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Histoplasma capsulatum-Induced Cytokine Secretion in Lung Epithelial Cells Is Dependent on Host Integrins, Src-Family Kinase Activation, and Membrane Raft Recruitment.

Frontiers in microbiology

Maza PK, Suzuki E.
PMID: 27148251
Front Microbiol. 2016 Apr 22;7:580. doi: 10.3389/fmicb.2016.00580. eCollection 2016.

Histoplasma capsulatum var. capsulatum is a dimorphic fungus that causes histoplasmosis, a human systemic mycosis with worldwide distribution. In the present work, we demonstrate that H. capsulatum yeasts are able to induce cytokine secretion by the human lung epithelial...

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Maza PK, Suzuki E. Histoplasma capsulatum-Induced Cytokine Secretion in Lung Epithelial Cells Is Dependent on Host Integrins, Src-Family Kinase Activation, and Membrane Raft Recruitment. Front Microbiol. 2016;7:580doi: 10.3389/fmicb.2016.00580.
Maza, P. K., & Suzuki, E. (2016). Histoplasma capsulatum-Induced Cytokine Secretion in Lung Epithelial Cells Is Dependent on Host Integrins, Src-Family Kinase Activation, and Membrane Raft Recruitment. Frontiers in microbiology, 7580. https://doi.org/10.3389/fmicb.2016.00580
Maza, Paloma K, and Suzuki, Erika. "Histoplasma capsulatum-Induced Cytokine Secretion in Lung Epithelial Cells Is Dependent on Host Integrins, Src-Family Kinase Activation, and Membrane Raft Recruitment." Frontiers in microbiology vol. 7 (2016): 580. doi: https://doi.org/10.3389/fmicb.2016.00580
Maza PK, Suzuki E. Histoplasma capsulatum-Induced Cytokine Secretion in Lung Epithelial Cells Is Dependent on Host Integrins, Src-Family Kinase Activation, and Membrane Raft Recruitment. Front Microbiol. 2016 Apr 22;7:580. doi: 10.3389/fmicb.2016.00580. eCollection 2016. PMID: 27148251; PMCID: PMC4840283.
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Excitatory and Mitogenic Signaling in Cell Death, Blood-brain Barrier Breakdown, and BBB Repair after Intracerebral Hemorrhage.

Translational stroke research

Liu DZ, Sharp FR.
PMID: 24323862
Transl Stroke Res. 2012 Jul;3:62-9. doi: 10.1007/s12975-012-0147-z. Epub 2012 Mar 15.

Intracerebral hemorrhage (ICH) results in the release of a large number of endogenous molecules, including glutamate, Ca(2+), ROS, thrombin, heme, iron, TNF-α, and others. These molecules participate in excitatory and mitogenic signaling transduction in which N-methyl-D-aspartate (NMDA) receptors and...

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Liu DZ, Sharp FR. Excitatory and Mitogenic Signaling in Cell Death, Blood-brain Barrier Breakdown, and BBB Repair after Intracerebral Hemorrhage. Transl Stroke Res. 2012;3:62-9doi: 10.1007/s12975-012-0147-z.
Liu, D. Z., & Sharp, F. R. (2012). Excitatory and Mitogenic Signaling in Cell Death, Blood-brain Barrier Breakdown, and BBB Repair after Intracerebral Hemorrhage. Translational stroke research, 362-9. https://doi.org/10.1007/s12975-012-0147-z
Liu, Da-Zhi, and Sharp, Frank R. "Excitatory and Mitogenic Signaling in Cell Death, Blood-brain Barrier Breakdown, and BBB Repair after Intracerebral Hemorrhage." Translational stroke research vol. 3 (2012): 62-9. doi: https://doi.org/10.1007/s12975-012-0147-z
Liu DZ, Sharp FR. Excitatory and Mitogenic Signaling in Cell Death, Blood-brain Barrier Breakdown, and BBB Repair after Intracerebral Hemorrhage. Transl Stroke Res. 2012 Jul;3:62-9. doi: 10.1007/s12975-012-0147-z. Epub 2012 Mar 15. PMID: 24323862.
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Src is required for migration, phagocytosis, and interferon beta production in Toll-like receptor-engaged macrophages.

