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Showing 1 to 12 of 24 entries
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Association of FOXO3 Expression with Tumor Pathogenesis, Prognosis and Clinicopathological Features in Hepatocellular Carcinoma: A Systematic Review with Meta-Analysis.

Cancers

Fondevila F, Fernández-Palanca P, Méndez-Blanco C, Payo-Serafín T, Lozano E, Marin JJG, González-Gallego J, Mauriz JL.
PMID: 34771514
Cancers (Basel). 2021 Oct 26;13(21). doi: 10.3390/cancers13215349.

Forkhead box O3 (FOXO3), an essential transcription factor related to liver disease, has been linked to cancer progression. The most frequent primary liver tumor, hepatocellular carcinoma (HCC), has an elevated mortality rate and patient outcomes remain very poor. Here,...

The Antioxidant Role of Selenium via GPx1 and GPx4 in LPS-Induced Oxidative Stress in Bovine Endometrial Cells.

Biological trace element research

Adeniran SO, Zheng P, Feng R, Adegoke EO, Huang F, Ma M, Wang Z, Ifarajimi OO, Li X, Zhang G.
PMID: 33895964
Biol Trace Elem Res. 2022 Mar;200(3):1140-1155. doi: 10.1007/s12011-021-02731-0. Epub 2021 Apr 24.

This study investigated the antioxidant role of selenium (Se) in the form of selenomethionine (SLM) in LPS-induced oxidative stress via the glutathione peroxidase (GPx) enzymes and the Nrf2/HO-1 transcription factor. The impact of serum supplementation in culture media on...

Lyl-1 regulates primitive macrophages and microglia development.

Communications biology

Wang S, Ren D, Arkoun B, Kaushik AL, Matherat G, Lécluse Y, Filipp D, Vainchenker W, Raslova H, Plo I, Godin I.
PMID: 34887504
Commun Biol. 2021 Dec 09;4(1):1382. doi: 10.1038/s42003-021-02886-5.

During ontogeny, macrophage populations emerge in the Yolk Sac (YS) via two distinct progenitor waves, prior to hematopoietic stem cell development. Macrophage progenitors from the primitive/"early EMP" and transient-definitive/"late EMP" waves both contribute to various resident primitive macrophage populations...

Increased Expression of Sox9 during Balance of BMSCs/Chondrocyte Bricks in Platelet-Rich Plasma Promotes Construction of a Stable 3-D Chondrogenesis Microenvironment for BMSCs.

Stem cells international

Ba R, Kong L, Wu G, Liu S, Dong Y, Li B, Zhao Y.
PMID: 32565827
Stem Cells Int. 2020 May 26;2020:5492059. doi: 10.1155/2020/5492059. eCollection 2020.

Sox9 is an intrinsic transcription factor related to the determination and maintenance of chondrogenic lineage of bone marrow mesenchymal stem cells (BMSCs). In recent research, we have proved that fragmented chondrocyte aggregates (cell bricks) could promote chondrogenesis of BMSCs...

High concentrations of H7 human embryonic stem cells at the point of care for acute myocardial infarction.

Annals of translational medicine

Shi Y, Zhao Y, Li Y, Yi J, Ma Y, Chen Y.
PMID: 33313255
Ann Transl Med. 2020 Nov;8(22):1510. doi: 10.21037/atm-20-7230.

BACKGROUND: Embryonic stem cell (ESC)-derived cardiomyocytes have become one of the most attractive sources of cellular therapy for minimizing heart tissue damage following myocardial infarction (MI). In this study, we investigated the differentiation of BMS-189453-induced H7 human ESCs (hESCs)...

Targeting the EMT transcription factor Snail overcomes resistance to osimertinib in EGFR-mutant non-small cell lung cancer.

Thoracic cancer

Qin Q, Li X, Liang X, Zeng L, Wang J, Sun L, Zhong D.
PMID: 33943009
Thorac Cancer. 2021 Jun;12(11):1708-1715. doi: 10.1111/1759-7714.13906. Epub 2021 May 04.

