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Showing 1 to 12 of 49 entries
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CRISPR-Cas9 delivery to hard-to-transfect cells via membrane deformation.

Science advances

Han X, Liu Z, Jo MC, Zhang K, Li Y, Zeng Z, Li N, Zu Y, Qin L.
PMID: 26601238
Sci Adv. 2015 Aug 14;1(7):e1500454. doi: 10.1126/sciadv.1500454. eCollection 2015 Aug.

The CRISPR (clustered regularly interspaced short palindromic repeats)-Cas (CRISPR-associated) nuclease system represents an efficient tool for genome editing and gene function analysis. It consists of two components: single-guide RNA (sgRNA) and the enzyme Cas9. Typical sgRNA and Cas9 intracellular...

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Han X, Liu Z, Jo MC, et al. CRISPR-Cas9 delivery to hard-to-transfect cells via membrane deformation. Sci Adv. 2015;1(7):e1500454doi: 10.1126/sciadv.1500454.
Han, X., Liu, Z., Jo, M. C., Zhang, K., Li, Y., Zeng, Z., Li, N., Zu, Y., & Qin, L. (2015). CRISPR-Cas9 delivery to hard-to-transfect cells via membrane deformation. Science advances, 1(7), e1500454. https://doi.org/10.1126/sciadv.1500454
Han, Xin, et al. "CRISPR-Cas9 delivery to hard-to-transfect cells via membrane deformation." Science advances vol. 1,7 (2015): e1500454. doi: https://doi.org/10.1126/sciadv.1500454
Han X, Liu Z, Jo MC, Zhang K, Li Y, Zeng Z, Li N, Zu Y, Qin L. CRISPR-Cas9 delivery to hard-to-transfect cells via membrane deformation. Sci Adv. 2015 Aug 14;1(7):e1500454. doi: 10.1126/sciadv.1500454. eCollection 2015 Aug. PMID: 26601238; PMCID: PMC4643799.
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Intravital microscopy for evaluating tumor perfusion of nanoparticles exposed to non-invasive radiofrequency electric fields.

Cancer nanotechnology

Lapin NA, Krzykawska-Serda M, Ware MJ, Curley SA, Corr SJ.
PMID: 27429662
Cancer Nanotechnol. 2016;7:5. doi: 10.1186/s12645-016-0016-7. Epub 2016 Jun 30.

Poor biodistribution and accumulation of chemotherapeutics in tumors due to limitations on diffusive transport and high intra-tumoral pressures (Jain RK, Nat Med. 7(9):987-989, 2001) have prompted the investigation of adjunctive therapies to improve treatment outcomes. Hyperthermia has been widely...

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Lapin NA, Krzykawska-Serda M, Ware MJ, et al. Intravital microscopy for evaluating tumor perfusion of nanoparticles exposed to non-invasive radiofrequency electric fields. Cancer Nanotechnol. 2016;7:5doi: 10.1186/s12645-016-0016-7.
Lapin, N. A., Krzykawska-Serda, M., Ware, M. J., Curley, S. A., & Corr, S. J. (2016). Intravital microscopy for evaluating tumor perfusion of nanoparticles exposed to non-invasive radiofrequency electric fields. Cancer nanotechnology, 75. https://doi.org/10.1186/s12645-016-0016-7
Lapin, Norman A, et al. "Intravital microscopy for evaluating tumor perfusion of nanoparticles exposed to non-invasive radiofrequency electric fields." Cancer nanotechnology vol. 7 (2016): 5. doi: https://doi.org/10.1186/s12645-016-0016-7
Lapin NA, Krzykawska-Serda M, Ware MJ, Curley SA, Corr SJ. Intravital microscopy for evaluating tumor perfusion of nanoparticles exposed to non-invasive radiofrequency electric fields. Cancer Nanotechnol. 2016;7:5. doi: 10.1186/s12645-016-0016-7. Epub 2016 Jun 30. PMID: 27429662; PMCID: PMC4927593.
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HSP70 promoter-driven activation of gene expression for immunotherapy using gold nanorods and near infrared light.

Vaccines

Andersson HA, Kim YS, O'Neill BE, Shi ZZ, Serda RE.
PMID: 25328682
Vaccines (Basel). 2014 Mar 25;2(2):216-27. doi: 10.3390/vaccines2020216.

Modulation of the cytokine milieu is one approach for vaccine development. However, therapy with pro-inflammatory cytokines, such as IL-12, is limited in practice due to adverse systemic effects. Spatially-restricted gene expression circumvents this problem by enabling localized amplification. Intracellular...

