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Effects of zafirlukast on the function of humanpolymorphonuclear neutrophil leukocytes in asthmatic patients: A prospective, controlled, in vitro study.

Current therapeutic research, clinical and experimental

Al-Zamil HA, Ai-Twaijiri AS, Al-Mobeireek AF, Mustafa AA.
PMID: 24672130
Curr Ther Res Clin Exp. 2005 Jul;66(4):279-93. doi: 10.1016/j.curtheres.2005.08.013.

BACKGROUND: Reactive oxygen species (ROSS) play an important role in the pathogenesis of asthma, and oxidative stress contributes to the initiation and worsening of inflammatory respiratory disorders (eg, asthma). Thus, antioxidant drugs may have a role in reducing or...

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Al-Zamil HA, Ai-Twaijiri AS, Al-Mobeireek AF, et al. Effects of zafirlukast on the function of humanpolymorphonuclear neutrophil leukocytes in asthmatic patients: A prospective, controlled, in vitro study. Curr Ther Res Clin Exp. 2005;66(4):279-93doi: 10.1016/j.curtheres.2005.08.013.
Al-Zamil, H. A., Ai-Twaijiri, A. S., Al-Mobeireek, A. F., & Mustafa, A. A. (2005). Effects of zafirlukast on the function of humanpolymorphonuclear neutrophil leukocytes in asthmatic patients: A prospective, controlled, in vitro study. Current therapeutic research, clinical and experimental, 66(4), 279-93. https://doi.org/10.1016/j.curtheres.2005.08.013
Al-Zamil, Hana A, et al. "Effects of zafirlukast on the function of humanpolymorphonuclear neutrophil leukocytes in asthmatic patients: A prospective, controlled, in vitro study." Current therapeutic research, clinical and experimental vol. 66,4 (2005): 279-93. doi: https://doi.org/10.1016/j.curtheres.2005.08.013
Al-Zamil HA, Ai-Twaijiri AS, Al-Mobeireek AF, Mustafa AA. Effects of zafirlukast on the function of humanpolymorphonuclear neutrophil leukocytes in asthmatic patients: A prospective, controlled, in vitro study. Curr Ther Res Clin Exp. 2005 Jul;66(4):279-93. doi: 10.1016/j.curtheres.2005.08.013. PMID: 24672130; PMCID: PMC3964553.
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Lesinurad, a Selective URAT-1 Inhibitor With a Novel Mechanism in Combination With a Xanthine Oxidase Inhibitor, for Hyperuricemia Associated With Gout.

Journal of pharmacy practice

Huneycutt E, Board C, Clements JN.
PMID: 28980503
J Pharm Pract. 2017 Jan 01;897190017734427. doi: 10.1177/0897190017734427. Epub 2017 Jan 01.

OBJECTIVE: To review the pharmacokinetics, clinical efficacy, safety, and role of lesinurad for the management of hyperuricemia associated with gout.DATA SELECTION: A MEDLINE search (2000 to April 2017) was conducted using the terms hyperuricemia, gout, URAT-1, URAT-1 transporter, and...

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Huneycutt E, Board C, Clements JN. Lesinurad, a Selective URAT-1 Inhibitor With a Novel Mechanism in Combination With a Xanthine Oxidase Inhibitor, for Hyperuricemia Associated With Gout. J Pharm Pract. 2017;897190017734427doi: 10.1177/0897190017734427.
Huneycutt, E., Board, C., & Clements, J. N. (2017). Lesinurad, a Selective URAT-1 Inhibitor With a Novel Mechanism in Combination With a Xanthine Oxidase Inhibitor, for Hyperuricemia Associated With Gout. Journal of pharmacy practice, 897190017734427. https://doi.org/10.1177/0897190017734427
Huneycutt, Emily, et al. "Lesinurad, a Selective URAT-1 Inhibitor With a Novel Mechanism in Combination With a Xanthine Oxidase Inhibitor, for Hyperuricemia Associated With Gout." Journal of pharmacy practice vol. (2017): 897190017734427. doi: https://doi.org/10.1177/0897190017734427
Huneycutt E, Board C, Clements JN. Lesinurad, a Selective URAT-1 Inhibitor With a Novel Mechanism in Combination With a Xanthine Oxidase Inhibitor, for Hyperuricemia Associated With Gout. J Pharm Pract. 2017 Jan 01;897190017734427. doi: 10.1177/0897190017734427. Epub 2017 Jan 01. PMID: 28980503.
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The role of reactive oxygen species in myocardial redox signaling and regulation.

