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Showing 1 to 12 of 120 entries
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Diabetes mellitus--current criteria for laboratory diagnosis.

California medicine

Alexander RW.
PMID: 5805334
Calif Med. 1969 Feb;110(2):107-13.
Free PMC Article

Among the laboratory methods and test procedures used for the diagnosis of diabetes mellitus in clinical practice, the oral glucose tolerance test, if performed properly, remains the cornerstone in the definitive diagnosis of diabetes. The intravenous glucose tolerance or...

Kinetics of cytochrome P450 enzymes for metabolism of sodium tanshinone IIA sulfonate in vitro.

Chinese medicine

Ouyang DS, Huang WH, Chen D, Zhang W, Tan ZR, Peng JB, Wang YC, Guo Y, Hu DL, Xiao J, Chen Y.
PMID: 27006687
Chin Med. 2016 Mar 22;11:11. doi: 10.1186/s13020-016-0083-z. eCollection 2016.

BACKGROUND: Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of tanshinone IIA for treating cardiovascular disorders. The roles of cytochrome P450 enzymes (CYPs) in the metabolism of STS have remained unclear. This study aims to screen the main...

Effect of Radix Sophorae Tonkinensis on the activity of cytochrome P450 isoforms in rats.

International journal of clinical and experimental medicine

Cai J, Ma J, Xu K, Gao G, Xiang Y, Lin C.
PMID: 26309650
Int J Clin Exp Med. 2015 Jun 15;8(6):9737-43. eCollection 2015.

Radix Sophorae Tonkinensis (S. tonkinensis) is the processed lateral root of Sophora subprostrata (Leguminosae) that widely distributed over the southwest China. Radix Sophorae Tonkinensis has been widely used as a Chinese medicinal herb for the treatment of disease such...

Clinical and functional characterization of the Pro1198Leu ABCC8 gene mutation associated with permanent neonatal diabetes mellitus.

Journal of diabetes investigation

Takagi T, Furuta H, Miyawaki M, Nagashima K, Shimada T, Doi A, Matsuno S, Tanaka D, Nishi M, Sasaki H, Inagaki N, Yoshikawa N, Nanjo K, Akamizu T.
PMID: 24843665
J Diabetes Investig. 2013 May 06;4(3):269-73. doi: 10.1111/jdi.12049. Epub 2013 Mar 11.

AIMS/INTRODUCTION: The adenosine triphosphate (ATP)-sensitive potassium (KATP) channel is a key component of insulin secretion in pancreatic β-cells. Activating mutations in ABCC8 encoding for the sulfonylurea receptor subunit of the KATP channel have been associated with the development of...

BLX-1002 restores glucose sensitivity and enhances insulin secretion stimulated by GLP-1 and sulfonylurea in type 2 diabetic pancreatic islets.

Physiological reports

Zhang Q, Zhang F, Sjöholm A.
PMID: 24872354
Physiol Rep. 2014 May 28;2(5). doi: 10.14814/phy2.12014. Print 2014 May 01.

BLX-1002 is a novel thiazolidinedione with no peroxisome proliferator-activated receptor (PPAR) activity that has been shown to improve glycemia in type 2 diabetes without weight gain. We previously found that BLX-1002 selectively augments glucose-sensitive (but not basal) insulin secretion...

Evaluation of the impact of Flos Daturae on rat hepatic cytochrome P450 enzymes by cocktail probe drugs.

International journal of clinical and experimental medicine

Geng P, Wang S, Wang C, Chen J, Zhang L, Yang S, Wen C, Zhou Y, Zhang M.
PMID: 26885208
Int J Clin Exp Med. 2015 Dec 15;8(12):22310-8. eCollection 2015.

Flos Daturae, known as "baimantuoluo" or "yangjinhua" in China, has been used for centuries in Traditional Chinese Medicine for the treatment of asthma, convulsions, pain, and rheumatism. To investigate the influences of Flos Daturae on the activities of rat...

The Effect of Centrally Administered Glibenclamide, Tolbutamide and Diazoxide on Feeding in Rats.

Nutritional neuroscience

Bounds JK, Adloo AA, Harp PR, Olivier K, Roane DS.
PMID: 27415150
Nutr Neurosci. 1999;2(3):155-62. doi: 10.1080/1028415X.1999.11747274.

While there are many theories on the control of feeding behavior that emphasize a role for energy substrates and their metabolism, the mechanism that couples changes in energy substrate supply and metabolism to alterations in food intake remains unclear....

[Not Available].

Diabetologia

Bottermann P, Schwarz K, Schulze-Solde R, Dambacher M.
PMID: 24173299
Diabetologia. 1966 Apr;1(3):180-6. doi: 10.1007/BF01257909.

Serum levels of non-esterified fatty acids, free glycerol and esterified fatty acids were estimated in obese patients and in persons of normal weight after intravenous administration of tolbutamide and glucose. In obesity non-esterified fatty acids and glycerol levels were...

Bioassay of tolbutamide for possible carcinogenicity.

National Cancer Institute carcinogenesis technical report series

[No authors listed]
PMID: 12844176
Natl Cancer Inst Carcinog Tech Rep Ser. 1977;31:1-83.

A bioassay of tolbutamide for possible carcinogenicity was conducted by administering the test material in the diet to Fischer 344 rats and B6C3F1 mice. Groups of 35 rats of each sex were administered tolbutamide at one of two doses,...

Effects of serum albumin and liver cytosol on CYP2C9- and CYP3A4-mediated drug metabolism.

Drug metabolism and pharmacokinetics

Baba T, Touchi A, Ito K, Yamaguchi Y, Yamazoe Y, Ohno Y, Sugiyama Y.
PMID: 15618707
Drug Metab Pharmacokinet. 2002;17(6):522-31. doi: 10.2133/dmpk.17.522.

To investigate whether the free-drug theory is accurate in that only unbound drug is available for drug metabolism or enzyme inhibition. The effect of addition of rat liver cytosol to an in vitro system using human liver microsomes was...

Modelling the electrical activity of pancreatic alpha-cells based on experimental data from intact mouse islets.

Journal of biological physics

Diderichsen PM, Göpel SO.
PMID: 19669464
J Biol Phys. 2006 Oct;32(3):209-29. doi: 10.1007/s10867-006-9013-0. Epub 2006 Nov 09.

Detailed experimental data from patch clamp experiments on pancreatic alpha-cells in intact mouse islets are used to model the electrical activity associated with glucagon secretion. Our model incorporates L- and T-type Ca(2+) currents, delayed rectifying and A-type K(+) currents,...

New mechanisms for sulfonylurea control of insulin secretion.

Endocrine

Satin LS.
PMID: 21153274
Endocrine. 1996 Jun;4(3):191-8. doi: 10.1007/BF02738684.

Oral antidiabetic sulfonylureas like tolbutamide and glyburide have been used to treat patients with noninsulin dependent diabetes mellitus. These agents lower blood glucose by stimulating insulin secretion from the pancreatic islets of Langerhans. A major component of this stimulation...

Showing 1 to 12 of 120 entries