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Showing 1 to 12 of 312 entries
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Screening glioma stem cells in U251 cells based on the P1 promoter of the CD133 gene.

Oncology letters

Wang X, Chen L, Xiao Z, Wang Y, Liu T, Zhang T, Zhang Y.
PMID: 27698813
Oncol Lett. 2016 Oct;12(4):2457-2462. doi: 10.3892/ol.2016.4966. Epub 2016 Aug 05.

Cluster of differentiation (CD)133 is an important cell surface marker of glioma stem cells (GSCs). The transcription of the CD133 gene is controlled by five alternative promoters (P1, P2, P3, P4 and P5), which are expressed in a tissue-specific...

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Wang X, Chen L, Xiao Z, et al. Screening glioma stem cells in U251 cells based on the P1 promoter of the CD133 gene. Oncol Lett. 2016;12(4):2457-2462doi: 10.3892/ol.2016.4966.
Wang, X., Chen, L., Xiao, Z., Wang, Y., Liu, T., Zhang, T., & Zhang, Y. (2016). Screening glioma stem cells in U251 cells based on the P1 promoter of the CD133 gene. Oncology letters, 12(4), 2457-2462. https://doi.org/10.3892/ol.2016.4966
Wang, Xiaofeng, et al. "Screening glioma stem cells in U251 cells based on the P1 promoter of the CD133 gene." Oncology letters vol. 12,4 (2016): 2457-2462. doi: https://doi.org/10.3892/ol.2016.4966
Wang X, Chen L, Xiao Z, Wang Y, Liu T, Zhang T, Zhang Y. Screening glioma stem cells in U251 cells based on the P1 promoter of the CD133 gene. Oncol Lett. 2016 Oct;12(4):2457-2462. doi: 10.3892/ol.2016.4966. Epub 2016 Aug 05. PMID: 27698813; PMCID: PMC5038209.
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A Positive Selection for Nucleoside Kinases in E. coli.

PloS one

Shelat NY, Parhi S, Ostermeier M.
PMID: 27677184
PLoS One. 2016 Sep 27;11(9):e0162921. doi: 10.1371/journal.pone.0162921. eCollection 2016.

Engineering heterologous nucleoside kinases inside E. coli is a difficult process due to the integral role nucleosides play in cell division and transcription. Nucleoside analogs are used in many kinase screens that depend on cellular metabolization of the analogs....

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Shelat NY, Parhi S, Ostermeier M. A Positive Selection for Nucleoside Kinases in E. coli. PLoS One. 2016;11(9):e0162921doi: 10.1371/journal.pone.0162921.
Shelat, N. Y., Parhi, S., & Ostermeier, M. (2016). A Positive Selection for Nucleoside Kinases in E. coli. PloS one, 11(9), e0162921. https://doi.org/10.1371/journal.pone.0162921
Shelat, Nirav Y, et al. "A Positive Selection for Nucleoside Kinases in E. coli." PloS one vol. 11,9 (2016): e0162921. doi: https://doi.org/10.1371/journal.pone.0162921
Shelat NY, Parhi S, Ostermeier M. A Positive Selection for Nucleoside Kinases in E. coli. PLoS One. 2016 Sep 27;11(9):e0162921. doi: 10.1371/journal.pone.0162921. eCollection 2016. PMID: 27677184; PMCID: PMC5038940.
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Metastatic Ovarian Cancer Can Be Efficiently Treated by Genetically Modified Mesenchymal Stromal Cells.

Stem cells and development

Toro L, Bohovic R, Matuskova M, Smolkova B, Kucerova L.
PMID: 27539058
Stem Cells Dev. 2016 Nov 01;25(21):1640-1651. doi: 10.1089/scd.2016.0064. Epub 2016 Aug 16.

Due to late diagnosis, often recurrence, formation of metastases and resistance to commonly used chemotherapeutics human ovarian carcinoma represents a serious disease with high mortality. Adipose tissue-derived mesenchymal stromal cells (AT-MSC) can serve as vehicles for therapeutic genes and...