Annals of translational medicine

Moris D, Spartalis M, Tzatzaki E, Spartalis E, Karachaliou GS, Triantafyllis AS, Karaolanis GI, Tsilimigras DI, Theocharis S.
PMID: 28861421
Ann Transl Med. 2017 Aug;5(16):324. doi: 10.21037/atm.2017.06.17.

Reactive oxygen species (ROS) are subcellular messengers in gene regulatory and signal transduction pathways. In pathological situations, ROS accumulate due to excessive production or insufficient degradation, leading to oxidative stress (OS). OS causes oxidation of DNA, membranes, cellular lipids,...

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Moris D, Spartalis M, Tzatzaki E, et al. The role of reactive oxygen species in myocardial redox signaling and regulation. Ann Transl Med. 2017;5(16):324doi: 10.21037/atm.2017.06.17.
Moris, D., Spartalis, M., Tzatzaki, E., Spartalis, E., Karachaliou, G. S., Triantafyllis, A. S., Karaolanis, G. I., Tsilimigras, D. I., & Theocharis, S. (2017). The role of reactive oxygen species in myocardial redox signaling and regulation. Annals of translational medicine, 5(16), 324. https://doi.org/10.21037/atm.2017.06.17
Moris, Demetrios, et al. "The role of reactive oxygen species in myocardial redox signaling and regulation." Annals of translational medicine vol. 5,16 (2017): 324. doi: https://doi.org/10.21037/atm.2017.06.17
Moris D, Spartalis M, Tzatzaki E, Spartalis E, Karachaliou GS, Triantafyllis AS, Karaolanis GI, Tsilimigras DI, Theocharis S. The role of reactive oxygen species in myocardial redox signaling and regulation. Ann Transl Med. 2017 Aug;5(16):324. doi: 10.21037/atm.2017.06.17. PMID: 28861421; PMCID: PMC5566737.
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An evaluation of the effects of perioperatively administered fluids on ischemia/reperfusion injury.

Pakistan journal of medical sciences

Ozciftci S, Gamli M, Ornek D, Horasanli E, Dikmen B, Canpolat O, Ciraci MZ, Kilci O.
PMID: 26870095
Pak J Med Sci. 2015 Nov-Dec;31(6):1349-54. doi: 10.12669/pjms.316.7630.

OBJECTIVE: To investigate the effects of normal saline (0.9% NaCl) and 6% Hydroxyethyl Starch 130/0.4(HES) solution on Ischemia/Reperfusion (I/R) injury in patients undergoing knee arthroscopy operations with spinal anesthesia using a tourniquet.METHODS: The study comprised 48 ASA I-II patients...

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Ozciftci S, Gamli M, Ornek D, et al. An evaluation of the effects of perioperatively administered fluids on ischemia/reperfusion injury. Pak J Med Sci. 2015;31(6):1349-54doi: 10.12669/pjms.316.7630.
Ozciftci, S., Gamli, M., Ornek, D., Horasanli, E., Dikmen, B., Canpolat, O., Ciraci, M. Z., & Kilci, O. (2015). An evaluation of the effects of perioperatively administered fluids on ischemia/reperfusion injury. Pakistan journal of medical sciences, 31(6), 1349-54. https://doi.org/10.12669/pjms.316.7630
Ozciftci, S, et al. "An evaluation of the effects of perioperatively administered fluids on ischemia/reperfusion injury." Pakistan journal of medical sciences vol. 31,6 (2015): 1349-54. doi: https://doi.org/10.12669/pjms.316.7630
Ozciftci S, Gamli M, Ornek D, Horasanli E, Dikmen B, Canpolat O, Ciraci MZ, Kilci O. An evaluation of the effects of perioperatively administered fluids on ischemia/reperfusion injury. Pak J Med Sci. 2015 Nov-Dec;31(6):1349-54. doi: 10.12669/pjms.316.7630. PMID: 26870095; PMCID: PMC4744280.
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Thermostable Xanthine Oxidase Activity from Bacillus pumilus RL-2d Isolated from Manikaran Thermal Spring: Production and Characterization.

