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Showing 1 to 12 of 85 entries
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Understanding investigators' attitudes through a results-based accountability framework within a single CTSA institution.

Journal of clinical and translational science

Rothwell E, Matheson T.
PMID: 28480058
J Clin Transl Sci. 2017 Feb;1(1):73-76. doi: 10.1017/cts.2016.15. Epub 2017 Jan 13.

PURPOSE: The National Center for Advancing Translation Science (NCATS) is implementing a new strategic management plan called the results-based accountability framework. This framework is part of the common metrics initiative. For successful implementation and adoption of new management strategies,...

Predictive Performance of a Vancomycin Population Pharmacokinetic Model in Neonates.

Infectious diseases and therapy

Stockmann C, Hersh AL, Roberts JK, Bhongsatiern J, Korgenski EK, Spigarelli MG, Sherwin CM, Frymoyer A.
PMID: 25998107
Infect Dis Ther. 2015 Jun;4(2):187-98. doi: 10.1007/s40121-015-0067-9. Epub 2015 May 22.

INTRODUCTION: The pharmacokinetics of vancomycin are highly variable among neonates, which makes dosing challenging in this population. However, adequate drug exposure is critical, especially when treating methicillin-resistant Staphylococcus aureus (MRSA) infections. Utilization of population pharmacokinetic models and Bayesian methods...

Age-Specific Patterns of Influenza Activity in Utah: Do Older School Age Children Drive the Epidemic?.

Journal of the Pediatric Infectious Diseases Society

Stockmann C, Pavia AT, Hersh AL, Spigarelli MG, Castle B, Korgenski K, Byington CL, Ampofo K.
PMID: 24872880
J Pediatric Infect Dis Soc. 2014 Jun;3(2):163-7. doi: 10.1093/jpids/pit004. Epub 2013 Feb 14.

Across 12 consecutive influenza seasons in Utah, medically-attended visits for laboratory-confirmed influenza infection peaked first among older children (12-18 years). Peak activity in older children preceded that of children 0-4 years by more than 2 days and that of...

A National Study of the Impact of Rapid Influenza Testing on Clinical Care in the Emergency Department.

Journal of the Pediatric Infectious Diseases Society

Blaschke AJ, Shapiro DJ, Pavia AT, Byington CL, Ampofo K, Stockmann C, Hersh AL.
PMID: 24872879
J Pediatric Infect Dis Soc. 2014 Jun;3(2):112-8. doi: 10.1093/jpids/pit071. Epub 2013 Nov 13.

BACKGROUND: Rapid influenza diagnostic tests (RIDT) may influence physician decision-making. Single-center studies suggest that influenza diagnosed in association with RIDT reduces ancillary testing and antibiotic prescribing. The extent of RIDT use in US emergency departments (EDs) and their impact...

LL-37 induced cystitis and the receptor for advanced glycation end-products (RAGE) pathway.

Advances in bioscience and biotechnology (Print)

Roundy LM, Jia W, Zhang J, Ye X, Prestwich GD, Oottamasathien S.
PMID: 24883227
Adv Biosci Biotechnol. 2013 Aug 01;4(8):1-8. doi: 10.4236/abb.2013.48a2001.

To elucidate pathways in bladder inflammation, we employed our physiologically relevant LL-37 induced cystitis model. Based on inflammatory studies involving other organ systems implicating the receptor for advanced glycation end-products (RAGE), we first hypothesized that RAGE is critically involved...

Crystal Structure Prediction from First Principles: The Crystal Structures of Glycine.

Chemical physics letters

Lund AM, Pagola GI, Orendt AM, Ferraro MB, Facelli JC.
PMID: 25843964
Chem Phys Lett. 2015 Apr 17;626:20-24. doi: 10.1016/j.cplett.2015.03.015.

Here we present the results of our unbiased searches of glycine polymorphs obtained using the Genetic Algorithms search implemented in Modified Genetic Algorithm for Crystals coupled with the local optimization and energy evaluation provided by Quantum Espresso. We demonstrate...

Clinical Value of an Ambulatory-Based Antibiogram for Uropathogens in Children.

