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The use of immobilised derivatives of urease and urate oxidase in automated analysis.

FEBS letters

Filippusson H, Hornby WE, McDonald A.
PMID: 11946440
FEBS Lett. 1972 Feb 15;20(3):291-293. doi: 10.1016/0014-5793(72)80089-9.

No abstract available.

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Filippusson H, Hornby WE, McDonald A. The use of immobilised derivatives of urease and urate oxidase in automated analysis. FEBS Lett. 1972;20(3):291-293doi: 10.1016/0014-5793(72)80089-9.
Filippusson, H., Hornby, W. E., & McDonald, A. (1972). The use of immobilised derivatives of urease and urate oxidase in automated analysis. FEBS letters, 20(3), 291-293. https://doi.org/10.1016/0014-5793(72)80089-9
Filippusson, H, et al. "The use of immobilised derivatives of urease and urate oxidase in automated analysis." FEBS letters vol. 20,3 (1972): 291-293. doi: https://doi.org/10.1016/0014-5793(72)80089-9
Filippusson H, Hornby WE, McDonald A. The use of immobilised derivatives of urease and urate oxidase in automated analysis. FEBS Lett. 1972 Feb 15;20(3):291-293. doi: 10.1016/0014-5793(72)80089-9. PMID: 11946440.
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Nitrogen nutrition and the development of biochemical functions associated with nitrogen fixation and ammonia assimilation of nodules on cowpea seedlings.

Planta

Atkins CA, Shelp BJ, Storer PJ, Pate JS.
PMID: 24253166
Planta. 1984 Oct;162(4):327-33. doi: 10.1007/BF00396744.

During early development (up to 18 d after sowing) of nodules of an "effective" cowpea symbiosis (Vigna unguiculata (L.) Walp cv. Vita 3: Rhizobium strain CB756), rapidly increasing nitrogenase (EC 1.7.99.2) activity and leghaemoglobin content were accompanied by rapid...

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Atkins CA, Shelp BJ, Storer PJ, et al. Nitrogen nutrition and the development of biochemical functions associated with nitrogen fixation and ammonia assimilation of nodules on cowpea seedlings. Planta. 1984;162(4):327-33doi: 10.1007/BF00396744.
Atkins, C. A., Shelp, B. J., Storer, P. J., & Pate, J. S. (1984). Nitrogen nutrition and the development of biochemical functions associated with nitrogen fixation and ammonia assimilation of nodules on cowpea seedlings. Planta, 162(4), 327-33. https://doi.org/10.1007/BF00396744
Atkins, C A, et al. "Nitrogen nutrition and the development of biochemical functions associated with nitrogen fixation and ammonia assimilation of nodules on cowpea seedlings." Planta vol. 162,4 (1984): 327-33. doi: https://doi.org/10.1007/BF00396744
Atkins CA, Shelp BJ, Storer PJ, Pate JS. Nitrogen nutrition and the development of biochemical functions associated with nitrogen fixation and ammonia assimilation of nodules on cowpea seedlings. Planta. 1984 Oct;162(4):327-33. doi: 10.1007/BF00396744. PMID: 24253166.
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Absence of CeCl3-detectable peroxisomal glycolate-oxidase activity in developing raphide crystal idioblasts in leaves of Psychotria punctata Vatke and roots of Yucca torreyi L.

Planta

Kausch AP, Horner HT.
PMID: 24249497
Planta. 1985 May;164(1):35-43. doi: 10.1007/BF00391023.

Three peroxisomal enzymes, glycolate oxidase, urate oxidase and catalase were localized cytochemically in Psychotria punctata (Rubiaceae) leaves and Yucca torreyi (Agavaceae) seedling root tips, both of which contain developing and mature calcium-oxalate raphide crystal idioblasts. Glycolate-oxidase (EC 1.1.3.1) and...