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Toro L, Bohovic R, Matuskova M, et al. Metastatic Ovarian Cancer Can Be Efficiently Treated by Genetically Modified Mesenchymal Stromal Cells. Stem Cells Dev. 2016;25(21):1640-1651doi: 10.1089/scd.2016.0064.
Toro, L., Bohovic, R., Matuskova, M., Smolkova, B., & Kucerova, L. (2016). Metastatic Ovarian Cancer Can Be Efficiently Treated by Genetically Modified Mesenchymal Stromal Cells. Stem cells and development, 25(21), 1640-1651. https://doi.org/10.1089/scd.2016.0064
Toro, Lenka, et al. "Metastatic Ovarian Cancer Can Be Efficiently Treated by Genetically Modified Mesenchymal Stromal Cells." Stem cells and development vol. 25,21 (2016): 1640-1651. doi: https://doi.org/10.1089/scd.2016.0064
Toro L, Bohovic R, Matuskova M, Smolkova B, Kucerova L. Metastatic Ovarian Cancer Can Be Efficiently Treated by Genetically Modified Mesenchymal Stromal Cells. Stem Cells Dev. 2016 Nov 01;25(21):1640-1651. doi: 10.1089/scd.2016.0064. Epub 2016 Aug 16. PMID: 27539058.
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Serum thymidine kinase 1 levels correlate with clinical characteristics of esophageal squamous cell carcinoma.

International journal of clinical and experimental medicine

Ji Y, Wu XB, Chen JY, Hu B, Zhu QK, Zhu XF, Zheng MF.
PMID: 26550200
Int J Clin Exp Med. 2015 Aug 15;8(8):12850-7. eCollection 2015.

Patients with esophageal cancer are often diagnosed at advanced stages, leading to poor prognosis. Biomarkers are needed to enable earlier detection as well as to aid in the prediction of prognosis, but to date these tools remain scarce. Thymidine...

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Ji Y, Wu XB, Chen JY, et al. Serum thymidine kinase 1 levels correlate with clinical characteristics of esophageal squamous cell carcinoma. Int J Clin Exp Med. 2015;8(8):12850-7
Ji, Y., Wu, X. B., Chen, J. Y., Hu, B., Zhu, Q. K., Zhu, X. F., & Zheng, M. F. (2015). Serum thymidine kinase 1 levels correlate with clinical characteristics of esophageal squamous cell carcinoma. International journal of clinical and experimental medicine, 8(8), 12850-7.
Ji, Yong, et al. "Serum thymidine kinase 1 levels correlate with clinical characteristics of esophageal squamous cell carcinoma." International journal of clinical and experimental medicine vol. 8,8 (2015): 12850-7.
Ji Y, Wu XB, Chen JY, Hu B, Zhu QK, Zhu XF, Zheng MF. Serum thymidine kinase 1 levels correlate with clinical characteristics of esophageal squamous cell carcinoma. Int J Clin Exp Med. 2015 Aug 15;8(8):12850-7. eCollection 2015. PMID: 26550200; PMCID: PMC4612885.
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Improving the safety of cell therapy products by suicide gene transfer.

Frontiers in pharmacology

Jones BS, Lamb LS, Goldman F, Di Stasi A.
PMID: 25505885
Front Pharmacol. 2014 Nov 27;5:254. doi: 10.3389/fphar.2014.00254. eCollection 2014.

Adoptive T-cell therapy can involve donor lymphocyte infusion after allogeneic hematopoietic stem cell transplantation, the administration of tumor infiltrating lymphocyte expanded ex-vivo, or more recently the use of T cell receptor or chimeric antigen receptor redirected T cells. However,...

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Jones BS, Lamb LS, Goldman F, et al. Improving the safety of cell therapy products by suicide gene transfer. Front Pharmacol. 2014;5:254doi: 10.3389/fphar.2014.00254.
Jones, B. S., Lamb, L. S., Goldman, F., & Di Stasi, A. (2014). Improving the safety of cell therapy products by suicide gene transfer. Frontiers in pharmacology, 5254. https://doi.org/10.3389/fphar.2014.00254
Jones, Benjamin S, et al. "Improving the safety of cell therapy products by suicide gene transfer." Frontiers in pharmacology vol. 5 (2014): 254. doi: https://doi.org/10.3389/fphar.2014.00254
Jones BS, Lamb LS, Goldman F, Di Stasi A. Improving the safety of cell therapy products by suicide gene transfer. Front Pharmacol. 2014 Nov 27;5:254. doi: 10.3389/fphar.2014.00254. eCollection 2014. PMID: 25505885; PMCID: PMC4245885.
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Vesicular Stomatitis Virus G Glycoprotein and ATRA Enhanced Bystander Killing of Chemoresistant Leukemic Cells by Herpes Simplex Virus Thymidine Kinase/Ganciclovir.

Biomolecules & therapeutics

Hu C, Chen Z, Zhao W, Wei L, Zheng Y, He C, Zeng Y, Yin B.
PMID: 24753816
Biomol Ther (Seoul). 2014 Feb;22(2):114-21. doi: 10.4062/biomolther.2013.112.

