Display options
Cite
Brantley EC, Guo L, Zhang C, et al. Nitric oxide-mediated tumoricidal activity of murine microglial cells. Transl Oncol. 2010;3(6):380-8doi: 10.1593/tlo.10208.
Brantley, E. C., Guo, L., Zhang, C., Lin, Q., Yokoi, K., Langley, R. R., Kruzel, E., Maya, M., Kim, S. W., Kim, S. J., Fan, D., & Fidler, I. J. (2010). Nitric oxide-mediated tumoricidal activity of murine microglial cells. Translational oncology, 3(6), 380-8. https://doi.org/10.1593/tlo.10208
Brantley, Emily C, et al. "Nitric oxide-mediated tumoricidal activity of murine microglial cells." Translational oncology vol. 3,6 (2010): 380-8. doi: https://doi.org/10.1593/tlo.10208
Brantley EC, Guo L, Zhang C, Lin Q, Yokoi K, Langley RR, Kruzel E, Maya M, Kim SW, Kim SJ, Fan D, Fidler IJ. Nitric oxide-mediated tumoricidal activity of murine microglial cells. Transl Oncol. 2010 Dec 01;3(6):380-8. doi: 10.1593/tlo.10208. PMID: 21151477; PMCID: PMC3000463.
Copy Download .nbib Format: NLM
Share it on

Transl Oncol. 2010 Dec 01;3(6):380-8. doi: 10.1593/tlo.10208.

Nitric oxide-mediated tumoricidal activity of murine microglial cells.

Translational oncology

Emily C Brantley, Lixia Guo, Chenyu Zhang, Qingtang Lin, Kenji Yokoi, Robert R Langley, Ewa Kruzel, Marva Maya, Seung Wook Kim, Sun-Jin Kim, Dominic Fan, Isaiah J Fidler

Affiliations

  1. Department of Cancer Biology, Cancer Metastasis Research Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

PMID: 21151477 PMCID: PMC3000463 DOI: 10.1593/tlo.10208

Abstract

Experimental metastases in the brain of mice are infiltrated by microglia, and parabiosis experiments of green fluorescent protein (GFP(+)) and GFP(-) mice revealed that these microglia are derived from circulating monocytes (GFP(+), F4/80(+), and CD68(+)). These findings raised the question as to whether microglia (specialized macrophages) possess tumoricidal activity. C8-B4 murine microglia cells were incubated in vitro in medium (control) or in medium containing both lipopolysaccharide and interferon-γ. Control microglia were not tumoricidal against a number of murine and human tumor cells, whereas lipopolysaccharide/interferon-γ-activated microglia lysed murine and human tumor cells by release of nitric oxide. Parallel experiments with murine peritoneal macrophages produced identical results. Neither activated microglia nor activated macrophages lysed nontumorigenic murine or human cells. Collectively, these data demonstrate that brain metastasis-associated microglia are derived from circulating mononuclear cells and exhibit selective and specific tumoricidal activity.

