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Correction to "Design, synthesis, and structure-activity relationship of a novel series of GluN2C-selective potentiators".

Journal of medicinal chemistry

Zimmerman SS, Khatri A, Garnier-Amblard EC, Mullasseril P, Kurtkaya NL, Gyoneva S, Hansen KB, Traynelis SF, Liotta DC.
PMID: 25738634
J Med Chem. 2015 Mar 26;58(6):2862. doi: 10.1021/acs.jmedchem.5b00199. Epub 2015 Mar 04.

No abstract available.

RGS14 regulates the lifetime of G.

Pharmacology research & perspectives

Brown NE, Lambert NA, Hepler JR.
PMID: 27713821
Pharmacol Res Perspect. 2016 Aug 18;4(5):e00249. doi: 10.1002/prp2.249. eCollection 2016 Oct.

RGS14 is a multifunctional scaffolding protein possessing two distinct G protein interaction sites including a regulator of G protein signaling (RGS) domain that acts as a GTPase activating protein (GAP) to deactivate G

A systematic pipeline for the objective comparison of whole-brain spectroscopic MRI with histology in biopsy specimens from grade III glioma.

Tomography (Ann Arbor, Mich.)

Cordova JS, Gurbani SS, Olson JJ, Liang Z, Cooper LA, Shu HG, Schreibmann E, Neill SG, Hadjipanayis CG, Holder CA, Shim H.
PMID: 27489883
Tomography. 2016 Jun;2(2):106-116. doi: 10.18383/j.tom.2016.00136.

The diagnosis, prognosis, and management of patients with gliomas are largely dictated by the pathological analysis of tissue biopsied from a selected region within the lesion. However, due to the heterogeneous and infiltrative nature of gliomas, identifying the optimal...

Effects of FVIII immunity on hepatocyte and hematopoietic stem cell-directed gene therapy of murine hemophilia A.

Molecular therapy. Methods & clinical development

Lytle AM, Brown HC, Paik NY, Knight KA, Wright JF, Spencer HT, Doering CB.
PMID: 26909355
Mol Ther Methods Clin Dev. 2016 Feb 10;3:15056. doi: 10.1038/mtm.2015.56. eCollection 2016.

Immune responses to coagulation factors VIII (FVIII) and IX (FIX) represent primary obstacles to hemophilia treatment. Previously, we showed that hematopoietic stem cell (HSC) retroviral gene therapy induces immune nonresponsiveness to FVIII in both naive and preimmunized murine hemophilia...

Human immunodeficiency virus-1 transgene expression increases pulmonary vascular resistance and exacerbates hypoxia-induced pulmonary hypertension development.

Pulmonary circulation

Porter KM, Walp ER, Elms SC, Raynor R, Mitchell PO, Guidot DM, Sutliff RL.
PMID: 23662175
Pulm Circ. 2013 Jan;3(1):58-67. doi: 10.4103/2045-8932.109915.

Pulmonary arterial hypertension (PAH) is a progressive disease characterized by increased pulmonary arterial resistance and vessel remodeling. Patients living with human immunodeficiency virus-1 (HIV-1) have an increased susceptibility to develop severe pulmonary hypertension (PH) irrespective of their CD4+ lymphocyte...

Development of chimeric antigen receptors targeting T-cell malignancies using two structurally different anti-CD5 antigen binding domains in NK and CRISPR-edited T cell lines.

Oncoimmunology

Raikar SS, Fleischer LC, Moot R, Fedanov A, Paik NY, Knight KA, Doering CB, Spencer HT.
PMID: 29399409
Oncoimmunology. 2017 Dec 26;7(3):e1407898. doi: 10.1080/2162402X.2017.1407898. eCollection 2018.

Relapsed T-cell malignancies have poor outcomes when treated with chemotherapy, but survival after allogeneic bone marrow transplantation (BMT) approaches 50%. A limitation to BMT is the difficulty of achieving remission prior to transplant. Chimeric antigen receptor (CAR) T-cell therapy...

Microbial metabolite delta-valerobetaine is a diet-dependent obesogen.

Nature metabolism

Liu KH, Owens JA, Saeedi B, Cohen CE, Bellissimo MP, Naudin C, Darby T, Druzak S, Maner-Smith K, Orr M, Hu X, Fernandes J, Camacho MC, Hunter-Chang S, VanInsberghe D, Ma C, Ganesh T, Yeligar SM, Uppal K, Go YM, Alvarez JA, Vos MB, Ziegler TR, Woodworth MH, Kraft CS, Jones RM, Ortlund E, Neish AS, Jones DP.
PMID: 34931082
Nat Metab. 2021 Dec;3(12):1694-1705. doi: 10.1038/s42255-021-00502-8. Epub 2021 Dec 20.

