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DNA methylation in blood as a mediator of the association of mid-childhood body mass index with cardio-metabolic risk score in early adolescence.

Epigenetics

Huang JV, Cardenas A, Colicino E, Schooling CM, Rifas-Shiman SL, Agha G, Zheng Y, Hou L, Just AC, Litonjua AA, DeMeo DL, Lin X, Oken E, Hivert MF, Baccarelli AA.
PMID: 30412002
Epigenetics. 2018;13(10):1072-1087. doi: 10.1080/15592294.2018.1543503. Epub 2018 Nov 13.

Obesity is associated with higher cardio-metabolic risk even in childhood and adolescence; whether this association is mediated by epigenetic mechanisms remains unclear. We examined the extent to which mid-childhood body mass index (BMI) z-score (median age 7.7 years) was...

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Huang JV, Cardenas A, Colicino E, et al. DNA methylation in blood as a mediator of the association of mid-childhood body mass index with cardio-metabolic risk score in early adolescence. Epigenetics. 2018;13(10):1072-1087doi: 10.1080/15592294.2018.1543503.
Huang, J. V., Cardenas, A., Colicino, E., Schooling, C. M., Rifas-Shiman, S. L., Agha, G., Zheng, Y., Hou, L., Just, A. C., Litonjua, A. A., DeMeo, D. L., Lin, X., Oken, E., Hivert, M. F., & Baccarelli, A. A. (2018). DNA methylation in blood as a mediator of the association of mid-childhood body mass index with cardio-metabolic risk score in early adolescence. Epigenetics, 13(10), 1072-1087. https://doi.org/10.1080/15592294.2018.1543503
Huang, Jian V, et al. "DNA methylation in blood as a mediator of the association of mid-childhood body mass index with cardio-metabolic risk score in early adolescence." Epigenetics vol. 13,10 (2018): 1072-1087. doi: https://doi.org/10.1080/15592294.2018.1543503
Huang JV, Cardenas A, Colicino E, Schooling CM, Rifas-Shiman SL, Agha G, Zheng Y, Hou L, Just AC, Litonjua AA, DeMeo DL, Lin X, Oken E, Hivert MF, Baccarelli AA. DNA methylation in blood as a mediator of the association of mid-childhood body mass index with cardio-metabolic risk score in early adolescence. Epigenetics. 2018;13(10):1072-1087. doi: 10.1080/15592294.2018.1543503. Epub 2018 Nov 13. PMID: 30412002; PMCID: PMC6342073.
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Associations of midchildhood to early adolescence central adiposity gain with cardiometabolic health in early adolescence.

Obesity (Silver Spring, Md.)

Wu AJ, Aris IM, Rifas-Shiman SL, Oken E, Taveras EM, Chavarro JE, Hivert MF.
PMID: 34529343
Obesity (Silver Spring). 2021 Nov;29(11):1882-1891. doi: 10.1002/oby.23261. Epub 2021 Sep 16.

OBJECTIVE: This study examined the associations of central adiposity gain from midchildhood to early adolescence with cardiometabolic health markers in early adolescence.METHODS: A total of 620 participants were studied in Project Viva. In midchildhood (mean age = 7.8 years)...

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Wu AJ, Aris IM, Rifas-Shiman SL, et al. Associations of midchildhood to early adolescence central adiposity gain with cardiometabolic health in early adolescence. Obesity (Silver Spring). 2021;29(11):1882-1891doi: 10.1002/oby.23261.
Wu, A. J., Aris, I. M., Rifas-Shiman, S. L., Oken, E., Taveras, E. M., Chavarro, J. E., & Hivert, M. F. (2021). Associations of midchildhood to early adolescence central adiposity gain with cardiometabolic health in early adolescence. Obesity (Silver Spring, Md.), 29(11), 1882-1891. https://doi.org/10.1002/oby.23261
Wu, Allison J, et al. "Associations of midchildhood to early adolescence central adiposity gain with cardiometabolic health in early adolescence." Obesity (Silver Spring, Md.) vol. 29,11 (2021): 1882-1891. doi: https://doi.org/10.1002/oby.23261
Wu AJ, Aris IM, Rifas-Shiman SL, Oken E, Taveras EM, Chavarro JE, Hivert MF. Associations of midchildhood to early adolescence central adiposity gain with cardiometabolic health in early adolescence. Obesity (Silver Spring). 2021 Nov;29(11):1882-1891. doi: 10.1002/oby.23261. Epub 2021 Sep 16. PMID: 34529343; PMCID: PMC8571062.
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Prenatal Exposure to Traffic Pollution and Childhood Body Mass Index Trajectory.

