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Epistatic interactions of CDKN2B-TCF7L2 for risk of type 2 diabetes and of CDKN2B-JAZF1 for triglyceride/high-density lipoprotein ratio longitudinal change: evidence from the Framingham Heart Study.

BMC proceedings

An P, Feitosa M, Ketkar S, Adelman A, Lin S, Borecki I, Province M.
PMID: 20018066
BMC Proc. 2009 Dec 15;3:S71. doi: 10.1186/1753-6561-3-s7-s71.

UNLABELLED: Fifteen known type 2 diabetes (T2D) gene variants were assessed for their associations with T2D status in 228 T2D families from the Framingham Heart Study (FHS) Original, Offspring, and Children Cohorts. Bayesian approach was used to test single-single-nucleotide...

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An P, Feitosa M, Ketkar S, et al. Epistatic interactions of CDKN2B-TCF7L2 for risk of type 2 diabetes and of CDKN2B-JAZF1 for triglyceride/high-density lipoprotein ratio longitudinal change: evidence from the Framingham Heart Study. BMC Proc. 2009;3:S71doi: 10.1186/1753-6561-3-s7-s71.
An, P., Feitosa, M., Ketkar, S., Adelman, A., Lin, S., Borecki, I., & Province, M. (2009). Epistatic interactions of CDKN2B-TCF7L2 for risk of type 2 diabetes and of CDKN2B-JAZF1 for triglyceride/high-density lipoprotein ratio longitudinal change: evidence from the Framingham Heart Study. BMC proceedings, 3S71. https://doi.org/10.1186/1753-6561-3-s7-s71
An, Ping, et al. "Epistatic interactions of CDKN2B-TCF7L2 for risk of type 2 diabetes and of CDKN2B-JAZF1 for triglyceride/high-density lipoprotein ratio longitudinal change: evidence from the Framingham Heart Study." BMC proceedings vol. 3 (2009): S71. doi: https://doi.org/10.1186/1753-6561-3-s7-s71
An P, Feitosa M, Ketkar S, Adelman A, Lin S, Borecki I, Province M. Epistatic interactions of CDKN2B-TCF7L2 for risk of type 2 diabetes and of CDKN2B-JAZF1 for triglyceride/high-density lipoprotein ratio longitudinal change: evidence from the Framingham Heart Study. BMC Proc. 2009 Dec 15;3:S71. doi: 10.1186/1753-6561-3-s7-s71. PMID: 20018066; PMCID: PMC2795973.
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Methods for detecting methylation by SNP interaction in GAW20 simulation.

BMC proceedings

Daw EW, Hicks J, Lenzini P, Lin SJ, Wang J, Williams C, An P, Province MA, Kraja AT.
PMID: 30263046
BMC Proc. 2018 Sep 17;12:37. doi: 10.1186/s12919-018-0140-y. eCollection 2018.

To examine whether single-nucleotide polymorphism (SNP) by methylation interactions can be detected, we analyzed GAW20 simulated triglycerides at visits 3 and 4 against baseline (visits 1 and 2) under 4 general linear models and 2 tree-based models in 200...

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Daw EW, Hicks J, Lenzini P, et al. Methods for detecting methylation by SNP interaction in GAW20 simulation. BMC Proc. 2018;12:37doi: 10.1186/s12919-018-0140-y.
Daw, E. W., Hicks, J., Lenzini, P., Lin, S. J., Wang, J., Williams, C., An, P., Province, M. A., & Kraja, A. T. (2018). Methods for detecting methylation by SNP interaction in GAW20 simulation. BMC proceedings, 1237. https://doi.org/10.1186/s12919-018-0140-y
Daw, E Warwick, et al. "Methods for detecting methylation by SNP interaction in GAW20 simulation." BMC proceedings vol. 12 (2018): 37. doi: https://doi.org/10.1186/s12919-018-0140-y
Daw EW, Hicks J, Lenzini P, Lin SJ, Wang J, Williams C, An P, Province MA, Kraja AT. Methods for detecting methylation by SNP interaction in GAW20 simulation. BMC Proc. 2018 Sep 17;12:37. doi: 10.1186/s12919-018-0140-y. eCollection 2018. PMID: 30263046; PMCID: PMC6156982.
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Genetic analysis of long-lived families reveals novel variants influencing high density-lipoprotein cholesterol.

