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Early Steps of Dauricine Biosynthesis in Cultured Roots of Menispermum dauricum.

Bioscience, biotechnology, and biochemistry

Sugimoto Y, Uchida S, Inanaga S, Kimura Y, Hashimoto M, Isogai A.
PMID: 27299554
Biosci Biotechnol Biochem. 1996 Jan;60(3):503-5. doi: 10.1271/bbb.60.503.

Cultured roots of Menispermum dauricum, a rich source of the bisbenzylisoquinoline alkaloid dauricine (1), were fed with l-[U-(14)C] tyrosine, L-[3-(13)C] tyrosine, and [2-(13)C] tvramine independently, and the incorporation of possible early precursors into 1 was studied. The results demonstrated...

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Sugimoto Y, Uchida S, Inanaga S, et al. Early Steps of Dauricine Biosynthesis in Cultured Roots of Menispermum dauricum. Biosci Biotechnol Biochem. 1996;60(3):503-5doi: 10.1271/bbb.60.503.
Sugimoto, Y., Uchida, S., Inanaga, S., Kimura, Y., Hashimoto, M., & Isogai, A. (1996). Early Steps of Dauricine Biosynthesis in Cultured Roots of Menispermum dauricum. Bioscience, biotechnology, and biochemistry, 60(3), 503-5. https://doi.org/10.1271/bbb.60.503
Sugimoto, Y, et al. "Early Steps of Dauricine Biosynthesis in Cultured Roots of Menispermum dauricum." Bioscience, biotechnology, and biochemistry vol. 60,3 (1996): 503-5. doi: https://doi.org/10.1271/bbb.60.503
Sugimoto Y, Uchida S, Inanaga S, Kimura Y, Hashimoto M, Isogai A. Early Steps of Dauricine Biosynthesis in Cultured Roots of Menispermum dauricum. Biosci Biotechnol Biochem. 1996 Jan;60(3):503-5. doi: 10.1271/bbb.60.503. PMID: 27299554.
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Dauricine Protects from LPS-Induced Bone Loss via the ROS/PP2A/NF-κB Axis in Osteoclasts.

Antioxidants (Basel, Switzerland)

Park HJ, Gholam Zadeh M, Suh JH, Choi HS.
PMID: 32640590
Antioxidants (Basel). 2020 Jul 06;9(7). doi: 10.3390/antiox9070588.

Dauricine (DAC), an isoquinoline alkaloid, exhibits anti-inflammatory activity. We hypothesized that DAC may prevent the inflammatory bone loss induced by lipopolysaccharide (LPS). LPS-induced bone loss was decreased by DAC in female C57BL/6J mice as evaluated by micro-computerized tomography (μCT)...

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Park HJ, Gholam Zadeh M, Suh JH, et al. Dauricine Protects from LPS-Induced Bone Loss via the ROS/PP2A/NF-κB Axis in Osteoclasts. Antioxidants (Basel). 2020;9(7)doi: 10.3390/antiox9070588.
Park, H. J., Gholam Zadeh, M., Suh, J. H., & Choi, H. S. (2020). Dauricine Protects from LPS-Induced Bone Loss via the ROS/PP2A/NF-κB Axis in Osteoclasts. Antioxidants (Basel, Switzerland), 9(7), . https://doi.org/10.3390/antiox9070588
Park, Hyun-Jung, et al. "Dauricine Protects from LPS-Induced Bone Loss via the ROS/PP2A/NF-κB Axis in Osteoclasts." Antioxidants (Basel, Switzerland) vol. 9,7 (2020). doi: https://doi.org/10.3390/antiox9070588
Park HJ, Gholam Zadeh M, Suh JH, Choi HS. Dauricine Protects from LPS-Induced Bone Loss via the ROS/PP2A/NF-κB Axis in Osteoclasts. Antioxidants (Basel). 2020 Jul 06;9(7). doi: 10.3390/antiox9070588. PMID: 32640590; PMCID: PMC7402093.
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Natural autophagy blockers, dauricine (DAC) and daurisoline (DAS), sensitize cancer cells to camptothecin-induced toxicity.

Oncotarget

Wu MY, Wang SF, Cai CZ, Tan JQ, Li M, Lu JJ, Chen XP, Wang YT, Zheng W, Lu JH.
PMID: 29100416
Oncotarget. 2017 Sep 08;8(44):77673-77684. doi: 10.18632/oncotarget.20767. eCollection 2017 Sep 29.

Autophagy is a cellular bulk degradation pathway implicated in various diseases. Inhibition of autophagy has been regarded as a new therapeutic strategy for cancer treatment, especially in combination with chemotherapy. In our study, we identified two natural compounds, dauricine...