Refractoriness of acute myeloid leukemia (AML) cells to chemotherapeutics represents a major clinical barrier. Suicide gene therapy for cancer has been attractive but with limited clinical efficacy. In this study, we investigated the potential application of herpes simplex virus...

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Hu C, Chen Z, Zhao W, et al. Vesicular Stomatitis Virus G Glycoprotein and ATRA Enhanced Bystander Killing of Chemoresistant Leukemic Cells by Herpes Simplex Virus Thymidine Kinase/Ganciclovir. Biomol Ther (Seoul). 2014;22(2):114-21doi: 10.4062/biomolther.2013.112.
Hu, C., Chen, Z., Zhao, W., Wei, L., Zheng, Y., He, C., Zeng, Y., & Yin, B. (2014). Vesicular Stomatitis Virus G Glycoprotein and ATRA Enhanced Bystander Killing of Chemoresistant Leukemic Cells by Herpes Simplex Virus Thymidine Kinase/Ganciclovir. Biomolecules & therapeutics, 22(2), 114-21. https://doi.org/10.4062/biomolther.2013.112
Hu, Chenxi, et al. "Vesicular Stomatitis Virus G Glycoprotein and ATRA Enhanced Bystander Killing of Chemoresistant Leukemic Cells by Herpes Simplex Virus Thymidine Kinase/Ganciclovir." Biomolecules & therapeutics vol. 22,2 (2014): 114-21. doi: https://doi.org/10.4062/biomolther.2013.112
Hu C, Chen Z, Zhao W, Wei L, Zheng Y, He C, Zeng Y, Yin B. Vesicular Stomatitis Virus G Glycoprotein and ATRA Enhanced Bystander Killing of Chemoresistant Leukemic Cells by Herpes Simplex Virus Thymidine Kinase/Ganciclovir. Biomol Ther (Seoul). 2014 Feb;22(2):114-21. doi: 10.4062/biomolther.2013.112. PMID: 24753816; PMCID: PMC3975477.
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An expression vector inhibits gene expression in Xenopus embryos by antisense RNA.

Roux's archives of developmental biology : the official organ of the EDBO

Schmid M, Steinbeisser H, Epperlein HH, Trendelenburg MF, Lipps HJ.
PMID: 28305852
Rouxs Arch Dev Biol. 1992 Oct;201(6):340-345. doi: 10.1007/BF00365121.

An expression vector was constructed containing the entire bovine papilloma virus (BPV-1) genome and part of the a-actin gene of Xenopus laevis cloned in the antisense orientation into the neomycin resistance gene under the control of the herpes simplex...

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Schmid M, Steinbeisser H, Epperlein HH, et al. An expression vector inhibits gene expression in Xenopus embryos by antisense RNA. Rouxs Arch Dev Biol. 1992;201(6):340-345doi: 10.1007/BF00365121.
Schmid, M., Steinbeisser, H., Epperlein, H. H., Trendelenburg, M. F., & Lipps, H. J. (1992). An expression vector inhibits gene expression in Xenopus embryos by antisense RNA. Roux's archives of developmental biology : the official organ of the EDBO, 201(6), 340-345. https://doi.org/10.1007/BF00365121
Schmid, Michael, et al. "An expression vector inhibits gene expression in Xenopus embryos by antisense RNA." Roux's archives of developmental biology : the official organ of the EDBO vol. 201,6 (1992): 340-345. doi: https://doi.org/10.1007/BF00365121
Schmid M, Steinbeisser H, Epperlein HH, Trendelenburg MF, Lipps HJ. An expression vector inhibits gene expression in Xenopus embryos by antisense RNA. Rouxs Arch Dev Biol. 1992 Oct;201(6):340-345. doi: 10.1007/BF00365121. PMID: 28305852.
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Escape Mutations, Ganciclovir Resistance, and Teratoma Formation in Human iPSCs Expressing an HSVtk Suicide Gene.

Molecular therapy. Nucleic acids

Kotini AG, de Stanchina E, Themeli M, Sadelain M, Papapetrou EP.
PMID: 26836371
Mol Ther Nucleic Acids. 2016 Feb 02;5:e284. doi: 10.1038/mtna.2015.57.

Human pluripotent stem cells (hPSCs) hold great promise for cell therapy. However, a major concern is the risk of tumor formation by residual undifferentiated cells contaminating the hPSC-derived cell product. Suicide genes could safeguard against such adverse events by...