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Kausch AP, Horner HT. Absence of CeCl3-detectable peroxisomal glycolate-oxidase activity in developing raphide crystal idioblasts in leaves of Psychotria punctata Vatke and roots of Yucca torreyi L. Planta. 1985;164(1):35-43doi: 10.1007/BF00391023.
Kausch, A. P., & Horner, H. T. (1985). Absence of CeCl3-detectable peroxisomal glycolate-oxidase activity in developing raphide crystal idioblasts in leaves of Psychotria punctata Vatke and roots of Yucca torreyi L. Planta, 164(1), 35-43. https://doi.org/10.1007/BF00391023
Kausch, A P, and Horner, H T. "Absence of CeCl3-detectable peroxisomal glycolate-oxidase activity in developing raphide crystal idioblasts in leaves of Psychotria punctata Vatke and roots of Yucca torreyi L." Planta vol. 164,1 (1985): 35-43. doi: https://doi.org/10.1007/BF00391023
Kausch AP, Horner HT. Absence of CeCl3-detectable peroxisomal glycolate-oxidase activity in developing raphide crystal idioblasts in leaves of Psychotria punctata Vatke and roots of Yucca torreyi L. Planta. 1985 May;164(1):35-43. doi: 10.1007/BF00391023. PMID: 24249497.
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Efficacy of Single Dose Rasburicase (1.5 mg) for Prophylaxis and Management of Laboratory Tumor Lysis Syndrome.

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

Philips A, Radhakrishnan V, Ganesan P, Ganesan TS, Ramamurthy J, Dhanushkodi M, Sagar TG.
PMID: 30369730
Indian J Hematol Blood Transfus. 2018 Oct;34(4):618-622. doi: 10.1007/s12288-018-0938-9. Epub 2018 Mar 03.

Rasburicase is a recombinant urate oxidase enzyme approved for use in tumor lysis syndrome (TLS) and it acts by reducing serum uric acid levels. Using rasburicase at the recommended dose of 0.2 mg/kg/day for 5 days is expensive and...

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Philips A, Radhakrishnan V, Ganesan P, et al. Efficacy of Single Dose Rasburicase (1.5 mg) for Prophylaxis and Management of Laboratory Tumor Lysis Syndrome. Indian J Hematol Blood Transfus. 2018;34(4):618-622doi: 10.1007/s12288-018-0938-9.
Philips, A., Radhakrishnan, V., Ganesan, P., Ganesan, T. S., Ramamurthy, J., Dhanushkodi, M., & Sagar, T. G. (2018). Efficacy of Single Dose Rasburicase (1.5 mg) for Prophylaxis and Management of Laboratory Tumor Lysis Syndrome. Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion, 34(4), 618-622. https://doi.org/10.1007/s12288-018-0938-9
Philips, Ashwin, et al. "Efficacy of Single Dose Rasburicase (1.5 mg) for Prophylaxis and Management of Laboratory Tumor Lysis Syndrome." Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion vol. 34,4 (2018): 618-622. doi: https://doi.org/10.1007/s12288-018-0938-9
Philips A, Radhakrishnan V, Ganesan P, Ganesan TS, Ramamurthy J, Dhanushkodi M, Sagar TG. Efficacy of Single Dose Rasburicase (1.5 mg) for Prophylaxis and Management of Laboratory Tumor Lysis Syndrome. Indian J Hematol Blood Transfus. 2018 Oct;34(4):618-622. doi: 10.1007/s12288-018-0938-9. Epub 2018 Mar 03. PMID: 30369730; PMCID: PMC6186245.
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Prevention and treatment of tumor lysis syndrome, and the efficacy and role of rasburicase.

OncoTargets and therapy

Alakel N, Middeke JM, Schetelig J, Bornhäuser M.
PMID: 28203093
Onco Targets Ther. 2017 Feb 02;10:597-605. doi: 10.2147/OTT.S103864. eCollection 2017.

Tumor lysis syndrome (TLS) is a potentially life-threatening condition that occurs in oncologic and hematologic patients with large tumor burden, either due to cytotoxic therapy or, less commonly, spontaneously because of massive tumor cell lysis. TLS is clinically characterized...

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Alakel N, Middeke JM, Schetelig J, et al. Prevention and treatment of tumor lysis syndrome, and the efficacy and role of rasburicase. Onco Targets Ther. 2017;10:597-605doi: 10.2147/OTT.S103864.
Alakel, N., Middeke, J. M., Schetelig, J., & Bornhäuser, M. (2017). Prevention and treatment of tumor lysis syndrome, and the efficacy and role of rasburicase. OncoTargets and therapy, 10597-605. https://doi.org/10.2147/OTT.S103864
Alakel, Nael, et al. "Prevention and treatment of tumor lysis syndrome, and the efficacy and role of rasburicase." OncoTargets and therapy vol. 10 (2017): 597-605. doi: https://doi.org/10.2147/OTT.S103864
Alakel N, Middeke JM, Schetelig J, Bornhäuser M. Prevention and treatment of tumor lysis syndrome, and the efficacy and role of rasburicase. Onco Targets Ther. 2017 Feb 02;10:597-605. doi: 10.2147/OTT.S103864. eCollection 2017. PMID: 28203093; PMCID: PMC5295804.
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Hyperuricemia causes kidney damage by promoting autophagy and NLRP3-mediated inflammation in rats with urate oxidase deficiency.