BioMedicine

Maa MC, Leu TH.
PMID: 27514533
Biomedicine (Taipei). 2016 Jun;6(3):14. doi: 10.7603/s40681-016-0014-4. Epub 2016 Aug 12.

As an evolutionarily conserved mechanism, innate immunity controls self-nonself discrimination to protect a host from invasive pathogens. Macrophages are major participants of the innate immune system. Through the activation of diverse Toll-like receptors (TLRs), macrophages are triggered to initiate...

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Maa MC, Leu TH. Src is required for migration, phagocytosis, and interferon beta production in Toll-like receptor-engaged macrophages. Biomedicine (Taipei). 2016;6(3):14doi: 10.7603/s40681-016-0014-4.
Maa, M. C., & Leu, T. H. (2016). Src is required for migration, phagocytosis, and interferon beta production in Toll-like receptor-engaged macrophages. BioMedicine, 6(3), 14. https://doi.org/10.7603/s40681-016-0014-4
Maa, Ming-Chei, and Leu, Tzeng-Horng. "Src is required for migration, phagocytosis, and interferon beta production in Toll-like receptor-engaged macrophages." BioMedicine vol. 6,3 (2016): 14. doi: https://doi.org/10.7603/s40681-016-0014-4
Maa MC, Leu TH. Src is required for migration, phagocytosis, and interferon beta production in Toll-like receptor-engaged macrophages. Biomedicine (Taipei). 2016 Jun;6(3):14. doi: 10.7603/s40681-016-0014-4. Epub 2016 Aug 12. PMID: 27514533; PMCID: PMC4980824.
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Odin (ANKS1A) is a Src family kinase target in colorectal cancer cells.

Cell communication and signaling : CCS

Emaduddin M, Edelmann MJ, Kessler BM, Feller SM.
PMID: 18844995
Cell Commun Signal. 2008 Oct 09;6:7. doi: 10.1186/1478-811X-6-7.

BACKGROUND: Src family kinases (SFK) are implicated in the development of some colorectal cancers (CRC). One SFK member, Lck, is not detectable in normal colonic epithelium, but becomes aberrantly expressed in a subset of CRCs. Although SFK have been...

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Emaduddin M, Edelmann MJ, Kessler BM, et al. Odin (ANKS1A) is a Src family kinase target in colorectal cancer cells. Cell Commun Signal. 2008;6:7doi: 10.1186/1478-811X-6-7.
Emaduddin, M., Edelmann, M. J., Kessler, B. M., & Feller, S. M. (2008). Odin (ANKS1A) is a Src family kinase target in colorectal cancer cells. Cell communication and signaling : CCS, 67. https://doi.org/10.1186/1478-811X-6-7
Emaduddin, Muhammad, et al. "Odin (ANKS1A) is a Src family kinase target in colorectal cancer cells." Cell communication and signaling : CCS vol. 6 (2008): 7. doi: https://doi.org/10.1186/1478-811X-6-7
Emaduddin M, Edelmann MJ, Kessler BM, Feller SM. Odin (ANKS1A) is a Src family kinase target in colorectal cancer cells. Cell Commun Signal. 2008 Oct 09;6:7. doi: 10.1186/1478-811X-6-7. PMID: 18844995; PMCID: PMC2584000.
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Reelin acts as a stop signal for radially migrating neurons by inducing phosphorylation of n-cofilin at the leading edge.

Communicative & integrative biology

Chai X, Förster E, Zhao S, Bock HH, Frotscher M.
PMID: 19721896
Commun Integr Biol. 2009 Jul;2(4):375-7. doi: 10.4161/cib.2.4.8614.

