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Wu AJ, Aris IM, Rifas-Shiman SL, et al. Associations of midchildhood to early adolescence central adiposity gain with cardiometabolic health in early adolescence. Obesity (Silver Spring). 2021;29(11):1882-1891doi: 10.1002/oby.23261.
Wu, A. J., Aris, I. M., Rifas-Shiman, S. L., Oken, E., Taveras, E. M., Chavarro, J. E., & Hivert, M. F. (2021). Associations of midchildhood to early adolescence central adiposity gain with cardiometabolic health in early adolescence. Obesity (Silver Spring, Md.), 29(11), 1882-1891. https://doi.org/10.1002/oby.23261
Wu, Allison J, et al. "Associations of midchildhood to early adolescence central adiposity gain with cardiometabolic health in early adolescence." Obesity (Silver Spring, Md.) vol. 29,11 (2021): 1882-1891. doi: https://doi.org/10.1002/oby.23261
Wu AJ, Aris IM, Rifas-Shiman SL, Oken E, Taveras EM, Chavarro JE, Hivert MF. Associations of midchildhood to early adolescence central adiposity gain with cardiometabolic health in early adolescence. Obesity (Silver Spring). 2021 Nov;29(11):1882-1891. doi: 10.1002/oby.23261. Epub 2021 Sep 16. PMID: 34529343; PMCID: PMC8571062.
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Obesity (Silver Spring). 2021 Nov;29(11):1882-1891. doi: 10.1002/oby.23261. Epub 2021 Sep 16.

Associations of midchildhood to early adolescence central adiposity gain with cardiometabolic health in early adolescence.

Obesity (Silver Spring, Md.)

Allison J Wu, Izzuddin M Aris, Sheryl L Rifas-Shiman, Emily Oken, Elsie M Taveras, Jorge E Chavarro, Marie-France Hivert

Affiliations

  1. Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.
  2. Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Massachusetts, USA.
  3. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
  4. Division of General Academic Pediatrics, Massachusetts General Hospital for Children, Boston, Massachusetts, USA.
  5. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
  6. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

PMID: 34529343 PMCID: PMC8571062 DOI: 10.1002/oby.23261

Abstract

OBJECTIVE: This study examined the associations of central adiposity gain from midchildhood to early adolescence with cardiometabolic health markers in early adolescence.

METHODS: A total of 620 participants were studied in Project Viva. In midchildhood (mean age = 7.8 years) and early adolescence (12.9 years), waist circumference and dual-energy x-ray absorptiometry-measured visceral adipose tissue, subcutaneous abdominal adipose tissue, and trunk fat were obtained. Central adiposity gain was calculated as change per year between visits. Cardiometabolic health markers, including blood pressure, lipids, markers of insulin resistance, inflammation, and adipokines, were collected in early adolescence.

RESULTS: Greater waist circumference gain was associated with higher log triglycerides (β 0.07 mg/dL; 95% CI: 0.02-0.13), log alanine aminotransferase (0.07 U/L; 95% CI: 0.03-0.12), log high-sensitivity C-reactive protein (0.43 mg/L; 95% CI: 0.28-0.58), and other cardiometabolic markers in early adolescence. Directly measured central adiposity gains were associated with higher systolic blood pressure z score in early adolescence (visceral adipose tissue [0.13 SD units; 95% CI: 0.04-0.23], subcutaneous abdominal adipose tissue [0.18 SD units; 95% CI: 0.04-0.31], and trunk fat [0.21 SD units; 95% CI: 0.06-0.36]). These associations were independent of baseline and change in total adiposity from midchildhood to early adolescence.

CONCLUSIONS: Monitoring central adiposity gain may enable identification and intervention in children vulnerable to developing cardiometabolic health risks.

© 2021 The Obesity Society.

References

  1. Ann Hum Biol. 2019 May;46(3):205-214 - PubMed
  2. Obesity (Silver Spring). 2013 Dec;21(12):2458-64 - PubMed
  3. Pediatr Obes. 2021 Feb;16(2):e12704 - PubMed
  4. Circulation. 2011 Nov 1;124(18):1996-2019 - PubMed
  5. Child Dev. 1987 Jun;58(3):829-41 - PubMed
  6. Physiol Rev. 2013 Jan;93(1):359-404 - PubMed
  7. J Pediatr. 2018 Jun;197:121-127.e1 - PubMed
  8. J Am Soc Nephrol. 2006 Dec;17(12):3438-46 - PubMed
  9. J Am Coll Cardiol. 2016 Oct 4;68(14):1509-21 - PubMed
  10. Obesity (Silver Spring). 2012 Jun;20(6):1313-8 - PubMed
  11. J Adolesc Health. 1993 May;14(3):190-5 - PubMed
  12. Am J Epidemiol. 2019 Nov 1;188(11):1913-1922 - PubMed
  13. Hypertension. 2016 Feb;67(2):301-8 - PubMed
  14. JAMA Netw Open. 2018 Sep 7;1(5):e182460 - PubMed
  15. Diabetes. 2002 Jun;51(6):1889-95 - PubMed
  16. Gastroenterology. 2007 Dec;133(6):1814-20 - PubMed
  17. J Am Heart Assoc. 2017 Oct 11;6(10): - PubMed
  18. JAMA. 1998 May 13;279(18):1477-82 - PubMed
  19. Vital Health Stat 11. 2002 May;(246):1-190 - PubMed
  20. J Clin Endocrinol Metab. 2016 Feb;101(2):678-85 - PubMed
  21. BMC Pediatr. 2013 Jun 24;13:99 - PubMed
  22. Int J Obes (Lond). 2016 Apr;40(4):601-6 - PubMed
  23. Obesity (Silver Spring). 2011 Aug;19(8):1699-706 - PubMed
  24. Int J Epidemiol. 2007 Dec;36(6):1275-82 - PubMed
  25. Circulation. 1995 Aug 15;92(4):1049-57 - PubMed
  26. Obesity (Silver Spring). 2013 Jun;21(6):1251-5 - PubMed
  27. Int J Epidemiol. 2015 Feb;44(1):37-48 - PubMed
  28. Hypertension. 2011 Nov;58(5):784-90 - PubMed
  29. Nat Rev Immunol. 2011 Feb;11(2):85-97 - PubMed
  30. Diabetes Care. 2000 Apr;23(4):465-71 - PubMed
  31. Pediatr Obes. 2015 Jun;10(3):172-9 - PubMed
  32. Int J Epidemiol. 2019 Feb 1;48(1):116-123 - PubMed
  33. Nutr J. 2017 Feb 23;16(1):15 - PubMed
  34. J Clin Densitom. 2015 Jan-Mar;18(1):30-6 - PubMed
  35. PLoS One. 2016 Oct 27;11(10):e0165275 - PubMed
  36. JAMA. 1999 Dec 8;282(22):2131-5 - PubMed

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