Disease models & mechanisms

Wu M, Ma Y, Chen X, Liang N, Qu S, Chen H.
PMID: 33648977
Dis Model Mech. 2021 Mar 24;14(3). doi: 10.1242/dmm.048041.

Epidemiological research has shown that elevated serum urate concentration is a risk factor for the development of kidney disease; however, the mechanisms underlying this process have not yet been elucidated. To examine the role of urate in the kidney,...

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Wu M, Ma Y, Chen X, et al. Hyperuricemia causes kidney damage by promoting autophagy and NLRP3-mediated inflammation in rats with urate oxidase deficiency. Dis Model Mech. 2021;14(3)doi: 10.1242/dmm.048041.
Wu, M., Ma, Y., Chen, X., Liang, N., Qu, S., & Chen, H. (2021). Hyperuricemia causes kidney damage by promoting autophagy and NLRP3-mediated inflammation in rats with urate oxidase deficiency. Disease models & mechanisms, 14(3), . https://doi.org/10.1242/dmm.048041
Wu, Mian, et al. "Hyperuricemia causes kidney damage by promoting autophagy and NLRP3-mediated inflammation in rats with urate oxidase deficiency." Disease models & mechanisms vol. 14,3 (2021). doi: https://doi.org/10.1242/dmm.048041
Wu M, Ma Y, Chen X, Liang N, Qu S, Chen H. Hyperuricemia causes kidney damage by promoting autophagy and NLRP3-mediated inflammation in rats with urate oxidase deficiency. Dis Model Mech. 2021 Mar 24;14(3). doi: 10.1242/dmm.048041. PMID: 33648977; PMCID: PMC8015218.
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Soluble expression of bioactive recombinant porcine-human chimeric uricase mutant employing MBP-SUMO fusion system.

Protein expression and purification

Zhou Z, Zhao H, Zhang L, Xie Q, Liu Q, Tong M, Yu X, Xiong S.
PMID: 34562586
Protein Expr Purif. 2022 Jan;189:105978. doi: 10.1016/j.pep.2021.105978. Epub 2021 Sep 22.

Urate oxidase is a promising biological medicine for hyperuricemia treatment, but immunogenicity obstructs the development of its clinical application. The recombinant porcine-human chimeric uricase mutant named dHU-wPU is a humanized chimeric uricase based on wild porcine uricase (wPU), which...

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Zhou Z, Zhao H, Zhang L, et al. Soluble expression of bioactive recombinant porcine-human chimeric uricase mutant employing MBP-SUMO fusion system. Protein Expr Purif. 2021;189:105978doi: 10.1016/j.pep.2021.105978.
Zhou, Z., Zhao, H., Zhang, L., Xie, Q., Liu, Q., Tong, M., Yu, X., & Xiong, S. (2022). Soluble expression of bioactive recombinant porcine-human chimeric uricase mutant employing MBP-SUMO fusion system. Protein expression and purification, 189105978. https://doi.org/10.1016/j.pep.2021.105978
Zhou, Zhenlong, et al. "Soluble expression of bioactive recombinant porcine-human chimeric uricase mutant employing MBP-SUMO fusion system." Protein expression and purification vol. 189 (2022): 105978. doi: https://doi.org/10.1016/j.pep.2021.105978
Zhou Z, Zhao H, Zhang L, Xie Q, Liu Q, Tong M, Yu X, Xiong S. Soluble expression of bioactive recombinant porcine-human chimeric uricase mutant employing MBP-SUMO fusion system. Protein Expr Purif. 2022 Jan;189:105978. doi: 10.1016/j.pep.2021.105978. Epub 2021 Sep 22. PMID: 34562586.
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Single-Dose Rasburicase Might Be Adequate To Overcome Tumor Lysis Syndrome In Hematological Malignancies.

Clinical lymphoma, myeloma & leukemia

Yaman S, Başcı S, Turan G, Ulu BU, Yiğenoğlu TN, Dal MS, Kızıl Çakar M, Altuntaş F.
PMID: 34565690
Clin Lymphoma Myeloma Leuk. 2021 Aug 28; doi: 10.1016/j.clml.2021.08.009. Epub 2021 Aug 28.

INTRODUCTION: Tumor lysis syndrome (TLS) is a commonly observed oncological emergency that requires prompt diagnosis and treatment. Rasburicase is a recombinant urate oxidase endorsed in TLS for the treatment of hyperuricemia. The effect of single-dose 7.5 mg rasburicase at...