Frontiers in genetics

Feitosa MF, Wojczynski MK, Straka R, Kammerer CM, Lee JH, Kraja AT, Christensen K, Newman AB, Province MA, Borecki IB.
PMID: 24917880
Front Genet. 2014 Jun 03;5:159. doi: 10.3389/fgene.2014.00159. eCollection 2014.

The plasma levels of high-density lipoprotein cholesterol (HDL) have an inverse relationship to the risks of atherosclerosis and cardiovascular disease (CVD), and have also been associated with longevity. We sought to identify novel loci for HDL that could potentially...

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Feitosa MF, Wojczynski MK, Straka R, et al. Genetic analysis of long-lived families reveals novel variants influencing high density-lipoprotein cholesterol. Front Genet. 2014;5:159doi: 10.3389/fgene.2014.00159.
Feitosa, M. F., Wojczynski, M. K., Straka, R., Kammerer, C. M., Lee, J. H., Kraja, A. T., Christensen, K., Newman, A. B., Province, M. A., & Borecki, I. B. (2014). Genetic analysis of long-lived families reveals novel variants influencing high density-lipoprotein cholesterol. Frontiers in genetics, 5159. https://doi.org/10.3389/fgene.2014.00159
Feitosa, Mary F, et al. "Genetic analysis of long-lived families reveals novel variants influencing high density-lipoprotein cholesterol." Frontiers in genetics vol. 5 (2014): 159. doi: https://doi.org/10.3389/fgene.2014.00159
Feitosa MF, Wojczynski MK, Straka R, Kammerer CM, Lee JH, Kraja AT, Christensen K, Newman AB, Province MA, Borecki IB. Genetic analysis of long-lived families reveals novel variants influencing high density-lipoprotein cholesterol. Front Genet. 2014 Jun 03;5:159. doi: 10.3389/fgene.2014.00159. eCollection 2014. PMID: 24917880; PMCID: PMC4042684.
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Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study.

Frontiers in genetics

Lee JH, Cheng R, Honig LS, Feitosa M, Kammerer CM, Kang MS, Schupf N, Lin SJ, Sanders JL, Bae H, Druley T, Perls T, Christensen K, Province M, Mayeux R.
PMID: 24478790
Front Genet. 2014 Jan 17;4:310. doi: 10.3389/fgene.2013.00310. eCollection 2013.

Leukocyte telomere length is believed to measure cellular aging in humans, and short leukocyte telomere length is associated with increased risks of late onset diseases, including cardiovascular disease, dementia, etc. Many studies have shown that leukocyte telomere length is...

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Lee JH, Cheng R, Honig LS, et al. Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study. Front Genet. 2014;4:310doi: 10.3389/fgene.2013.00310.
Lee, J. H., Cheng, R., Honig, L. S., Feitosa, M., Kammerer, C. M., Kang, M. S., Schupf, N., Lin, S. J., Sanders, J. L., Bae, H., Druley, T., Perls, T., Christensen, K., Province, M., & Mayeux, R. (2013). Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study. Frontiers in genetics, 4310. https://doi.org/10.3389/fgene.2013.00310
Lee, Joseph H, et al. "Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study." Frontiers in genetics vol. 4 (2013): 310. doi: https://doi.org/10.3389/fgene.2013.00310
Lee JH, Cheng R, Honig LS, Feitosa M, Kammerer CM, Kang MS, Schupf N, Lin SJ, Sanders JL, Bae H, Druley T, Perls T, Christensen K, Province M, Mayeux R. Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study. Front Genet. 2014 Jan 17;4:310. doi: 10.3389/fgene.2013.00310. eCollection 2013. PMID: 24478790; PMCID: PMC3894567.
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Heterogeneity of the Predictive Polygenic Risk Scores for Coronary Heart Disease Age-at-Onset in Three Different Coronary Heart Disease Family-Based Ascertainments.

Circulation. Genomic and precision medicine

Feitosa MF, Kuipers AL, Wojczynski MK, Wang L, Barinas-Mitchell E, Kulminski AM, Thyagarajan B, Lee JH, Perls T, Christensen K, Newman AB, Zmuda JM, Province MA.
PMID: 33844929
Circ Genom Precis Med. 2021 Jun;14(3):e003201. doi: 10.1161/CIRCGEN.120.003201. Epub 2021 Apr 12.

