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Heard KL, Killington K, Mughal N, et al. Clinical outcomes of temocillin use for invasive Enterobacterales infections: a single-centre retrospective analysis. JAC Antimicrob Resist. 2021;3(1):dlab005doi: 10.1093/jacamr/dlab005.
Heard, K. L., Killington, K., Mughal, N., Moore, L. S. P., & Hughes, S. (2021). Clinical outcomes of temocillin use for invasive Enterobacterales infections: a single-centre retrospective analysis. JAC-antimicrobial resistance, 3(1), dlab005. https://doi.org/10.1093/jacamr/dlab005
Heard, Katie L, et al. "Clinical outcomes of temocillin use for invasive Enterobacterales infections: a single-centre retrospective analysis." JAC-antimicrobial resistance vol. 3,1 (2021): dlab005. doi: https://doi.org/10.1093/jacamr/dlab005
Heard KL, Killington K, Mughal N, Moore LSP, Hughes S. Clinical outcomes of temocillin use for invasive Enterobacterales infections: a single-centre retrospective analysis. JAC Antimicrob Resist. 2021 Feb 14;3(1):dlab005. doi: 10.1093/jacamr/dlab005. eCollection 2021 Mar. PMID: 34223083; PMCID: PMC8210019.
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JAC Antimicrob Resist. 2021 Feb 14;3(1):dlab005. doi: 10.1093/jacamr/dlab005. eCollection 2021 Mar.

Clinical outcomes of temocillin use for invasive Enterobacterales infections: a single-centre retrospective analysis.

JAC-antimicrobial resistance

Katie L Heard, Kieran Killington, Nabeela Mughal, Luke S P Moore, Stephen Hughes

Affiliations

  1. Chelsea and Westminster NHS Foundation Trust, 369 Fulham Road, London SW10 9NH, UK.
  2. North West London Pathology, Imperial College Healthcare NHS Trust, Fulham Palace Road. London W6 8RF, UK.
  3. National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK.

PMID: 34223083 PMCID: PMC8210019 DOI: 10.1093/jacamr/dlab005

Abstract

BACKGROUND: With increasing frequency of resistant Gram-negative bacteria, temocillin has potential utility in reducing carbapenem use. The 2020 EUCAST guideline changes temocillin breakpoints and reclassifies isolates with an MIC of 0.001-16 mg/L as 'susceptible, increased exposure' necessitating 6 g/day rather than the previous 4 g/day, associated with significant cost implications.

OBJECTIVES: We explore the clinical utility and treatment failure rate of temocillin at 4 g/day dosing.

METHODS: All adult inpatient electronic prescriptions of temocillin (3 days or greater) from March 2016 to October 2019 were retrieved using a clinical decision support system (ICNET

RESULTS: Temocillin was used in 205 eligible patient-episodes, median age 79 years (IQR : 71-87 years), 42.4% female. Median temocillin course length was 5.9 days (IQR : 4.6-7.8 days). Indications for use: urinary tract infection (UTI) (

CONCLUSIONS: Temocillin at 4 g/day is an effective and safe alternative in treating patients with Gram-negative infections, but should be considered in the context of patient age and comorbidities. Increased dosing or alternate strategies may be indicated when the infection is not of a urinary source.

© The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy.

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