Indian journal of microbiology

Sharma NK, Thakur S, Thakur N, Savitri, Bhalla TC.
PMID: 26843701
Indian J Microbiol. 2016 Mar;56(1):88-98. doi: 10.1007/s12088-015-0547-3. Epub 2015 Aug 21.

Xanthine oxidase is an important enzyme of purine metabolism that catalyzes the hydroxylation of hypoxanthine to xanthine and then xanthine to uric acid. A thermostable xanthine oxidase is being reported from a thermophilic organism RL-2d isolated from the Manikaran...

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Sharma NK, Thakur S, Thakur N, et al. Thermostable Xanthine Oxidase Activity from Bacillus pumilus RL-2d Isolated from Manikaran Thermal Spring: Production and Characterization. Indian J Microbiol. 2015;56(1):88-98doi: 10.1007/s12088-015-0547-3.
Sharma, N. K., Thakur, S., Thakur, N., Savitri, & Bhalla, T. C. (2016). Thermostable Xanthine Oxidase Activity from Bacillus pumilus RL-2d Isolated from Manikaran Thermal Spring: Production and Characterization. Indian journal of microbiology, 56(1), 88-98. https://doi.org/10.1007/s12088-015-0547-3
Sharma, Nirmal Kant, et al. "Thermostable Xanthine Oxidase Activity from Bacillus pumilus RL-2d Isolated from Manikaran Thermal Spring: Production and Characterization." Indian journal of microbiology vol. 56,1 (2016): 88-98. doi: https://doi.org/10.1007/s12088-015-0547-3
Sharma NK, Thakur S, Thakur N, Savitri, Bhalla TC. Thermostable Xanthine Oxidase Activity from Bacillus pumilus RL-2d Isolated from Manikaran Thermal Spring: Production and Characterization. Indian J Microbiol. 2016 Mar;56(1):88-98. doi: 10.1007/s12088-015-0547-3. Epub 2015 Aug 21. PMID: 26843701; PMCID: PMC4729748.
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Relationship between NADPH and Th1/Th2 ratio in patients with non-Hodgkin lymphoma who have been exposed to pesticides.

Journal of blood medicine

Zahzeh MR, Loukidi B, Meziane W, Haddouche M, Mesli N, Zouaoui Z, Aribi M.
PMID: 25878515
J Blood Med. 2015 Mar 31;6:99-107. doi: 10.2147/JBM.S78759. eCollection 2015.

The effect of pesticides on nicotinamide adenine dinucleotide phosphate hydrogen (NADPH), including its level and relationship with the T helper 1 (Th1)/Th2 ratio, in patients suffering from non-Hodgkin lymphoma (NHL) was investigated. One hundred newly diagnosed patients with aggressive...

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Zahzeh MR, Loukidi B, Meziane W, et al. Relationship between NADPH and Th1/Th2 ratio in patients with non-Hodgkin lymphoma who have been exposed to pesticides. J Blood Med. 2015;6:99-107doi: 10.2147/JBM.S78759.
Zahzeh, M. R., Loukidi, B., Meziane, W., Haddouche, M., Mesli, N., Zouaoui, Z., & Aribi, M. (2015). Relationship between NADPH and Th1/Th2 ratio in patients with non-Hodgkin lymphoma who have been exposed to pesticides. Journal of blood medicine, 699-107. https://doi.org/10.2147/JBM.S78759
Zahzeh, Meriem Rabia, et al. "Relationship between NADPH and Th1/Th2 ratio in patients with non-Hodgkin lymphoma who have been exposed to pesticides." Journal of blood medicine vol. 6 (2015): 99-107. doi: https://doi.org/10.2147/JBM.S78759
Zahzeh MR, Loukidi B, Meziane W, Haddouche M, Mesli N, Zouaoui Z, Aribi M. Relationship between NADPH and Th1/Th2 ratio in patients with non-Hodgkin lymphoma who have been exposed to pesticides. J Blood Med. 2015 Mar 31;6:99-107. doi: 10.2147/JBM.S78759. eCollection 2015. PMID: 25878515; PMCID: PMC4386798.
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The protective effects of ischemic preconditioning on rats with renal ischemia-reperfusion injury and the effects on the expression of Bcl-2 and Bax.