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Wu MY, Wang SF, Cai CZ, et al. Natural autophagy blockers, dauricine (DAC) and daurisoline (DAS), sensitize cancer cells to camptothecin-induced toxicity. Oncotarget. 2017;8(44):77673-77684doi: 10.18632/oncotarget.20767.
Wu, M. Y., Wang, S. F., Cai, C. Z., Tan, J. Q., Li, M., Lu, J. J., Chen, X. P., Wang, Y. T., Zheng, W., & Lu, J. H. (2017). Natural autophagy blockers, dauricine (DAC) and daurisoline (DAS), sensitize cancer cells to camptothecin-induced toxicity. Oncotarget, 8(44), 77673-77684. https://doi.org/10.18632/oncotarget.20767
Wu, Ming-Yue, et al. "Natural autophagy blockers, dauricine (DAC) and daurisoline (DAS), sensitize cancer cells to camptothecin-induced toxicity." Oncotarget vol. 8,44 (2017): 77673-77684. doi: https://doi.org/10.18632/oncotarget.20767
Wu MY, Wang SF, Cai CZ, Tan JQ, Li M, Lu JJ, Chen XP, Wang YT, Zheng W, Lu JH. Natural autophagy blockers, dauricine (DAC) and daurisoline (DAS), sensitize cancer cells to camptothecin-induced toxicity. Oncotarget. 2017 Sep 08;8(44):77673-77684. doi: 10.18632/oncotarget.20767. eCollection 2017 Sep 29. PMID: 29100416; PMCID: PMC5652807.
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Testing of VKORC1 and CYP2C9 alleles to guide warfarin dosing. Test category: pharmacogenomic (treatment).

PLoS currents

Grossniklaus D.
PMID: 20877452
PLoS Curr. 2010 Sep 14;2. doi: 10.1371/currents.RRN1155.

Warfarin is an oral anticoagulant that is widely prescribed to prevent thromboembolic events in persons at increased risk. The optimal dose is difficult to establish because it can vary 10-fold among individuals due to clinical and demographic factors. Testing...

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Grossniklaus D. Testing of VKORC1 and CYP2C9 alleles to guide warfarin dosing. Test category: pharmacogenomic (treatment). PLoS Curr. 2010;2doi: 10.1371/currents.RRN1155.
Grossniklaus, D. (2010). Testing of VKORC1 and CYP2C9 alleles to guide warfarin dosing. Test category: pharmacogenomic (treatment). PLoS currents, 2. https://doi.org/10.1371/currents.RRN1155
Grossniklaus, Daurice. "Testing of VKORC1 and CYP2C9 alleles to guide warfarin dosing. Test category: pharmacogenomic (treatment)." PLoS currents vol. 2 (2010). doi: https://doi.org/10.1371/currents.RRN1155
Grossniklaus D. Testing of VKORC1 and CYP2C9 alleles to guide warfarin dosing. Test category: pharmacogenomic (treatment). PLoS Curr. 2010 Sep 14;2. doi: 10.1371/currents.RRN1155. PMID: 20877452; PMCID: PMC2940214.
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Dauricine Attenuates Vascular Endothelial Inflammation Through Inhibiting NF-κB Pathway.

Frontiers in pharmacology

Hu J, Chen R, An J, Wang Y, Liang M, Huang K.
PMID: 34925018
Front Pharmacol. 2021 Dec 01;12:758962. doi: 10.3389/fphar.2021.758962. eCollection 2021.

Endothelial cells are the fundamental components of blood vessels that regulate several physiological processes including immune responses, angiogenesis, and vascular tone. Endothelial dysfunction contributes to the development of various diseases such as acute lung injury, and endothelial inflammation is...

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Hu J, Chen R, An J, et al. Dauricine Attenuates Vascular Endothelial Inflammation Through Inhibiting NF-κB Pathway. Front Pharmacol. 2021;12:758962doi: 10.3389/fphar.2021.758962.
Hu, J., Chen, R., An, J., Wang, Y., Liang, M., & Huang, K. (2021). Dauricine Attenuates Vascular Endothelial Inflammation Through Inhibiting NF-κB Pathway. Frontiers in pharmacology, 12758962. https://doi.org/10.3389/fphar.2021.758962
Hu, Ji, et al. "Dauricine Attenuates Vascular Endothelial Inflammation Through Inhibiting NF-κB Pathway." Frontiers in pharmacology vol. 12 (2021): 758962. doi: https://doi.org/10.3389/fphar.2021.758962
Hu J, Chen R, An J, Wang Y, Liang M, Huang K. Dauricine Attenuates Vascular Endothelial Inflammation Through Inhibiting NF-κB Pathway. Front Pharmacol. 2021 Dec 01;12:758962. doi: 10.3389/fphar.2021.758962. eCollection 2021. PMID: 34925018; PMCID: PMC8672219.
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Dauricine Attenuates Vascular Endothelial Inflammation Through Inhibiting NF-κB Pathway.

