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Showing 1 to 8 of 8 entries
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Mercury interferes with endogenous antioxidant levels in Yukon River subsistence-fed sled dogs.

Environmental research letters : ERL [Web site]

Dunlap KL, Reynolds AJ, Gerlach SC, Duffy LK.
PMID: 28781607
Environ Res Lett. 2011 Oct-Dec;6(4). doi: 10.1088/1748-9326/6/4/044015. Epub 2011 Nov 21.

Before adopting modern corn-and-grain-based western processed diets, circumpolar people had a high fat and protein subsistence diet and exhibited a low incidence of obesity, diabetes and cardiovascular disease. Some health benefits are attributable to a subsistence diet that is...

Engaging Students in Science Courses: Lessons of Change from the Arctic.

Interchange (Toronto, Ont. : 1984)

Duffy LK, Godduhn A, Nicholas-Figueroa L, Fabbri CE, van Muelken M.
PMID: 27976754
Interchange (Tor : 1984). 2011 May;42(2):105-136. doi: 10.1007/s10780-011-9151-6. Epub 2011 Aug 07.

Where you live should have something to do with what you teach. In the Arctic, this idea of place-based education-teaching and sharing knowledge that is needed to live well- is central to the UARCTIC consortium and the 4

Arctic ground squirrel neuronal progenitor cells resist oxygen and glucose deprivation-induced death.

World journal of biological chemistry

Drew KL, Wells M, McGee R, Ross AP, Kelleher-Andersson J.
PMID: 26981205
World J Biol Chem. 2016 Feb 26;7(1):168-77. doi: 10.4331/wjbc.v7.i1.168.

AIM: To investigate the influence of ischemia/reperfusion on arctic ground squirrel (AGS) neuronal progenitor cells (NPCs), we subjected these cultured cells to oxygen and glucose deprivation.METHODS: AGS NPCs were expanded and differentiated into NPCs and as an ischemia vulnerable...

Mechanisms of innate preconditioning towards ischemia/anoxia tolerance: Lessons from mammalian hibernators.

Conditioning medicine

Bhowmick S, Drew KL.
PMID: 32542230
Cond Med. 2019 Jun;2(3):134-141.

Hibernating mammals exhibit an innate physiological ability to withstand dramatic fluctuations in blood flow that occurs during hibernation and arousal or experimental models of ischemia reperfusion without significant damage. These innate adaptations are of significance particularly to organs that...

Glucose transporter-4 in white blood cells of young and old sled dogs: a model for human biomarker development.

The Polar record

Schnurr TM, Reynolds AJ, Duffy LK, Dunlap KL.
PMID: 28713178
Polar Rec (Gr Brit). 2015 Mar;51(2):160-164. doi: 10.1017/S0032247413000831. Epub 2013 Nov 28.

The insulin responsive glucose transporter, GLUT4 is found predominantly in muscle and adipose cells. Maratou and others (2007) reported that there is GLUT4 in white blood cells (WBC) collected from human subjects in response to insulin activation. This study...

Insulin signaling in the aging of healthy and proteotoxically stressed mechanosensory neurons.

Frontiers in genetics

Scerbak C, Vayndorf EM, Parker JA, Neri C, Driscoll M, Taylor BE.
PMID: 25101108
Front Genet. 2014 Jul 23;5:212. doi: 10.3389/fgene.2014.00212. eCollection 2014.

Insulin signaling is central to cellular metabolism and organismal aging. However, the role of insulin signaling in natural and proteotoxically stressed aging neurons has yet to be fully described. We studied aging of Caenorbaditis elegans mechanosensory neurons expressing a...

Habituation of Arctic ground squirrels (Urocitellus parryii) to handling and movement during torpor to prevent artificial arousal.

Frontiers in physiology

Christian SL, Rasley BT, Roe T, Moore JT, Harris MB, Drew KL.
PMID: 24847278
Front Physiol. 2014 May 09;5:174. doi: 10.3389/fphys.2014.00174. eCollection 2014.

Hibernation is a unique physiological adaptation characterized by periods of torpor that consist of repeated, reversible, and dramatic reductions of body temperature, metabolism, and blood flow. External and internal triggers can induce arousal from torpor in the hibernator. Studies...

Morphological remodeling of .

NPJ aging and mechanisms of disease

Vayndorf EM, Scerbak C, Hunter S, Neuswanger JR, Toth M, Parker JA, Neri C, Driscoll M, Taylor BE.
PMID: 27347427
NPJ Aging Mech Dis. 2016;2. doi: 10.1038/npjamd.2016.1. Epub 2016 Apr 07.

Understanding cellular outcomes, such as neuronal remodeling, that are common to both healthy and diseased aging brains is essential to the development of successful brain aging strategies. Here, we used

Showing 1 to 8 of 8 entries