Experimental and therapeutic medicine

Shen S, Zhou J, Meng S, Wu J, Ma J, Zhu C, Deng G, Liu D.
PMID: 29067100
Exp Ther Med. 2017 Nov;14(5):4077-4082. doi: 10.3892/etm.2017.5047. Epub 2017 Aug 28.

The aim of the present study was to investigate the protective effects of ischemic preconditioning on rats with renal ischemia-reperfusion injury and the effects on the expression of Bcl-2 and Bax. Thirty-six SD rats were randomly divided into three...

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Shen S, Zhou J, Meng S, et al. The protective effects of ischemic preconditioning on rats with renal ischemia-reperfusion injury and the effects on the expression of Bcl-2 and Bax. Exp Ther Med. 2017;14(5):4077-4082doi: 10.3892/etm.2017.5047.
Shen, S., Zhou, J., Meng, S., Wu, J., Ma, J., Zhu, C., Deng, G., & Liu, D. (2017). The protective effects of ischemic preconditioning on rats with renal ischemia-reperfusion injury and the effects on the expression of Bcl-2 and Bax. Experimental and therapeutic medicine, 14(5), 4077-4082. https://doi.org/10.3892/etm.2017.5047
Shen, Sheng, et al. "The protective effects of ischemic preconditioning on rats with renal ischemia-reperfusion injury and the effects on the expression of Bcl-2 and Bax." Experimental and therapeutic medicine vol. 14,5 (2017): 4077-4082. doi: https://doi.org/10.3892/etm.2017.5047
Shen S, Zhou J, Meng S, Wu J, Ma J, Zhu C, Deng G, Liu D. The protective effects of ischemic preconditioning on rats with renal ischemia-reperfusion injury and the effects on the expression of Bcl-2 and Bax. Exp Ther Med. 2017 Nov;14(5):4077-4082. doi: 10.3892/etm.2017.5047. Epub 2017 Aug 28. PMID: 29067100; PMCID: PMC5647708.
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Is Xanthine Oxidase, a Marker in Pre-eclampsia? A Case-Control Study.

Journal of clinical and diagnostic research : JCDR

Bambrana V, Dayanand CD, Kotur PP.
PMID: 26557508
J Clin Diagn Res. 2015 Oct;9(10):BC01-3. doi: 10.7860/JCDR/2015/15114.6607. Epub 2015 Oct 01.

INTRODUCTION: Pre-eclampsia is an obstetrics problem that affects multiple systemic functions and leads to the increased maternal and fetal morbidity and mortality. The objective of the study was to evaluate the plasma levels of Xanthine oxidase (XO) activity, uric...

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Bambrana V, Dayanand CD, Kotur PP. Is Xanthine Oxidase, a Marker in Pre-eclampsia? A Case-Control Study. J Clin Diagn Res. 2015;9(10):BC01-3doi: 10.7860/JCDR/2015/15114.6607.
Bambrana, V., Dayanand, C. D., & Kotur, P. P. (2015). Is Xanthine Oxidase, a Marker in Pre-eclampsia? A Case-Control Study. Journal of clinical and diagnostic research : JCDR, 9(10), BC01-3. https://doi.org/10.7860/JCDR/2015/15114.6607
Bambrana, Vanishree, et al. "Is Xanthine Oxidase, a Marker in Pre-eclampsia? A Case-Control Study." Journal of clinical and diagnostic research : JCDR vol. 9,10 (2015): BC01-3. doi: https://doi.org/10.7860/JCDR/2015/15114.6607
Bambrana V, Dayanand CD, Kotur PP. Is Xanthine Oxidase, a Marker in Pre-eclampsia? A Case-Control Study. J Clin Diagn Res. 2015 Oct;9(10):BC01-3. doi: 10.7860/JCDR/2015/15114.6607. Epub 2015 Oct 01. PMID: 26557508; PMCID: PMC4625227.
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Delayed uric Acid accumulation in plasma provides additional anti-oxidant protection against iron-triggered oxidative stress after a wingate test.

