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Clearance of rapid adenosine release is regulated by nucleoside transporters and metabolism.

Pharmacology research & perspectives

Nguyen MD, Ross AE, Ryals M, Lee ST, Venton BJ.
PMID: 27022463
Pharmacol Res Perspect. 2015 Nov 16;3(6):e00189. doi: 10.1002/prp2.189. eCollection 2015 Dec.

Adenosine is a neuromodulator that regulates neurotransmission in the brain and central nervous system. Recently, spontaneous adenosine release that is cleared in 3-4 sec was discovered in mouse spinal cord slices and anesthetized rat brains. Here, we examined the...

Adenosine Release Evoked by Short Electrical Stimulations in Striatal Brain Slices is Primarily Activity Dependent.

ACS chemical neuroscience

Pajski ML, Venton BJ.
PMID: 21218131
ACS Chem Neurosci. 2010 Oct 01;1(12):775-787. doi: 10.1021/cn100037d.

Adenosine is an important neuromodulator in the brain. Traditionally, adenosine is thought to arise in the extracellular space by either an extracellular mechanism, where it is formed outside the cell by the breakdown of released ATP, or an intracellular...

Features of adenosine metabolism of mouse heart.

Purinergic signalling

Deussen A, Weichsel J, Pexa A.
PMID: 18404469
Purinergic Signal. 2006 Nov;2(4):663-8. doi: 10.1007/s11302-006-9013-3. Epub 2006 Jul 21.

Adenosine metabolism and transport were evaluated in the isolated perfused mouse heart and compared with the well-established model of isolated perfused guinea pig heart. Coronary venous release of adenosine under well-oxygenated conditions in the mouse exceeds that in the...

Expression and functional activity of nucleoside transporters in human choroid plexus.

Cerebrospinal fluid research

Redzic ZB, Malatiali SA, Grujicic D, Isakovic AJ.
PMID: 20150980
Cerebrospinal Fluid Res. 2010 Jan 11;7:2. doi: 10.1186/1743-8454-7-2.

BACKGROUND: Human equilibrative nucleoside transporters (hENTs) 1-3 and human concentrative nucleoside transporters (hCNTs) 1-3 in the human choroid plexus (hCP) play a role in the homeostasis of adenosine and other naturally occurring nucleosides in the brain; in addition, hENT1,...

Showing 1 to 4 of 4 entries