Display options
Cite
Wang X, Malawista A, Qian F, et al. Age-related changes in expression and signaling of TAM receptor inflammatory regulators in monocytes. Oncotarget. 2018;9(11):9572-9580doi: 10.18632/oncotarget.23851.
Wang, X., Malawista, A., Qian, F., Ramsey, C., Allore, H. G., & Montgomery, R. R. (2018). Age-related changes in expression and signaling of TAM receptor inflammatory regulators in monocytes. Oncotarget, 9(11), 9572-9580. https://doi.org/10.18632/oncotarget.23851
Wang, Xiaomei, et al. "Age-related changes in expression and signaling of TAM receptor inflammatory regulators in monocytes." Oncotarget vol. 9,11 (2018): 9572-9580. doi: https://doi.org/10.18632/oncotarget.23851
Wang X, Malawista A, Qian F, Ramsey C, Allore HG, Montgomery RR. Age-related changes in expression and signaling of TAM receptor inflammatory regulators in monocytes. Oncotarget. 2018 Jan 03;9(11):9572-9580. doi: 10.18632/oncotarget.23851. eCollection 2018 Feb 09. PMID: 29515754; PMCID: PMC5839385.
Copy Download .nbib Format: NLM
Share it on

Oncotarget. 2018 Jan 03;9(11):9572-9580. doi: 10.18632/oncotarget.23851. eCollection 2018 Feb 09.

Age-related changes in expression and signaling of TAM receptor inflammatory regulators in monocytes.

Oncotarget

Xiaomei Wang, Anna Malawista, Feng Qian, Christine Ramsey, Heather G Allore, Ruth R Montgomery

Affiliations

  1. Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
  2. State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China.
  3. Yale Center for Medical Informatics, Yale University School of Medicine, New Haven, Connecticut.
  4. Human Translational Immunology, Yale University School of Medicine, New Haven, Connecticut.

PMID: 29515754 PMCID: PMC5839385 DOI: 10.18632/oncotarget.23851

Abstract

The multifactorial immune deterioration in aging--termed "inflamm-aging"--is comprised of a state of low-grade, chronic inflammation and complex dysregulation of responses to immune stimulation. The TAM family (Tyro 3, Axl, and Mer) of receptor tyrosine kinases are negative regulators of Toll like receptor-mediated immune responses that broadly inhibit cytokine receptor cascades to inhibit inflammation. Here we demonstrate elevated expression of TAM receptors in monocytes of older adults, and an age-dependent difference in signaling mediator AKT resulting in dysregulated responses to signaling though Mer. Our results may be especially significant in tissue, where levels of Mer are highest, and may present avenues for modulation of chronic tissue inflammation noted in aging.

Keywords: 5 immunosenescence; Gerotarget; TAM receptors; age-related immune dysregulation; monocyte; protein S

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare no competing financial interests.