BACKGROUND: Polygenic risk scores (PRS) for coronary heart disease (CHD) may contribute to assess the overall risk of CHD. We evaluated how PRS may influence CHD risk when the distribution of age-at-onset, sex, and family health history differ significantly.METHODS:...

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Feitosa MF, Kuipers AL, Wojczynski MK, et al. Heterogeneity of the Predictive Polygenic Risk Scores for Coronary Heart Disease Age-at-Onset in Three Different Coronary Heart Disease Family-Based Ascertainments. Circ Genom Precis Med. 2021;14(3):e003201doi: 10.1161/CIRCGEN.120.003201.
Feitosa, M. F., Kuipers, A. L., Wojczynski, M. K., Wang, L., Barinas-Mitchell, E., Kulminski, A. M., Thyagarajan, B., Lee, J. H., Perls, T., Christensen, K., Newman, A. B., Zmuda, J. M., & Province, M. A. (2021). Heterogeneity of the Predictive Polygenic Risk Scores for Coronary Heart Disease Age-at-Onset in Three Different Coronary Heart Disease Family-Based Ascertainments. Circulation. Genomic and precision medicine, 14(3), e003201. https://doi.org/10.1161/CIRCGEN.120.003201
Feitosa, Mary F, et al. "Heterogeneity of the Predictive Polygenic Risk Scores for Coronary Heart Disease Age-at-Onset in Three Different Coronary Heart Disease Family-Based Ascertainments." Circulation. Genomic and precision medicine vol. 14,3 (2021): e003201. doi: https://doi.org/10.1161/CIRCGEN.120.003201
Feitosa MF, Kuipers AL, Wojczynski MK, Wang L, Barinas-Mitchell E, Kulminski AM, Thyagarajan B, Lee JH, Perls T, Christensen K, Newman AB, Zmuda JM, Province MA. Heterogeneity of the Predictive Polygenic Risk Scores for Coronary Heart Disease Age-at-Onset in Three Different Coronary Heart Disease Family-Based Ascertainments. Circ Genom Precis Med. 2021 Jun;14(3):e003201. doi: 10.1161/CIRCGEN.120.003201. Epub 2021 Apr 12. PMID: 33844929; PMCID: PMC8214825.
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Identification of a Novel Locus for Gait Speed Decline With Aging: The Long Life Family Study.

The journals of gerontology. Series A, Biological sciences and medical sciences

Santanasto AJ, Wojczynski MK, Cvejkus RK, Lin S, Wang L, Thyagarajan B, Christensen K, Schupf N, Feitosa MF, An P, Zmuda JM.
PMID: 34156441
J Gerontol A Biol Sci Med Sci. 2021 Sep 13;76(10):e307-e313. doi: 10.1093/gerona/glab177.

BACKGROUND: Gait speed is a powerful indicator of health with aging. Potential genetic contributions to gait speed and its decline with aging are not well defined. We determined the heritability of and potential genetic regions underlying change in gait...

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Santanasto AJ, Wojczynski MK, Cvejkus RK, et al. Identification of a Novel Locus for Gait Speed Decline With Aging: The Long Life Family Study. J Gerontol A Biol Sci Med Sci. 2021;76(10):e307-e313doi: 10.1093/gerona/glab177.
Santanasto, A. J., Wojczynski, M. K., Cvejkus, R. K., Lin, S., Wang, L., Thyagarajan, B., Christensen, K., Schupf, N., Feitosa, M. F., An, P., & Zmuda, J. M. (2021). Identification of a Novel Locus for Gait Speed Decline With Aging: The Long Life Family Study. The journals of gerontology. Series A, Biological sciences and medical sciences, 76(10), e307-e313. https://doi.org/10.1093/gerona/glab177
Santanasto, Adam J, et al. "Identification of a Novel Locus for Gait Speed Decline With Aging: The Long Life Family Study." The journals of gerontology. Series A, Biological sciences and medical sciences vol. 76,10 (2021): e307-e313. doi: https://doi.org/10.1093/gerona/glab177
Santanasto AJ, Wojczynski MK, Cvejkus RK, Lin S, Wang L, Thyagarajan B, Christensen K, Schupf N, Feitosa MF, An P, Zmuda JM. Identification of a Novel Locus for Gait Speed Decline With Aging: The Long Life Family Study. J Gerontol A Biol Sci Med Sci. 2021 Sep 13;76(10):e307-e313. doi: 10.1093/gerona/glab177. PMID: 34156441; PMCID: PMC8436996.
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Families Enriched for Exceptional Longevity also have Increased Health-Span: Findings from the Long Life Family Study.

