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Homotypic CARD-CARD interaction is critical for the activation of NLRP1 inflammasome.

Cell death & disease

Xu Z, Zhou Y, Liu M, Ma H, Sun L, Zahid A, Chen Y, Zhou R, Cao M, Wu D, Zhao W, Li B, Jin T.
PMID: 33431827
Cell Death Dis. 2021 Jan 11;12(1):57. doi: 10.1038/s41419-020-03342-8.

Cytosolic inflammasomes are supramolecular complexes that are formed in response to intracellular pathogens and danger signals. However, as to date, the detailed description of a homotypic caspase recruitment domain (CARD) interaction between NLRP1 and ASC has not been presented....

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