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Showing 1 to 12 of 14 entries
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Mechanisms of resistance to piperacillin of Enterobacter cloacae strains differ by antibiotic prescription policy.

International journal of antimicrobial agents

Namavar F, Verboom T, van de Klundert JA, van Gestel MH, Zaal J, Maclarena DM.
PMID: 18611803
Int J Antimicrob Agents. 1997;8(3):205-8. doi: 10.1016/s0924-8579(97)00377-4.

During a study of piperacillin resistance among aerobic Gram-negative bacteria, 18 resistant strains of Enterobacter cloacae were obtained from a General Hospital in Rotterdam and 13 from a University Hospital in Amsterdam. The patterns of antibiotic susceptibilities were different:...

In vitro activities of two drug combinations of ceftazidime, cefotaxime, cefuroxime, ciprofloxacin, chloramphenicol, imipenem and temocillin against clinical isolates of Pseudomonas cepacia from patients with cystic fibrosis.

International journal of antimicrobial agents

Kerr JR.
PMID: 18611561
Int J Antimicrob Agents. 1993;3(3):205-9. doi: 10.1016/0924-8579(93)90013-u.

This study utilised the killing curve method to determine the in vitro effects of all possible two drug combinations of ceftazidine, cefotaxime, cefuroxime, ciprofloxacin, chloramphenicol, imipenem and temocillin against 10 strains of Pseudomonas cepacia isolated from the sputa of...

An Update on Eight "New" Antibiotics against Multidrug-Resistant Gram-Negative Bacteria.

Journal of clinical medicine

Yusuf E, Bax HI, Verkaik NJ, van Westreenen M.
PMID: 33806604
J Clin Med. 2021 Mar 04;10(5). doi: 10.3390/jcm10051068.

Infections in the ICU are often caused by Gram-negative bacteria. When these microorganisms are resistant to third-generation cephalosporines (due to extended-spectrum (ESBL) or AmpC beta-lactamases) or to carbapenems (for example carbapenem producing Enterobacteriales (CPE)), the treatment options become limited....

CON: Carbapenems are NOT necessary for all infections caused by ceftriaxone-resistant Enterobacterales.

JAC-antimicrobial resistance

Rodríguez-Baño J, Gutiérrez-Gutiérrez B, Pascual A.
PMID: 34223064
JAC Antimicrob Resist. 2021 Feb 24;3(1):dlaa112. doi: 10.1093/jacamr/dlaa112. eCollection 2021 Mar.

Carbapenems are considered the drugs of choice for the treatment of serious infections caused by ceftriaxone-resistant Enterobacterales. However, because of the dramatic increase in carbapenem-resistant organisms worldwide, finding alternatives to carbapenems is a must. The potential options include β-lactam/β-lactamase...

Activity of temocillin against third-generation cephalosporin-resistant .

JAC-antimicrobial resistance

Stewart AG, Henderson A, Bauer MJ, Paterson DL, Harris PNA.
PMID: 34988445
JAC Antimicrob Resist. 2021 Dec 28;4(1):dlab192. doi: 10.1093/jacamr/dlab192. eCollection 2022 Mar.

BACKGROUND: Extended spectrum β-lactamase (ESBL) and AmpC-producing Gram-negative bacilli contribute significantly to the antimicrobial resistance (AMR) burden worldwide. Temocillin is an intravenous semisynthetic antibiotic that is stable to hydrolysis by ESBLs and AmpC. Temocillin may be a treatment option...

Clinical outcomes of temocillin use for invasive Enterobacterales infections: a single-centre retrospective analysis.

JAC-antimicrobial resistance

Heard KL, Killington K, Mughal N, Moore LSP, Hughes S.
PMID: 34223083
JAC Antimicrob Resist. 2021 Feb 14;3(1):dlab005. doi: 10.1093/jacamr/dlab005. eCollection 2021 Mar.