Frontiers in public health

Sebastiani P, Sun FX, Andersen SL, Lee JH, Wojczynski MK, Sanders JL, Yashin A, Newman AB, Perls TT.
PMID: 24350207
Front Public Health. 2013 Sep 30;1:38. doi: 10.3389/fpubh.2013.00038. eCollection 2013.

Hypothesizing that members of families enriched for longevity delay morbidity compared to population controls and approximate the health-span of centenarians, we compared the health-spans of older generation subjects of the Long Life Family Study (LLFS) to controls without family...

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Sebastiani P, Sun FX, Andersen SL, et al. Families Enriched for Exceptional Longevity also have Increased Health-Span: Findings from the Long Life Family Study. Front Public Health. 2013;1:38doi: 10.3389/fpubh.2013.00038.
Sebastiani, P., Sun, F. X., Andersen, S. L., Lee, J. H., Wojczynski, M. K., Sanders, J. L., Yashin, A., Newman, A. B., & Perls, T. T. (2013). Families Enriched for Exceptional Longevity also have Increased Health-Span: Findings from the Long Life Family Study. Frontiers in public health, 138. https://doi.org/10.3389/fpubh.2013.00038
Sebastiani, Paola, et al. "Families Enriched for Exceptional Longevity also have Increased Health-Span: Findings from the Long Life Family Study." Frontiers in public health vol. 1 (2013): 38. doi: https://doi.org/10.3389/fpubh.2013.00038
Sebastiani P, Sun FX, Andersen SL, Lee JH, Wojczynski MK, Sanders JL, Yashin A, Newman AB, Perls TT. Families Enriched for Exceptional Longevity also have Increased Health-Span: Findings from the Long Life Family Study. Front Public Health. 2013 Sep 30;1:38. doi: 10.3389/fpubh.2013.00038. eCollection 2013. PMID: 24350207; PMCID: PMC3859985.
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Evaluation of the Bidirectional Relations of Perceived Physical Fatigability and Physical Activity on Slower Gait Speed.

The journals of gerontology. Series A, Biological sciences and medical sciences

Qiao YS, Gmelin T, Renner SW, Boudreau RM, Martin S, Wojczynski MK, Christensen K, Andersen SL, Cosentino S, Santanasto AJ, Glynn NW.
PMID: 33170216
J Gerontol A Biol Sci Med Sci. 2021 Sep 13;76(10):e237-e244. doi: 10.1093/gerona/glaa281.

BACKGROUND: Lower physical activity levels and greater fatigability contribute independently to slower gait speed in older adults. To fully understand the bidirectional relations between physical activity and fatigability, and to inform potential intervention strategies, we examined whether physical activity...

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Qiao YS, Gmelin T, Renner SW, et al. Evaluation of the Bidirectional Relations of Perceived Physical Fatigability and Physical Activity on Slower Gait Speed. J Gerontol A Biol Sci Med Sci. 2021;76(10):e237-e244doi: 10.1093/gerona/glaa281.
Qiao, Y. S., Gmelin, T., Renner, S. W., Boudreau, R. M., Martin, S., Wojczynski, M. K., Christensen, K., Andersen, S. L., Cosentino, S., Santanasto, A. J., & Glynn, N. W. (2021). Evaluation of the Bidirectional Relations of Perceived Physical Fatigability and Physical Activity on Slower Gait Speed. The journals of gerontology. Series A, Biological sciences and medical sciences, 76(10), e237-e244. https://doi.org/10.1093/gerona/glaa281
Qiao, Yujia Susanna, et al. "Evaluation of the Bidirectional Relations of Perceived Physical Fatigability and Physical Activity on Slower Gait Speed." The journals of gerontology. Series A, Biological sciences and medical sciences vol. 76,10 (2021): e237-e244. doi: https://doi.org/10.1093/gerona/glaa281
Qiao YS, Gmelin T, Renner SW, Boudreau RM, Martin S, Wojczynski MK, Christensen K, Andersen SL, Cosentino S, Santanasto AJ, Glynn NW. Evaluation of the Bidirectional Relations of Perceived Physical Fatigability and Physical Activity on Slower Gait Speed. J Gerontol A Biol Sci Med Sci. 2021 Sep 13;76(10):e237-e244. doi: 10.1093/gerona/glaa281. PMID: 33170216; PMCID: PMC8436994.
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Genome-wide association study of personality traits in the long life family study.