Frontiers in pharmacology

Hu J, Chen R, An J, Wang Y, Liang M, Huang K.
PMID: 34925018
Front Pharmacol. 2021 Dec 01;12:758962. doi: 10.3389/fphar.2021.758962. eCollection 2021.

Endothelial cells are the fundamental components of blood vessels that regulate several physiological processes including immune responses, angiogenesis, and vascular tone. Endothelial dysfunction contributes to the development of various diseases such as acute lung injury, and endothelial inflammation is...

Cite
Hu J, Chen R, An J, et al. Dauricine Attenuates Vascular Endothelial Inflammation Through Inhibiting NF-κB Pathway. Front Pharmacol. 2021;12:758962doi: 10.3389/fphar.2021.758962.
Hu, J., Chen, R., An, J., Wang, Y., Liang, M., & Huang, K. (2021). Dauricine Attenuates Vascular Endothelial Inflammation Through Inhibiting NF-κB Pathway. Frontiers in pharmacology, 12758962. https://doi.org/10.3389/fphar.2021.758962
Hu, Ji, et al. "Dauricine Attenuates Vascular Endothelial Inflammation Through Inhibiting NF-κB Pathway." Frontiers in pharmacology vol. 12 (2021): 758962. doi: https://doi.org/10.3389/fphar.2021.758962
Hu J, Chen R, An J, Wang Y, Liang M, Huang K. Dauricine Attenuates Vascular Endothelial Inflammation Through Inhibiting NF-κB Pathway. Front Pharmacol. 2021 Dec 01;12:758962. doi: 10.3389/fphar.2021.758962. eCollection 2021. PMID: 34925018; PMCID: PMC8672219.
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Corrigendum to "Amyloid-beta Degradation and Neuroprotection of Dauricine Mediated by Unfolded Protein Response in a Caenorhabditis elegans Model of Alzheimer's Disease" [Neuroscience 392C (2018) 25-37].

Neuroscience

Pu Z, Ma S, Wang L, Li M, Shang L, Luo Y, Chen W.
PMID: 30811972
Neuroscience. 2019 Apr 15;404:557. doi: 10.1016/j.neuroscience.2019.01.048. Epub 2019 Feb 24.

No abstract available.

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Pu Z, Ma S, Wang L, et al. Corrigendum to "Amyloid-beta Degradation and Neuroprotection of Dauricine Mediated by Unfolded Protein Response in a Caenorhabditis elegans Model of Alzheimer's Disease" [Neuroscience 392C (2018) 25-37]. Neuroscience. 2019;404:557doi: 10.1016/j.neuroscience.2019.01.048.
Pu, Z., Ma, S., Wang, L., Li, M., Shang, L., Luo, Y., & Chen, W. (2019). Corrigendum to "Amyloid-beta Degradation and Neuroprotection of Dauricine Mediated by Unfolded Protein Response in a Caenorhabditis elegans Model of Alzheimer's Disease" [Neuroscience 392C (2018) 25-37]. Neuroscience, 404557. https://doi.org/10.1016/j.neuroscience.2019.01.048
Pu, Zhijun, et al. "Corrigendum to "Amyloid-beta Degradation and Neuroprotection of Dauricine Mediated by Unfolded Protein Response in a Caenorhabditis elegans Model of Alzheimer's Disease" [Neuroscience 392C (2018) 25-37]." Neuroscience vol. 404 (2019): 557. doi: https://doi.org/10.1016/j.neuroscience.2019.01.048
Pu Z, Ma S, Wang L, Li M, Shang L, Luo Y, Chen W. Corrigendum to "Amyloid-beta Degradation and Neuroprotection of Dauricine Mediated by Unfolded Protein Response in a Caenorhabditis elegans Model of Alzheimer's Disease" [Neuroscience 392C (2018) 25-37]. Neuroscience. 2019 Apr 15;404:557. doi: 10.1016/j.neuroscience.2019.01.048. Epub 2019 Feb 24. PMID: 30811972.
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A review on plants and herbal components with antiarrhythmic activities and their interaction with current cardiac drugs.

Journal of traditional and complementary medicine

Beik A, Joukar S, Najafipour H.
PMID: 32670823
J Tradit Complement Med. 2020 Apr 06;10(3):275-287. doi: 10.1016/j.jtcme.2020.03.002. eCollection 2020 May.