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Andersson HA, Kim YS, O'Neill BE, et al. HSP70 promoter-driven activation of gene expression for immunotherapy using gold nanorods and near infrared light. Vaccines (Basel). 2014;2(2):216-27doi: 10.3390/vaccines2020216.
Andersson, H. A., Kim, Y. S., O'Neill, B. E., Shi, Z. Z., & Serda, R. E. (2014). HSP70 promoter-driven activation of gene expression for immunotherapy using gold nanorods and near infrared light. Vaccines, 2(2), 216-27. https://doi.org/10.3390/vaccines2020216
Andersson, Helen A, et al. "HSP70 promoter-driven activation of gene expression for immunotherapy using gold nanorods and near infrared light." Vaccines vol. 2,2 (2014): 216-27. doi: https://doi.org/10.3390/vaccines2020216
Andersson HA, Kim YS, O'Neill BE, Shi ZZ, Serda RE. HSP70 promoter-driven activation of gene expression for immunotherapy using gold nanorods and near infrared light. Vaccines (Basel). 2014 Mar 25;2(2):216-27. doi: 10.3390/vaccines2020216. PMID: 25328682; PMCID: PMC4199457.
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Nitric oxide-mediated tumoricidal activity of murine microglial cells.

Translational oncology

Brantley EC, Guo L, Zhang C, Lin Q, Yokoi K, Langley RR, Kruzel E, Maya M, Kim SW, Kim SJ, Fan D, Fidler IJ.
PMID: 21151477
Transl Oncol. 2010 Dec 01;3(6):380-8. doi: 10.1593/tlo.10208.

Experimental metastases in the brain of mice are infiltrated by microglia, and parabiosis experiments of green fluorescent protein (GFP(+)) and GFP(-) mice revealed that these microglia are derived from circulating monocytes (GFP(+), F4/80(+), and CD68(+)). These findings raised the...

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Brantley EC, Guo L, Zhang C, et al. Nitric oxide-mediated tumoricidal activity of murine microglial cells. Transl Oncol. 2010;3(6):380-8doi: 10.1593/tlo.10208.
Brantley, E. C., Guo, L., Zhang, C., Lin, Q., Yokoi, K., Langley, R. R., Kruzel, E., Maya, M., Kim, S. W., Kim, S. J., Fan, D., & Fidler, I. J. (2010). Nitric oxide-mediated tumoricidal activity of murine microglial cells. Translational oncology, 3(6), 380-8. https://doi.org/10.1593/tlo.10208
Brantley, Emily C, et al. "Nitric oxide-mediated tumoricidal activity of murine microglial cells." Translational oncology vol. 3,6 (2010): 380-8. doi: https://doi.org/10.1593/tlo.10208
Brantley EC, Guo L, Zhang C, Lin Q, Yokoi K, Langley RR, Kruzel E, Maya M, Kim SW, Kim SJ, Fan D, Fidler IJ. Nitric oxide-mediated tumoricidal activity of murine microglial cells. Transl Oncol. 2010 Dec 01;3(6):380-8. doi: 10.1593/tlo.10208. PMID: 21151477; PMCID: PMC3000463.
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Discoidal Porous Silicon Particles: Fabrication and Biodistribution in Breast Cancer Bearing Mice.

Advanced functional materials

Godin B, Chiappini C, Srinivasan S, Alexander JF, Yokoi K, Ferrari M, Decuzzi P, Liu X.
PMID: 23227000
Adv Funct Mater. 2012 Oct 23;22(20):4225-4235. doi: 10.1002/adfm.201200869.

Porous silicon (pSi) is emerging as a promising material in the development of nanovectors for the systemic delivery of therapeutic and imaging agents. The integration of photolithographic patterning, typical of the semiconductor industry, with electrochemical silicon etching provides a...