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Yaman S, Başcı S, Turan G, et al. Single-Dose Rasburicase Might Be Adequate To Overcome Tumor Lysis Syndrome In Hematological Malignancies. Clin Lymphoma Myeloma Leuk. 2021;doi: 10.1016/j.clml.2021.08.009.
Yaman, S., Başcı, S., Turan, G., Ulu, B. U., Yiğenoğlu, T. N., Dal, M. S., Kızıl Çakar, M., & Altuntaş, F. (2021). Single-Dose Rasburicase Might Be Adequate To Overcome Tumor Lysis Syndrome In Hematological Malignancies. Clinical lymphoma, myeloma & leukemia, . https://doi.org/10.1016/j.clml.2021.08.009
Yaman, Samet, et al. "Single-Dose Rasburicase Might Be Adequate To Overcome Tumor Lysis Syndrome In Hematological Malignancies." Clinical lymphoma, myeloma & leukemia vol. (2021). doi: https://doi.org/10.1016/j.clml.2021.08.009
Yaman S, Başcı S, Turan G, Ulu BU, Yiğenoğlu TN, Dal MS, Kızıl Çakar M, Altuntaş F. Single-Dose Rasburicase Might Be Adequate To Overcome Tumor Lysis Syndrome In Hematological Malignancies. Clin Lymphoma Myeloma Leuk. 2021 Aug 28; doi: 10.1016/j.clml.2021.08.009. Epub 2021 Aug 28. PMID: 34565690.
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Computational Approach for Rational Design of Fusion Uricase with PAS Sequences.

International journal of molecular and cellular medicine

Najjari A, Rahimi H, Nojoumi SA, Omidinia E.
PMID: 32832488
Int J Mol Cell Med. 2020;9(1):90-103. doi: 10.22088/IJMCM.BUMS.9.1.90.

Tumor lysis syndrome is a life-threatening condition for humans due to the lack of urate oxidase. In this study, several variants of PASylated uricase from the

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Najjari A, Rahimi H, Nojoumi SA, et al. Computational Approach for Rational Design of Fusion Uricase with PAS Sequences. Int J Mol Cell Med. 2020;9(1):90-103doi: 10.22088/IJMCM.BUMS.9.1.90.
Najjari, A., Rahimi, H., Nojoumi, S. A., & Omidinia, E. (2020). Computational Approach for Rational Design of Fusion Uricase with PAS Sequences. International journal of molecular and cellular medicine, 9(1), 90-103. https://doi.org/10.22088/IJMCM.BUMS.9.1.90
Najjari, Abbas, et al. "Computational Approach for Rational Design of Fusion Uricase with PAS Sequences." International journal of molecular and cellular medicine vol. 9,1 (2020): 90-103. doi: https://doi.org/10.22088/IJMCM.BUMS.9.1.90
Najjari A, Rahimi H, Nojoumi SA, Omidinia E. Computational Approach for Rational Design of Fusion Uricase with PAS Sequences. Int J Mol Cell Med. 2020;9(1):90-103. doi: 10.22088/IJMCM.BUMS.9.1.90. PMID: 32832488; PMCID: PMC7422847.
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Pegloticase Induced Hemolytic Anemia in a Patient With G6PD Deficiency.

Journal of hematology

Adashek ML, Bourji KI.
PMID: 32300419
J Hematol. 2018 May;7(2):83-85. doi: 10.14740/jh402w. Epub 2018 May 10.

Gout is a metabolic disorder of purine metabolism that results in crystallization of uric acid in the form of monosodium urate crystals, affects 8.3 million Americans and is the most common cause of inflammatory arthritis in adults. Urate lowering...

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Adashek ML, Bourji KI. Pegloticase Induced Hemolytic Anemia in a Patient With G6PD Deficiency. J Hematol. 2018;7(2):83-85doi: 10.14740/jh402w.
Adashek, M. L., & Bourji, K. I. (2018). Pegloticase Induced Hemolytic Anemia in a Patient With G6PD Deficiency. Journal of hematology, 7(2), 83-85. https://doi.org/10.14740/jh402w
Adashek, Michael L, and Bourji, Khalil I. "Pegloticase Induced Hemolytic Anemia in a Patient With G6PD Deficiency." Journal of hematology vol. 7,2 (2018): 83-85. doi: https://doi.org/10.14740/jh402w
Adashek ML, Bourji KI. Pegloticase Induced Hemolytic Anemia in a Patient With G6PD Deficiency. J Hematol. 2018 May;7(2):83-85. doi: 10.14740/jh402w. Epub 2018 May 10. PMID: 32300419; PMCID: PMC7155862.
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The role of thrifty genes in the origin of alcoholism: A narrative review and hypothesis.