References

  1. J Virol. 2008 Aug;82(15):7613-23 - PubMed
  2. Nat Rev Immunol. 2008 May;8(5):327-36 - PubMed
  3. Cell Metab. 2013 Oct 1;18(4):519-32 - PubMed
  4. J Leukoc Biol. 2015 Dec;98 (6):937-43 - PubMed
  5. Nat Med. 2015 Dec;21(12 ):1464-72 - PubMed
  6. Nature. 2001 May 10;411(6834):207-11 - PubMed
  7. J Immunol. 2015 Feb 15;194(4):1928-37 - PubMed
  8. Annu Rev Immunol. 2003;21:335-76 - PubMed
  9. Aging (Albany NY). 2015 Jan;7(1):38-52 - PubMed
  10. Nat Rev Immunol. 2001 Nov;1(2):135-45 - PubMed
  11. J Gerontol A Biol Sci Med Sci. 2017 Oct 12;72 (11):1453-1464 - PubMed
  12. J Biol Chem. 2010 Dec 17;285(51):39914-21 - PubMed
  13. Nat Immunol. 2016 Apr;17 (4):461-468 - PubMed
  14. Annu Rev Immunol. 2015;33:257-90 - PubMed
  15. Cell Host Microbe. 2013 Aug 14;14 (2):136-47 - PubMed
  16. Ann N Y Acad Sci. 2000 Jun;908:244-54 - PubMed
  17. J Infect Dis. 2011 May 15;203(10):1415-24 - PubMed
  18. Oncotarget. 2015 Mar 30;6(9):6722-36 - PubMed
  19. Blood. 2014 Jan 9;123(2):239-48 - PubMed
  20. Nat Rev Immunol. 2013 Dec;13(12):875-87 - PubMed
  21. Science. 2016 Apr 1;352(6281):99-103 - PubMed
  22. Oncotarget. 2014 Nov 15;5(21):10434-45 - PubMed
  23. Adv Cancer Res. 2008;100:35-83 - PubMed
  24. J Immunol. 2010 Mar 1;184(5):2518-27 - PubMed
  25. Int Immunol. 2009 Apr;21(4):317-37 - PubMed
  26. Exp Gerontol. 2017 Aug 16;: - PubMed
  27. PLoS Biol. 2017 Sep 5;15(9):e2002458 - PubMed
  28. Sci Rep. 2016 Feb 10;6:20686 - PubMed
  29. J Immunol. 2012 Mar 15;188(6):2815-24 - PubMed
  30. J Immunol. 2007 Jun 1;178(11):6912-22 - PubMed
  31. Sci Signal. 2015 Feb 24;8(365):ra21 - PubMed
  32. J Immunol. 2007 Jan 15;178(2):970-5 - PubMed
  33. Aging Cell. 2012 Feb;11(1):104-10 - PubMed
  34. Joint Bone Spine. 2015 Jul;82(4):258-63 - PubMed
  35. J Biol Chem. 2014 Sep 12;289(37):25750-63 - PubMed
  36. Aging Cell. 2015 Jun;14(3):421-32 - PubMed
  37. Aging (Albany NY). 2014 Feb;6(2):131-9 - PubMed
  38. Elife. 2014 Sep 29;3:null - PubMed
  39. Cell Rep. 2017 Apr 18;19(3):558-568 - PubMed
  40. Blood. 2007 Jan 15;109 (2):653-60 - PubMed
  41. Nat Commun. 2017 Jul 27;8:15842 - PubMed
  42. Annu Rev Immunol. 2015;33:107-38 - PubMed
  43. Clin Exp Immunol. 2017 Jan;187(1):26-34 - PubMed
  44. J Infect Dis. 2015 Apr 1;211(7):1174-84 - PubMed
  45. Science. 2001 Jul 13;293(5528):306-11 - PubMed
  46. Cell Res. 2014 Jan;24(1):92-104 - PubMed
  47. Science. 2016 Apr 22;352(6284):463-6 - PubMed
  48. Mol Biol Cell. 2012 Aug;23 (16):3254-65 - PubMed
  49. Cell Host Microbe. 2011 Apr 21;9(4):286-98 - PubMed
  50. Curr Opin Immunol. 2014 Aug;29:49-55 - PubMed
  51. J Immunol. 2007 May 1;178(9):5635-42 - PubMed
  52. J Immunol. 2016 Oct 1;197(7):2900-8 - PubMed
  53. Genetics. 2017 Jul;206(3):1659-1674 - PubMed
  54. Ageing Res Rev. 2015 Nov;24(Pt A):40-53 - PubMed
  55. Macrophage (Houst). 2016;3: - PubMed
  56. J Clin Immunol. 2010 Nov;30(6):806-13 - PubMed
  57. Annu Rev Immunol. 2015;33:355-91 - PubMed
  58. Aging (Albany NY). 2014 Nov;6(11):957-74 - PubMed

Publication Types

Grant support