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Systems Genetics Analysis of Genome-Wide Association Study Reveals Novel Associations Between Key Biological Processes and Coronary Artery Disease.

Arteriosclerosis, thrombosis, and vascular biology

Ghosh S, Vivar J, Nelson CP, Willenborg C, Segrè AV, Mäkinen VP, Nikpay M, Erdmann J, Blankenberg S, O'Donnell C, März W, Laaksonen R, Stewart AF, Epstein SE, Shah SH, Granger CB, Hazen SL, Kathiresan S, Reilly MP, Yang X, Quertermous T, Samani NJ, Schunkert H, Assimes TL, McPherson R.
PMID: 25977570
Arterioscler Thromb Vasc Biol. 2015 Jul;35(7):1712-22. doi: 10.1161/ATVBAHA.115.305513. Epub 2015 May 14.

OBJECTIVE: Genome-wide association studies have identified multiple genetic variants affecting the risk of coronary artery disease (CAD). However, individually these explain only a small fraction of the heritability of CAD and for most, the causal biological mechanisms remain unclear....

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Ghosh S, Vivar J, Nelson CP, et al. Systems Genetics Analysis of Genome-Wide Association Study Reveals Novel Associations Between Key Biological Processes and Coronary Artery Disease. Arterioscler Thromb Vasc Biol. 2015;35(7):1712-22doi: 10.1161/ATVBAHA.115.305513.
Ghosh, S., Vivar, J., Nelson, C. P., Willenborg, C., Segrè, A. V., Mäkinen, V. P., Nikpay, M., Erdmann, J., Blankenberg, S., O'Donnell, C., März, W., Laaksonen, R., Stewart, A. F., Epstein, S. E., Shah, S. H., Granger, C. B., Hazen, S. L., Kathiresan, S., Reilly, M. P., Yang, X., Quertermous, T., Samani, N. J., Schunkert, H., Assimes, T. L., & McPherson, R. (2015). Systems Genetics Analysis of Genome-Wide Association Study Reveals Novel Associations Between Key Biological Processes and Coronary Artery Disease. Arteriosclerosis, thrombosis, and vascular biology, 35(7), 1712-22. https://doi.org/10.1161/ATVBAHA.115.305513
Ghosh, Sujoy, et al. "Systems Genetics Analysis of Genome-Wide Association Study Reveals Novel Associations Between Key Biological Processes and Coronary Artery Disease." Arteriosclerosis, thrombosis, and vascular biology vol. 35,7 (2015): 1712-22. doi: https://doi.org/10.1161/ATVBAHA.115.305513
Ghosh S, Vivar J, Nelson CP, Willenborg C, Segrè AV, Mäkinen VP, Nikpay M, Erdmann J, Blankenberg S, O'Donnell C, März W, Laaksonen R, Stewart AF, Epstein SE, Shah SH, Granger CB, Hazen SL, Kathiresan S, Reilly MP, Yang X, Quertermous T, Samani NJ, Schunkert H, Assimes TL, McPherson R. Systems Genetics Analysis of Genome-Wide Association Study Reveals Novel Associations Between Key Biological Processes and Coronary Artery Disease. Arterioscler Thromb Vasc Biol. 2015 Jul;35(7):1712-22. doi: 10.1161/ATVBAHA.115.305513. Epub 2015 May 14. PMID: 25977570; PMCID: PMC4841833.
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Is Coronary Atherosclerosis One Disease or Many? Setting Realistic Expectations for Precision Medicine.

Circulation

Khera AV, Kathiresan S.
PMID: 28289003
Circulation. 2017 Mar 14;135(11):1005-1007. doi: 10.1161/CIRCULATIONAHA.116.026479.

No abstract available.

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Khera AV, Kathiresan S. Is Coronary Atherosclerosis One Disease or Many? Setting Realistic Expectations for Precision Medicine. Circulation. 2017;135(11):1005-1007doi: 10.1161/CIRCULATIONAHA.116.026479.
Khera, A. V., & Kathiresan, S. (2017). Is Coronary Atherosclerosis One Disease or Many? Setting Realistic Expectations for Precision Medicine. Circulation, 135(11), 1005-1007. https://doi.org/10.1161/CIRCULATIONAHA.116.026479
Khera, Amit V, and Kathiresan, Sekar. "Is Coronary Atherosclerosis One Disease or Many? Setting Realistic Expectations for Precision Medicine." Circulation vol. 135,11 (2017): 1005-1007. doi: https://doi.org/10.1161/CIRCULATIONAHA.116.026479
Khera AV, Kathiresan S. Is Coronary Atherosclerosis One Disease or Many? Setting Realistic Expectations for Precision Medicine. Circulation. 2017 Mar 14;135(11):1005-1007. doi: 10.1161/CIRCULATIONAHA.116.026479. PMID: 28289003; PMCID: PMC5395046.
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Metabolomics applications in coronary artery disease personalized medicine.

