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Rapid method of obtaining area under curve for any compartment of any linear pharmacokinetic model in terms of rate constants.

Journal of pharmacokinetics and biopharmaceutics

Wagner JG.
PMID: 978393
J Pharmacokinet Biopharm. 1976 Jun;4(3):281-5. doi: 10.1007/BF01063618.

No abstract available.

[Drugs and the culturing of hepatocytes].

Bulletin de l'Academie nationale de medecine

Bourel M, Guillouzo A, Guguen-Guillouzo C.
PMID: 2790528
Bull Acad Natl Med. 1989 Apr;173(4):409-12; discussion 412-4.

Two model systems are described for studying isolated hepatocytes in vitro: pure culture for short-term designs and co-culture with epithelial rat liver cells (for long duration procedures). Acute or chronic liver toxicities are discussed as well as indirect toxicities....

Curve fitting and modeling in pharmacokinetics.

Journal of pharmacokinetics and biopharmaceutics

Muir KT, Riegelman S.
PMID: 529031
J Pharmacokinet Biopharm. 1979 Dec;7(6):685-7. doi: 10.1007/BF01061216.

No abstract available.

Estimation of kinetic parameters from a two-point determination of the drug cumulation factor.

Clinical pharmacology and therapeutics

Bjornsson TD, Shand DG.
PMID: 498694
Clin Pharmacol Ther. 1979 Nov;26(5):540-7. doi: 10.1002/cpt1979265540.

A method is described which allows the calculation of kinetic parameters of drugs from two data points, involving a set of simple algebraic equations. This method is based on cumulation characteristics of drugs during multiple dosing. The necessary two...

[Significance of pharmacokinetics for the therapeutic practice].

Casopis lekaru ceskych

[No authors listed]
PMID: 427870
Cas Lek Cesk. 1979 Jan 26;118(4):126-7.

No abstract available.

Model-independent definition of the initial volume of distribution of drugs in the body.

International journal of clinical pharmacology, therapy, and toxicology

Piotrovskii VK.
PMID: 3759276
Int J Clin Pharmacol Ther Toxicol. 1986 Aug;24(8):403-7.

Model-independent definition of the initial volume of distribution of drugs in the body as a limit of the ratio of the drug content in the body to its blood concentration with time from the start of drug administration tending...

Data analysis problems in the area of pharmacokinetics research.


Shah BK.
PMID: 1276365
Biometrics. 1976 Mar;32(1):145-57.

Of interest in compartment analysis is the estimation of kinetic first order rate constants and quantification of the amount of drug present in each compartment at every point in time. From the data pertaining to only one compartment, it...

[A multiple iteration program for determining global pharmacokinetic constants on a digital computer (author's transl)].


Lücker PW.
PMID: 580758
Arzneimittelforschung. 1978;28(3):471-2.

A program for determining pharmacokinetic constants on the basis of multiple iterations is described. After obtaining values for tmax, cmax and kel by means of graphs, the program calculates all important constants as well as the Bateman function between...

[Iteration program for determining pharmacokinetic constants with a digital computer (author's transl)].


Lücker PW.
PMID: 580053
Arzneimittelforschung. 1977;27(12):2371-2.

An iteration program is reported by which it will be possible to determine the constants k1 and y0 by the graphical constants tmax and k2. The program is designed for the desk-calculator HP 97. It makes a relatively exact...

Programmable solution for the Michaelis-Menten equation.

Drug intelligence & clinical pharmacy

Collier PS.
PMID: 6688219
Drug Intell Clin Pharm. 1983 Jul-Aug;17(7):559-60. doi: 10.1177/106002808301700720.

No abstract available.

Kinetics of pharmacologic effects.

Clinical pharmacology and therapeutics

Levy G.
PMID: 5937003
Clin Pharmacol Ther. 1966 May-Jun;7(3):362-72. doi: 10.1002/cpt196673362.

No abstract available.

Symbols in pharmacokinetics.

Journal of pharmacokinetics and biopharmaceutics

Rowland M, Tucker G.
PMID: 7252793
J Pharmacokinet Biopharm. 1980 Oct;8(5):497-507. doi: 10.1007/BF01059548.

To encourage uniformity in the presentation of pharmacokinetic data, a general nomenclature has been developed. The system has wide application. Flexibility is achieved through the use of general variables, constants, qualifying terms, and subscripts. Yet, through the use of...

Showing 1 to 12 of 79 entries