Frontiers in endocrinology

Fleisch AF, Aris IM, Rifas-Shiman SL, Coull BA, Luttmann-Gibson H, Koutrakis P, Schwartz JD, Kloog I, Gold DR, Oken E.
PMID: 30666232
Front Endocrinol (Lausanne). 2019 Jan 07;9:771. doi: 10.3389/fendo.2018.00771. eCollection 2018.

No abstract available.

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Fleisch AF, Aris IM, Rifas-Shiman SL, et al. Prenatal Exposure to Traffic Pollution and Childhood Body Mass Index Trajectory. Front Endocrinol (Lausanne). 2019;9:771doi: 10.3389/fendo.2018.00771.
Fleisch, A. F., Aris, I. M., Rifas-Shiman, S. L., Coull, B. A., Luttmann-Gibson, H., Koutrakis, P., Schwartz, J. D., Kloog, I., Gold, D. R., & Oken, E. (2018). Prenatal Exposure to Traffic Pollution and Childhood Body Mass Index Trajectory. Frontiers in endocrinology, 9771. https://doi.org/10.3389/fendo.2018.00771
Fleisch, Abby F, et al. "Prenatal Exposure to Traffic Pollution and Childhood Body Mass Index Trajectory." Frontiers in endocrinology vol. 9 (2018): 771. doi: https://doi.org/10.3389/fendo.2018.00771
Fleisch AF, Aris IM, Rifas-Shiman SL, Coull BA, Luttmann-Gibson H, Koutrakis P, Schwartz JD, Kloog I, Gold DR, Oken E. Prenatal Exposure to Traffic Pollution and Childhood Body Mass Index Trajectory. Front Endocrinol (Lausanne). 2019 Jan 07;9:771. doi: 10.3389/fendo.2018.00771. eCollection 2018. PMID: 30666232; PMCID: PMC6330299.
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Chronotype, Social Jet Lag, and Cardiometabolic Risk Factors in Early Adolescence.

JAMA pediatrics

Cespedes Feliciano EM, Rifas-Shiman SL, Quante M, Redline S, Oken E, Taveras EM.
PMID: 31524936
JAMA Pediatr. 2019 Nov 01;173(11):1049-1057. doi: 10.1001/jamapediatrics.2019.3089.

IMPORTANCE: Inadequate sleep duration and quality increase the risk of obesity. Sleep timing, while less studied, is important in adolescents because increasing evening preferences (chronotypes), early school start times, and irregular sleep schedules may cause circadian misalignment.OBJECTIVE: To investigate...

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Cespedes Feliciano EM, Rifas-Shiman SL, Quante M, et al. Chronotype, Social Jet Lag, and Cardiometabolic Risk Factors in Early Adolescence. JAMA Pediatr. 2019;173(11):1049-1057doi: 10.1001/jamapediatrics.2019.3089.
Cespedes Feliciano, E. M., Rifas-Shiman, S. L., Quante, M., Redline, S., Oken, E., & Taveras, E. M. (2019). Chronotype, Social Jet Lag, and Cardiometabolic Risk Factors in Early Adolescence. JAMA pediatrics, 173(11), 1049-1057. https://doi.org/10.1001/jamapediatrics.2019.3089
Cespedes Feliciano, Elizabeth M, et al. "Chronotype, Social Jet Lag, and Cardiometabolic Risk Factors in Early Adolescence." JAMA pediatrics vol. 173,11 (2019): 1049-1057. doi: https://doi.org/10.1001/jamapediatrics.2019.3089
Cespedes Feliciano EM, Rifas-Shiman SL, Quante M, Redline S, Oken E, Taveras EM. Chronotype, Social Jet Lag, and Cardiometabolic Risk Factors in Early Adolescence. JAMA Pediatr. 2019 Nov 01;173(11):1049-1057. doi: 10.1001/jamapediatrics.2019.3089. PMID: 31524936; PMCID: PMC6749538.
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Developmental Origins of Disease: Emerging Prenatal Risk Factors and Future Disease Risk.