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Godin B, Chiappini C, Srinivasan S, et al. Discoidal Porous Silicon Particles: Fabrication and Biodistribution in Breast Cancer Bearing Mice. Adv Funct Mater. 2012;22(20):4225-4235doi: 10.1002/adfm.201200869.
Godin, B., Chiappini, C., Srinivasan, S., Alexander, J. F., Yokoi, K., Ferrari, M., Decuzzi, P., & Liu, X. (2012). Discoidal Porous Silicon Particles: Fabrication and Biodistribution in Breast Cancer Bearing Mice. Advanced functional materials, 22(20), 4225-4235. https://doi.org/10.1002/adfm.201200869
Godin, Biana, et al. "Discoidal Porous Silicon Particles: Fabrication and Biodistribution in Breast Cancer Bearing Mice." Advanced functional materials vol. 22,20 (2012): 4225-4235. doi: https://doi.org/10.1002/adfm.201200869
Godin B, Chiappini C, Srinivasan S, Alexander JF, Yokoi K, Ferrari M, Decuzzi P, Liu X. Discoidal Porous Silicon Particles: Fabrication and Biodistribution in Breast Cancer Bearing Mice. Adv Funct Mater. 2012 Oct 23;22(20):4225-4235. doi: 10.1002/adfm.201200869. PMID: 23227000; PMCID: PMC3516182.
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Integrated intravital microscopy and mathematical modeling to optimize nanotherapeutics delivery to tumors.

AIP advances

van de Ven AL, Wu M, Lowengrub J, McDougall SR, Chaplain MA, Cristini V, Ferrari M, Frieboes HB.
PMID: 22489278
AIP Adv. 2012 Mar;2(1):11208. doi: 10.1063/1.3699060. Epub 2012 Mar 22.

Inefficient vascularization hinders the optimal transport of cell nutrients, oxygen, and drugs to cancer cells in solid tumors. Gradients of these substances maintain a heterogeneous cell-scale microenvironment through which drugs and their carriers must travel, significantly limiting optimal drug...

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van de Ven AL, Wu M, Lowengrub J, et al. Integrated intravital microscopy and mathematical modeling to optimize nanotherapeutics delivery to tumors. AIP Adv. 2012;2(1):11208doi: 10.1063/1.3699060.
van de Ven, A. L., Wu, M., Lowengrub, J., McDougall, S. R., Chaplain, M. A., Cristini, V., Ferrari, M., & Frieboes, H. B. (2012). Integrated intravital microscopy and mathematical modeling to optimize nanotherapeutics delivery to tumors. AIP advances, 2(1), 11208. https://doi.org/10.1063/1.3699060
van de Ven, Anne L, et al. "Integrated intravital microscopy and mathematical modeling to optimize nanotherapeutics delivery to tumors." AIP advances vol. 2,1 (2012): 11208. doi: https://doi.org/10.1063/1.3699060
van de Ven AL, Wu M, Lowengrub J, McDougall SR, Chaplain MA, Cristini V, Ferrari M, Frieboes HB. Integrated intravital microscopy and mathematical modeling to optimize nanotherapeutics delivery to tumors. AIP Adv. 2012 Mar;2(1):11208. doi: 10.1063/1.3699060. Epub 2012 Mar 22. PMID: 22489278; PMCID: PMC3321519.
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A multiphase model for three-dimensional tumor growth.

New journal of physics

Sciumè G, Shelton S, Gray W, Miller C, Hussain F, Ferrari M, Decuzzi P, Schrefler B.
PMID: 24554920
New J Phys. 2013 Jan;15:015005. doi: 10.1088/1367-2630/15/1/015005.

Several mathematical formulations have analyzed the time-dependent behaviour of a tumor mass. However, most of these propose simplifications that compromise the physical soundness of the model. Here, multiphase porous media mechanics is extended to model tumor evolution, using governing...

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Sciumè G, Shelton S, Gray W, et al. A multiphase model for three-dimensional tumor growth. New J Phys. 2013;15:015005doi: 10.1088/1367-2630/15/1/015005.
Sciumè, G., Shelton, S., Gray, W., Miller, C., Hussain, F., Ferrari, M., Decuzzi, P., & Schrefler, B. (2013). A multiphase model for three-dimensional tumor growth. New journal of physics, 15015005. https://doi.org/10.1088/1367-2630/15/1/015005
Sciumè, G, et al. "A multiphase model for three-dimensional tumor growth." New journal of physics vol. 15 (2013): 015005. doi: https://doi.org/10.1088/1367-2630/15/1/015005
Sciumè G, Shelton S, Gray W, Miller C, Hussain F, Ferrari M, Decuzzi P, Schrefler B. A multiphase model for three-dimensional tumor growth. New J Phys. 2013 Jan;15:015005. doi: 10.1088/1367-2630/15/1/015005. PMID: 24554920; PMCID: PMC3926362.
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Simulating cancer growth with multiscale agent-based modeling.