The extracellular matrix protein Reelin, secreted by Cajal-Retzius (CR) cells in the marginal zone (MZ) of the cerebral cortex, is important for neuronal migration during development. Two lipoprotein receptors for Reelin have been identified, apolipoprotein E receptor 2 (ApoER2)...

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Chai X, Förster E, Zhao S, et al. Reelin acts as a stop signal for radially migrating neurons by inducing phosphorylation of n-cofilin at the leading edge. Commun Integr Biol. 2009;2(4):375-7doi: 10.4161/cib.2.4.8614.
Chai, X., Förster, E., Zhao, S., Bock, H. H., & Frotscher, M. (2009). Reelin acts as a stop signal for radially migrating neurons by inducing phosphorylation of n-cofilin at the leading edge. Communicative & integrative biology, 2(4), 375-7. https://doi.org/10.4161/cib.2.4.8614
Chai, Xuejun, et al. "Reelin acts as a stop signal for radially migrating neurons by inducing phosphorylation of n-cofilin at the leading edge." Communicative & integrative biology vol. 2,4 (2009): 375-7. doi: https://doi.org/10.4161/cib.2.4.8614
Chai X, Förster E, Zhao S, Bock HH, Frotscher M. Reelin acts as a stop signal for radially migrating neurons by inducing phosphorylation of n-cofilin at the leading edge. Commun Integr Biol. 2009 Jul;2(4):375-7. doi: 10.4161/cib.2.4.8614. PMID: 19721896; PMCID: PMC2734053.
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Dasatinib Inhibits DNA Repair after Radiotherapy Specifically in pSFK-Expressing Tumor Areas in Head and Neck Xenograft Tumors.

Translational oncology

Stegeman H, Span PN, Rijken PF, Cockx SC, Wheeler DL, Iida M, van der Kogel AJ, Kaanders JH, Bussink J.
PMID: 23908684
Transl Oncol. 2013 Aug 01;6(4):413-9. doi: 10.1593/tlo.13259. Print 2013 Aug.

Src family kinases (SFKs) have been implicated in resistance to both radiation and epidermal growth factor receptor (EGFR) inhibition. Therefore, we investigated whether inhibition of SFK through dasatinib (DSB) can enhance the effect of radiotherapy in two in vivo...

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Stegeman H, Span PN, Rijken PF, et al. Dasatinib Inhibits DNA Repair after Radiotherapy Specifically in pSFK-Expressing Tumor Areas in Head and Neck Xenograft Tumors. Transl Oncol. 2013;6(4):413-9doi: 10.1593/tlo.13259.
Stegeman, H., Span, P. N., Rijken, P. F., Cockx, S. C., Wheeler, D. L., Iida, M., van der Kogel, A. J., Kaanders, J. H., & Bussink, J. (2013). Dasatinib Inhibits DNA Repair after Radiotherapy Specifically in pSFK-Expressing Tumor Areas in Head and Neck Xenograft Tumors. Translational oncology, 6(4), 413-9. https://doi.org/10.1593/tlo.13259
Stegeman, Hanneke, et al. "Dasatinib Inhibits DNA Repair after Radiotherapy Specifically in pSFK-Expressing Tumor Areas in Head and Neck Xenograft Tumors." Translational oncology vol. 6,4 (2013): 413-9. doi: https://doi.org/10.1593/tlo.13259
Stegeman H, Span PN, Rijken PF, Cockx SC, Wheeler DL, Iida M, van der Kogel AJ, Kaanders JH, Bussink J. Dasatinib Inhibits DNA Repair after Radiotherapy Specifically in pSFK-Expressing Tumor Areas in Head and Neck Xenograft Tumors. Transl Oncol. 2013 Aug 01;6(4):413-9. doi: 10.1593/tlo.13259. Print 2013 Aug. PMID: 23908684; PMCID: PMC3730016.
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The family infighting continues: dualling SRC family kinases now linked to activating IgG receptor signaling and anaphylaxis.