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Kotini AG, de Stanchina E, Themeli M, et al. Escape Mutations, Ganciclovir Resistance, and Teratoma Formation in Human iPSCs Expressing an HSVtk Suicide Gene. Mol Ther Nucleic Acids. 2016;5:e284doi: 10.1038/mtna.2015.57.
Kotini, A. G., de Stanchina, E., Themeli, M., Sadelain, M., & Papapetrou, E. P. (2016). Escape Mutations, Ganciclovir Resistance, and Teratoma Formation in Human iPSCs Expressing an HSVtk Suicide Gene. Molecular therapy. Nucleic acids, 5e284. https://doi.org/10.1038/mtna.2015.57
Kotini, Andriana G, et al. "Escape Mutations, Ganciclovir Resistance, and Teratoma Formation in Human iPSCs Expressing an HSVtk Suicide Gene." Molecular therapy. Nucleic acids vol. 5 (2016): e284. doi: https://doi.org/10.1038/mtna.2015.57
Kotini AG, de Stanchina E, Themeli M, Sadelain M, Papapetrou EP. Escape Mutations, Ganciclovir Resistance, and Teratoma Formation in Human iPSCs Expressing an HSVtk Suicide Gene. Mol Ther Nucleic Acids. 2016 Feb 02;5:e284. doi: 10.1038/mtna.2015.57. PMID: 26836371; PMCID: PMC4884789.
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Evaluation of the diagnostic value of alpha-l-fucosidase, alpha-fetoprotein and thymidine kinase 1 with ROC and logistic regression for hepatocellular carcinoma.

FEBS open bio

Zhang SY, Lin BD, Li BR.
PMID: 25870783
FEBS Open Bio. 2015 Mar 26;5:240-4. doi: 10.1016/j.fob.2015.03.010. eCollection 2015.

The purpose of this study was to evaluate the diagnostic efficiency for hepatocellular carcinoma (HCC) with the combined analysis of alpha-l-fucosidase (AFU), alpha-fetoprotein (AFP) and thymidine kinase 1 (TK1). Serum levels of AFU, AFP and TK1 were measured in:...

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Zhang SY, Lin BD, Li BR. Evaluation of the diagnostic value of alpha-l-fucosidase, alpha-fetoprotein and thymidine kinase 1 with ROC and logistic regression for hepatocellular carcinoma. FEBS Open Bio. 2015;5:240-4doi: 10.1016/j.fob.2015.03.010.
Zhang, S. Y., Lin, B. D., & Li, B. R. (2015). Evaluation of the diagnostic value of alpha-l-fucosidase, alpha-fetoprotein and thymidine kinase 1 with ROC and logistic regression for hepatocellular carcinoma. FEBS open bio, 5240-4. https://doi.org/10.1016/j.fob.2015.03.010
Zhang, Shi-Yan, et al. "Evaluation of the diagnostic value of alpha-l-fucosidase, alpha-fetoprotein and thymidine kinase 1 with ROC and logistic regression for hepatocellular carcinoma." FEBS open bio vol. 5 (2015): 240-4. doi: https://doi.org/10.1016/j.fob.2015.03.010
Zhang SY, Lin BD, Li BR. Evaluation of the diagnostic value of alpha-l-fucosidase, alpha-fetoprotein and thymidine kinase 1 with ROC and logistic regression for hepatocellular carcinoma. FEBS Open Bio. 2015 Mar 26;5:240-4. doi: 10.1016/j.fob.2015.03.010. eCollection 2015. PMID: 25870783; PMCID: PMC4392066.
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Long-term Branched Chain Amino Acid Supplementation Ameliorates Diethylnitrosamine-induced Liver Glutathione S-transferase-p Positivity in Zucker Fatty Rats.

Journal of clinical and experimental hepatology

Ishizaki S, Nishiyama M, Hagiwara A.
PMID: 25755500
J Clin Exp Hepatol. 2013 Sep;3(3):192-7. doi: 10.1016/j.jceh.2013.08.008. Epub 2013 Sep 06.

BACKGROUND: Obesity increases the risk of fatty liver disease and liver cancer. There are several models of obesity-associated hepatocellular carcinoma, but tumor development in these models is slow.MATERIALS AND METHODS: We investigated Zucker fatty rats, a model of obesity...