BACKGROUND: With increasing frequency of resistant Gram-negative bacteria, temocillin has potential utility in reducing carbapenem use. The 2020 EUCAST guideline changes temocillin breakpoints and reclassifies isolates with an MIC of 0.001-16 mg/L as 'susceptible, increased exposure' necessitating 6 g/day...

The penicillins.

Mayo Clinic proceedings

Wright AJ, Wilkowske CJ.
PMID: 1921489
Mayo Clin Proc. 1991 Oct;66(10):1047-63. doi: 10.1016/s0025-6196(12)61730-3.

The penicillin family of antibiotics remains an important part of our antimicrobial armamentarium. In general, these agents have bactericidal activity, excellent distribution throughout the body, low toxicity, and efficacy against infections caused by susceptible bacteria. The initial introduction of...

Evaluation of Combined Use of Temocillin Disk and Mastdisks Inhibitor Combination Set Against Polymerase Chain Reaction for Detection of Carbapenem-Resistant .

Open access Macedonian journal of medical sciences

Shaker OA, Gomaa HE, ElMasry SA, Halim RMA, Abdelrahman AH, Kamal JS.
PMID: 29531581
Open Access Maced J Med Sci. 2018 Feb 01;6(2):242-247. doi: 10.3889/oamjms.2018.090. eCollection 2018 Feb 15.

AIM: To evaluate the diagnostic performance of MDI and temocillin disk (30 μg) for detection of carbapenem-resistant MATERIAL AND METHODS: Fifty specimens submitted to the Microbiology Laboratory of Ain Shams University Hospitals and showed resistance to carbapenem drugs through...

Insights into Newer Antimicrobial Agents Against Gram-negative Bacteria.

Microbiology insights

Taneja N, Kaur H.
PMID: 27013887
Microbiol Insights. 2016 Mar 20;9:9-19. doi: 10.4137/MBI.S29459. eCollection 2016.

Currently, drug resistance, especially against cephalosporins and carbapenems, among gram-negative bacteria is an important challenge, which is further enhanced by the limited availability of drugs against these bugs. There are certain antibiotics (colistin, fosfomycin, temocillin, and rifampicin) that have...

Carbapenem-Sparing Strategies for ESBL Producers: When and How.

Antibiotics (Basel, Switzerland)

Karaiskos I, Giamarellou H.
PMID: 32033322
Antibiotics (Basel). 2020 Feb 05;9(2). doi: 10.3390/antibiotics9020061.

Extended spectrum β-lactamase (ESBL)-producing bacteria are prevalent worldwide and correlated with hospital infections, but they have been evolving as an increasing cause of community acquired infections. The spread of ESBL constitutes a major threat for public health, and infections...

Successful Use of Temocillin as Salvage Therapy for Cervical Osteomyelitis Secondary to Multidrug-Resistant Burkholderia cepacia.

Journal of the Pediatric Infectious Diseases Society

Rodriguez M, Nelson M, Kelly JE, Elward A, Morley SC.
PMID: 26624908
J Pediatric Infect Dis Soc. 2014 Mar;3(1):77-80. doi: 10.1093/jpids/pis110. Epub 2013 Jan 08.

Infection with multidrug resistant Burkholderia cepacia presents a therapeutic challenge in patients with cystic fibrosis. In this study, we present a case of progressive cervical osteomyelitis secondary to B cepacia that failed surgical drainage and extended therapy with meropenem,...

Intravenous colistin in the treatment of multidrug-resistant gram-negative organism in tertiary hospital, Jazan, KSA.

Journal of family medicine and primary care

Ali EM, Albarraq AA, Makeen HA, Ezzi A, Mashragi YAM.
PMID: 34017749
J Family Med Prim Care. 2021 Jan;10(1):333-338. doi: 10.4103/jfmpc.jfmpc_1148_20. Epub 2021 Jan 30.

BACKGROUND: It was considered that the resistance of drugs such as carbapenems and cephalosporins against severe or high risk gram-negative bacteria became a tremendous confront. This might be attributed to the little amount of these drugs to be used...

Showing 1 to 12 of 14 entries