Current epidemiology reports

Aris IM, Fleisch AF, Oken E.
PMID: 30687591
Curr Epidemiol Rep. 2018 Sep;5(3):293-302. doi: 10.1007/s40471-018-0161-0. Epub 2018 Jul 13.

PURPOSE OF REVIEW: Many of the diseases and dysfunctions described in the paradigm of the developmental origins of health and disease have been studied in relation to prenatal nutrition or environmental toxicant exposures. Here, we selectively review the current...

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Aris IM, Fleisch AF, Oken E. Developmental Origins of Disease: Emerging Prenatal Risk Factors and Future Disease Risk. Curr Epidemiol Rep. 2018;5(3):293-302doi: 10.1007/s40471-018-0161-0.
Aris, I. M., Fleisch, A. F., & Oken, E. (2018). Developmental Origins of Disease: Emerging Prenatal Risk Factors and Future Disease Risk. Current epidemiology reports, 5(3), 293-302. https://doi.org/10.1007/s40471-018-0161-0
Aris, Izzuddin M, et al. "Developmental Origins of Disease: Emerging Prenatal Risk Factors and Future Disease Risk." Current epidemiology reports vol. 5,3 (2018): 293-302. doi: https://doi.org/10.1007/s40471-018-0161-0
Aris IM, Fleisch AF, Oken E. Developmental Origins of Disease: Emerging Prenatal Risk Factors and Future Disease Risk. Curr Epidemiol Rep. 2018 Sep;5(3):293-302. doi: 10.1007/s40471-018-0161-0. Epub 2018 Jul 13. PMID: 30687591; PMCID: PMC6345523.
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Associations of Gestational Glucose Tolerance With Offspring Body Composition and Estimated Insulin Resistance in Early Adolescence.

Diabetes care

Gingras V, Rifas-Shiman SL, Derks IPM, Aris IM, Oken E, Hivert MF.
PMID: 30327360
Diabetes Care. 2018 Dec;41(12):e164-e166. doi: 10.2337/dc18-1490. Epub 2018 Oct 16.

No abstract available.

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Gingras V, Rifas-Shiman SL, Derks IPM, et al. Associations of Gestational Glucose Tolerance With Offspring Body Composition and Estimated Insulin Resistance in Early Adolescence. Diabetes Care. 2018;41(12):e164-e166doi: 10.2337/dc18-1490.
Gingras, V., Rifas-Shiman, S. L., Derks, I. P. M., Aris, I. M., Oken, E., & Hivert, M. F. (2018). Associations of Gestational Glucose Tolerance With Offspring Body Composition and Estimated Insulin Resistance in Early Adolescence. Diabetes care, 41(12), e164-e166. https://doi.org/10.2337/dc18-1490
Gingras, Véronique, et al. "Associations of Gestational Glucose Tolerance With Offspring Body Composition and Estimated Insulin Resistance in Early Adolescence." Diabetes care vol. 41,12 (2018): e164-e166. doi: https://doi.org/10.2337/dc18-1490
Gingras V, Rifas-Shiman SL, Derks IPM, Aris IM, Oken E, Hivert MF. Associations of Gestational Glucose Tolerance With Offspring Body Composition and Estimated Insulin Resistance in Early Adolescence. Diabetes Care. 2018 Dec;41(12):e164-e166. doi: 10.2337/dc18-1490. Epub 2018 Oct 16. PMID: 30327360; PMCID: PMC6245205.
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The Role of Childhood Asthma in Obesity Development: A Nationwide US Multicohort Study.