Alcoholism, clinical and experimental research

Carn D, Lanaspa MA, Benner SA, Andrews P, Dudley R, Andres-Hernando A, Tolan DR, Johnson RJ.
PMID: 34120350
Alcohol Clin Exp Res. 2021 Aug;45(8):1519-1526. doi: 10.1111/acer.14655. Epub 2021 Jul 16.

In this narrative review, we present the hypothesis that key mutations in two genes, occurring 15 and 10 million years ago (MYA), were individually and then collectively adaptive for ancestral humans during periods of starvation, but are maladaptive in...

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Carn D, Lanaspa MA, Benner SA, et al. The role of thrifty genes in the origin of alcoholism: A narrative review and hypothesis. Alcohol Clin Exp Res. 2021;45(8):1519-1526doi: 10.1111/acer.14655.
Carn, D., Lanaspa, M. A., Benner, S. A., Andrews, P., Dudley, R., Andres-Hernando, A., Tolan, D. R., & Johnson, R. J. (2021). The role of thrifty genes in the origin of alcoholism: A narrative review and hypothesis. Alcoholism, clinical and experimental research, 45(8), 1519-1526. https://doi.org/10.1111/acer.14655
Carn, David, et al. "The role of thrifty genes in the origin of alcoholism: A narrative review and hypothesis." Alcoholism, clinical and experimental research vol. 45,8 (2021): 1519-1526. doi: https://doi.org/10.1111/acer.14655
Carn D, Lanaspa MA, Benner SA, Andrews P, Dudley R, Andres-Hernando A, Tolan DR, Johnson RJ. The role of thrifty genes in the origin of alcoholism: A narrative review and hypothesis. Alcohol Clin Exp Res. 2021 Aug;45(8):1519-1526. doi: 10.1111/acer.14655. Epub 2021 Jul 16. PMID: 34120350; PMCID: PMC8429132.
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Oral Treatment With an Engineered Uricase, ALLN-346, Reduces Hyperuricemia, and Uricosuria in Urate Oxidase-Deficient Mice.

Frontiers in medicine

Pierzynowska K, Deshpande A, Mosiichuk N, Terkeltaub R, Szczurek P, Salido E, Pierzynowski S, Grujic D.
PMID: 33330529
Front Med (Lausanne). 2020 Nov 24;7:569215. doi: 10.3389/fmed.2020.569215. eCollection 2020.

Limitations in efficacy and/or tolerance of currently available urate-lowering therapies (ULTs), such as oral xanthine oxidase inhibitors, uricosurics, and intravenous uricase agents contribute to the development of refractory gout. Renal excretion is the major route of uric acid elimination,...

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Pierzynowska K, Deshpande A, Mosiichuk N, et al. Oral Treatment With an Engineered Uricase, ALLN-346, Reduces Hyperuricemia, and Uricosuria in Urate Oxidase-Deficient Mice. Front Med (Lausanne). 2020;7:569215doi: 10.3389/fmed.2020.569215.
Pierzynowska, K., Deshpande, A., Mosiichuk, N., Terkeltaub, R., Szczurek, P., Salido, E., Pierzynowski, S., & Grujic, D. (2020). Oral Treatment With an Engineered Uricase, ALLN-346, Reduces Hyperuricemia, and Uricosuria in Urate Oxidase-Deficient Mice. Frontiers in medicine, 7569215. https://doi.org/10.3389/fmed.2020.569215
Pierzynowska, Kateryna, et al. "Oral Treatment With an Engineered Uricase, ALLN-346, Reduces Hyperuricemia, and Uricosuria in Urate Oxidase-Deficient Mice." Frontiers in medicine vol. 7 (2020): 569215. doi: https://doi.org/10.3389/fmed.2020.569215
Pierzynowska K, Deshpande A, Mosiichuk N, Terkeltaub R, Szczurek P, Salido E, Pierzynowski S, Grujic D. Oral Treatment With an Engineered Uricase, ALLN-346, Reduces Hyperuricemia, and Uricosuria in Urate Oxidase-Deficient Mice. Front Med (Lausanne). 2020 Nov 24;7:569215. doi: 10.3389/fmed.2020.569215. eCollection 2020. PMID: 33330529; PMCID: PMC7732547.
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