Drug Dev Ind Pharm. 2014 Oct;40(10):1277-82. doi: 10.3109/03639045.2013.841184. Epub 2013 Oct 04.

Advances in dissolution instrumentation and their practical applications.

Drug development and industrial pharmacy

Martin Culen, Jiri Dohnal

PMID: 24093430 DOI: 10.3109/03639045.2013.841184

Abstract

The rising demands on discriminatory and prediction abilities of dissolution methods and the increasing complexity of new drug products are the main driving forces of the progress in this field. The research moves forward as imperfections and shortcomings of classical methods are being described, and where the capabilities of the contemporary methods are insufficient, new methods are being developed. The review discusses these advances with respect to the issues that currently draw the most attention, i.e. correct simulation of hydrodynamics and stress forces, maintenance of sink conditions, study of precipitation, use of biorelevant media and the employment of more physiologically relevant methods in general.

Keywords: Apparatus; biorelevant; dissolution; precipitation; sink conditions

Substances

• Pharmaceutical Preparations

MeSH terms

• Chemistry, Pharmaceutical / instrumentation
• Chemistry, Pharmaceutical / methods
• Drug Design*
• Drug Liberation
• Humans
• Hydrodynamics
• Pharmaceutical Preparations / chemistry

Publication Types

• Journal Article
• Research Support, Non-U.S. Gov't
• Review