Advances in clinical chemistry

Amin AM.
PMID: 34044911
Adv Clin Chem. 2021;102:233-270. doi: 10.1016/bs.acc.2020.08.003. Epub 2020 Sep 24.

Coronary artery disease (CAD), the most common cardiovascular disease (CVD), contributes to significant mortality worldwide. CAD is a multifactorial disease wherein various factors contribute to its pathogenesis often complicating management. Biomarker based personalized medicine may provide a more effective...

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Amin AM. Metabolomics applications in coronary artery disease personalized medicine. Adv Clin Chem. 2020;102:233-270doi: 10.1016/bs.acc.2020.08.003.
Amin, A. M. (2021). Metabolomics applications in coronary artery disease personalized medicine. Advances in clinical chemistry, 102233-270. https://doi.org/10.1016/bs.acc.2020.08.003
Amin, Arwa M. "Metabolomics applications in coronary artery disease personalized medicine." Advances in clinical chemistry vol. 102 (2021): 233-270. doi: https://doi.org/10.1016/bs.acc.2020.08.003
Amin AM. Metabolomics applications in coronary artery disease personalized medicine. Adv Clin Chem. 2021;102:233-270. doi: 10.1016/bs.acc.2020.08.003. Epub 2020 Sep 24. PMID: 34044911.
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Association of chronic obstructive pulmonary disease with coronary artery disease.

Chinese medical journal

Liang BM, Xu ZB, Yi Q, Ou XM, Feng YL.
PMID: 24033937
Chin Med J (Engl). 2013;126(17):3205-8.

BACKGROUND: The relationship between chronic obstructive pulmonary disease (COPD) and coronary artery disease (CAD) remains largely unknown. This study aimed to explore the association of COPD with CAD, especially with multi-vessel disease (VD).METHODS: The data of 354 patients who...

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Liang BM, Xu ZB, Yi Q, et al. Association of chronic obstructive pulmonary disease with coronary artery disease. Chin Med J (Engl). 2013;126(17):3205-8
Liang, B. M., Xu, Z. B., Yi, Q., Ou, X. M., & Feng, Y. L. (2013). Association of chronic obstructive pulmonary disease with coronary artery disease. Chinese medical journal, 126(17), 3205-8.
Liang, Bin-Miao, et al. "Association of chronic obstructive pulmonary disease with coronary artery disease." Chinese medical journal vol. 126,17 (2013): 3205-8.
Liang BM, Xu ZB, Yi Q, Ou XM, Feng YL. Association of chronic obstructive pulmonary disease with coronary artery disease. Chin Med J (Engl). 2013;126(17):3205-8. PMID: 24033937.
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Microvascular (dys)Function in Stable Coronary Artery Disease: Cross Talk with Epicardial Segments.

Current pharmaceutical design

Calmac L, Bataila V, Dragoescu B, Mihai C, Scafa-Udriste A, Dorobantu M.
PMID: 29962337
Curr Pharm Des. 2018;24(25):2900-2905. doi: 10.2174/1381612824666180702113448.

Myocardial ischemia is the consequence of an unbalance between coronary flow that can be achieved and myocardial metabolic needs. Pathological state of both epicardial and intramyocardial vessels may be responsible for inducing ischemia. However, revascularization decision should be based...