References

  1. Proc Natl Acad Sci U S A. 1991 Feb 15;88(4):1541-5 - PubMed
  2. Int J Oncol. 2009 Oct;35(4):665-72 - PubMed
  3. J Exp Med. 1987 Oct 1;166(4):1138-43 - PubMed
  4. Ann Med. 2010 Apr;42(3):161-70 - PubMed
  5. Biochem Pharmacol. 2006 Nov 30;72(11):1469-76 - PubMed
  6. Cancer Res. 1991 Jun 1;51(11):3062-6 - PubMed
  7. Neuroscience. 1992;48(2):405-15 - PubMed
  8. Mol Neurobiol. 2010 Jun;41(2-3):242-7 - PubMed
  9. Science. 2005 May 27;308(5726):1314-8 - PubMed
  10. Brain Res. 2006 Apr 21;1084(1):1-15 - PubMed
  11. Neuroscience. 2009 Feb 6;158(3):1030-8 - PubMed
  12. Nat New Biol. 1973 Apr 4;242(118):148-9 - PubMed
  13. Neoplasia. 2010 Sep;12(9):748-54 - PubMed
  14. Cytokine Growth Factor Rev. 1998 Sep-Dec;9(3-4):259-75 - PubMed
  15. Am J Pathol. 2009 May;174(5):1972-80 - PubMed
  16. Clin Microbiol Rev. 2004 Oct;17(4):942-64, table of contents - PubMed
  17. Int J Cancer. 1997 Jan 17;70(2):169-74 - PubMed
  18. J Neurosurg. 1979 Mar;50(3):305-11 - PubMed
  19. Cell. 2010 Apr 2;141(1):39-51 - PubMed
  20. J Exp Ther Oncol. 2002 Sep-Oct;2(5):286-97 - PubMed
  21. Biochim Biophys Acta. 1988 Nov 15;948(2):151-73 - PubMed
  22. Oncol Res. 1997;9(11-12):573-9 - PubMed
  23. Cancer Res. 2006 Nov 1;66(21):10576-85 - PubMed
  24. Mol Med. 2006 Jul-Aug;12(7-8):161-70 - PubMed
  25. Annu Rev Immunol. 2009;27:119-45 - PubMed
  26. Endocr Rev. 2007 May;28(3):297-321 - PubMed
  27. Lancet Oncol. 2008 Aug;9(8):808 - PubMed
  28. Gynecol Oncol. 2010 May;117(2):366-72 - PubMed
  29. Neuroscience. 1990;39(1):151-70 - PubMed
  30. Science. 2010 Feb 5;327(5966):656-61 - PubMed
  31. Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5096-100 - PubMed
  32. J Neurosurg. 1979 Mar;50(3):298-304 - PubMed
  33. J Pathol. 2010 Jul;221(3):248-63 - PubMed
  34. Brain Res Dev Brain Res. 1996 Aug 20;95(1):140-3 - PubMed
  35. Brain Res. 2009 Jul 7;1279:9-20 - PubMed
  36. J Immunother. 1998 Sep;21(5):340-51 - PubMed
  37. J Neurosci Res. 2005 Aug 1;81(3):447-55 - PubMed
  38. Am J Pathol. 1979 Dec;97(3):587-600 - PubMed
  39. J Natl Cancer Inst. 1974 Sep;53(3):661-74 - PubMed
  40. Neuroscience. 1985 Jun;15(2):313-26 - PubMed
  41. Cancer Res. 1995 Jul 15;55(14):3123-31 - PubMed
  42. J Natl Cancer Inst. 1979 Sep;63(3):541-8 - PubMed
  43. Science. 1980 Jun 27;208(4451):1469-71 - PubMed
  44. Cancer Res. 1988 Jun 15;48(12):3478-84 - PubMed
  45. Nat Rev Immunol. 2009 Apr;9(4):259-70 - PubMed
  46. Hum Gene Ther. 1998 Dec 10;9(18):2699-708 - PubMed
  47. Cell. 1994 Oct 21;79(2):315-28 - PubMed
  48. FASEB J. 2006 Oct;20(12):2081-92 - PubMed
  49. Brain Res Rev. 2007 Feb;53(2):344-54 - PubMed
  50. Nat Neurosci. 2005 Jun;8(6):752-8 - PubMed
  51. Mol Genet Metab. 2005 Jan;84(1):9-17 - PubMed
  52. J Natl Cancer Inst. 1977 Jun;58(6):1867-72 - PubMed
  53. Antioxid Redox Signal. 2005 Sep-Oct;7(9-10):1223-33 - PubMed
  54. J Neurol Sci. 1995 Dec;134(1-2):26-32 - PubMed
  55. Trends Immunol. 2008 May;29(5):227-34 - PubMed
  56. J Exp Med. 1995 Apr 1;181(4):1333-43 - PubMed
  57. Cancer Res. 1985 Oct;45(10):4714-26 - PubMed
  58. J Clin Neurosci. 2010 Jan;17(1):6-10 - PubMed
  59. J Cell Biol. 1983 Jul;97(1):253-7 - PubMed

Publication Types

Grant support