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Vella L, Giles JR, Baxter AE, et al. Deep Immune Profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19. medRxiv. 2020;doi: 10.1101/2020.09.25.20201863.
Vella, L., Giles, J. R., Baxter, A. E., Oldridge, D. A., Diorio, C., Kuri-Cervantes, L., Alanio, C., Pampena, M. B., Wu, J. E., Chen, Z., Huang, Y. J., Anderson, E. M., Gouma, S., McNerney, K. O., Chase, J., Burudpakdee, C., Lee, J. H., Apostolidis, S. A., Huang, A. C., Mathew, D., Kuthuru, O., Goodwin, E. C., Weirick, M. E., Bolton, M. J., Arevalo, C. P., Ramos, A., Jasen, C., Giannini, H. M., DAndrea, K., Meyer, N. J., Behrens, E. M., Bassiri, H., Hensley, S. E., Henrickson, S. E., Teachey, D. T., Betts, M. R., & Wherry, E. J. (2020). Deep Immune Profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19. medRxiv : the preprint server for health sciences, . https://doi.org/10.1101/2020.09.25.20201863
Vella, Laura, et al. "Deep Immune Profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19." medRxiv : the preprint server for health sciences vol. (2020). doi: https://doi.org/10.1101/2020.09.25.20201863
Vella L, Giles JR, Baxter AE, Oldridge DA, Diorio C, Kuri-Cervantes L, Alanio C, Pampena MB, Wu JE, Chen Z, Huang YJ, Anderson EM, Gouma S, McNerney KO, Chase J, Burudpakdee C, Lee JH, Apostolidis SA, Huang AC, Mathew D, Kuthuru O, Goodwin EC, Weirick ME, Bolton MJ, Arevalo CP, Ramos A, Jasen C, Giannini HM, DAndrea K, Meyer NJ, Behrens EM, Bassiri H, Hensley SE, Henrickson SE, Teachey DT, Betts MR, Wherry EJ. Deep Immune Profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19. medRxiv. 2020 Oct 06; doi: 10.1101/2020.09.25.20201863. PMID: 32995826; PMCID: PMC7523167.
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medRxiv. 2020 Oct 06; doi: 10.1101/2020.09.25.20201863.

Deep Immune Profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19.

medRxiv : the preprint server for health sciences

Laura Vella, Josephine R Giles, Amy E Baxter, Derek A Oldridge, Caroline Diorio, Leticia Kuri-Cervantes, Cecile Alanio, Maria Betina Pampena, Jennifer E Wu, Zeyu Chen, Yinghui Jane Huang, Elizabeth M Anderson, Sigrid Gouma, Kevin O McNerney, Julie Chase, Chakkapong Burudpakdee, Jessica H Lee, Sokratis A Apostolidis, Alexander C Huang, Divij Mathew, Oliva Kuthuru, Eileen C Goodwin, Madison E Weirick, Marcus J Bolton, Claudia P Arevalo, Andre Ramos, Cristina Jasen, Heather M Giannini, Kurt DAndrea, Nuala J Meyer, Edward M Behrens, Hamid Bassiri, Scott E Hensley, Sarah E Henrickson, David T Teachey, Michael R Betts, E John Wherry

PMID: 32995826 PMCID: PMC7523167 DOI: 10.1101/2020.09.25.20201863

Abstract

Pediatric COVID-19 following SARS-CoV-2 infection is associated with fewer hospitalizations and often milder disease than in adults. A subset of children, however, present with Multisystem Inflammatory Syndrome in Children (MIS-C) that can lead to vascular complications and shock, but rarely death. The immune features of MIS-C compared to pediatric COVID-19 or adult disease remain poorly understood. We analyzed peripheral blood immune responses in hospitalized SARS-CoV-2 infected pediatric patients (pediatric COVID-19) and patients with MIS-C. MIS-C patients had patterns of T cell-biased lymphopenia and T cell activation similar to severely ill adults, and all patients with MIS-C had SARS-CoV-2 spike-specific antibodies at admission. A distinct feature of MIS-C patients was robust activation of vascular patrolling CX3CR1+ CD8 T cells that correlated with use of vasoactive medication. Finally, whereas pediatric COVID-19 patients with acute respiratory distress syndrome (ARDS) had sustained immune activation, MIS-C patients displayed clinical improvement over time, concomitant with decreasing immune activation. Thus, non-MIS-C versus MIS-C SARS-CoV-2 associated illnesses are characterized by divergent immune signatures that are temporally distinct and implicate CD8 T cells in clinical presentation and trajectory of MIS-C.

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