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Calmac L, Bataila V, Dragoescu B, et al. Microvascular (dys)Function in Stable Coronary Artery Disease: Cross Talk with Epicardial Segments. Curr Pharm Des. 2018;24(25):2900-2905doi: 10.2174/1381612824666180702113448.
Calmac, L., Bataila, V., Dragoescu, B., Mihai, C., Scafa-Udriste, A., & Dorobantu, M. (2018). Microvascular (dys)Function in Stable Coronary Artery Disease: Cross Talk with Epicardial Segments. Current pharmaceutical design, 24(25), 2900-2905. https://doi.org/10.2174/1381612824666180702113448
Calmac, Lucian, et al. "Microvascular (dys)Function in Stable Coronary Artery Disease: Cross Talk with Epicardial Segments." Current pharmaceutical design vol. 24,25 (2018): 2900-2905. doi: https://doi.org/10.2174/1381612824666180702113448
Calmac L, Bataila V, Dragoescu B, Mihai C, Scafa-Udriste A, Dorobantu M. Microvascular (dys)Function in Stable Coronary Artery Disease: Cross Talk with Epicardial Segments. Curr Pharm Des. 2018;24(25):2900-2905. doi: 10.2174/1381612824666180702113448. PMID: 29962337.
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The insulin resistance syndrome and coronary artery disease.

Coronary artery disease

Kendall DM, Sobel BE, Coulston AM, Peters Harmel AL, McLean BK, Peragallo-Dittko V, Buse JB, Fonseca VA, Hill JO, Nesto RW, Sunyer FX.
PMID: 12826934
Coron Artery Dis. 2003 Jun;14(4):335-48. doi: 10.1097/01.mca.0000076512.29238.2a.

Insulin resistance is an increasingly common metabolic abnormality characterized by an impaired physiological response to insulin. The constellation of insulin resistance and several other metabolic and vascular disorders is known as the insulin resistance syndrome. The characteristic features of...

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Kendall DM, Sobel BE, Coulston AM, et al. The insulin resistance syndrome and coronary artery disease. Coron Artery Dis. 2003;14(4):335-48doi: 10.1097/01.mca.0000076512.29238.2a.
Kendall, D. M., Sobel, B. E., Coulston, A. M., Peters Harmel, A. L., McLean, B. K., Peragallo-Dittko, V., Buse, J. B., Fonseca, V. A., Hill, J. O., Nesto, R. W., Sunyer, F. X. (2003). The insulin resistance syndrome and coronary artery disease. Coronary artery disease, 14(4), 335-48. https://doi.org/10.1097/01.mca.0000076512.29238.2a
Kendall, David M, et al. "The insulin resistance syndrome and coronary artery disease." Coronary artery disease vol. 14,4 (2003): 335-48. doi: https://doi.org/10.1097/01.mca.0000076512.29238.2a
Kendall DM, Sobel BE, Coulston AM, Peters Harmel AL, McLean BK, Peragallo-Dittko V, Buse JB, Fonseca VA, Hill JO, Nesto RW, Sunyer FX. The insulin resistance syndrome and coronary artery disease. Coron Artery Dis. 2003 Jun;14(4):335-48. doi: 10.1097/01.mca.0000076512.29238.2a. PMID: 12826934.
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Gut Microbiota and Coronary Artery Disease.

International heart journal

Yamashita T, Emoto T, Sasaki N, Hirata KI.
PMID: 27818484
Int Heart J. 2016 Dec 02;57(6):663-671. doi: 10.1536/ihj.16-414. Epub 2016 Nov 04.

Gut microbiota have been attracting increased attention in many fields of medicine recently. We can perform a comprehensive analysis of gut microbiota using next-generation sequencing techniques together with bioinformatics technology, which expands our knowledge of a large ecosystem consisting...

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Yamashita T, Emoto T, Sasaki N, et al. Gut Microbiota and Coronary Artery Disease. Int Heart J. 2016;57(6):663-671doi: 10.1536/ihj.16-414.
Yamashita, T., Emoto, T., Sasaki, N., & Hirata, K. I. (2016). Gut Microbiota and Coronary Artery Disease. International heart journal, 57(6), 663-671. https://doi.org/10.1536/ihj.16-414
Yamashita, Tomoya, et al. "Gut Microbiota and Coronary Artery Disease." International heart journal vol. 57,6 (2016): 663-671. doi: https://doi.org/10.1536/ihj.16-414
Yamashita T, Emoto T, Sasaki N, Hirata KI. Gut Microbiota and Coronary Artery Disease. Int Heart J. 2016 Dec 02;57(6):663-671. doi: 10.1536/ihj.16-414. Epub 2016 Nov 04. PMID: 27818484.
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Showing 1 to 7 of 7 entries