Biology of sport

Souza-Junior T, Lorenço-Lima L, Ganini D, Vardaris C, Polotow T, Barros M.
PMID: 25435669
Biol Sport. 2014 Dec;31(4):271-6. doi: 10.5604/20831862.1120934. Epub 2014 Sep 12.

Reactive oxygen species are produced during anaerobic exercise mostly by Fe ions released into plasma and endothelial/muscle xanthine oxidase activation that generates uric acid (UA) as the endpoint metabolite. Paradoxically, UA is considered a major antioxidant by virtue of...

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Souza-Junior T, Lorenço-Lima L, Ganini D, et al. Delayed uric Acid accumulation in plasma provides additional anti-oxidant protection against iron-triggered oxidative stress after a wingate test. Biol Sport. 2014;31(4):271-6doi: 10.5604/20831862.1120934.
Souza-Junior, T., Lorenço-Lima, L., Ganini, D., Vardaris, C., Polotow, T., & Barros, M. (2014). Delayed uric Acid accumulation in plasma provides additional anti-oxidant protection against iron-triggered oxidative stress after a wingate test. Biology of sport, 31(4), 271-6. https://doi.org/10.5604/20831862.1120934
Souza-Junior, Tp, et al. "Delayed uric Acid accumulation in plasma provides additional anti-oxidant protection against iron-triggered oxidative stress after a wingate test." Biology of sport vol. 31,4 (2014): 271-6. doi: https://doi.org/10.5604/20831862.1120934
Souza-Junior T, Lorenço-Lima L, Ganini D, Vardaris C, Polotow T, Barros M. Delayed uric Acid accumulation in plasma provides additional anti-oxidant protection against iron-triggered oxidative stress after a wingate test. Biol Sport. 2014 Dec;31(4):271-6. doi: 10.5604/20831862.1120934. Epub 2014 Sep 12. PMID: 25435669; PMCID: PMC4203843.
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Linking uric acid metabolism to diabetic complications.

World journal of diabetes

Kushiyama A, Tanaka K, Hara S, Kawazu S.
PMID: 25512781
World J Diabetes. 2014 Dec 15;5(6):787-95. doi: 10.4239/wjd.v5.i6.787.

Hyperuricemia have been thought to be caused by the ingestion of large amounts of purines, and prevention or treatment of hyperuricemia has intended to prevent gout. Xanthine dehydrogenase/xanthine oxidase (XDH/XO) is rate-limiting enzyme of uric acid generation, and allopurinol...

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Kushiyama A, Tanaka K, Hara S, et al. Linking uric acid metabolism to diabetic complications. World J Diabetes. 2014;5(6):787-95doi: 10.4239/wjd.v5.i6.787.
Kushiyama, A., Tanaka, K., Hara, S., & Kawazu, S. (2014). Linking uric acid metabolism to diabetic complications. World journal of diabetes, 5(6), 787-95. https://doi.org/10.4239/wjd.v5.i6.787
Kushiyama, Akifumi, et al. "Linking uric acid metabolism to diabetic complications." World journal of diabetes vol. 5,6 (2014): 787-95. doi: https://doi.org/10.4239/wjd.v5.i6.787
Kushiyama A, Tanaka K, Hara S, Kawazu S. Linking uric acid metabolism to diabetic complications. World J Diabetes. 2014 Dec 15;5(6):787-95. doi: 10.4239/wjd.v5.i6.787. PMID: 25512781; PMCID: PMC4265865.
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Uric Acid-Induced Adipocyte Dysfunction Is Attenuated by HO-1 Upregulation: Potential Role of Antioxidant Therapy to Target Obesity.

Stem cells international

Sodhi K, Hilgefort J, Banks G, Gilliam C, Stevens S, Ansinelli HA, Getty M, Abraham NG, Shapiro JI, Khitan Z.
PMID: 26681956
Stem Cells Int. 2016;2016:8197325. doi: 10.1155/2016/8197325. Epub 2015 Nov 22.

Increased uric acid levels have been implicated in the pathogenesis of metabolic syndrome. To examine the mechanisms by which this occurs, we hypothesized that an increase in heme oxygenase 1, a potent antioxidant gene, will decrease uric acid levels...