BACKGROUND: The resistance mechanism of the third generation of epidermal growth factor (EGFR) tyrosine kinase inhibitor (TKI) osimertinib is complex. Epithelial mesenchymal transition (EMT) is a common mechanism of EGFR-TKI acquired resistance. Snail is an important transcription factor related...

Effects of hypothermia on c-fos and zif/268 gene expression following rat forebrain ischemia.

Journal of anesthesia

Matsuda T.
PMID: 14530948
J Anesth. 1999;13(2):99-106. doi: 10.1007/s005400050034.

PURPOSE: To determine the effects of prophylactic mild hypothermia against transient forebrain ischemia, we examined the levels and localization of c-fos and zif/268 gene expression in the rat hippocampal formation at an early period during reperfusion.METHODS: For the histochemical...

Antioxidant Graphene Oxide Nanoribbon as a Novel Whitening Agent Inhibits Microphthalmia-Associated Transcription Factor-Related Melanogenesis Mechanism.

ACS omega

Chou HY, Wang HD, Kuo CH, Lu PH, Wang L, Kang W, Sun CL.
PMID: 32258894
ACS Omega. 2020 Mar 19;5(12):6588-6597. doi: 10.1021/acsomega.9b04316. eCollection 2020 Mar 31.

In the melanin synthesis process, oxidative reactions play an essential role, and it is a good strategy to inhibit melanin production by reducing oxidative stress. Fullerene and its derivatives, or the complexes, were considered as strong free-radical scavengers, and...

Identification of Transcription Factor-Related Gene Signature and Risk Score Model for Colon Adenocarcinoma.

Frontiers in genetics

Lin J, Cao Z, Yu D, Cai W.
PMID: 34603375
Front Genet. 2021 Sep 17;12:709133. doi: 10.3389/fgene.2021.709133. eCollection 2021.

The prognosis of colon adenocarcinoma (COAD) remains poor. However, the specific and sensitive biomarkers for diagnosis and prognosis of COAD are absent. Transcription factors (TFs) are involved in many biological processes in cells. As the molecule of the signal...

Lyl-1 regulates primitive macrophages and microglia development.

Communications biology

Wang S, Ren D, Arkoun B, Kaushik AL, Matherat G, Lécluse Y, Filipp D, Vainchenker W, Raslova H, Plo I, Godin I.
PMID: 34887504
Commun Biol. 2021 Dec 09;4(1):1382. doi: 10.1038/s42003-021-02886-5.

During ontogeny, macrophage populations emerge in the Yolk Sac (YS) via two distinct progenitor waves, prior to hematopoietic stem cell development. Macrophage progenitors from the primitive/"early EMP" and transient-definitive/"late EMP" waves both contribute to various resident primitive macrophage populations...

Metabolite profiling and transcriptome analyses reveal novel regulatory mechanisms of melatonin biosynthesis in hickory.

Horticulture research

Chen W, Zhang J, Zheng S, Wang Z, Xu C, Zhang Q, Wu J, Lou H.
PMID: 34465767
Hortic Res. 2021 Sep 01;8(1):196. doi: 10.1038/s41438-021-00631-x.

Studies have shown that melatonin regulates the expression of various elements in the biosynthesis and catabolism of plant hormones. In contrast, the effects of these different plant hormones on the biosynthesis and metabolism of melatonin and their underlying molecular...

The miRNA199a/SIRT1/P300/Yy1/sST2 signaling axis regulates adverse cardiac remodeling following MI.

Scientific reports

Asensio-Lopez MC, Sassi Y, Soler F, Fernandez Del Palacio MJ, Pascual-Figal D, Lax A.
PMID: 33594087
Sci Rep. 2021 Feb 16;11(1):3915. doi: 10.1038/s41598-021-82745-9.

Left ventricular remodeling following myocardial infarction (MI) is related to adverse outcome. It has been shown that an up-regulation of plasma soluble ST2 (sST2) levels are associated with lower pre-discharge left ventricular (LV) ejection fraction, adverse cardiovascular outcomes and...

Showing 1 to 12 of 24 entries