Epidemiology (Cambridge, Mass.)

Stratakis N, Garcia E, Chandran A, Hsu T, Alshawabkeh A, Aris IM, Aschner JL, Breton C, Burbank A, Camargo CA, Carroll KN, Chen Z, Claud EC, Dabelea D, Dunlop AL, Elliott AJ, Ferrara A, Ganiban JM, Gern JE, Gold DR, Gower WA, Hertz-Picciotto I, Karagas MR, Karr CJ, Lester B, Leve LD, Litonjua AA, Ludena Y, McEvoy CT, Miller RL, Mueller NT, O'Connor TG, Oken E, O'Shea TM, Perera F, Stanford JB, Rivera-Spoljaric K, Rundle A, Trasande L, Wright RJ, Zhang Y, Zhu Y, Berhane K, Gilliland F, Chatzi L.
PMID: 34561347
Epidemiology. 2022 Jan 01;33(1):131-140. doi: 10.1097/EDE.0000000000001421.

RATIONALE: Asthma and obesity often co-occur. It has been hypothesized that asthma may contribute to childhood obesity onset.OBJECTIVES: To determine if childhood asthma is associated with incident obesity and examine the role of asthma medication in this association.METHODS: We...

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Stratakis N, Garcia E, Chandran A, et al. The Role of Childhood Asthma in Obesity Development: A Nationwide US Multicohort Study. Epidemiology. 2022;33(1):131-140doi: 10.1097/EDE.0000000000001421.
Stratakis, N., Garcia, E., Chandran, A., Hsu, T., Alshawabkeh, A., Aris, I. M., Aschner, J. L., Breton, C., Burbank, A., Camargo, C. A., Carroll, K. N., Chen, Z., Claud, E. C., Dabelea, D., Dunlop, A. L., Elliott, A. J., Ferrara, A., Ganiban, J. M., Gern, J. E., Gold, D. R., Gower, W. A., Hertz-Picciotto, I., Karagas, M. R., Karr, C. J., Lester, B., Leve, L. D., Litonjua, A. A., Ludena, Y., McEvoy, C. T., Miller, R. L., Mueller, N. T., O'Connor, T. G., Oken, E., O'Shea, T. M., Perera, F., Stanford, J. B., Rivera-Spoljaric, K., Rundle, A., Trasande, L., Wright, R. J., Zhang, Y., Zhu, Y., Berhane, K., Gilliland, F., Chatzi, L. (2022). The Role of Childhood Asthma in Obesity Development: A Nationwide US Multicohort Study. Epidemiology (Cambridge, Mass.), 33(1), 131-140. https://doi.org/10.1097/EDE.0000000000001421
Stratakis, Nikos, et al. "The Role of Childhood Asthma in Obesity Development: A Nationwide US Multicohort Study." Epidemiology (Cambridge, Mass.) vol. 33,1 (2022): 131-140. doi: https://doi.org/10.1097/EDE.0000000000001421
Stratakis N, Garcia E, Chandran A, Hsu T, Alshawabkeh A, Aris IM, Aschner JL, Breton C, Burbank A, Camargo CA, Carroll KN, Chen Z, Claud EC, Dabelea D, Dunlop AL, Elliott AJ, Ferrara A, Ganiban JM, Gern JE, Gold DR, Gower WA, Hertz-Picciotto I, Karagas MR, Karr CJ, Lester B, Leve LD, Litonjua AA, Ludena Y, McEvoy CT, Miller RL, Mueller NT, O'Connor TG, Oken E, O'Shea TM, Perera F, Stanford JB, Rivera-Spoljaric K, Rundle A, Trasande L, Wright RJ, Zhang Y, Zhu Y, Berhane K, Gilliland F, Chatzi L. The Role of Childhood Asthma in Obesity Development: A Nationwide US Multicohort Study. Epidemiology. 2022 Jan 01;33(1):131-140. doi: 10.1097/EDE.0000000000001421. PMID: 34561347; PMCID: PMC8633057.
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Modeling the health effects of time-varying complex environmental mixtures: Mean field variational Bayes for lagged kernel machine regression.

