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Showing 1 to 12 of 1901 entries
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Loss of LZAP inactivates p53 and regulates sensitivity of cells to DNA damage in a p53-dependent manner.

Oncogenesis

Wamsley JJ, Gary C, Biktasova A, Hajek M, Bellinger G, Virk R, Issaeva N, Yarbrough WG.
PMID: 28394357
Oncogenesis. 2017 Apr 10;6(4):e314. doi: 10.1038/oncsis.2017.12.

Chemotherapy and radiation, the two most common cancer therapies, exert their anticancer effects by causing damage to cellular DNA. However, systemic treatment damages DNA not only in cancer, but also in healthy cells, resulting in the progression of serious...

Asymptotically Normal and Efficient Estimation of Covariate-Adjusted Gaussian Graphical Model.

Journal of the American Statistical Association

Chen M, Ren Z, Zhao H, Zhou H.
PMID: 27499564
J Am Stat Assoc. 2016 Mar;111(513):394-406. doi: 10.1080/01621459.2015.1010039. Epub 2016 May 05.

A tuning-free procedure is proposed to estimate the covariate-adjusted Gaussian graphical model. For each finite subgraph, this estimator is asymptotically normal and efficient. As a consequence, a confidence interval can be obtained for each edge. The procedure enjoys easy...

Epigenome-wide differential DNA methylation between HIV-infected and uninfected individuals.

Epigenetics

Zhang X, Justice AC, Hu Y, Wang Z, Zhao H, Wang G, Johnson EO, Emu B, Sutton RE, Krystal JH, Xu K.
PMID: 27672717
Epigenetics. 2016 Oct 02;11(10):750-760. doi: 10.1080/15592294.2016.1221569. Epub 2016 Sep 27.

Epigenetic control of human immunodeficiency virus-1 (HIV-1) genes is critical for viral integration and latency. However, epigenetic changes in the HIV-1-infected host genome have not been well characterized. Here, we report the first large-scale epigenome-wide association study of DNA...

CXCL12 Promotes Stem Cell Recruitment and Uterine Repair after Injury in Asherman's Syndrome.

Molecular therapy. Methods & clinical development

Sahin Ersoy G, Zolbin MM, Cosar E, Moridi I, Mamillapalli R, Taylor HS.
PMID: 28345002
Mol Ther Methods Clin Dev. 2017 Jan 11;4:169-177. doi: 10.1016/j.omtm.2017.01.001. eCollection 2017 Mar 17.

Asherman's syndrome is an acquired condition of uterine fibrosis and adhesions in response to injury that adversely affects fertility and pregnancy. We have previously demonstrated that bone marrow-derived mesenchymal stem cells (BMDSCs) contribute to uterine repair after injury and...

Interspinous implants to treat spinal stenosis.

Current reviews in musculoskeletal medicine

Gala RJ, Russo GS, Whang PG.
PMID: 28324328
Curr Rev Musculoskelet Med. 2017 Jun;10(2):182-188. doi: 10.1007/s12178-017-9413-8.

PURPOSE OF REVIEW: Lumbar spinal stenosis has historically been treated with open decompressive surgery which is associated with significant morbidity and may give rise to various complications. Interspinous spacers (ISS) have been developed as a less invasive strategy which...

Using fine-scale spatial genetics of Norway rats to improve control efforts and reduce leptospirosis risk in urban slum environments.

Evolutionary applications

Richardson JL, Burak MK, Hernandez C, Shirvell JM, Mariani C, Carvalho-Pereira TS, Pertile AC, Panti-May JA, Pedra GG, Serrano S, Taylor J, Carvalho M, Rodrigues G, Costa F, Childs JE, Ko AI, Caccone A.
PMID: 28352293
Evol Appl. 2017 Feb 23;10(4):323-337. doi: 10.1111/eva.12449. eCollection 2017 Apr.

The Norway rat (

In Reply.

Anesthesiology

Kertai MD, Zhou S, Karhausen JA, Cooter M, Jooste E, Li YJ, White WD, Aronson S, Podgoreanu MV, Gaca J, Welsby IJ, Levy JH, Stafford-Smith M, Mathew JP, Fontes ML.
PMID: 27433767
Anesthesiology. 2016 Aug;125(2):438-9. doi: 10.1097/ALN.0000000000001190.

No abstract available.

Age-related changes in expression and signaling of TAM receptor inflammatory regulators in monocytes.

Oncotarget

Wang X, Malawista A, Qian F, Ramsey C, Allore HG, Montgomery RR.
PMID: 29515754
Oncotarget. 2018 Jan 03;9(11):9572-9580. doi: 10.18632/oncotarget.23851. eCollection 2018 Feb 09.

The multifactorial immune deterioration in aging--termed "inflamm-aging"--is comprised of a state of low-grade, chronic inflammation and complex dysregulation of responses to immune stimulation. The TAM family (Tyro 3, Axl, and Mer) of receptor tyrosine kinases are negative regulators of...

Neuroendocrine Associations Underlying the Persistent Therapeutic Effects of Classic Serotonergic Psychedelics.

Frontiers in pharmacology

Schindler EAD, Wallace RM, Sloshower JA, D'Souza DC.
PMID: 29545753
Front Pharmacol. 2018 Mar 01;9:177. doi: 10.3389/fphar.2018.00177. eCollection 2018.

Recent reports on the effects of psychedelic-assisted therapies for mood disorders and addiction, as well as the effects of psychedelics in the treatment of cluster headache, have demonstrated promising therapeutic results. In addition, the beneficial effects appear to persist...

Combination liposomal amphotericin B, posaconazole and oral amphotericin B for treatment of gastrointestinal .

Medical mycology case reports

Anderson A, McManus D, Perreault S, Lo YC, Seropian S, Topal JE.
PMID: 28580237
Med Mycol Case Rep. 2017 May 24;17:11-13. doi: 10.1016/j.mmcr.2017.05.004. eCollection 2017 Sep.

Mucormycosis is a life threatening infection caused by fungi in the order Mucorales. Mucormycosis can affect any organ system with rhino-orbital-cerebral and pulmonary infections being the most predominant infection types. Gastrointestinal mucormycosis is rare and accounts for only 4-7%...

Measurement of Pressure in Compressive Magnet Therapy for Auricular Keloids.

Plastic and reconstructive surgery. Global open

David JA, Ghodbane SA, Chee M, Hsia HC.
PMID: 28607859
Plast Reconstr Surg Glob Open. 2017 May 23;5(5):e1333. doi: 10.1097/GOX.0000000000001333. eCollection 2017 May.

No abstract available.

New Regio- and Stereoselective Cascades via Unstabilized Azomethine Ylide Cycloadditions for the Synthesis of Highly Substituted Tropane and Indolizidine Frameworks.

Journal of the American Chemical Society

Chen S, Bacauanu V, Knecht T, Mercado BQ, Bergman RG, Ellman JA.
PMID: 27642766
J Am Chem Soc. 2016 Sep 28;138(38):12664-70. doi: 10.1021/jacs.6b08355. Epub 2016 Sep 19.

Multisubstituted tropanes and indolizidines have been prepared with high regio- and stereoselectivity by the [3+2] cycloaddition of unstabilized azomethine ylides generated from readily prepared trimethylsilyl-substituted 1,2-dihydropyridines via protonation or alkylation followed by desilylation. Starting from 1,2-dihydropyridines bearing a ring...

Showing 1 to 12 of 1901 entries