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Showing 1 to 12 of 12 entries
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Evaluation of the DDSolver software applications.

BioMed research international

Zuo J, Gao Y, Bou-Chacra N, Löbenberg R.
PMID: 24877067
Biomed Res Int. 2014;2014:204925. doi: 10.1155/2014/204925. Epub 2014 Apr 27.

When a new oral dosage form is developed, its dissolution behavior must be quantitatively analyzed. Dissolution analysis involves a comparison of the dissolution profiles and the application of mathematical models to describe the drug release pattern. This report aims...

Advances in dissolution instrumentation and their practical applications.

Drug development and industrial pharmacy

Culen M, Dohnal J.
PMID: 24093430
Drug Dev Ind Pharm. 2014 Oct;40(10):1277-82. doi: 10.3109/03639045.2013.841184. Epub 2013 Oct 04.

The rising demands on discriminatory and prediction abilities of dissolution methods and the increasing complexity of new drug products are the main driving forces of the progress in this field. The research moves forward as imperfections and shortcomings of...

Open innovation: Towards sharing of data, models and workflows.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Conrado DJ, Karlsson MO, Romero K, Sarr C, Wilkins JJ.
PMID: 28684136
Eur J Pharm Sci. 2017 Nov 15;109:S65-S71. doi: 10.1016/j.ejps.2017.06.035. Epub 2017 Jul 04.

Sharing of resources across organisations to support open innovation is an old idea, but which is being taken up by the scientific community at increasing speed, concerning public sharing in particular. The ability to address new questions or provide...

Enhanced Analytic Approach for Describing pH Triggered Fast Drug Release Systems.

Current drug delivery

Elmas A, Akyuz G, Bergal A, Andac M, Andac O.
PMID: 33438539
Curr Drug Deliv. 2021;18(8):1130-1136. doi: 10.2174/1567201818999210112181853.

BACKGROUND: pH sensitive dendrimers attached to nanocarriers, as one of the drug release systems, have become quite popular due to their ease of manufacture in experimental conditions and the ability to generate fast drug release in the targeted area....

Enhanced Analytic Approach for Describing pH Triggered Fast Drug Release Systems.

Current drug delivery

Elmas A, Akyuz G, Bergal A, Andac M, Andac O.
PMID: 33438539
Curr Drug Deliv. 2021;18(8):1130-1136. doi: 10.2174/1567201818999210112181853.

BACKGROUND: pH sensitive dendrimers attached to nanocarriers, as one of the drug release systems, have become quite popular due to their ease of manufacture in experimental conditions and the ability to generate fast drug release in the targeted area....

Advancement in nanogel formulations provides controlled drug release.

International journal of pharmaceutics

Ahmed S, Alhareth K, Mignet N.
PMID: 32439585
Int J Pharm. 2020 Jun 30;584:119435. doi: 10.1016/j.ijpharm.2020.119435. Epub 2020 May 19.

Nanogels are currently considered as promising nanosized drug delivery carriers. Nanogels are made of a crosslinked polymeric network which could encapsulate both hydrophilic and hydrophobic drugs due to their tunable nature. The ability of nanogels to control drug release...

Comparison of Alternative Population Modeling Approaches for Implementing a Level A IVIVC and for Assessing the Time-Scaling Factor Using Deconvolution and Convolution-Based Methods.

The AAPS journal

Gomeni R, Bressolle-Gomeni F.
PMID: 32297044
AAPS J. 2020 Apr 15;22(3):67. doi: 10.1208/s12248-020-00445-0.

Different approaches based on deconvolution and convolution analyses have been proposed to establish IVIVC. A new implementation of the convolution-based model was used to evaluate the time-scaled IVIVC using the convolution (method 1) and the deconvolution-based (method 2) approaches....

Drug delivery systems for programmed and on-demand release.

Advanced drug delivery reviews

Davoodi P, Lee LY, Xu Q, Sunil V, Sun Y, Soh S, Wang CH.
PMID: 30415656
Adv Drug Deliv Rev. 2018 Jul;132:104-138. doi: 10.1016/j.addr.2018.07.002. Epub 2018 Jul 06.

With the advancement in medical science and understanding the importance of biodistribution and pharmacokinetics of therapeutic agents, modern drug delivery research strives to utilize novel materials and fabrication technologies for the preparation of robust drug delivery systems to combat...

Automated digital design for 3D-printed individualized therapies.

International journal of pharmaceutics

Eleftheriadis GK, Kantarelis E, Monou PK, Andriotis EG, Bouropoulos N, Tzimtzimis EK, Tzetzis D, Rantanen J, Fatouros DG.
PMID: 33662466
Int J Pharm. 2021 Apr 15;599:120437. doi: 10.1016/j.ijpharm.2021.120437. Epub 2021 Mar 01.

Customization of pharmaceutical products is a central requirement for personalized medicines. However, the existing processing and supply chain solutions do not support such manufacturing-on-demand approaches. In order to solve this challenge, three-dimensional (3D) printing has been applied for customization...

Analysis of Drug Release Dynamics of the Reservoir-type Dry Powder Inhalers.

The Tokai journal of experimental and clinical medicine

Tajiri S, Kondo T, Tanigaki T, Asano K, Hibino M, Horiuchi S, Kobayashi I, Nishiya K.
PMID: 32901895
Tokai J Exp Clin Med. 2020 Sep 20;45(3):102-107.

OBJECTIVE: Dry powder inhalers (DPIs) are classified as capsule, blister, and reservoir types. Currently, two reservoir-type DPIs, i.e., TurbuhalerMETHODS: An inhalation f low simulator was set to reach peak inhalation f low (PIF) at two time points, 0.4 s...

Catalogue of self-targeting nano-medical inventions to accelerate clinical trials.

Biomaterials science

Alsudir SA, Almalik A, Alhasan AH.
PMID: 33912874
Biomater Sci. 2021 Jun 04;9(11):3898-3910. doi: 10.1039/d1bm00235j.

Repetitive outbreaks and prolonged epidemics represent mortal threats to global health, creating chaos in our globalized world. To date, scientists have been compelled to follow FDA guidelines for conventional clinical trials, which decelerates the release of effective therapies to...

Magnetic resonance imaging of high-intensity focused ultrasound-stimulated drug release from a self-reporting core@shell nanoparticle platform.

Chemical communications (Cambridge, England)

Cheng CA, Chen W, Zhang L, Wu HH, Zink JI.
PMID: 32756711
Chem Commun (Camb). 2020 Sep 14;56(71):10297-10300. doi: 10.1039/d0cc03179h. Epub 2020 Aug 05.

We developed a theranostic approach exemplifying a concept called an "exchange method" that controls and "images" drug release from nanoparticles using magnetic resonance imaging-guided high-intensity focused ultrasound. The controllable amount of released drug and therapeutic efficacy can be self-reported...

Showing 1 to 12 of 12 entries