Environmetrics

Liu SH, Bobb JF, Claus Henn B, Schnaas L, Tellez-Rojo MM, Gennings C, Arora M, Wright RO, Coull BA, Wand MP.
PMID: 30686915
Environmetrics. 2018 Jun;29(4). doi: 10.1002/env.2504. Epub 2018 May 18.

There is substantial interest in assessing how exposure to environmental mixtures, such as chemical mixtures, affect child health. Researchers are also interested in identifying critical time windows of susceptibility to these complex mixtures. A recently developed method, called lagged...

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Liu SH, Bobb JF, Claus Henn B, et al. Modeling the health effects of time-varying complex environmental mixtures: Mean field variational Bayes for lagged kernel machine regression. Environmetrics. 2018;29(4)doi: 10.1002/env.2504.
Liu, S. H., Bobb, J. F., Claus Henn, B., Schnaas, L., Tellez-Rojo, M. M., Gennings, C., Arora, M., Wright, R. O., Coull, B. A., & Wand, M. P. (2018). Modeling the health effects of time-varying complex environmental mixtures: Mean field variational Bayes for lagged kernel machine regression. Environmetrics, 29(4), . https://doi.org/10.1002/env.2504
Liu, Shelley H, et al. "Modeling the health effects of time-varying complex environmental mixtures: Mean field variational Bayes for lagged kernel machine regression." Environmetrics vol. 29,4 (2018). doi: https://doi.org/10.1002/env.2504
Liu SH, Bobb JF, Claus Henn B, Schnaas L, Tellez-Rojo MM, Gennings C, Arora M, Wright RO, Coull BA, Wand MP. Modeling the health effects of time-varying complex environmental mixtures: Mean field variational Bayes for lagged kernel machine regression. Environmetrics. 2018 Jun;29(4). doi: 10.1002/env.2504. Epub 2018 May 18. PMID: 30686915; PMCID: PMC6345544.
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Cord blood vitamin D status is associated with cord blood insulin and c-peptide in two cohorts of mother-newborn pairs.

The Journal of clinical endocrinology and metabolism

Switkowski KM, Camargo CA, Perron P, Rifas-Shiman SL, Oken E, Hivert MF.
PMID: 31127822
J Clin Endocrinol Metab. 2019 Apr 24; doi: 10.1210/jc.2018-02550. Epub 2019 Apr 24.

CONTEXT: Vitamin D may be important for prenatal programming of insulin and glucose regulation, but maternal vitamin D deficiency during pregnancy is common.OBJECTIVE: We examined associations of early vitamin D status with markers of fetal insulin secretion (cord blood...

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Switkowski KM, Camargo CA, Perron P, et al. Cord blood vitamin D status is associated with cord blood insulin and c-peptide in two cohorts of mother-newborn pairs. J Clin Endocrinol Metab. 2019;doi: 10.1210/jc.2018-02550.
Switkowski, K. M., Camargo, C. A., Perron, P., Rifas-Shiman, S. L., Oken, E., & Hivert, M. F. (2019). Cord blood vitamin D status is associated with cord blood insulin and c-peptide in two cohorts of mother-newborn pairs. The Journal of clinical endocrinology and metabolism, . https://doi.org/10.1210/jc.2018-02550
Switkowski, Karen M, et al. "Cord blood vitamin D status is associated with cord blood insulin and c-peptide in two cohorts of mother-newborn pairs." The Journal of clinical endocrinology and metabolism vol. (2019). doi: https://doi.org/10.1210/jc.2018-02550
Switkowski KM, Camargo CA, Perron P, Rifas-Shiman SL, Oken E, Hivert MF. Cord blood vitamin D status is associated with cord blood insulin and c-peptide in two cohorts of mother-newborn pairs. J Clin Endocrinol Metab. 2019 Apr 24; doi: 10.1210/jc.2018-02550. Epub 2019 Apr 24. PMID: 31127822; PMCID: PMC6656419.
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Associations of midchildhood to early adolescence central adiposity gain with cardiometabolic health in early adolescence.

