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Metabolic reprogramming through fatty acid transport protein 1 (FATP1) regulates macrophage inflammatory potential and adipose inflammation.

Molecular metabolism

Johnson AR, Qin Y, Cozzo AJ, Freemerman AJ, Huang MJ, Zhao L, Sampey BP, Milner JJ, Beck MA, Damania B, Rashid N, Galanko JA, Lee DP, Edin ML, Zeldin DC, Fueger PT, Dietz B, Stahl A, Wu Y, Mohlke KL, Makowski L.
PMID: 27408776
Mol Metab. 2016 Apr 23;5(7):506-526. doi: 10.1016/j.molmet.2016.04.005. eCollection 2016 Jul.

OBJECTIVE: A novel approach to regulate obesity-associated adipose inflammation may be through metabolic reprogramming of macrophages (MΦs). Broadly speaking, MΦs dependent on glucose are pro-inflammatory, classically activated MΦs (CAM), which contribute to adipose inflammation and insulin resistance. In contrast,...

Cite
Johnson AR, Qin Y, Cozzo AJ, et al. Metabolic reprogramming through fatty acid transport protein 1 (FATP1) regulates macrophage inflammatory potential and adipose inflammation. Mol Metab. 2016;5(7):506-526doi: 10.1016/j.molmet.2016.04.005.
Johnson, A. R., Qin, Y., Cozzo, A. J., Freemerman, A. J., Huang, M. J., Zhao, L., Sampey, B. P., Milner, J. J., Beck, M. A., Damania, B., Rashid, N., Galanko, J. A., Lee, D. P., Edin, M. L., Zeldin, D. C., Fueger, P. T., Dietz, B., Stahl, A., Wu, Y., Mohlke, K. L., & Makowski, L. (2016). Metabolic reprogramming through fatty acid transport protein 1 (FATP1) regulates macrophage inflammatory potential and adipose inflammation. Molecular metabolism, 5(7), 506-526. https://doi.org/10.1016/j.molmet.2016.04.005
Johnson, Amy R, et al. "Metabolic reprogramming through fatty acid transport protein 1 (FATP1) regulates macrophage inflammatory potential and adipose inflammation." Molecular metabolism vol. 5,7 (2016): 506-526. doi: https://doi.org/10.1016/j.molmet.2016.04.005
Johnson AR, Qin Y, Cozzo AJ, Freemerman AJ, Huang MJ, Zhao L, Sampey BP, Milner JJ, Beck MA, Damania B, Rashid N, Galanko JA, Lee DP, Edin ML, Zeldin DC, Fueger PT, Dietz B, Stahl A, Wu Y, Mohlke KL, Makowski L. Metabolic reprogramming through fatty acid transport protein 1 (FATP1) regulates macrophage inflammatory potential and adipose inflammation. Mol Metab. 2016 Apr 23;5(7):506-526. doi: 10.1016/j.molmet.2016.04.005. eCollection 2016 Jul. PMID: 27408776; PMCID: PMC4921943.
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Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes.

Genome medicine

Pan DZ, Miao Z, Comenho C, Rajkumar S, Koka A, Lee SHT, Alvarez M, Kaminska D, Ko A, Sinsheimer JS, Mohlke KL, Mancuso N, Muñoz-Hernandez LL, Herrera-Hernandez M, Tusié-Luna MT, Aguilar-Salinas C, Pietiläinen KH, Pihlajamäki J, Laakso M, Garske KM, Pajukanta P.
PMID: 34340684
Genome Med. 2021 Aug 02;13(1):123. doi: 10.1186/s13073-021-00939-2.

BACKGROUND: Obesity predisposes individuals to multiple cardiometabolic disorders, including type 2 diabetes (T2D). As body mass index (BMI) cannot reliably differentiate fat from lean mass, the metabolically detrimental abdominal obesity has been estimated using waist-hip ratio (WHR). Waist-hip ratio...

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Pan DZ, Miao Z, Comenho C, et al. Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes. Genome Med. 2021;13(1):123doi: 10.1186/s13073-021-00939-2.
Pan, D. Z., Miao, Z., Comenho, C., Rajkumar, S., Koka, A., Lee, S. H. T., Alvarez, M., Kaminska, D., Ko, A., Sinsheimer, J. S., Mohlke, K. L., Mancuso, N., Muñoz-Hernandez, L. L., Herrera-Hernandez, M., Tusié-Luna, M. T., Aguilar-Salinas, C., Pietiläinen, K. H., Pihlajamäki, J., Laakso, M., Garske, K. M., & Pajukanta, P. (2021). Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes. Genome medicine, 13(1), 123. https://doi.org/10.1186/s13073-021-00939-2
Pan, David Z, et al. "Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes." Genome medicine vol. 13,1 (2021): 123. doi: https://doi.org/10.1186/s13073-021-00939-2
Pan DZ, Miao Z, Comenho C, Rajkumar S, Koka A, Lee SHT, Alvarez M, Kaminska D, Ko A, Sinsheimer JS, Mohlke KL, Mancuso N, Muñoz-Hernandez LL, Herrera-Hernandez M, Tusié-Luna MT, Aguilar-Salinas C, Pietiläinen KH, Pihlajamäki J, Laakso M, Garske KM, Pajukanta P. Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes. Genome Med. 2021 Aug 02;13(1):123. doi: 10.1186/s13073-021-00939-2. PMID: 34340684; PMCID: PMC8327600.
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