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Sodhi K, Hilgefort J, Banks G, et al. Uric Acid-Induced Adipocyte Dysfunction Is Attenuated by HO-1 Upregulation: Potential Role of Antioxidant Therapy to Target Obesity. Stem Cells Int. 2015;2016:8197325doi: 10.1155/2016/8197325.
Sodhi, K., Hilgefort, J., Banks, G., Gilliam, C., Stevens, S., Ansinelli, H. A., Getty, M., Abraham, N. G., Shapiro, J. I., & Khitan, Z. (2016). Uric Acid-Induced Adipocyte Dysfunction Is Attenuated by HO-1 Upregulation: Potential Role of Antioxidant Therapy to Target Obesity. Stem cells international, 20168197325. https://doi.org/10.1155/2016/8197325
Sodhi, Komal, et al. "Uric Acid-Induced Adipocyte Dysfunction Is Attenuated by HO-1 Upregulation: Potential Role of Antioxidant Therapy to Target Obesity." Stem cells international vol. 2016 (2016): 8197325. doi: https://doi.org/10.1155/2016/8197325
Sodhi K, Hilgefort J, Banks G, Gilliam C, Stevens S, Ansinelli HA, Getty M, Abraham NG, Shapiro JI, Khitan Z. Uric Acid-Induced Adipocyte Dysfunction Is Attenuated by HO-1 Upregulation: Potential Role of Antioxidant Therapy to Target Obesity. Stem Cells Int. 2016;2016:8197325. doi: 10.1155/2016/8197325. Epub 2015 Nov 22. PMID: 26681956; PMCID: PMC4670680.
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The Radioprotective Effects of Caffeic Acid Phenethyl Ester and Thymoquinone on Oxidative and Nitrosative Stress in Liver Tissue of Rats Exposed to Total Head Irradiation.

The West Indian medical journal

Cikman O, Taysi S, Gulsen MT, Demir E, Akan M, Diril H, Kiraz HA, Karaayvaz M, Tarakcioglu M.
PMID: 26716794
West Indian Med J. 2015 May 12;65(1):1-7. doi: 10.7727/wimj.2014.176.

OBJECTIVE: The aim of this study is to investigate the effects of addition of caffeic acid phenethyl ester (CAPE) and thymoquinone (TQ) on oxidative and nitrosative stress in the liver tissue of irradiated rats.METHODS: Forty Sprague-Dawley rats were divided...

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Cikman O, Taysi S, Gulsen MT, et al. The Radioprotective Effects of Caffeic Acid Phenethyl Ester and Thymoquinone on Oxidative and Nitrosative Stress in Liver Tissue of Rats Exposed to Total Head Irradiation. West Indian Med J. 2015;65(1):1-7doi: 10.7727/wimj.2014.176.
Cikman, O., Taysi, S., Gulsen, M. T., Demir, E., Akan, M., Diril, H., Kiraz, H. A., Karaayvaz, M., & Tarakcioglu, M. (2015). The Radioprotective Effects of Caffeic Acid Phenethyl Ester and Thymoquinone on Oxidative and Nitrosative Stress in Liver Tissue of Rats Exposed to Total Head Irradiation. The West Indian medical journal, 65(1), 1-7. https://doi.org/10.7727/wimj.2014.176
Cikman, O, et al. "The Radioprotective Effects of Caffeic Acid Phenethyl Ester and Thymoquinone on Oxidative and Nitrosative Stress in Liver Tissue of Rats Exposed to Total Head Irradiation." The West Indian medical journal vol. 65,1 (2015): 1-7. doi: https://doi.org/10.7727/wimj.2014.176
Cikman O, Taysi S, Gulsen MT, Demir E, Akan M, Diril H, Kiraz HA, Karaayvaz M, Tarakcioglu M. The Radioprotective Effects of Caffeic Acid Phenethyl Ester and Thymoquinone on Oxidative and Nitrosative Stress in Liver Tissue of Rats Exposed to Total Head Irradiation. West Indian Med J. 2015 May 12;65(1):1-7. doi: 10.7727/wimj.2014.176. PMID: 26716794.
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