Frontiers in genetics

Bae HT, Sebastiani P, Sun JX, Andersen SL, Daw EW, Terracciano A, Ferrucci L, Perls TT.
PMID: 23658558
Front Genet. 2013 May 08;4:65. doi: 10.3389/fgene.2013.00065. eCollection 2013.

Personality traits have been shown to be associated with longevity and healthy aging. In order to discover novel genetic modifiers associated with personality traits as related with longevity, we performed a genome-wide association study (GWAS) on personality factors assessed...

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Bae HT, Sebastiani P, Sun JX, et al. Genome-wide association study of personality traits in the long life family study. Front Genet. 2013;4:65doi: 10.3389/fgene.2013.00065.
Bae, H. T., Sebastiani, P., Sun, J. X., Andersen, S. L., Daw, E. W., Terracciano, A., Ferrucci, L., & Perls, T. T. (2013). Genome-wide association study of personality traits in the long life family study. Frontiers in genetics, 465. https://doi.org/10.3389/fgene.2013.00065
Bae, Harold T, et al. "Genome-wide association study of personality traits in the long life family study." Frontiers in genetics vol. 4 (2013): 65. doi: https://doi.org/10.3389/fgene.2013.00065
Bae HT, Sebastiani P, Sun JX, Andersen SL, Daw EW, Terracciano A, Ferrucci L, Perls TT. Genome-wide association study of personality traits in the long life family study. Front Genet. 2013 May 08;4:65. doi: 10.3389/fgene.2013.00065. eCollection 2013. PMID: 23658558; PMCID: PMC3647245.
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Association of fatigue, inflammation, and physical activity on gait speed: the Long Life Family Study.

Aging clinical and experimental research

Renner SW, Qiao Y, Gmelin T, Santanasto AJ, Boudreau RM, Walston JD, Perls TT, Christensen K, Newman AB, Glynn NW.
PMID: 34196949
Aging Clin Exp Res. 2021 Jul 01; doi: 10.1007/s40520-021-01923-x. Epub 2021 Jul 01.

BACKGROUND: Fatigue, inflammation, and physical activity (PA) are all independently associated with gait speed, but their directionality is not fully elucidated.AIMS: Evaluate the bidirectional associations amongst fatigue, inflammation, and PA on gait speed.METHODS: This cross sectional study included probands...

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Renner SW, Qiao Y, Gmelin T, et al. Association of fatigue, inflammation, and physical activity on gait speed: the Long Life Family Study. Aging Clin Exp Res. 2021;doi: 10.1007/s40520-021-01923-x.
Renner, S. W., Qiao, Y., Gmelin, T., Santanasto, A. J., Boudreau, R. M., Walston, J. D., Perls, T. T., Christensen, K., Newman, A. B., Glynn, N. W. (2021). Association of fatigue, inflammation, and physical activity on gait speed: the Long Life Family Study. Aging clinical and experimental research, . https://doi.org/10.1007/s40520-021-01923-x
Renner, Sharon W, et al. "Association of fatigue, inflammation, and physical activity on gait speed: the Long Life Family Study." Aging clinical and experimental research vol. (2021). doi: https://doi.org/10.1007/s40520-021-01923-x
Renner SW, Qiao Y, Gmelin T, Santanasto AJ, Boudreau RM, Walston JD, Perls TT, Christensen K, Newman AB, Glynn NW. Association of fatigue, inflammation, and physical activity on gait speed: the Long Life Family Study. Aging Clin Exp Res. 2021 Jul 01; doi: 10.1007/s40520-021-01923-x. Epub 2021 Jul 01. PMID: 34196949.
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