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Xu Z, Zhou Y, Liu M, et al. Homotypic CARD-CARD interaction is critical for the activation of NLRP1 inflammasome. Cell Death Dis. 2021;12(1):57doi: 10.1038/s41419-020-03342-8.
Xu, Z., Zhou, Y., Liu, M., Ma, H., Sun, L., Zahid, A., Chen, Y., Zhou, R., Cao, M., Wu, D., Zhao, W., Li, B., & Jin, T. (2021). Homotypic CARD-CARD interaction is critical for the activation of NLRP1 inflammasome. Cell death & disease, 12(1), 57. https://doi.org/10.1038/s41419-020-03342-8
Xu, Zhihao, et al. "Homotypic CARD-CARD interaction is critical for the activation of NLRP1 inflammasome." Cell death & disease vol. 12,1 (2021): 57. doi: https://doi.org/10.1038/s41419-020-03342-8
Xu Z, Zhou Y, Liu M, Ma H, Sun L, Zahid A, Chen Y, Zhou R, Cao M, Wu D, Zhao W, Li B, Jin T. Homotypic CARD-CARD interaction is critical for the activation of NLRP1 inflammasome. Cell Death Dis. 2021 Jan 11;12(1):57. doi: 10.1038/s41419-020-03342-8. PMID: 33431827; PMCID: PMC7801473.
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Cell Death Dis. 2021 Jan 11;12(1):57. doi: 10.1038/s41419-020-03342-8.

Homotypic CARD-CARD interaction is critical for the activation of NLRP1 inflammasome.

Cell death & disease

Zhihao Xu, Ying Zhou, Muziying Liu, Huan Ma, Liangqi Sun, Ayesha Zahid, Yulei Chen, Rongbin Zhou, Minjie Cao, Dabao Wu, Weidong Zhao, Bofeng Li, Tengchuan Jin

Affiliations

  1. Department of Obstetrics and Gynecology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China.
  2. Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medicine Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230027, China.
  3. College of Food and Biological Engineering, Jimei University, Xiamen, Fujian, 361021, China.
  4. CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Science, Shanghai, 200031, China.
  5. Department of Medical Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China, 230001. [email protected].
  6. Department of Obstetrics and Gynecology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China. [email protected].
  7. Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medicine Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230027, China. [email protected].
  8. CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Science, Shanghai, 200031, China. [email protected].

PMID: 33431827 PMCID: PMC7801473 DOI: 10.1038/s41419-020-03342-8

Abstract

Cytosolic inflammasomes are supramolecular complexes that are formed in response to intracellular pathogens and danger signals. However, as to date, the detailed description of a homotypic caspase recruitment domain (CARD) interaction between NLRP1 and ASC has not been presented. We found the CARD-CARD interaction between purified NLRP1

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