This paper aimed to compile information on plants or their compounds which have experimentally shown antiarrhythmic effect and to scrutinize the efficacy and potency of them and their potential interaction with conventional cardiac drugs. Literature searches were accomplished by...

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Beik A, Joukar S, Najafipour H. A review on plants and herbal components with antiarrhythmic activities and their interaction with current cardiac drugs. J Tradit Complement Med. 2020;10(3):275-287doi: 10.1016/j.jtcme.2020.03.002.
Beik, A., Joukar, S., & Najafipour, H. (2020). A review on plants and herbal components with antiarrhythmic activities and their interaction with current cardiac drugs. Journal of traditional and complementary medicine, 10(3), 275-287. https://doi.org/10.1016/j.jtcme.2020.03.002
Beik, Ahmad, et al. "A review on plants and herbal components with antiarrhythmic activities and their interaction with current cardiac drugs." Journal of traditional and complementary medicine vol. 10,3 (2020): 275-287. doi: https://doi.org/10.1016/j.jtcme.2020.03.002
Beik A, Joukar S, Najafipour H. A review on plants and herbal components with antiarrhythmic activities and their interaction with current cardiac drugs. J Tradit Complement Med. 2020 Apr 06;10(3):275-287. doi: 10.1016/j.jtcme.2020.03.002. eCollection 2020 May. PMID: 32670823; PMCID: PMC7340875.
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A Strategy for Quality Control of Menispermum dauricum DC Based on Cytotoxic Activity and HPLC Fingerprint Analysis.

Indian journal of pharmaceutical sciences

Liu LJ, Liu JN.
PMID: 27168693
Indian J Pharm Sci. 2016 Jan-Feb;78(1):143-50. doi: 10.4103/0250-474x.180257.

The rhizome of Menispermum dauricum DC known as a traditional Chinese medicine, with high content of alkaloids, has been found to possess antitumor activity. In this research, an attempt to correlate fingerprinting with bioactivity was made for quality control...

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Liu LJ, Liu JN. A Strategy for Quality Control of Menispermum dauricum DC Based on Cytotoxic Activity and HPLC Fingerprint Analysis. Indian J Pharm Sci. 2016;78(1):143-50doi: 10.4103/0250-474x.180257.
Liu, L. J., & Liu, J. N. (2016). A Strategy for Quality Control of Menispermum dauricum DC Based on Cytotoxic Activity and HPLC Fingerprint Analysis. Indian journal of pharmaceutical sciences, 78(1), 143-50. https://doi.org/10.4103/0250-474x.180257
Liu, L J, and Liu, J N. "A Strategy for Quality Control of Menispermum dauricum DC Based on Cytotoxic Activity and HPLC Fingerprint Analysis." Indian journal of pharmaceutical sciences vol. 78,1 (2016): 143-50. doi: https://doi.org/10.4103/0250-474x.180257
Liu LJ, Liu JN. A Strategy for Quality Control of Menispermum dauricum DC Based on Cytotoxic Activity and HPLC Fingerprint Analysis. Indian J Pharm Sci. 2016 Jan-Feb;78(1):143-50. doi: 10.4103/0250-474x.180257. PMID: 27168693; PMCID: PMC4852564.
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Dauricine alleviated secondary brain injury after intracerebral hemorrhage by upregulating GPX4 expression and inhibiting ferroptosis of nerve cells.

European journal of pharmacology

Peng C, Fu X, Wang K, Chen L, Luo B, Huang N, Luo Y, Chen W.
PMID: 34469757
Eur J Pharmacol. 2022 Jan 05;914:174461. doi: 10.1016/j.ejphar.2021.174461. Epub 2021 Aug 29.

Intracerebral hemorrhage (ICH) is a severe stroke subtype with high disability and mortality, and no effective treatment is available. Previous research on intracerebral hemorrhage secondary brain injury drugs mainly targeted at cell apoptosis, inflammation and oxidative stress, but did...

