Display options
Share it on

Pharmacol Res Perspect. 2016 Aug 18;4(5):e00249. doi: 10.1002/prp2.249. eCollection 2016 Oct.

RGS14 regulates the lifetime of G.

Pharmacology research & perspectives

Nicole E Brown, Nevin A Lambert, John R Hepler

Affiliations

  1. Department of Pharmacology Emory University School of Medicine Atlanta Georgia 30322.
  2. Department of Pharmacology and Toxicology Medical College of Georgia at Augusta University Augusta Georgia 30912.

PMID: 27713821 PMCID: PMC5045935 DOI: 10.1002/prp2.249

Abstract

RGS14 is a multifunctional scaffolding protein possessing two distinct G protein interaction sites including a regulator of G protein signaling (RGS) domain that acts as a GTPase activating protein (GAP) to deactivate G

Keywords: G protein; GPCR; Gαi1; Gβγ; RGS protein; RGS14.

References

  1. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):16077-82 - PubMed
  2. Annu Rev Pharmacol Toxicol. 2000;40:235-71 - PubMed
  3. Mol Pharmacol. 2000 Sep;58(3):569-76 - PubMed
  4. J Physiol. 2008 Jul 15;586(14):3325-35 - PubMed
  5. J Comp Neurol. 2014 Jan 1;522(1):186-203 - PubMed
  6. J Neurochem. 2005 Mar;92(6):1408-18 - PubMed
  7. Methods Mol Biol. 2015;1278:457-65 - PubMed
  8. J Biol Chem. 2016 Mar 25;291(13):7195-204 - PubMed
  9. Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16994-8 - PubMed
  10. J Biol Chem. 2013 Feb 1;288(5):3620-31 - PubMed
  11. Pharmacol Res Perspect. 2016 Aug 18;4(5):e00249 - PubMed
  12. Cell Signal. 2009 Jun;21(6):1015-21 - PubMed
  13. Pharmacol Rev. 2002 Sep;54(3):527-59 - PubMed
  14. Biochem J. 2000 Aug 15;350 Pt 1:19-29 - PubMed
  15. Mol Pharmacol. 2015 Aug;88(2):231-7 - PubMed
  16. J Biol Chem. 1998 Jan 9;273(2):669-72 - PubMed
  17. Trends Biochem Sci. 1992 Oct;17(10):383-7 - PubMed
  18. Nature. 2002 Apr 25;416(6883):878-81 - PubMed
  19. J Biol Chem. 2001 Aug 3;276(31):29275-81 - PubMed
  20. Methods Enzymol. 2004;389:131-54 - PubMed
  21. Curr Opin Cell Biol. 1997 Apr;9(2):134-42 - PubMed
  22. J Biol Chem. 2004 Nov 5;279(45):46772-8 - PubMed
  23. Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):7066-71 - PubMed
  24. Annu Rev Biochem. 1987;56:615-49 - PubMed
  25. Cell Signal. 2007 Jan;19(1):163-76 - PubMed
  26. Semin Cell Dev Biol. 2006 Jun;17(3):383-9 - PubMed
  27. J Neurochem. 2001 Dec;79(5):941-9 - PubMed
  28. J Biol Chem. 2015 Apr 3;290(14):9037-49 - PubMed
  29. Biochem J. 2006 Feb 15;394(Pt 1):309-15 - PubMed
  30. Sci Signal. 2015 Dec 01;8(405):ra123 - PubMed
  31. PLoS One. 2009;4(3):e4884 - PubMed
  32. J Biol Chem. 2011 Nov 4;286(44):38659-69 - PubMed
  33. Methods Mol Biol. 2015;1335:107-13 - PubMed
  34. Cell Logist. 2014 Jun 04;4:e29392 - PubMed
  35. Cell Signal. 2010 Mar;22(3):366-76 - PubMed
  36. Methods Mol Biol. 2011;756:229-43 - PubMed
  37. Biochemistry. 2002 Oct 22;41(42):12858-67 - PubMed
  38. Annu Rev Biochem. 2000;69:795-827 - PubMed
  39. J Biol Chem. 2004 May 14;279(20):21248-56 - PubMed

Publication Types

Grant support