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Ishizaki S, Nishiyama M, Hagiwara A. Long-term Branched Chain Amino Acid Supplementation Ameliorates Diethylnitrosamine-induced Liver Glutathione S-transferase-p Positivity in Zucker Fatty Rats. J Clin Exp Hepatol. 2013;3(3):192-7doi: 10.1016/j.jceh.2013.08.008.
Ishizaki, S., Nishiyama, M., & Hagiwara, A. (2013). Long-term Branched Chain Amino Acid Supplementation Ameliorates Diethylnitrosamine-induced Liver Glutathione S-transferase-p Positivity in Zucker Fatty Rats. Journal of clinical and experimental hepatology, 3(3), 192-7. https://doi.org/10.1016/j.jceh.2013.08.008
Ishizaki, Sonoko, et al. "Long-term Branched Chain Amino Acid Supplementation Ameliorates Diethylnitrosamine-induced Liver Glutathione S-transferase-p Positivity in Zucker Fatty Rats." Journal of clinical and experimental hepatology vol. 3,3 (2013): 192-7. doi: https://doi.org/10.1016/j.jceh.2013.08.008
Ishizaki S, Nishiyama M, Hagiwara A. Long-term Branched Chain Amino Acid Supplementation Ameliorates Diethylnitrosamine-induced Liver Glutathione S-transferase-p Positivity in Zucker Fatty Rats. J Clin Exp Hepatol. 2013 Sep;3(3):192-7. doi: 10.1016/j.jceh.2013.08.008. Epub 2013 Sep 06. PMID: 25755500; PMCID: PMC3940393.
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Thymidine kinase and adenosine kinase activities in homogenates of thyroid lobes in hemithyroidectomized rats; effects of melatonin in vitro.

Neuro endocrinology letters

Gesing A, Modrzejewska H, Karbownik M, Sewerynek E, Greger J, Lewinski A.
PMID: 11335866
Neuro Endocrinol Lett. 2000;21(6):453-459.

OBJECTIVES: Thymidine kinase (TK, EC 2.7.1.21) is a part of the pyrimidine salvage pathway, involved in DNA synthesis. In turn, adenosine kinase (AK, EC 2.7.1.20) functions as a part of the purine metabolic pathway, involved in DNA synthesis. Melatonin...

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Gesing A, Modrzejewska H, Karbownik M, et al. Thymidine kinase and adenosine kinase activities in homogenates of thyroid lobes in hemithyroidectomized rats; effects of melatonin in vitro. Neuro Endocrinol Lett. 2000;21(6):453-459
Gesing, A., Modrzejewska, H., Karbownik, M., Sewerynek, E., Greger, J., & Lewinski, A. (2000). Thymidine kinase and adenosine kinase activities in homogenates of thyroid lobes in hemithyroidectomized rats; effects of melatonin in vitro. Neuro endocrinology letters, 21(6), 453-459.
Gesing, Adam, et al. "Thymidine kinase and adenosine kinase activities in homogenates of thyroid lobes in hemithyroidectomized rats; effects of melatonin in vitro." Neuro endocrinology letters vol. 21,6 (2000): 453-459.
Gesing A, Modrzejewska H, Karbownik M, Sewerynek E, Greger J, Lewinski A. Thymidine kinase and adenosine kinase activities in homogenates of thyroid lobes in hemithyroidectomized rats; effects of melatonin in vitro. Neuro Endocrinol Lett. 2000;21(6):453-459. PMID: 11335866.
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Retroviruses and DNA: gene therapy for brain tumours.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Brown JY, Saleh M.
PMID: 18638778
J Clin Neurosci. 1995 Jan;2(1):16-23. doi: 10.1016/0967-5868(95)90024-1.

Gene therapy is a revolutionary new approach to the treatment of cancer, with potential use as an adjuvant and possibly even primary therapy for malignant brain tumours. Retroviral vector mediated transfer is the first mechanism for the introduction of...

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Brown JY, Saleh M. Retroviruses and DNA: gene therapy for brain tumours. J Clin Neurosci. 1995;2(1):16-23doi: 10.1016/0967-5868(95)90024-1.
Brown, J. Y., & Saleh, M. (1995). Retroviruses and DNA: gene therapy for brain tumours. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2(1), 16-23. https://doi.org/10.1016/0967-5868(95)90024-1
Brown, J Y, and Saleh, M. "Retroviruses and DNA: gene therapy for brain tumours." Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia vol. 2,1 (1995): 16-23. doi: https://doi.org/10.1016/0967-5868(95)90024-1
Brown JY, Saleh M. Retroviruses and DNA: gene therapy for brain tumours. J Clin Neurosci. 1995 Jan;2(1):16-23. doi: 10.1016/0967-5868(95)90024-1. PMID: 18638778.
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