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Showing 1 to 5 of 5 entries
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Protein kinase modulators interfere with bud formation in Hydra vulgaris.

Roux's archives of developmental biology : the official organ of the EDBO

Pérez F, Berking S.
PMID: 28305626
Rouxs Arch Dev Biol. 1994 Mar;203(5):284-289. doi: 10.1007/BF00360524.

The fresh water polyp Hydra can reproduce asexually by forming buds. These buds separate from the parent animal due to the development of foot tissue in a belt-like region and the formation of a constriction basal to that region....

Molecular Events as Targets of Anticancer Drug Therapy.

Pathology oncology research : POR

Aszalós A, Eckhardt S.
PMID: 11173644
Pathol Oncol Res. 1997;3(2):147-158. doi: 10.1007/BF02907812.

The aim of this review is to introduce some molecular targets for cancer chemotherapy, with comments on their mode of action, preclinical and clinical results. The representatives of the following groups are covered: phosphorylation inhibitors, protein kinase modulators, receptor...

Natural Compounds and Derivatives as Ser/Thr Protein Kinase Modulators and Inhibitors.

Pharmaceuticals (Basel, Switzerland)

Guerra B, Issinger OG.
PMID: 30609679
Pharmaceuticals (Basel). 2019 Jan 01;12(1). doi: 10.3390/ph12010004.

The need for new drugs is compelling, irrespective of the disease. Focusing on medical problems in the Western countries, heart disease and cancer are at the moment predominant illnesses. Owing to the fact that ~90% of all 21,000 cellular...

Catalytic Direct-type 1,4-Addition Reactions of Alkylazaarenes.

Angewandte Chemie (International ed. in English)

Suzuki H, Igarashi R, Yamashita Y, Kobayashi S.
PMID: 28318086
Angew Chem Int Ed Engl. 2017 Apr 10;56(16):4520-4524. doi: 10.1002/anie.201611374. Epub 2017 Mar 20.

1,4-addition reactions of alkylazaarenes catalyzed by strong Brønsted bases have been developed for the first time. The desired reactions with α,β-unsaturated amides proceeded under mild reaction conditions to give the 1,4-adducts in high yields. Both ortho- and para-substituted azaarenes...

5' Adenosine Monophosphate-Activated Protein Kinase Modulators as Anticancer Agents.

Anti-cancer agents in medicinal chemistry

Thakur A, Dan N, Bhakat S, Jayaprakash V, Banerjee S.
PMID: 26863881
Anticancer Agents Med Chem. 2016;16(8):961-972. doi: 10.2174/1871520616666160211124240.

In spite of tremendous advancement in the field of cancer therapy, it is still one of the leading causes of death worldwide. One of the newest targets in the field of cancer therapeutics is 5'Adenosine Mono Phosphate activated protein...

Showing 1 to 5 of 5 entries