Obesity and obesity-related metabolic disorders are linked to the intestinal microbiome. However, the causality of changes in the microbiome-host interaction affecting energy metabolism remains controversial. Here, we show the microbiome-derived metabolite δ-valerobetaine (VB) is a diet-dependent obesogen that is...

Microbial metabolite delta-valerobetaine is a diet-dependent obesogen.

Nature metabolism

Liu KH, Owens JA, Saeedi B, Cohen CE, Bellissimo MP, Naudin C, Darby T, Druzak S, Maner-Smith K, Orr M, Hu X, Fernandes J, Camacho MC, Hunter-Chang S, VanInsberghe D, Ma C, Ganesh T, Yeligar SM, Uppal K, Go YM, Alvarez JA, Vos MB, Ziegler TR, Woodworth MH, Kraft CS, Jones RM, Ortlund E, Neish AS, Jones DP.
PMID: 34931082
Nat Metab. 2021 Dec;3(12):1694-1705. doi: 10.1038/s42255-021-00502-8. Epub 2021 Dec 20.

Obesity and obesity-related metabolic disorders are linked to the intestinal microbiome. However, the causality of changes in the microbiome-host interaction affecting energy metabolism remains controversial. Here, we show the microbiome-derived metabolite δ-valerobetaine (VB) is a diet-dependent obesogen that is...

Ex vivo expanded patient-derived γδ T-cell immunotherapy enhances neuroblastoma tumor regression in a murine model.

Oncoimmunology

Zoine JT, Knight KA, Fleischer LC, Sutton KS, Goldsmith KC, Doering CB, Spencer HT.
PMID: 31413905
Oncoimmunology. 2019 May 27;8(8):1593804. doi: 10.1080/2162402X.2019.1593804. eCollection 2019.

An effective therapy regimen for relapsed/refractory high-risk neuroblastoma (NB) includes the anti-GD2 monoclonal antibody, dinutuximab, in combination with temozolomide and irinotecan, supporting a role for chemo-immunotherapy in NB. γδ T cells are an attractive anti-tumor immunotherapy because of their...

Development of a Versatile and Sensitive Direct Ligand Binding Assay for Human NR5A Nuclear Receptors.

ACS medicinal chemistry letters

D'Agostino EH, Flynn AR, Cornelison JL, Mays SG, Patel A, Jui NT, Ortlund EA.
PMID: 32184971
ACS Med Chem Lett. 2019 Nov 21;11(3):365-370. doi: 10.1021/acsmedchemlett.9b00442. eCollection 2020 Mar 12.

As regulators of steroidogenesis, development, and metabolism, the nuclear receptor 5A (NR5A) subfamily members steroidogenic factor 1 (SF-1) and liver receptor homologue 1 (LRH-1) are important pharmacological targets for cancers and metabolic diseases. Evaluation of small molecule modulators and...

Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor.

Nature communications

Deng W, Xu Y, Chen W, Paul DS, Syed AK, Dragovich MA, Liang X, Zakas P, Berndt MC, Di Paola J, Ware J, Lanza F, Doering CB, Bergmeier W, Zhang XF, Li R.
PMID: 27670775
Nat Commun. 2016 Sep 27;7:12863. doi: 10.1038/ncomms12863.

Mechanisms by which blood cells sense shear stress are poorly characterized. In platelets, glycoprotein (GP)Ib-IX receptor complex has been long suggested to be a shear sensor and receptor. Recently, a relatively unstable and mechanosensitive domain in the GPIbα subunit...

Neuroinflammation and Behavior in HIV-1 Transgenic Rats Exposed to Chronic Adolescent Stress.

Frontiers in psychiatry

Rowson SA, Harrell CS, Bekhbat M, Gangavelli A, Wu MJ, Kelly SD, Reddy R, Neigh GN.
PMID: 27378953
Front Psychiatry. 2016 Jun 20;7:102. doi: 10.3389/fpsyt.2016.00102. eCollection 2016.

Highly active antiretroviral therapy (HAART) has improved prognosis for people living with HIV (PLWH) and dramatically reduced the incidence of AIDS. However, even when viral load is controlled, PLWH develop psychiatric and neurological disorders more frequently than those living...

Showing 1 to 12 of 38 entries