Frontiers in immunology

Craig AW.
PMID: 22685445
Front Immunol. 2012 Jun 06;3:137. doi: 10.3389/fimmu.2012.00137. eCollection 2012.

No abstract available.

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Craig AW. The family infighting continues: dualling SRC family kinases now linked to activating IgG receptor signaling and anaphylaxis. Front Immunol. 2012;3:137doi: 10.3389/fimmu.2012.00137.
Craig, A. W. (2012). The family infighting continues: dualling SRC family kinases now linked to activating IgG receptor signaling and anaphylaxis. Frontiers in immunology, 3137. https://doi.org/10.3389/fimmu.2012.00137
Craig, Andrew W B. "The family infighting continues: dualling SRC family kinases now linked to activating IgG receptor signaling and anaphylaxis." Frontiers in immunology vol. 3 (2012): 137. doi: https://doi.org/10.3389/fimmu.2012.00137
Craig AW. The family infighting continues: dualling SRC family kinases now linked to activating IgG receptor signaling and anaphylaxis. Front Immunol. 2012 Jun 06;3:137. doi: 10.3389/fimmu.2012.00137. eCollection 2012. PMID: 22685445; PMCID: PMC3368209.
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PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells.

Cell communication and signaling : CCS

Smida M, Cammann C, Gurbiel S, Kerstin N, Lingel H, Lindquist S, Simeoni L, Brunner-Weinzierl MC, Suchanek M, Schraven B, Lindquist JA.
PMID: 23601194
Cell Commun Signal. 2013 Apr 19;11(1):28. doi: 10.1186/1478-811X-11-28.

BACKGROUND: PAG/Cbp represents a ubiquitous mechanism for regulating Src family kinases by recruiting Csk to the plasma membrane, thereby controlling cellular activation. Since Src kinases are known oncogenes, we used RNA interference in primary human T cells to test...

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Smida M, Cammann C, Gurbiel S, et al. PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells. Cell Commun Signal. 2013;11(1):28doi: 10.1186/1478-811X-11-28.
Smida, M., Cammann, C., Gurbiel, S., Kerstin, N., Lingel, H., Lindquist, S., Simeoni, L., Brunner-Weinzierl, M. C., Suchanek, M., Schraven, B., & Lindquist, J. A. (2013). PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells. Cell communication and signaling : CCS, 11(1), 28. https://doi.org/10.1186/1478-811X-11-28
Smida, Michal, et al. "PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells." Cell communication and signaling : CCS vol. 11,1 (2013): 28. doi: https://doi.org/10.1186/1478-811X-11-28
Smida M, Cammann C, Gurbiel S, Kerstin N, Lingel H, Lindquist S, Simeoni L, Brunner-Weinzierl MC, Suchanek M, Schraven B, Lindquist JA. PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells. Cell Commun Signal. 2013 Apr 19;11(1):28. doi: 10.1186/1478-811X-11-28. PMID: 23601194; PMCID: PMC3763844.
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The activation of SRC family kinases and focal adhesion kinase with the loss of the amplified, mutated .

Oncotarget

Murakami Y, Sonoda K, Abe H, Watari K, Kusakabe D, Azuma K, Kawahara A, Akiba J, Oneyama C, Pachter JA, Sakai K, Nishio K, Kuwano M, Ono M.
PMID: 29050315
Oncotarget. 2017 Aug 07;8(41):70736-70751. doi: 10.18632/oncotarget.19982. eCollection 2017 Sep 19.

Second- and third-generation inhibitors of epidermal growth factor receptor (EGFR) tyrosine kinase activity (EGFR-TKIs) are improving the treatment of patients with non-small cell lung cancer. Here we established two sublines (BR1-8 and BR2-3) resistant to a second-generation inhibitor, afatinib,...

