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Lacey L, Dunne A. The design of pharmacokinetic experiments for model discrimination. J Pharmacokinet Biopharm. 1984;12(3):351-65doi: 10.1007/BF01061725.
Lacey, L., & Dunne, A. (1984). The design of pharmacokinetic experiments for model discrimination. Journal of pharmacokinetics and biopharmaceutics, 12(3), 351-65. https://doi.org/10.1007/BF01061725
Lacey, L, and Dunne, A. "The design of pharmacokinetic experiments for model discrimination." Journal of pharmacokinetics and biopharmaceutics vol. 12,3 (1984): 351-65. doi: https://doi.org/10.1007/BF01061725
Lacey L, Dunne A. The design of pharmacokinetic experiments for model discrimination. J Pharmacokinet Biopharm. 1984 Jun;12(3):351-65. doi: 10.1007/BF01061725. PMID: 6502475.
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J Pharmacokinet Biopharm. 1984 Jun;12(3):351-65. doi: 10.1007/BF01061725.

The design of pharmacokinetic experiments for model discrimination.

Journal of pharmacokinetics and biopharmaceutics

L Lacey, A Dunne

PMID: 6502475 DOI: 10.1007/BF01061725

Abstract

The need for objective design of pharmacokinetic experiments aimed at model discrimination is argued. A sequential design strategy based on information theory is outlined. The characteristics of this strategy and its applicability to pharmacokinetic experiments is examined by means of computer simulated experiments. The limitation of the technique are discussed and alternative approaches outlined.

References

  1. J Pharmacokinet Biopharm. 1978 Apr;6(2):165-75 - PubMed

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