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Showing 1 to 12 of 689 entries
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Guest editorial. Computational systems biology.

IET systems biology

Chen L.
PMID: 24067411
IET Syst Biol. 2013 Oct;7(5):125. doi: 10.1049/iet-syb.2013.0019.

No abstract available.

SNPTransformer: a lightweight toolkit for genome-wide association studies.

Genomics, proteomics & bioinformatics

Dong C.
PMID: 21382596
Genomics Proteomics Bioinformatics. 2010 Dec;8(4):268-73. doi: 10.1016/S1672-0229(10)60029-0.

High-throughput genotyping chips have produced huge datasets for genome-wide association studies (GWAS) that have contributed greatly to discovering susceptibility genes for complex diseases. There are two strategies for performing data analysis for GWAS. One strategy is to use open-source...

[Bioinformatics and Next -generation Sequencing].

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti

Krejčí A, Müller P, Vojtěšek B.
PMID: 26374164
Klin Onkol. 2015;28:2S91-6. doi: 10.14735/amko20152s91.

Next-generation sequencing technologies are currently well-established in the research field and progressively find their way towards clinical applications. Sequencers produce vast amounts of data and therefore bioinformatics methods are needed for processing. Without computational methods, sequencing would not be...

An Agile Functional Analysis of Metagenomic Data Using SUPER-FOCUS.

Methods in molecular biology (Clifton, N.J.)

Silva GGZ, Lopes FAC, Edwards RA.
PMID: 28451970
Methods Mol Biol. 2017;1611:35-44. doi: 10.1007/978-1-4939-7015-5_4.

One of the main goals in metagenomics is to identify the functional profile of a microbial community from unannotated shotgun sequencing reads. Functional annotation is important in biological research because it enables researchers to identify the abundance of functional...

Enzyme Annotation and Metabolic Reconstruction Using KEGG.

Methods in molecular biology (Clifton, N.J.)

Kanehisa M.
PMID: 28451977
Methods Mol Biol. 2017;1611:135-145. doi: 10.1007/978-1-4939-7015-5_11.

KEGG is an integrated database resource for linking sequences to biological functions from molecular to higher levels. Knowledge on molecular functions is stored in the KO (KEGG Orthology) database, while cellular- and organism-level functions are represented in the PATHWAY...

SSER: Species specific essential reactions database.

BMC systems biology

Labena AA, Ye YN, Dong C, Zhang FZ, Guo FB.
PMID: 28420402
BMC Syst Biol. 2017 Apr 19;11(1):50. doi: 10.1186/s12918-017-0426-0.

BACKGROUND: Essential reactions are vital components of cellular networks. They are the foundations of synthetic biology and are potential candidate targets for antimetabolic drug design. Especially if a single reaction is catalyzed by multiple enzymes, then inhibiting the reaction...

DistributedFBA.jl: high-level, high-performance flux balance analysis in Julia.

Bioinformatics (Oxford, England)

Heirendt L, Thiele I, Fleming RMT.
PMID: 28453682
Bioinformatics. 2017 May 01;33(9):1421-1423. doi: 10.1093/bioinformatics/btw838.

MOTIVATION: Flux balance analysis and its variants are widely used methods for predicting steady-state reaction rates in biochemical reaction networks. The exploration of high dimensional networks with such methods is currently hampered by software performance limitations.RESULTS: DistributedFBA.jl is a...

A heuristic approach to determine an appropriate number of topics in topic modeling.

BMC bioinformatics

Zhao W, Chen JJ, Perkins R, Liu Z, Ge W, Ding Y, Zou W.
PMID: 26424364
BMC Bioinformatics. 2015;16:S8. doi: 10.1186/1471-2105-16-S13-S8. Epub 2015 Sep 25.

BACKGROUND: Topic modelling is an active research field in machine learning. While mainly used to build models from unstructured textual data, it offers an effective means of data mining where samples represent documents, and different biological endpoints or omics...

tmBioC: improving interoperability of text-mining tools with BioC.

Database : the journal of biological databases and curation

Khare R, Wei CH, Mao Y, Leaman R, Lu Z.
PMID: 25062914
Database (Oxford). 2014 Jul 25;2014. doi: 10.1093/database/bau073. Print 2014.

The lack of interoperability among biomedical text-mining tools is a major bottleneck in creating more complex applications. Despite the availability of numerous methods and techniques for various text-mining tasks, combining different tools requires substantial efforts and time owing to...

Current Progress in Bioinformatics 2016.

Briefings in bioinformatics

Altman R.
PMID: 26628559
Brief Bioinform. 2016 Jan;17(1):1. doi: 10.1093/bib/bbv105. Epub 2015 Nov 30.

No abstract available.

mORCA: sailing bioinformatics world with mobile devices.

Bioinformatics (Oxford, England)

Díaz-Del-Pino S, Falgueras J, Perez-Wohlfeil E, Trelles O.
PMID: 29069310
Bioinformatics. 2018 Mar 01;34(5):869-870. doi: 10.1093/bioinformatics/btx673.

MOTIVATION: Nearly 10 years have passed since the first mobile apps appeared. Given the fact that bioinformatics is a web-based world and that mobile devices are endowed with web-browsers, it seemed natural that bioinformatics would transit from personal computers...

Computational approaches for systems metabolomics.

Current opinion in biotechnology

Krumsiek J, Bartel J, Theis FJ.
PMID: 27135552
Curr Opin Biotechnol. 2016 Jun;39:198-206. doi: 10.1016/j.copbio.2016.04.009. Epub 2016 Apr 30.

Systems genetics is defined as the simultaneous assessment and analysis of multi-omics datasets. In the past few years, metabolomics has been established as a robust tool describing an important functional layer in this approach. The metabolome of a biological...

Showing 1 to 12 of 689 entries