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Showing 1 to 8 of 8 entries
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Emerging roles of microRNA-22 in human disease and normal physiology.

Current molecular medicine

Xiong J.
PMID: 22300138
Curr Mol Med. 2012 Mar;12(3):247-58. doi: 10.2174/156652412799218886.

MicroRNAs (miRNAs) are an abundant class of small noncoding RNAs that have critical regulatory functions in various biological processes. MicroRNA-22 (miR-22) is a highly-conserved 22-nt miRNA, whose roles in human diseases and normal physiology are just beginning to emerge....

Gene correction in human embryonic and induced pluripotent stem cells: promises and challenges ahead.

Molecular therapy : the journal of the American Society of Gene Therapy

Narsinh KH, Wu JC.
PMID: 20514030
Mol Ther. 2010 Jun;18(6):1061-3. doi: 10.1038/mt.2010.92.

No abstract available.

An audience with Ruth McKernan.

Nature reviews. Drug discovery

McKernan R.
PMID: 19247301
Nat Rev Drug Discov. 2009 Mar;8(3):188. doi: 10.1038/nrd2842.

No abstract available.

The proteomes of native and induced pluripotent stem cells.

Nature methods

Pera MF.
PMID: 21959134
Nat Methods. 2011 Sep 29;8(10):807-8. doi: 10.1038/nmeth.1707.

No abstract available.

Array-comparative genomic hybridization characterization of human pluripotent stem cells.

Methods in molecular biology (Clifton, N.J.)

Elliott AM, Elliott KA, Kammesheidt A.
PMID: 22528361
Methods Mol Biol. 2012;873:261-7. doi: 10.1007/978-1-61779-794-1_17.

During culture adaptation, human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) tend to acquire chromosomal aberrations. Generally, stem cell lines are screened for large-scale chromosomal changes using low resolution karyotype analysis. Recent studies characterizing human stem...

Proteomics of human embryonic stem cells.

Proteomics

Hughes CS, Nuhn AA, Postovit LM, Lajoie GA.
PMID: 21225999
Proteomics. 2011 Feb;11(4):675-90. doi: 10.1002/pmic.201000407. Epub 2011 Jan 11.

Human embryonic stem cells (hESCs) offer exciting potential in regenerative medicine for the treatment of a host of diseases including cancer, Alzheimer's and Parkinson's disease. They also provide insight into human development and disease and can be used as...

The Janus face of pluripotent stem cells--connection between pluripotency and tumourigenicity.

BioEssays : news and reviews in molecular, cellular and developmental biology

Wobus AM.
PMID: 21105293
Bioessays. 2010 Nov;32(11):993-1002. doi: 10.1002/bies.201000065.

Pluripotent stem cells have gained special attraction because of their almost unlimited proliferation and differentiation capacity in vitro. These properties substantiate the potential of pluripotent stem cells in basic research and regenerative medicine. Here three types of in vitro...

Proteomic and phosphoproteomic comparison of human ES and iPS cells.

Nature methods

Phanstiel DH, Brumbaugh J, Wenger CD, Tian S, Probasco MD, Bailey DJ, Swaney DL, Tervo MA, Bolin JM, Ruotti V, Stewart R, Thomson JA, Coon JJ.
PMID: 21983960
Nat Methods. 2011 Sep 11;8(10):821-7. doi: 10.1038/nmeth.1699.

Combining high-mass-accuracy mass spectrometry, isobaric tagging and software for multiplexed, large-scale protein quantification, we report deep proteomic coverage of four human embryonic stem cell and four induced pluripotent stem cell lines in biological triplicate. This 24-sample comparison resulted in...

Showing 1 to 8 of 8 entries