Obesity (Silver Spring, Md.)

Wu AJ, Aris IM, Rifas-Shiman SL, Oken E, Taveras EM, Chavarro JE, Hivert MF.
PMID: 34529343
Obesity (Silver Spring). 2021 Nov;29(11):1882-1891. doi: 10.1002/oby.23261. Epub 2021 Sep 16.

OBJECTIVE: This study examined the associations of central adiposity gain from midchildhood to early adolescence with cardiometabolic health markers in early adolescence.METHODS: A total of 620 participants were studied in Project Viva. In midchildhood (mean age = 7.8 years)...

Cite
Wu AJ, Aris IM, Rifas-Shiman SL, et al. Associations of midchildhood to early adolescence central adiposity gain with cardiometabolic health in early adolescence. Obesity (Silver Spring). 2021;29(11):1882-1891doi: 10.1002/oby.23261.
Wu, A. J., Aris, I. M., Rifas-Shiman, S. L., Oken, E., Taveras, E. M., Chavarro, J. E., & Hivert, M. F. (2021). Associations of midchildhood to early adolescence central adiposity gain with cardiometabolic health in early adolescence. Obesity (Silver Spring, Md.), 29(11), 1882-1891. https://doi.org/10.1002/oby.23261
Wu, Allison J, et al. "Associations of midchildhood to early adolescence central adiposity gain with cardiometabolic health in early adolescence." Obesity (Silver Spring, Md.) vol. 29,11 (2021): 1882-1891. doi: https://doi.org/10.1002/oby.23261
Wu AJ, Aris IM, Rifas-Shiman SL, Oken E, Taveras EM, Chavarro JE, Hivert MF. Associations of midchildhood to early adolescence central adiposity gain with cardiometabolic health in early adolescence. Obesity (Silver Spring). 2021 Nov;29(11):1882-1891. doi: 10.1002/oby.23261. Epub 2021 Sep 16. PMID: 34529343; PMCID: PMC8571062.
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Longitudinal associations of modifiable risk factors in the first 1000 days with weight status and metabolic risk in early adolescence.

The American journal of clinical nutrition

Hu J, Aris IM, Lin PD, Rifas-Shiman SL, Perng W, Woo Baidal JA, Wen D, Oken E.
PMID: 33184628
Am J Clin Nutr. 2020 Nov 12; doi: 10.1093/ajcn/nqaa297. Epub 2020 Nov 12.

BACKGROUND: Many studies have identified early-life risk factors for childhood overweight/obesity (OwOb), but few have evaluated how they combine to influence later cardiometabolic health.OBJECTIVES: We aimed to examine the association of risk factors in the first 1000 d with...

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Hu J, Aris IM, Lin PD, et al. Longitudinal associations of modifiable risk factors in the first 1000 days with weight status and metabolic risk in early adolescence. Am J Clin Nutr. 2020;doi: 10.1093/ajcn/nqaa297.
Hu, J., Aris, I. M., Lin, P. D., Rifas-Shiman, S. L., Perng, W., Woo Baidal, J. A., Wen, D., & Oken, E. (2020). Longitudinal associations of modifiable risk factors in the first 1000 days with weight status and metabolic risk in early adolescence. The American journal of clinical nutrition, . https://doi.org/10.1093/ajcn/nqaa297
Hu, Jiajin, et al. "Longitudinal associations of modifiable risk factors in the first 1000 days with weight status and metabolic risk in early adolescence." The American journal of clinical nutrition vol. (2020). doi: https://doi.org/10.1093/ajcn/nqaa297
Hu J, Aris IM, Lin PD, Rifas-Shiman SL, Perng W, Woo Baidal JA, Wen D, Oken E. Longitudinal associations of modifiable risk factors in the first 1000 days with weight status and metabolic risk in early adolescence. Am J Clin Nutr. 2020 Nov 12; doi: 10.1093/ajcn/nqaa297. Epub 2020 Nov 12. PMID: 33184628; PMCID: PMC7779210.
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