Seminars in cancer biology

Wang Z, Butner JD, Kerketta R, Cristini V, Deisboeck TS.
PMID: 24793698
Semin Cancer Biol. 2015 Feb;30:70-8. doi: 10.1016/j.semcancer.2014.04.001. Epub 2014 May 02.

There have been many techniques developed in recent years to in silico model a variety of cancer behaviors. Agent-based modeling is a specific discrete-based hybrid modeling approach that allows simulating the role of diversity in cell populations as well...

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Wang Z, Butner JD, Kerketta R, et al. Simulating cancer growth with multiscale agent-based modeling. Semin Cancer Biol. 2014;30:70-8doi: 10.1016/j.semcancer.2014.04.001.
Wang, Z., Butner, J. D., Kerketta, R., Cristini, V., & Deisboeck, T. S. (2015). Simulating cancer growth with multiscale agent-based modeling. Seminars in cancer biology, 3070-8. https://doi.org/10.1016/j.semcancer.2014.04.001
Wang, Zhihui, et al. "Simulating cancer growth with multiscale agent-based modeling." Seminars in cancer biology vol. 30 (2015): 70-8. doi: https://doi.org/10.1016/j.semcancer.2014.04.001
Wang Z, Butner JD, Kerketta R, Cristini V, Deisboeck TS. Simulating cancer growth with multiscale agent-based modeling. Semin Cancer Biol. 2015 Feb;30:70-8. doi: 10.1016/j.semcancer.2014.04.001. Epub 2014 May 02. PMID: 24793698; PMCID: PMC4216775.
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A method to measure specific absorption rate of nanoparticles in colloidal suspension using different configurations of radio-frequency fields.

Applied physics letters

Ketharnath D, Pande R, Xie L, Srinivasan S, Godin B, Wosik J.
PMID: 22991480
Appl Phys Lett. 2012 Aug 20;101(8):83118. doi: 10.1063/1.4748285. Epub 2012 Aug 24.

We report a method for characterization of the efficiency of radio-frequency (rf) heating of nanoparticles (NPs) suspended in an aqueous medium. Measurements were carried out for water suspended 5 nm superparamagnetic iron-oxide NPs with 30 nm dextran matrix for...

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Ketharnath D, Pande R, Xie L, et al. A method to measure specific absorption rate of nanoparticles in colloidal suspension using different configurations of radio-frequency fields. Appl Phys Lett. 2012;101(8):83118doi: 10.1063/1.4748285.
Ketharnath, D., Pande, R., Xie, L., Srinivasan, S., Godin, B., & Wosik, J. (2012). A method to measure specific absorption rate of nanoparticles in colloidal suspension using different configurations of radio-frequency fields. Applied physics letters, 101(8), 83118. https://doi.org/10.1063/1.4748285
Ketharnath, Dhivya, et al. "A method to measure specific absorption rate of nanoparticles in colloidal suspension using different configurations of radio-frequency fields." Applied physics letters vol. 101,8 (2012): 83118. doi: https://doi.org/10.1063/1.4748285
Ketharnath D, Pande R, Xie L, Srinivasan S, Godin B, Wosik J. A method to measure specific absorption rate of nanoparticles in colloidal suspension using different configurations of radio-frequency fields. Appl Phys Lett. 2012 Aug 20;101(8):83118. doi: 10.1063/1.4748285. Epub 2012 Aug 24. PMID: 22991480; PMCID: PMC3436911.
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Modeling of nanotherapeutics delivery based on tumor perfusion.

New journal of physics

van de Ven AL, Abdollahi B, Martinez CJ, Burey LA, Landis MD, Chang JC, Ferrari M, Frieboes HB.
PMID: 24039540
New J Phys. 2013 May 08;15:55004. doi: 10.1088/1367-2630/15/5/055004.

Heterogeneities in the perfusion of solid tumors prevent optimal delivery of nanotherapeutics. Clinical imaging protocols to obtain patient-specific data have proven difficult to implement. It is challenging to determine which perfusion features hold greater prognostic value and to relate...

