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RasGRP Ras guanine nucleotide exchange factors in cancer.

Frontiers in biology

Ksionda O, Limnander A, Roose JP.
PMID: 24744772
Front Biol (Beijing). 2013 Oct 01;8(5):508-532. doi: 10.1007/s11515-013-1276-9.

RasGRP proteins are activators of Ras and other related small GTPases by the virtue of functioning as guanine nucleotide exchange factors (GEFs). In vertebrates, four RasGRP family members have been described. RasGRP-1 through -4 share many structural domains but...

Regulation of ras exchange factors and cellular localization of ras activation by lipid messengers in T cells.

Frontiers in immunology

Jun JE, Rubio I, Roose JP.
PMID: 24027568
Front Immunol. 2013 Sep 04;4:239. doi: 10.3389/fimmu.2013.00239.

The Ras-MAPK signaling pathway is highly conserved throughout evolution and is activated downstream of a wide range of receptor stimuli. Ras guanine nucleotide exchange factors (RasGEFs) catalyze GTP loading of Ras and play a pivotal role in regulating receptor-ligand...

Showing 1 to 2 of 2 entries