Journal of the Pediatric Infectious Diseases Society

Dahle KW, Korgenski EK, Hersh AL, Srivastava R, Gesteland PH.
PMID: 23687582
J Pediatric Infect Dis Soc. 2012 Dec;1(4):333-6. doi: 10.1093/jpids/pis055. Epub 2012 Jun 29.

Unnecessarily broad-spectrum antibiotic prescribing for ambulatory pediatric urinary tract infection may result from clinicians not having antibiograms specific to this population. Comparing an existing hospital-based with a proposed ambulatory uropathogen antibiogram for children in Utah, Escherichia coli accounted for...

Epidemiological Evaluation of Blood Culture Patterns among Neonates Receiving Vancomycin.

Indian journal of microbiology

Yakub SY, Constance JE, Stockmann C, Linakis M, Campbell SC, Sherwin CM, Korgenski EK, Balch A, Spigarelli MG.
PMID: 25320436
Indian J Microbiol. 2014 Dec;54(4):389-95. doi: 10.1007/s12088-014-0478-4. Epub 2014 Jun 17.

The objective of this study was to assess the frequency of blood culture (BC) collection among neonates who received vancomycin. Demographic, clinical, microbiologic, and pharmacy data were collected for 1275 neonates (postnatal age 0-27 days) who received vancomycin at...

A survey of practices for the use of electronic health records to support research recruitment.

Journal of clinical and translational science

Obeid JS, Beskow LM, Rape M, Gouripeddi R, Black RA, Cimino JJ, Embi PJ, Weng C, Marnocha R, Buse JB.
PMID: 29657859
J Clin Transl Sci. 2017 Aug;1(4):246-252. doi: 10.1017/cts.2017.301.

Electronic health records (EHRs) provide great promise for identifying cohorts and enhancing research recruitment. Such approaches are sorely needed, but there are few descriptions in the literature of prevailing practices to guide their use. A multidisciplinary workgroup was formed...

An Evaluation to Establish the Acceptable Serum Triglyceride Levels in Neonates Receiving Intravenous Fat Emulsion Infusion in a Multicenter Retrospective Study.

American journal of perinatology

Chan B, Lian A, Baer V, Robinson M, Ou Z, Presson AP, Zinkhan EK.
PMID: 32120418
Am J Perinatol. 2021 Aug;38:e92-e101. doi: 10.1055/s-0040-1705174. Epub 2020 Mar 02.

OBJECTIVE: This study aimed to establish neonatal serum triglyceride (TG) level reference ranges during lipid infusion and correlate peak TG with neonatal outcomes.STUDY DESIGN: This is a retrospective review of 356 neonates with 696 TG measures obtained in four...

The Effect of a Quality Improvement Intervention on Sleep and Delirium in Critically Ill Patients in a Surgical ICU.

Chest

Tonna JE, Dalton A, Presson AP, Zhang C, Colantuoni E, Lander K, Howard S, Beynon J, Kamdar BB.
PMID: 33773988
Chest. 2021 Sep;160(3):899-908. doi: 10.1016/j.chest.2021.03.030. Epub 2021 Mar 24.

BACKGROUND: Delirium is a deleterious condition affecting up to 60% of patients in the surgical ICU (SICU). Few SICU-focused delirium interventions have been implemented, including those addressing sleep-wake disruption, a modifiable delirium risk factor common in critically ill patients.RESEARCH...

Human activity pattern implications for modeling SARS-CoV-2 transmission.

Computer methods and programs in biomedicine

Wang Y, Li B, Gouripeddi R, Facelli JC.
PMID: 33326924
Comput Methods Programs Biomed. 2021 Feb;199:105896. doi: 10.1016/j.cmpb.2020.105896. Epub 2020 Dec 08.

BACKGROUND AND OBJECTIVES: SARS-CoV-2 emerged in December 2019 and rapidly spread into a global pandemic. Designing optimal community responses (social distancing, vaccination) is dependent on the stage of the disease progression, discovery of asymptomatic individuals, changes in virulence of...

Showing 1 to 12 of 85 entries