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Murakami Y, Sonoda K, Abe H, et al. The activation of SRC family kinases and focal adhesion kinase with the loss of the amplified, mutated . Oncotarget. 2017;8(41):70736-70751doi: 10.18632/oncotarget.19982.
Murakami, Y., Sonoda, K., Abe, H., Watari, K., Kusakabe, D., Azuma, K., Kawahara, A., Akiba, J., Oneyama, C., Pachter, J. A., Sakai, K., Nishio, K., Kuwano, M., & Ono, M. (2017). The activation of SRC family kinases and focal adhesion kinase with the loss of the amplified, mutated . Oncotarget, 8(41), 70736-70751. https://doi.org/10.18632/oncotarget.19982
Murakami, Yuichi, et al. "The activation of SRC family kinases and focal adhesion kinase with the loss of the amplified, mutated ." Oncotarget vol. 8,41 (2017): 70736-70751. doi: https://doi.org/10.18632/oncotarget.19982
Murakami Y, Sonoda K, Abe H, Watari K, Kusakabe D, Azuma K, Kawahara A, Akiba J, Oneyama C, Pachter JA, Sakai K, Nishio K, Kuwano M, Ono M. The activation of SRC family kinases and focal adhesion kinase with the loss of the amplified, mutated . Oncotarget. 2017 Aug 07;8(41):70736-70751. doi: 10.18632/oncotarget.19982. eCollection 2017 Sep 19. PMID: 29050315; PMCID: PMC5642590.
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The SRC Inhibitor Dasatinib Induces Stem Cell-Like Properties in Head and Neck Cancer Cells that are Effectively Counteracted by the Mithralog EC-8042.

Journal of clinical medicine

Hermida-Prado F, Villaronga MÁ, Granda-Díaz R, Del-Río-Ibisate N, Santos L, Hermosilla MA, Oro P, Allonca E, Agorreta J, Garmendia I, Tornín J, Perez-Escuredo J, Fuente R, Montuenga LM, Morís F, Rodrigo JP, Rodríguez R, García-Pedrero JM.
PMID: 31382448
J Clin Med. 2019 Aug 02;8(8). doi: 10.3390/jcm8081157.

The frequent dysregulation of SRC family kinases (SFK) in multiple cancers prompted various inhibitors to be actively tested in preclinical and clinical trials. Disappointingly, dasatinib and saracatinib failed to demonstrate monotherapeutic efficacy in patients with head and neck squamous...

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Hermida-Prado F, Villaronga MÁ, Granda-Díaz R, et al. The SRC Inhibitor Dasatinib Induces Stem Cell-Like Properties in Head and Neck Cancer Cells that are Effectively Counteracted by the Mithralog EC-8042. J Clin Med. 2019;8(8)doi: 10.3390/jcm8081157.
Hermida-Prado, F., Villaronga, M. �. �., Granda-Díaz, R., Del-Río-Ibisate, N., Santos, L., Hermosilla, M. A., Oro, P., Allonca, E., Agorreta, J., Garmendia, I., Tornín, J., Perez-Escuredo, J., Fuente, R., Montuenga, L. M., Morís, F., Rodrigo, J. P., Rodríguez, R., & García-Pedrero, J. M. (2019). The SRC Inhibitor Dasatinib Induces Stem Cell-Like Properties in Head and Neck Cancer Cells that are Effectively Counteracted by the Mithralog EC-8042. Journal of clinical medicine, 8(8), . https://doi.org/10.3390/jcm8081157
Hermida-Prado, Francisco, et al. "The SRC Inhibitor Dasatinib Induces Stem Cell-Like Properties in Head and Neck Cancer Cells that are Effectively Counteracted by the Mithralog EC-8042." Journal of clinical medicine vol. 8,8 (2019). doi: https://doi.org/10.3390/jcm8081157
Hermida-Prado F, Villaronga MÁ, Granda-Díaz R, Del-Río-Ibisate N, Santos L, Hermosilla MA, Oro P, Allonca E, Agorreta J, Garmendia I, Tornín J, Perez-Escuredo J, Fuente R, Montuenga LM, Morís F, Rodrigo JP, Rodríguez R, García-Pedrero JM. The SRC Inhibitor Dasatinib Induces Stem Cell-Like Properties in Head and Neck Cancer Cells that are Effectively Counteracted by the Mithralog EC-8042. J Clin Med. 2019 Aug 02;8(8). doi: 10.3390/jcm8081157. PMID: 31382448; PMCID: PMC6722627.
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Homophilic complex formation of CDCP1 via the extracellular CUB2 domain facilitates SFK activation and promotes cancer cell migration.