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Peng C, Fu X, Wang K, et al. Dauricine alleviated secondary brain injury after intracerebral hemorrhage by upregulating GPX4 expression and inhibiting ferroptosis of nerve cells. Eur J Pharmacol. 2021;914:174461doi: 10.1016/j.ejphar.2021.174461.
Peng, C., Fu, X., Wang, K., Chen, L., Luo, B., Huang, N., Luo, Y., & Chen, W. (2022). Dauricine alleviated secondary brain injury after intracerebral hemorrhage by upregulating GPX4 expression and inhibiting ferroptosis of nerve cells. European journal of pharmacology, 914174461. https://doi.org/10.1016/j.ejphar.2021.174461
Peng, Chiwei, et al. "Dauricine alleviated secondary brain injury after intracerebral hemorrhage by upregulating GPX4 expression and inhibiting ferroptosis of nerve cells." European journal of pharmacology vol. 914 (2022): 174461. doi: https://doi.org/10.1016/j.ejphar.2021.174461
Peng C, Fu X, Wang K, Chen L, Luo B, Huang N, Luo Y, Chen W. Dauricine alleviated secondary brain injury after intracerebral hemorrhage by upregulating GPX4 expression and inhibiting ferroptosis of nerve cells. Eur J Pharmacol. 2022 Jan 05;914:174461. doi: 10.1016/j.ejphar.2021.174461. Epub 2021 Aug 29. PMID: 34469757.
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Dauricine suppresses the growth of pancreatic cancer .

Oncology letters

Zhang YB, Fei HX, Guo J, Zhang XJ, Wu SL, Zhong LL.
PMID: 31611949
Oncol Lett. 2019 Nov;18(5):4403-4414. doi: 10.3892/ol.2019.10790. Epub 2019 Sep 03.

Pancreatic cancer is a highly malignant cancer associated with high expression levels of sonic hedgehog signaling molecule (Shh), patched 1 (Ptch1), smoothened frizzled class receptor (Smo) and glioma-associated oncogene family zinc finger 1 (Gli1) in the hedgehog (Hh) signaling...

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Zhang YB, Fei HX, Guo J, et al. Dauricine suppresses the growth of pancreatic cancer . Oncol Lett. 2019;18(5):4403-4414doi: 10.3892/ol.2019.10790.
Zhang, Y. B., Fei, H. X., Guo, J., Zhang, X. J., Wu, S. L., & Zhong, L. L. (2019). Dauricine suppresses the growth of pancreatic cancer . Oncology letters, 18(5), 4403-4414. https://doi.org/10.3892/ol.2019.10790
Zhang, Ying-Bo, et al. "Dauricine suppresses the growth of pancreatic cancer ." Oncology letters vol. 18,5 (2019): 4403-4414. doi: https://doi.org/10.3892/ol.2019.10790
Zhang YB, Fei HX, Guo J, Zhang XJ, Wu SL, Zhong LL. Dauricine suppresses the growth of pancreatic cancer . Oncol Lett. 2019 Nov;18(5):4403-4414. doi: 10.3892/ol.2019.10790. Epub 2019 Sep 03. PMID: 31611949; PMCID: PMC6781764.
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Dauricine alleviated secondary brain injury after intracerebral hemorrhage by upregulating GPX4 expression and inhibiting ferroptosis of nerve cells.

European journal of pharmacology

Peng C, Fu X, Wang K, Chen L, Luo B, Huang N, Luo Y, Chen W.
PMID: 34469757
Eur J Pharmacol. 2021 Aug 29;174461. doi: 10.1016/j.ejphar.2021.174461. Epub 2021 Aug 29.

Intracerebral hemorrhage (ICH) is a severe stroke subtype with high disability and mortality, and no effective treatment is available. Previous research on intracerebral hemorrhage secondary brain injury drugs mainly targeted at cell apoptosis, inflammation and oxidative stress, but did...

Cite
Peng C, Fu X, Wang K, et al. Dauricine alleviated secondary brain injury after intracerebral hemorrhage by upregulating GPX4 expression and inhibiting ferroptosis of nerve cells. Eur J Pharmacol. 2021;174461doi: 10.1016/j.ejphar.2021.174461.
Peng, C., Fu, X., Wang, K., Chen, L., Luo, B., Huang, N., Luo, Y., & Chen, W. (2021). Dauricine alleviated secondary brain injury after intracerebral hemorrhage by upregulating GPX4 expression and inhibiting ferroptosis of nerve cells. European journal of pharmacology, 174461. https://doi.org/10.1016/j.ejphar.2021.174461
Peng, Chiwei, et al. "Dauricine alleviated secondary brain injury after intracerebral hemorrhage by upregulating GPX4 expression and inhibiting ferroptosis of nerve cells." European journal of pharmacology vol. (2021): 174461. doi: https://doi.org/10.1016/j.ejphar.2021.174461
Peng C, Fu X, Wang K, Chen L, Luo B, Huang N, Luo Y, Chen W. Dauricine alleviated secondary brain injury after intracerebral hemorrhage by upregulating GPX4 expression and inhibiting ferroptosis of nerve cells. Eur J Pharmacol. 2021 Aug 29;174461. doi: 10.1016/j.ejphar.2021.174461. Epub 2021 Aug 29. PMID: 34469757.
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