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van de Ven AL, Abdollahi B, Martinez CJ, et al. Modeling of nanotherapeutics delivery based on tumor perfusion. New J Phys. 2013;15:55004doi: 10.1088/1367-2630/15/5/055004.
van de Ven, A. L., Abdollahi, B., Martinez, C. J., Burey, L. A., Landis, M. D., Chang, J. C., Ferrari, M., & Frieboes, H. B. (2013). Modeling of nanotherapeutics delivery based on tumor perfusion. New journal of physics, 1555004. https://doi.org/10.1088/1367-2630/15/5/055004
van de Ven, Anne L, et al. "Modeling of nanotherapeutics delivery based on tumor perfusion." New journal of physics vol. 15 (2013): 55004. doi: https://doi.org/10.1088/1367-2630/15/5/055004
van de Ven AL, Abdollahi B, Martinez CJ, Burey LA, Landis MD, Chang JC, Ferrari M, Frieboes HB. Modeling of nanotherapeutics delivery based on tumor perfusion. New J Phys. 2013 May 08;15:55004. doi: 10.1088/1367-2630/15/5/055004. PMID: 24039540; PMCID: PMC3770306.
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Unique heating curves generated by radiofrequency electric-field interactions with semi-aqueous solutions.

Applied physics letters

Lara NC, Haider AA, Wilson LJ, Curley SA, Corr SJ.
PMID: 28104923
Appl Phys Lett. 2017 Jan 02;110(1):013701. doi: 10.1063/1.4973218. Epub 2017 Jan 04.

Aqueous and nanoparticle-based solutions have been reported to heat when exposed to an alternating radiofrequency (RF) electric-field. Although the theoretical models have been developed to accurately model such a behavior given the solution composition as well as the geometrical...

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Lara NC, Haider AA, Wilson LJ, et al. Unique heating curves generated by radiofrequency electric-field interactions with semi-aqueous solutions. Appl Phys Lett. 2017;110(1):013701doi: 10.1063/1.4973218.
Lara, N. C., Haider, A. A., Wilson, L. J., Curley, S. A., & Corr, S. J. (2017). Unique heating curves generated by radiofrequency electric-field interactions with semi-aqueous solutions. Applied physics letters, 110(1), 013701. https://doi.org/10.1063/1.4973218
Lara, Nadia C, et al. "Unique heating curves generated by radiofrequency electric-field interactions with semi-aqueous solutions." Applied physics letters vol. 110,1 (2017): 013701. doi: https://doi.org/10.1063/1.4973218
Lara NC, Haider AA, Wilson LJ, Curley SA, Corr SJ. Unique heating curves generated by radiofrequency electric-field interactions with semi-aqueous solutions. Appl Phys Lett. 2017 Jan 02;110(1):013701. doi: 10.1063/1.4973218. Epub 2017 Jan 04. PMID: 28104923; PMCID: PMC5218968.
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Identification and validation of SRC and phospho-SRC family proteins in circulating mononuclear cells as novel biomarkers for pancreatic cancer.

Translational oncology

Yokoi K, Hawke D, Oborn CJ, Jang JY, Nishioka Y, Fan D, Kim SW, Kim SJ, Fidler IJ.
PMID: 21461171
Transl Oncol. 2011 Apr 01;4(2):83-91. doi: 10.1593/tlo.10202.

There is an urgent need to develop novel markers of pancreatic cancer to facilitate early diagnosis. Pancreatic carcinoma is characterized by marked stroma formation with a high number of infiltrating tumor-associated macrophages (TAMs) that originate from circulating mononuclear cells...

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Yokoi K, Hawke D, Oborn CJ, et al. Identification and validation of SRC and phospho-SRC family proteins in circulating mononuclear cells as novel biomarkers for pancreatic cancer. Transl Oncol. 2011;4(2):83-91doi: 10.1593/tlo.10202.
Yokoi, K., Hawke, D., Oborn, C. J., Jang, J. Y., Nishioka, Y., Fan, D., Kim, S. W., Kim, S. J., & Fidler, I. J. (2011). Identification and validation of SRC and phospho-SRC family proteins in circulating mononuclear cells as novel biomarkers for pancreatic cancer. Translational oncology, 4(2), 83-91. https://doi.org/10.1593/tlo.10202
Yokoi, Kenji, et al. "Identification and validation of SRC and phospho-SRC family proteins in circulating mononuclear cells as novel biomarkers for pancreatic cancer." Translational oncology vol. 4,2 (2011): 83-91. doi: https://doi.org/10.1593/tlo.10202
Yokoi K, Hawke D, Oborn CJ, Jang JY, Nishioka Y, Fan D, Kim SW, Kim SJ, Fidler IJ. Identification and validation of SRC and phospho-SRC family proteins in circulating mononuclear cells as novel biomarkers for pancreatic cancer. Transl Oncol. 2011 Apr 01;4(2):83-91. doi: 10.1593/tlo.10202. PMID: 21461171; PMCID: PMC3069651.
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Showing 1 to 12 of 49 entries