Oncology reports

Sawayama T, Nakashima K, Ichimura T, Sakai R, Uekita T.
PMID: 31524271
Oncol Rep. 2019 Oct;42(4):1507-1516. doi: 10.3892/or.2019.7271. Epub 2019 Aug 08.

CUB domain‑containing protein 1 (CDCP1) is phosphorylated by Src family kinases (SFK), and is thought to serve an important role in tumor metastasis through downstream signaling subsequent to its interaction with protein kinase C δ. The present study investigated...

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Sawayama T, Nakashima K, Ichimura T, et al. Homophilic complex formation of CDCP1 via the extracellular CUB2 domain facilitates SFK activation and promotes cancer cell migration. Oncol Rep. 2019;42(4):1507-1516doi: 10.3892/or.2019.7271.
Sawayama, T., Nakashima, K., Ichimura, T., Sakai, R., & Uekita, T. (2019). Homophilic complex formation of CDCP1 via the extracellular CUB2 domain facilitates SFK activation and promotes cancer cell migration. Oncology reports, 42(4), 1507-1516. https://doi.org/10.3892/or.2019.7271
Sawayama, Tadashi, et al. "Homophilic complex formation of CDCP1 via the extracellular CUB2 domain facilitates SFK activation and promotes cancer cell migration." Oncology reports vol. 42,4 (2019): 1507-1516. doi: https://doi.org/10.3892/or.2019.7271
Sawayama T, Nakashima K, Ichimura T, Sakai R, Uekita T. Homophilic complex formation of CDCP1 via the extracellular CUB2 domain facilitates SFK activation and promotes cancer cell migration. Oncol Rep. 2019 Oct;42(4):1507-1516. doi: 10.3892/or.2019.7271. Epub 2019 Aug 08. PMID: 31524271.
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Targeting SRC Family Kinases in Mesothelioma: Time to Upgrade.

Cancers

Indovina P, Forte IM, Pentimalli F, Giordano A.
PMID: 32664483
Cancers (Basel). 2020 Jul 11;12(7). doi: 10.3390/cancers12071866.

No abstract available.

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Indovina P, Forte IM, Pentimalli F, et al. Targeting SRC Family Kinases in Mesothelioma: Time to Upgrade. Cancers (Basel). 2020;12(7)doi: 10.3390/cancers12071866.
Indovina, P., Forte, I. M., Pentimalli, F., & Giordano, A. (2020). Targeting SRC Family Kinases in Mesothelioma: Time to Upgrade. Cancers, 12(7), . https://doi.org/10.3390/cancers12071866
Indovina, Paola, et al. "Targeting SRC Family Kinases in Mesothelioma: Time to Upgrade." Cancers vol. 12,7 (2020). doi: https://doi.org/10.3390/cancers12071866
Indovina P, Forte IM, Pentimalli F, Giordano A. Targeting SRC Family Kinases in Mesothelioma: Time to Upgrade. Cancers (Basel). 2020 Jul 11;12(7). doi: 10.3390/cancers12071866. PMID: 32664483; PMCID: PMC7408838.
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Showing 1 to 12 of 144 entries