PMID: 34406857
J Virol. 2021 Oct 13;95(21):e0081721. doi: 10.1128/JVI.00817-21. Epub 2021 Aug 18.

No abstract available.

Redondovirus Diversity and Evolution on Global, Individual, and Molecular Scales.

Journal of virology

Taylor LJ, Dothard MI, Rubel MA, Allen AA, Hwang Y, Roche AM, Graham-Wooten J, Fitzgerald AS, Khatib LA, Ranciaro A, Thompson SR, Beggs WR, Campbell MC, Mokone GG, Mpoloka SW, Fokunang C, Njamnshi AK, Mbunwe E, Woldemeskel D, Belay G, Nyambo T, Tishkoff SA, Collman RG, Bushman FD.
PMID: 34406857
J Virol. 2021 Oct 13;95(21):e0081721. doi: 10.1128/JVI.00817-21. Epub 2021 Aug 18.

No abstract available.

Murine Coronavirus Cell Type Dependent Interaction with the Type I Interferon Response.

Viruses

Rose KM, Weiss SR.
PMID: 20221421
Viruses. 2009 Dec 01;1(3):689-712. doi: 10.3390/v1030689.

Coronaviruses infect many species of animal including humans, causing acute and chronic diseases of many organ systems. Murine coronavirus, mouse hepatitis virus (MHV) infection of the mouse, provides animal models for the study of central nervous system disease, including...

SARS-CoV-2 antibody responses in children with MIS-C and mild and severe COVID-19.

medRxiv : the preprint server for health sciences

Anderson EM, Diorio C, Goodwin EC, McNerney KO, Weirick ME, Gouma S, Bolton MJ, Arevalo CP, Chase J, Hicks P, Manzoni TB, Baxter AE, Andrea KP, Burudpakdee C, Lee JH, Vella LA, Henrickson SE, Harris RM, Wherry EJ, Bates P, Bassiri H, Behrens EM, Teachey DT, Hensley SE.
PMID: 32839782
medRxiv. 2020 Aug 18; doi: 10.1101/2020.08.17.20176552.

SARS-CoV-2 antibody responses in children remain poorly characterized. Here, we show that pediatric patients with multisystem inflammatory syndrome in children (MIS-C) possess higher SARS-CoV-2 spike IgG titers compared to those with severe coronavirus disease 2019 (COVID-19), likely reflecting a...

Deep Immune Profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19.

medRxiv : the preprint server for health sciences

Vella L, Giles JR, Baxter AE, Oldridge DA, Diorio C, Kuri-Cervantes L, Alanio C, Pampena MB, Wu JE, Chen Z, Huang YJ, Anderson EM, Gouma S, McNerney KO, Chase J, Burudpakdee C, Lee JH, Apostolidis SA, Huang AC, Mathew D, Kuthuru O, Goodwin EC, Weirick ME, Bolton MJ, Arevalo CP, Ramos A, Jasen C, Giannini HM, DAndrea K, Meyer NJ, Behrens EM, Bassiri H, Hensley SE, Henrickson SE, Teachey DT, Betts MR, Wherry EJ.
PMID: 32995826
medRxiv. 2020 Oct 06; doi: 10.1101/2020.09.25.20201863.

Pediatric COVID-19 following SARS-CoV-2 infection is associated with fewer hospitalizations and often milder disease than in adults. A subset of children, however, present with Multisystem Inflammatory Syndrome in Children (MIS-C) that can lead to vascular complications and shock, but...

Deep Immune Profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19.

medRxiv : the preprint server for health sciences

Vella L, Giles JR, Baxter AE, Oldridge DA, Diorio C, Kuri-Cervantes L, Alanio C, Pampena MB, Wu JE, Chen Z, Huang YJ, Anderson EM, Gouma S, McNerney KO, Chase J, Burudpakdee C, Lee JH, Apostolidis SA, Huang AC, Mathew D, Kuthuru O, Goodwin EC, Weirick ME, Bolton MJ, Arevalo CP, Ramos A, Jasen C, Giannini HM, DAndrea K, Meyer NJ, Behrens EM, Bassiri H, Hensley SE, Henrickson SE, Teachey DT, Betts MR, Wherry EJ.
PMID: 32995826
medRxiv. 2020 Oct 06; doi: 10.1101/2020.09.25.20201863.

Pediatric COVID-19 following SARS-CoV-2 infection is associated with fewer hospitalizations and often milder disease than in adults. A subset of children, however, present with Multisystem Inflammatory Syndrome in Children (MIS-C) that can lead to vascular complications and shock, but...

Showing 1 to 10 of 10 entries